John H Krystal

John H Krystal

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John H Krystal

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Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study.

J Psychiatr Res 2019 Dec 12;119:23-31. Epub 2019 Sep 12.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2019.09.005DOI Listing
December 2019

Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study.

J Psychiatr Res 2019 Dec 12;119:23-31. Epub 2019 Sep 12.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2019.09.005DOI Listing
December 2019

The Association of Impulsivity and Family History of Alcohol Use Disorder on Alcohol Use and Consequences.

Alcohol Clin Exp Res 2019 Nov 6. Epub 2019 Nov 6.

Yale School of Medicine, Department of Psychiatry, New Haven, CT, 06511, United States.

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http://dx.doi.org/10.1111/acer.14230DOI Listing
November 2019

Measuring the effects of ketamine on mGluR5 using [F]FPEB and PET.

J Cereb Blood Flow Metab 2019 Nov 19:271678X19886316. Epub 2019 Nov 19.

Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1177/0271678X19886316DOI Listing
November 2019

Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial.

Neuropsychopharmacology 2019 Oct 7. Epub 2019 Oct 7.

Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, Office S-208, 34 Park Street, New Haven, CT, 06519, USA.

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http://dx.doi.org/10.1038/s41386-019-0536-zDOI Listing
October 2019

Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers.

J Psychiatr Res 2019 Sep 8;116:74-82. Epub 2019 Jun 8.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06520, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT, 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2019.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606341PMC
September 2019

Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study.

Depress Anxiety 2019 Sep 6;36(9):834-845. Epub 2019 Aug 6.

U.S. Department of Veterans Affairs National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, Connecticut.

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http://dx.doi.org/10.1002/da.22912DOI Listing
September 2019

Altered functional connectivity and low-frequency signal fluctuations in early psychosis and genetic high risk.

Schizophr Res 2019 Aug 23;210:172-179. Epub 2019 Jan 23.

Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA; Veterans Affairs Connecticut Health System, West Haven, CT 06516, USA.

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http://dx.doi.org/10.1016/j.schres.2018.12.041DOI Listing
August 2019

Insomnia symptom trajectories among adult survivors of childhood sexual abuse: A longitudinal study.

Child Abuse Negl 2019 Jul 23;93:263-276. Epub 2019 May 23.

Department of Psychosocial Science, University of Bergen, Christiesgate 12, 5015, Bergen, Norway; Norwegian Competence Center of Sleep Disorders, Haukeland University Hospital, PO Box 1400, 5021, Bergen, Norway.

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http://dx.doi.org/10.1016/j.chiabu.2019.05.009DOI Listing
July 2019

Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial.

Contemp Clin Trials 2019 Jun 15;81:11-18. Epub 2019 Apr 15.

National Center for PTSD, Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cct.2019.04.009DOI Listing
June 2019

Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine's Antidepressant Effect-Reply.

JAMA Psychiatry 2019 Jun;76(6):658-659

Department of Psychiatry, Veterans Affairs Connecticut Healthcare System, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1001/jamapsychiatry.2019.0763DOI Listing
June 2019

Insomnia symptom trajectories among adult survivors of childhood sexual abuse: A longitudinal study.

Child Abuse Negl 2019 Jul 23;93:263-276. Epub 2019 May 23.

Department of Psychosocial Science, University of Bergen, Christiesgate 12, 5015, Bergen, Norway; Norwegian Competence Center of Sleep Disorders, Haukeland University Hospital, PO Box 1400, 5021, Bergen, Norway.

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http://dx.doi.org/10.1016/j.chiabu.2019.05.009DOI Listing
July 2019

Alcohol Expectancy and Cerebral Responses to Cue-Elicited Craving in Adult Nondependent Drinkers.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 05 12;4(5):493-504. Epub 2018 Dec 12.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut; Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2018.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500759PMC
May 2019

Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study.

Am J Geriatr Psychiatry 2019 May 7;27(5):528-532. Epub 2019 Jan 7.

Department of Psychiatry (JLM, SMS, JHK, RHP), Yale University School of Medicine, New Haven, CT; Clinical Neurosciences Division (SMS, JHK, RHP), U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT; Yale School of Public Health (BRL, RHP), New Haven, CT.

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http://dx.doi.org/10.1016/j.jagp.2019.01.001DOI Listing
May 2019

Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.

J Clin Psychiatry 2017 Sep/Oct;78(8):e1058-e1059

US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, Connecticut, USA.

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http://www.psychiatrist.com/JCP/article/Pages/2017/v78n08/17
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http://dx.doi.org/10.4088/JCP.17l11646DOI Listing
April 2019

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.

Neuron 2019 04;102(1):75-90

Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA.

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http://dx.doi.org/10.1016/j.neuron.2019.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450409PMC
April 2019

Association of Combined Naltrexone and Ketamine With Depressive Symptoms in a Case series of Patients With Depression and Alcohol Use Disorder.

JAMA Psychiatry 2019 Mar;76(3):337-338

Department of Psychiatry, VA Connecticut Healthcare System, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1001/jamapsychiatry.2018.3990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439824PMC
March 2019

Neural computations of threat in the aftermath of combat trauma.

Nat Neurosci 2019 03 21;22(3):470-476. Epub 2019 Jan 21.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41593-018-0315-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829910PMC
March 2019

Ketamine: A Paradigm Shift for Depression Research and Treatment.

Neuron 2019 03;101(5):774-778

Departments of Psychiatry, Neuroscience, and Psychology, Yale University, New Haven, CT, USA; National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.neuron.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560624PMC
March 2019

BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise.

Psychoneuroendocrinology 2019 02 17;100:198-202. Epub 2018 Oct 17.

U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03064530183089
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http://dx.doi.org/10.1016/j.psyneuen.2018.10.011DOI Listing
February 2019

The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder.

Annu Rev Pharmacol Toxicol 2019 Jan 14;59:171-189. Epub 2018 Sep 14.

Clinical Neuroscience Division, Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA; email:

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https://www.annualreviews.org/doi/10.1146/annurev-pharmtox-0
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http://dx.doi.org/10.1146/annurev-pharmtox-010818-021701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326888PMC
January 2019

Celebrating 50 Years of Biological Psychiatry: To the Future, and Beyond.

Authors:
John H Krystal

Biol Psychiatry 2019 01 31;85(1):2-4. Epub 2018 Aug 31.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.08.015DOI Listing
January 2019

Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development.

Methods Mol Biol 2019 ;2011:3-22

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1007/978-1-4939-9554-7_1DOI Listing
January 2019

Physical activity and mental health - Author's reply.

Lancet Psychiatry 2018 11 21;5(11):874. Epub 2018 Sep 21.

Section of Cardiovascular Medicine, and School of Medicine, Yale University, New Haven, CT 06510, USA; Department of Psychiatry, Yale University, New Haven, CT 06510, USA; Spring Health, New York City, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/S2215-0366(18)30354-7DOI Listing
November 2018

The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

Pharmacol Ther 2018 10 25;190:148-158. Epub 2018 May 25.

Department of Psychiatry, Yale University School of Medicine, New Haven, USA; Clinical Neuroscience Division, Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, West Haven, USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165688PMC
October 2018

Thalamic Cortical Error-Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 10 3;3(10):868-877. Epub 2018 May 3.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut; Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2018.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177312PMC
October 2018

Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder.

Mol Neuropsychiatry 2018 Oct 19;4(2):75-82. Epub 2018 Jul 19.

National Center for PTSD, Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, Connecticut, USA.

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https://www.karger.com/Article/FullText/490464
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http://dx.doi.org/10.1159/000490464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206974PMC
October 2018

Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects.

Biol Psychiatry 2018 09 31;84(6):413-421. Epub 2018 Jan 31.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut; Yale-New Haven Hospital, New Haven, Connecticut; Mental Health Service Line, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut.

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http://dx.doi.org/10.1016/j.biopsych.2017.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068006PMC
September 2018

Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia.

Schizophr Res 2018 09 3;199:313-318. Epub 2018 Mar 3.

Department of Psychiatry, Yale School of Medicine, VA CT Healthcare Center, West Haven, CT, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09209964183013
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http://dx.doi.org/10.1016/j.schres.2018.02.049DOI Listing
September 2018

Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study.

Lancet Psychiatry 2018 09 8;5(9):739-746. Epub 2018 Aug 8.

School of Medicine, Yale University, New Haven, CT, USA; Department of Psychiatry, Yale University, New Haven, CT, USA; Spring Health, New York City, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/S2215-0366(18)30227-XDOI Listing
September 2018

Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach.

Neuroimage 2018 08 3;176:489-498. Epub 2018 May 3.

National Center for PTSD - Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2018.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976548PMC
August 2018

The Prescription of Benzodiazepines for Panic Disorder: Time for an Evidence-Based Educational Approach.

J Clin Psychopharmacol 2018 Aug;38(4):283-285

Clinical Pharmacology and Toxicology Program, McGill University and Researcher Emeritus, Mental Health Institute of Montreal Fernand Seguin Research Centre, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1097/JCP.0000000000000908DOI Listing
August 2018

Predicting Barriers to Treatment for Depression in a U.S. National Sample: A Cross-Sectional, Proof-of-Concept Study.

Psychiatr Serv 2018 08 2;69(8):927-934. Epub 2018 Jul 2.

Dr. Chekroud, Dr. Gerhard, Dr. Gueorguieva, and Dr. Krystal are with the Department of Psychiatry and Dr. Roy is with the Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut. Dr. Chekroud is also with Spring Health, New York, where Mr. Chandra and Dr. Subramanyan are affiliated. Dr. Gueorguieva is also with the Department of Biostatistics, Yale University, New Haven, Connecticut. Mr. Foster is with Applied Data Science Partners, London. Dr. Zheutlin is with the Center for Genomic Medicine, Massachusetts General Hospital, Boston. Dr. Koutsouleris is with the Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich. Ms. Degli Esposti is with the Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom. Dr. Paulus is with the Laureate Institute for Brain Research, Tulsa, Oklahoma.

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http://dx.doi.org/10.1176/appi.ps.201800094DOI Listing
August 2018

Metabotropic Glutamatergic Receptor 5 and Stress Disorders: Knowledge Gained From Receptor Imaging Studies.

Biol Psychiatry 2018 07 19;84(2):95-105. Epub 2017 Sep 19.

Department of Psychiatry, Stony Brook University, Stony Brook, New York; Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York.

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http://dx.doi.org/10.1016/j.biopsych.2017.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858955PMC
July 2018

Reply to: It Is Time to Look for New Treatments for Posttraumatic Stress Disorder: Can Sympathetic System Modulation Be an Answer?

Biol Psychiatry 2018 07 12;84(2):e19-e20. Epub 2017 Oct 12.

VA Cooperative Studies Program Central Office, VA Office of Research and Development, Washington, DC.

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http://dx.doi.org/10.1016/j.biopsych.2017.09.031DOI Listing
July 2018

Enhanced Striatal Dopamine Release to Expectation of Alcohol: A Potential Risk Factor for Alcohol Use Disorder.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 07 21;3(7):591-598. Epub 2018 Apr 21.

Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York; Department of Radiology, Columbia University College of Physicians and Surgeons, New York, New York.

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http://dx.doi.org/10.1016/j.bpsc.2018.03.018DOI Listing
July 2018

Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS?

Schizophr Res 2018 05 29;195:455-462. Epub 2017 Sep 29.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, USA; Department of Psychology, Yale University, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2017.09.020DOI Listing
May 2018

The Self-Report Habit Index: Assessing habitual marijuana, alcohol, e-cigarette, and cigarette use.

Drug Alcohol Depend 2018 May 13;186:207-214. Epub 2018 Mar 13.

Yale School of Medicine, Department of Psychiatry, CMHC, 34 Park Street, New Haven, CT, 06519, United States. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2018.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912163PMC
May 2018

Minimal Clinically Important Differences (MCID) in Assessing Outcomes of Post-Traumatic Stress Disorder.

Psychiatr Q 2018 03;89(1):141-155

VA New England Mental Illness Research and Education Center, VA Connecticut Healthcare System (116A-4), 950 Campbell Avenue, Building 36, West Haven, CT, 06516, USA.

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http://dx.doi.org/10.1007/s11126-017-9522-yDOI Listing
March 2018

Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.

Depress Anxiety 2018 02 24;35(2):168-177. Epub 2017 Nov 24.

Clinical Neurosciences Division, U.S. Department of Veterans Affairs National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA.

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http://dx.doi.org/10.1002/da.22698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794529PMC
February 2018

Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia.

Biol Psychiatry 2018 02 20;83(3):244-253. Epub 2017 Sep 20.

Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, Durham, North Carolina; Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.09.006DOI Listing
February 2018

Locus Coeruleus Hyperactivity in Posttraumatic Stress Disorder: Answers and Questions.

Biol Psychiatry 2018 02;83(3):197-199

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Neuroscience, Child Study Center, Yale University School of Medicine, New Haven, Connecticut; Clinical Neuroscience Division, National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut.

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http://dx.doi.org/10.1016/j.biopsych.2017.09.027DOI Listing
February 2018

Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression.

Neuropsychopharmacology 2017 Dec 11;42(13):2482-2492. Epub 2017 May 11.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/npp.2017.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686503PMC
December 2017

A comparison of ICD-11 and DSM criteria for posttraumatic stress disorder in two national samples of U.S. military veterans.

J Affect Disord 2017 12 6;223:17-19. Epub 2017 Jul 6.

National Center for PTSD, VA Connecticut Healthcare System/Yale University, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S01650327173025
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http://dx.doi.org/10.1016/j.jad.2017.07.006DOI Listing
December 2017

Correlates of Nonimprovement to Pharmacotherapy for Chronic, Antidepressant-Resistant, Military Service-Related Posttraumatic Stress Disorder: Insights From the Veterans Affairs Cooperative Study No. 504.

J Clin Psychopharmacol 2017 Dec;37(6):717-721

From the *Yale Child Study Center, Yale University School of Medicine, New Haven; †Clinical Neurosciences Division, Department of Veterans Affairs National Center for PTSD, and ‡Psychiatry Service, VA Connecticut Healthcare System, West Haven; and §Department of Psychiatry, Yale University School of Medicine; ∥Department of Neurobiology, Yale University School of Medicine; and ¶Psychiatry Services, Yale-New Haven Hospital, New Haven, CT.

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http://dx.doi.org/10.1097/JCP.0000000000000777DOI Listing
December 2017

GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers.

Alcohol Clin Exp Res 2017 Dec 13;41(12):2025-2032. Epub 2017 Nov 13.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1111/acer.13516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764175PMC
December 2017

DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty.

Nat Commun 2017 12 21;8(1):2243. Epub 2017 Dec 21.

Department of Psychiatry, Yale School of Medicine, 300 George Street, New Haven, CT, 06511, USA.

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http://dx.doi.org/10.1038/s41467-017-02326-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740109PMC
December 2017

Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.

J Psychiatr Res 2017 11 8;94:139-147. Epub 2017 Jul 8.

U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605420PMC
November 2017

Biological Psychiatry: A New Approach to Reviews.

Authors:
John H Krystal

Biol Psychiatry 2017 11 8;82(9):620. Epub 2017 Sep 8.

Department of Psychiatry, Yale University School of Medicin, New Haven, Connecticut; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut; Psychiatry and Behavioral Health Services, Yale New Haven Hospital, New Haven, Connecticut; Clinical Neuroscience Division, VA National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.07.025DOI Listing
November 2017

It Is Time to Address the Crisis in the Pharmacotherapy of Posttraumatic Stress Disorder: A Consensus Statement of the PTSD Psychopharmacology Working Group.

Biol Psychiatry 2017 10 14;82(7):e51-e59. Epub 2017 Mar 14.

Department of Veterans Affairs, Office of Research & Development, Washington, DC; Cooperative Studies Program Central Office, VA Office of Research and Development, Washington, DC.

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http://dx.doi.org/10.1016/j.biopsych.2017.03.007DOI Listing
October 2017

Posttraumatic Stress Disorder: an integrated overview and neurobiological rationale for pharmacology.

Clin Psychol (New York) 2017 Sep 18;24(3):281-297. Epub 2017 Jul 18.

Clinical Neuroscience Division, Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, West Haven, CT.

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http://dx.doi.org/10.1111/cpsp.12202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688474PMC
September 2017

Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic.

Curr Psychiatry Rep 2017 Aug 26;19(10):74. Epub 2017 Aug 26.

Department of Psychiatry, Yale University School of Medicine, 300 George St., Suite #901, New Haven, CT, 06511, USA.

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http://dx.doi.org/10.1007/s11920-017-0829-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904792PMC
August 2017

Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies.

Neurosci Lett 2017 05 1;649:147-155. Epub 2016 Dec 1.

Clinical Neurosciences Division, United States Department of Veterans Affairs, National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT, 06516, USA; Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT, 06511, USA.

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http://dx.doi.org/10.1016/j.neulet.2016.11.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482215PMC
May 2017

Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD.

Eur Neuropsychopharmacol 2017 05 6;27(5):515-525. Epub 2017 Mar 6.

National Center for PTSD - Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2017.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429865PMC
May 2017

Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal study.

Child Abuse Negl 2017 05 19;67:280-293. Epub 2017 Mar 19.

Norwegian Competence Center of Sleep Disorders, Haukeland University Hospital, PO Box 1400, 5021 Bergen, Norway; Department of Psychosocial Science, University of Bergen, Christiesgate 12, 5015 Bergen, Norway.

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http://dx.doi.org/10.1016/j.chiabu.2017.03.002DOI Listing
May 2017

Computational Psychiatry and the Challenge of Schizophrenia.

Schizophr Bull 2017 05;43(3):473-475

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1093/schbul/sbx025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464204PMC
May 2017

Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders.

Biol Psychiatry 2017 05 14;81(10):848-861. Epub 2017 Mar 14.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Division of Neurocognition, Neurocomputation, & Neurogenetics (N3), Yale University School of Medicine, New Haven, Connecticut; Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut; Department of Psychology, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1016/j.biopsych.2017.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436134PMC
May 2017

Neurobiology of posttraumatic stress disorder (PTSD): A path from novel pathophysiology to innovative therapeutics.

Neurosci Lett 2017 05;649:130-132

National Center for PTSD, Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.

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http://dx.doi.org/10.1016/j.neulet.2017.04.046DOI Listing
May 2017

NMDA Glutamate Receptor Antagonism and the Heritable Risk for Alcoholism: New Insights from a Study of Nitrous Oxide.

Int J Neuropsychopharmacol 2017 04;20(4):351-353

Departments of Psychiatry and Neuroscience, Yale University School of Medicine, New Haven, Connecticut; Psychiatry Services, VA Connecticut Healthcare System, West Haven, Connecticut; Behavioral Health Services, Yale-New Haven Hospital, New Haven, Connecticut; Olin Center for Neuropsychiatry Research, Institute of Living, Hartford, Connecticut.

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http://dx.doi.org/10.1093/ijnp/pyw118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409033PMC
April 2017

Undergraduate Neuroscience Majors: A Missed Opportunity for Psychiatry Workforce Development.

Acad Psychiatry 2017 Apr 10;41(2):239-242. Epub 2017 Feb 10.

Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1007/s40596-017-0670-zDOI Listing
April 2017

Mental illness and mental health.

Lancet Psychiatry 2017 04;4(4):276-277

Department of Psychiatry, New Haven, CT, USA.

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http://dx.doi.org/10.1016/S2215-0366(17)30088-3DOI Listing
April 2017

Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study.

Neuroimage Clin 2017 31;14:750-759. Epub 2017 Mar 31.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, United States.

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http://dx.doi.org/10.1016/j.nicl.2017.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385596PMC
April 2017

Cumulative childhood maltreatment and its dose-response relation with adult symptomatology: Findings in a sample of adult survivors of sexual abuse.

Child Abuse Negl 2017 Mar 26;65:99-111. Epub 2017 Jan 26.

Norwegian Competence Center of Sleep Disorders, Haukeland University Hospital, PO Box 1400, 5021 Bergen, Norway; Department of Psychosocial Science, University of Bergen, Christiesgate 12, 5015 Bergen, Norway.

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http://dx.doi.org/10.1016/j.chiabu.2017.01.008DOI Listing
March 2017

Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis.

Lancet Psychiatry 2017 Mar 9;4(3):230-237. Epub 2017 Feb 9.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA.

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http://dx.doi.org/10.1016/S2215-0366(17)30038-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340978PMC
March 2017

Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study.

Neuroimage Clin 2017 31;14:750-759. Epub 2017 Mar 31.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, United States.

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http://dx.doi.org/10.1016/j.nicl.2017.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385596PMC
April 2017

Alcohol Triggers Reemergence of Ketamine-Like Experience in a Ketamine Ex-User.

J Clin Psychopharmacol 2017 Feb;37(1):110-112

Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, TaiwanDepartment of Psychiatry, Yale School of Medicine, New Haven, and VA CT Healthcare Center, West Haven, CTDepartment of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, and Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan of Psychiatry, Yale School of Medicine, New Haven, and VA CT Healthcare Center, West Haven, CT.

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http://dx.doi.org/10.1097/JCP.0000000000000635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193231PMC
February 2017

The Association of PTSD Symptom Severity with Localized Hippocampus and Amygdala Abnormalities.

Chronic Stress (Thousand Oaks) 2017 Feb 8;1. Epub 2017 Aug 8.

National Center for PTSD - Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, Connecticut.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562232PMC
http://dx.doi.org/10.1177/2470547017724069DOI Listing
February 2017

Psychological resilience in U.S. military veterans: A 2-year, nationally representative prospective cohort study.

J Psychiatr Res 2017 01 22;84:301-309. Epub 2016 Oct 22.

Department of Psychiatry, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA; US. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, 950 Campbell Ave., West Haven, CT 06516, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2016.10.017DOI Listing
January 2017

Combat Exposure Severity is Associated with Reduced Cortical Thickness in Combat Veterans: A Preliminary Report.

Chronic Stress (Thousand Oaks) 2017 Jan 22;1. Epub 2017 Aug 22.

Clinical Neurosciences Division, U.S. Department of Veterans Affairs National Center for PTSD, VA Connecticut Healthcare System West Haven, CT, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568834PMC
http://dx.doi.org/10.1177/2470547017724714DOI Listing
January 2017

The role of psychedelics in palliative care reconsidered: A case for psilocybin.

J Psychopharmacol 2016 12;30(12):1212-1214

Clinical Neuroscience Division, Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.

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http://dx.doi.org/10.1177/0269881116675781DOI Listing
December 2016

PTSD: from neurobiology to pharmacological treatments.

Eur J Psychotraumatol 2016 8;7:31858. Epub 2016 Nov 8.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106865PMC
http://dx.doi.org/10.3402/ejpt.v7.31858DOI Listing
November 2016

What I have changed my mind about and why.

Eur J Psychotraumatol 2016 8;7:33768. Epub 2016 Nov 8.

Yale University School of Medicine, New Haven, CT, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106864PMC
http://dx.doi.org/10.3402/ejpt.v7.33768DOI Listing
November 2016