Publications by authors named "John Hilkens"

18Publications

Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance.

Authors:
Gerjon J Ikink Mandy Boer Elvira R M Bakker Annabel Vendel-Zwaagstra Chris Klijn Jelle Ten Hoeve Jos Jonkers Lodewyk F Wessels John Hilkens

Oncogene 2018 03 12;37(12):1594-1609. Epub 2018 Jan 12.

Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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March 2018

Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells.

Authors:
Tushar Piyush Anisha R Chacko Paulina Sindrewicz John Hilkens Jonathan M Rhodes Lu-Gang Yu

Cell Death Differ 2017 11 21;24(11):1937-1947. Epub 2017 Jul 21.

Gastroenterology Unit, Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK.

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November 2017

Insulin receptor substrate 4 (IRS4) is a constitutive active oncogenic driver collaborating with HER2 and causing therapeutic resistance.

Authors:
Gerjon J Ikink John Hilkens

Mol Cell Oncol 2017 17;4(2):e1279722. Epub 2017 Jan 17.

Division of Molecular Genetics, The Netherlands Cancer Institute , Amsterdam, the Netherlands.

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January 2017

IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation.

Authors:
Gerjon J Ikink Mandy Boer Elvira R M Bakker John Hilkens

Nat Commun 2016 11 23;7:13567. Epub 2016 Nov 23.

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, CX 1066 Amsterdam, The Netherlands.

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November 2016

MUC1-ARF-A Novel MUC1 Protein That Resides in the Nucleus and Is Expressed by Alternate Reading Frame Translation of MUC1 mRNA.

Authors:
Michael Chalick Oded Jacobi Edward Pichinuk Christian Garbar Armand Bensussan Alan Meeker Ravit Ziv Tania Zehavi Nechama I Smorodinsky John Hilkens Franz-Georg Hanisch Daniel B Rubinstein Daniel H Wreschner

PLoS One 2016 21;11(10):e0165031. Epub 2016 Oct 21.

Department of Cell Research and Immunology, Tel Aviv University, Ramat Aviv, Israel.

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June 2017

RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.

Authors:
John Hilkens Nikki C Timmer Mandy Boer Gerjon J Ikink Matthias Schewe Andrea Sacchetti Martijn A J Koppens Ji-Ying Song Elvira R M Bakker

Gut 2017 06 10;66(6):1095-1105. Epub 2016 Aug 10.

Department of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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June 2017

Chromatin landscapes of retroviral and transposon integration profiles.

Authors:
Johann de Jong Waseem Akhtar Jitendra Badhai Alistair G Rust Roland Rad John Hilkens Anton Berns Maarten van Lohuizen Lodewyk F A Wessels Jeroen de Ridder

PLoS Genet 2014 Apr 10;10(4):e1004250. Epub 2014 Apr 10.

Delft Bioinformatics Lab, Faculty of EEMCS, TU Delft, Delft, The Netherlands.

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April 2014

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

Authors:
Christiaan Klijn Marco J Koudijs Jaap Kool Jelle ten Hoeve Mandy Boer Joost de Moes Waseem Akhtar Martine van Miltenburg Annabel Vendel-Zwaagstra Marcel J T Reinders David J Adams Maarten van Lohuizen John Hilkens Lodewyk F A Wessels Jos Jonkers

PLoS One 2013 14;8(5):e62113. Epub 2013 May 14.

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands ; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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December 2013

Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis.

Authors:
Qicheng Zhao Monica Barclay John Hilkens Xiuli Guo Hannah Barrow Jonathan M Rhodes Lu-Gang Yu

Mol Cancer 2010 Jun 18;9:154. Epub 2010 Jun 18.

Gastroenterology Research Unit, School of Clinical Sciences, Centre for Glycobiology, University of Liverpool, Liverpool L69 3GE, UK.

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June 2010

AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression.

Authors:
Severine Van Slambrouck John Hilkens Marco Bisoffi Wim F A Steelant

Int J Oncol 2009 Oct;35(4):693-9

Department of Chemistry, Laboratory of Biochemical and Biomedical Research, New Mexico Tech, Socorro, NM 87801, USA.

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October 2009

Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface.

Authors:
Qicheng Zhao Xiuli Guo Gerard B Nash Philip C Stone John Hilkens Jonathan M Rhodes Lu-Gang Yu

Cancer Res 2009 Sep 18;69(17):6799-806. Epub 2009 Aug 18.

Gastroenterology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom.

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September 2009

Ether lipid 1-O-octadecyl-2-O-methyl-3-glycero-phosphocholine inhibits cell-cell adhesion through translocation and clustering of E-cadherin and episialin in membrane microdomains.

Authors:
Severine Van Slambrouck John Hilkens Wim F A Steelant

Oncol Rep 2008 Jan;19(1):123-8

Laboratory of Biochemical and Biomedical Research, Department of Chemistry, New Mexico Tech, Socorro, NM 87801, USA.

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January 2008

MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.

Authors:
Vassiliki Theodorou Melanie A Kimm Mandy Boer Lodewyk Wessels Wendy Theelen Jos Jonkers John Hilkens

Nat Genet 2007 Jun 29;39(6):759-69. Epub 2007 Apr 29.

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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June 2007

Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion.

Authors:
Lu-Gang Yu Nigel Andrews Qicheng Zhao Daniel McKean Jennifer F Williams Lucy J Connor Oleg V Gerasimenko John Hilkens Jun Hirabayashi Kenichi Kasai Jonathan M Rhodes

J Biol Chem 2007 Jan 7;282(1):773-81. Epub 2006 Nov 7.

Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, School of Clinical Science, University of Liverpool, UK.

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January 2007

Recent translational research: oncogene discovery by insertional mutagenesis gets a new boost.

Authors:
John Hilkens

Breast Cancer Res 2006 16;8(1):102. Epub 2006 Jan 16.

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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March 2006

Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas.

Authors:
Vassiliki Theodorou Mandy Boer Britta Weigelt Jos Jonkers Martin van der Valk John Hilkens

Oncogene 2004 Aug;23(36):6047-55

Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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August 2004

Tumor-host interactions regulate glucocorticoid-mediated epiglycanin expression in TA3Ha murine mammary carcinoma cells.

Authors:
Torunn Thingstad John Hilkens

Tumour Biol 2003 May-Jun;24(3):116-29

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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December 2003

Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis.

Authors:
Lynne E Vinall Marie King Marco Novelli Carole A Green Geoff Daniels John Hilkens Martin Sarner Dallas M Swallow

Gastroenterology 2002 Jul;123(1):41-9

Galton Laboratory, Department of Biology, University College London, London, England.

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July 2002