Publications by authors named "John Hilkens"

18Publications

Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells.

Cell Death Differ 2017 11 21;24(11):1937-1947. Epub 2017 Jul 21.

Gastroenterology Unit, Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK.

View Article and Find Full Text PDF
November 2017

Insulin receptor substrate 4 (IRS4) is a constitutive active oncogenic driver collaborating with HER2 and causing therapeutic resistance.

Mol Cell Oncol 2017 17;4(2):e1279722. Epub 2017 Jan 17.

Division of Molecular Genetics, The Netherlands Cancer Institute , Amsterdam, the Netherlands.

View Article and Find Full Text PDF
January 2017

IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation.

Nat Commun 2016 11 23;7:13567. Epub 2016 Nov 23.

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, CX 1066 Amsterdam, The Netherlands.

View Article and Find Full Text PDF
November 2016

RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.

Gut 2017 06 10;66(6):1095-1105. Epub 2016 Aug 10.

Department of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
June 2017

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

PLoS One 2013 14;8(5):e62113. Epub 2013 May 14.

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands ; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
December 2013

Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis.

Mol Cancer 2010 Jun 18;9:154. Epub 2010 Jun 18.

Gastroenterology Research Unit, School of Clinical Sciences, Centre for Glycobiology, University of Liverpool, Liverpool L69 3GE, UK.

View Article and Find Full Text PDF
June 2010

AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression.

Int J Oncol 2009 Oct;35(4):693-9

Department of Chemistry, Laboratory of Biochemical and Biomedical Research, New Mexico Tech, Socorro, NM 87801, USA.

View Article and Find Full Text PDF
October 2009

Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface.

Cancer Res 2009 Sep 18;69(17):6799-806. Epub 2009 Aug 18.

Gastroenterology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom.

View Article and Find Full Text PDF
September 2009

MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.

Nat Genet 2007 Jun 29;39(6):759-69. Epub 2007 Apr 29.

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

View Article and Find Full Text PDF
June 2007

Recent translational research: oncogene discovery by insertional mutagenesis gets a new boost.

Authors:
John Hilkens

Breast Cancer Res 2006 16;8(1):102. Epub 2006 Jan 16.

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
March 2006

Tumor-host interactions regulate glucocorticoid-mediated epiglycanin expression in TA3Ha murine mammary carcinoma cells.

Tumour Biol 2003 May-Jun;24(3):116-29

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
December 2003