John Heymach

John Heymach

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John Heymach

John Heymach

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miR-125a-5p Functions as Tumor Suppressor microRNA And Is a Marker of Locoregional Recurrence And Poor prognosis in Head And Neck Cancer.

Neoplasia 2019 Sep 18;21(9):849-862. Epub 2019 Jul 18.

Department of Radiation Oncology, Division of Molecular Radiation Biology, UT Southwestern Medical Center, Dallas, TX 75390. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2019.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642270PMC
September 2019

Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy.

Nat Rev Cancer 2019 Sep 12;19(9):495-509. Epub 2019 Aug 12.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41568-019-0179-8DOI Listing
September 2019

Correction: LCE: an open web portal to explore gene expression and clinical associations in lung cancer.

Oncogene 2019 Sep 9. Epub 2019 Sep 9.

Quantitative Biomedical Research Center, Department of Clinical Sciences, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41388-019-1000-6DOI Listing
September 2019

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.

Mol Cell 2019 Sep 24. Epub 2019 Sep 24.

Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.08.028DOI Listing
September 2019

Improved Overall Survival With Comprehensive Local Consolidative Therapy in Synchronous Oligometastatic Non-Small-Cell Lung Cancer.

Clin Lung Cancer 2019 Aug 1. Epub 2019 Aug 1.

Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2019.07.007DOI Listing
August 2019

Impact of Corticosteroid Administration on Outcomes Following Stereotactic Ablative Radiotherapy for Non-small-cell Lung Cancer.

Clin Lung Cancer 2019 Jul 15;20(4):e480-e488. Epub 2019 Mar 15.

Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2019.03.001DOI Listing
July 2019

LCE: an open web portal to explore gene expression and clinical associations in lung cancer.

Oncogene 2019 04 7;38(14):2551-2564. Epub 2018 Dec 7.

Quantitative Biomedical Research Center, Department of Clinical Sciences, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41388-018-0588-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477796PMC
April 2019

Targeting angiogenesis for patients with unresectable malignant pleural mesothelioma.

Semin Oncol 2019 Apr 18;46(2):145-154. Epub 2019 Jun 18.

Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2019.06.001DOI Listing
April 2019

Stereotactic ablative body radiation for oligometastatic and oligoprogressive disease.

Transl Lung Cancer Res 2019 Feb;8(1):97-106

Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.21037/tlcr.2018.09.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351406PMC
February 2019

Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers.

Clin Cancer Res 2019 01 26;25(1):346-357. Epub 2018 Sep 26.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320267PMC
January 2019

Advanced Non-Small Cell Lung Cancer: Sequencing Agents in the EGFR-Mutated/ALK-Rearranged Populations.

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:e187-e197. Epub 2019 May 17.

4 Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1200/EDBK_237821DOI Listing
January 2019

Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer.

J Transl Med 2018 11 26;16(1):328. Epub 2018 Nov 26.

Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s12967-018-1704-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260563PMC
November 2018

Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer.

J Clin Oncol 2018 08 15;36(23):2386-2394. Epub 2018 Jun 15.

M. Catherine Pietanza, Lee M. Krug, Mark G. Kris, and Charles M. Rudin, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College; Kaitlin M. Woo, Yevgeniva Bensman, Brenda Hurtado, and Martin Fleisher, Memorial Sloan Kettering Cancer Center, New York, NY; Saiama N. Waqar, Washington University School of Medicine in St. Louis, St Louis, MO; Afshin Dowlati, Case Western Reserve University and University Hospitals Seidman Cancer Center, Cleveland, OH; Christine L. Hann, Johns Hopkins University, Baltimore; Alice Chen, National Institutes of Health, Bethesda, MD; Alberto Chiappori, H. Lee Moffitt Cancer Center, Tampa, FL; Taofeek K. Owonikoko, Emory University, Atlanta, GA; and Robert J. Cardnell, Junya Fujimoto, Lihong Long, Lixia Diao, Jing Wang, Patricia de Groot, Erik P. Sulman, Ignacio I. Wistuba, John V. Heymach, and Lauren Averett Byers, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2018.77.7672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085179PMC
August 2018

Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models.

Oncogene 2018 07 6;37(27):3686-3697. Epub 2018 Apr 6.

Thoracic Head and Neck Medical Oncology, UT MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41388-018-0187-2DOI Listing
July 2018

Mutations and PD-1 Inhibitor Resistance in -Mutant Lung Adenocarcinoma.

Cancer Discov 2018 07 17;8(7):822-835. Epub 2018 May 17.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030433PMC
July 2018

Bayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer.

J Clin Oncol 2018 06 2;36(18):1813-1822. Epub 2018 Jan 2.

Zhongxing Liao, J. Jack Lee, Ritsuko Komaki, Daniel R. Gomez, Michael S. O'Reilly, Frank V. Fossella, George R. Blumenschein Jr, John V. Heymach, Ara A. Vaporciyan, Stephen G. Swisher, Pamela K. Allen, Stephen M. Hahn, James D. Cox, Charles S. Lu, and Radhe Mohan, The University of Texas MD Anderson Cancer Center, Houston, TX; and Noah Chan Choi and Thomas F. DeLaney, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://ascopubs.org/doi/10.1200/JCO.2017.74.0720
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http://dx.doi.org/10.1200/JCO.2017.74.0720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008104PMC
June 2018

Prognostic Value of PD-L1 mRNA Sequencing Expression Profile in Non-Small Cell Lung Cancer.

Ann Thorac Surg 2018 06 3;105(6):1621-1626. Epub 2018 Mar 3.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1016/j.athoracsur.2018.01.081DOI Listing
June 2018

Immunohistochemical and Image Analysis-Based Study Shows That Several Immune Checkpoints are Co-expressed in Non-Small Cell Lung Carcinoma Tumors.

J Thorac Oncol 2018 06 8;13(6):779-791. Epub 2018 Mar 8.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.03.002DOI Listing
June 2018

Clinical Cancer Advances 2018: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology.

J Clin Oncol 2018 04 30;36(10):1020-1044. Epub 2018 Jan 30.

John Heymach, Maura L. Gillison, and Shannon Neville Westin, The University of Texas MD Anderson Cancer Center, Houston, TX; Lada Krilov and Richard L. Schilsky, American Society of Clinical Oncology, Alexandria; Robert Dreicer, University of Virginia School of Medicine, Charlottesville, VA; Anthony Alberg, Medical University of South Carolina, Charleston, SC; Nancy Baxter, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Susan Marina Chang and Andrew H. Ko, University of California, San Francisco; William Dale, City of Hope National Medical Center, Duarte, CA; Ryan Corcoran, Massachusetts General Hospital; Harold Burstein, Dana-Farber Cancer Institute, Boston, MA; Angela DeMichele and Joshua Jones, University of Pennsylvania, Philadelphia, PA; Catherine S. Magid Diefenbach, University of New York; Andrew S. Epstein, Memorial Sloan Kettering Cancer Center, New York; Robert G. Maki, Hofstra-Northwell School of Medicine, Hempstead, NY; David L. Graham, Carolinas Medical Center, Charlotte, NC; Ana Maria Lopez, University of Utah, Salt Lake City, UT; Carlos Rodriguez-Galindo, St Jude Children's Research Hospital, Memphis, TN; and Mario Sznol, Yale University, New Haven, CT.

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http://dx.doi.org/10.1200/JCO.2017.77.0446DOI Listing
April 2018

BAP1 Is a Novel Target in HPV-Negative Head and Neck Cancer.

Clin Cancer Res 2018 02 7;24(3):600-607. Epub 2017 Nov 7.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1573DOI Listing
February 2018

Induction Cisplatin Docetaxel Followed by Surgery and Erlotinib in Non-Small Cell Lung Cancer.

Ann Thorac Surg 2018 Feb 6;105(2):418-424. Epub 2017 Dec 6.

Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2017.08.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783769PMC
February 2018

Biomarker-Integrated Neoadjuvant Dasatinib Trial in Resectable Malignant Pleural Mesothelioma.

J Thorac Oncol 2018 02 5;13(2):246-257. Epub 2017 Dec 5.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1016/j.jtho.2017.10.033DOI Listing
February 2018

RAD50 Expression Is Associated with Poor Clinical Outcomes after Radiotherapy for Resected Non-small Cell Lung Cancer.

Clin Cancer Res 2018 01 13;24(2):341-350. Epub 2017 Oct 13.

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1455DOI Listing
January 2018

PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.

Cancer Prev Res (Phila) 2017 Dec 10;10(12):684-693. Epub 2017 Oct 10.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://cancerpreventionresearch.aacrjournals.org/lookup/doi/
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http://dx.doi.org/10.1158/1940-6207.CAPR-17-0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716880PMC
December 2017

Circulating metabolite profiles to predict overall survival in advanced non-small cell lung cancer patients receiving first-line chemotherapy.

Lung Cancer 2017 12 2;114:70-78. Epub 2017 Nov 2.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1016/j.lungcan.2017.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715727PMC
December 2017

Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer.

Clin Cancer Res 2017 Oct 11;23(20):6239-6253. Epub 2017 Jul 11.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882197PMC
October 2017

Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer.

J Am Soc Mass Spectrom 2017 10 27;28(10):2078-2089. Epub 2017 Jul 27.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1007/s13361-017-1706-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693617PMC
October 2017

Taking it up a NOTCH: a novel subgroup of ACC is identified.

Oncotarget 2017 Oct 14;8(47):81725-81726. Epub 2017 Sep 14.

Renata Ferrarotto: Thoracic and Head and Neck Medical Oncology Department, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.20879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669839PMC
October 2017

Response rates to single-agent chemotherapy after exposure to immune checkpoint inhibitors in advanced non-small cell lung cancer.

Lung Cancer 2017 10 3;112:90-95. Epub 2017 Aug 3.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 432, Houston, TX, 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.07.034DOI Listing
October 2017

The Influence of Body Mass Index on Overall Survival Following Surgical Resection of Non-Small Cell Lung Cancer.

J Thorac Oncol 2017 08 25;12(8):1280-1287. Epub 2017 May 25.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2017.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532070PMC
August 2017

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.

Cell Rep 2017 05;19(8):1669-1684

Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531293PMC
May 2017

Clinical Cancer Advances 2017: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology.

J Clin Oncol 2017 04 1;35(12):1341-1367. Epub 2017 Feb 1.

Harold J. Burstein and Steven G. DuBois, Dana-Farber Cancer Institute; Rebecca A. Miksad and Nadine Tung, Beth Israel Deaconess Medical Center; Lori J. Wirth and Don S. Dizon, Massachusetts General Hospital, Boston, MA; Lada Krilov and Richard L. Schilsky, American Society of Clinical Oncology, Alexandria; Jeanny B. Aragon-Ching, Inova Schar Cancer Institute, Fairfax, VA; E. Gabriela Chiorean, University of Washington, Seattle, WA; Warren Allen Chow, City of Hope, Duarte, CA; John Frederick De Groot and John Heymach, University of Texas MD Anderson Cancer Center, Houston, TX; Steven Michael Devine, Ohio State University, Columbus; Nathan A. Pennell, Cleveland Clinic, Cleveland, OH; Wafik S. El-Deiry, Fox Chase Cancer Center; Joshua Adam Jones, University of Pennsylvania Health Systems; Lynn Mara Schuchter, University of Pennsylvania, Philadelphia, PA; Andrew S. Epstein, Memorial Sloan Kettering Cancer Center, New York, NY; Deborah K. Mayer, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill; Karen Marie Winkfield, Wake Forest Baptist Medical Center, Winston-Salem, NC; Michael S. Sabel, University of Michigan, Ann Arbor, MI; and Nancy N. Baxter, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2016.71.5292DOI Listing
April 2017

Analysis of Factors Affecting Successful Clinical Trial Enrollment in the Context of Three Prospective, Randomized, Controlled Trials.

Int J Radiat Oncol Biol Phys 2017 03 27;97(4):770-777. Epub 2016 Nov 27.

Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2016.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901977PMC
March 2017

Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays.

Cancer Cell 2017 02;31(2):225-239

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501076PMC
February 2017

Consolidative local therapy in oligometastatic patients - Authors' reply.

Lancet Oncol 2017 02;18(2):e62

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1016/S1470-2045(17)30028-1DOI Listing
February 2017

Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors.

J Clin Oncol 2017 Jan 21;35(3):352-360. Epub 2016 Nov 21.

Renata Ferrarotto, Yoshitsugu Mitani, Lixia Diao, Irene Guijarro, Jing Wang, Patrick Zweidler-McKay, Diana Bell, William N. William Jr, Bonnie S. Glisson, J. Jack Lee, Andrew Futreal, Adel K. El-Naggar, and John V. Heymach, University of Texas MD Anderson Cancer Center, Houston; Michael J. Wick and Amita Patnaik, South Texas Accelerated Research Therapeutics, San Antonio, TX; Ann M. Kapoun, Leonardo Faoro, and Jakob Dupont, OncoMed Pharmaceuticals, Redwood City; Pamela Munster, University of California San Francisco, San Francisco, CA; and Gail Eckhardt, University of Colorado Denver School of Medicine, Denver, CO.

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http://dx.doi.org/10.1200/JCO.2016.67.5264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456373PMC
January 2017