John Farrell

John Farrell

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A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease.

Alzheimers Dement 2019 Jan 3. Epub 2019 Jan 3.

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.10.005DOI Listing
January 2019

PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects.

Bioinformatics 2019 Jan 8. Epub 2019 Jan 8.

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btz017DOI Listing
January 2019

"Cat got your lung?": Case of a trapped lung following cat bite.

IDCases 2019 29;15:e00482. Epub 2018 Dec 29.

University of Illinois College of Medicine, Peoria, IL, USA.

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http://dx.doi.org/10.1016/j.idcr.2018.e00482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317276PMC
December 2018

HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors.

Chem Res Toxicol 2018 Oct 13;31(10):1022-1024. Epub 2018 Sep 13.

MRC Center for Drug Safety Science, Department of Molecular and Clinical Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , Liverpool , L69 3GE , England.

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http://pubs.acs.org/doi/10.1021/acs.chemrestox.8b00163
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http://dx.doi.org/10.1021/acs.chemrestox.8b00163DOI Listing
October 2018

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

Authors:
Joshua C Bis Xueqiu Jian Brian W Kunkle Yuning Chen Kara L Hamilton-Nelson William S Bush William J Salerno Daniel Lancour Yiyi Ma Alan E Renton Edoardo Marcora John J Farrell Yi Zhao Liming Qu Shahzad Ahmad Najaf Amin Philippe Amouyel Gary W Beecham Jennifer E Below Dominique Campion Camille Charbonnier Jaeyoon Chung Paul K Crane Carlos Cruchaga L Adrienne Cupples Jean-François Dartigues Stéphanie Debette Jean-François Deleuze Lucinda Fulton Stacey B Gabriel Emmanuelle Genin Richard A Gibbs Alison Goate Benjamin Grenier-Boley Namrata Gupta Jonathan L Haines Aki S Havulinna Seppo Helisalmi Mikko Hiltunen Daniel P Howrigan M Arfan Ikram Jaakko Kaprio Jan Konrad Amanda Kuzma Eric S Lander Mark Lathrop Terho Lehtimäki Honghuang Lin Kari Mattila Richard Mayeux Donna M Muzny Waleed Nasser Benjamin Neale Kwangsik Nho Gaël Nicolas Devanshi Patel Margaret A Pericak-Vance Markus Perola Bruce M Psaty Olivier Quenez Farid Rajabli Richard Redon Christiane Reitz Anne M Remes Veikko Salomaa Chloe Sarnowski Helena Schmidt Michael Schmidt Reinhold Schmidt Hilkka Soininen Timothy A Thornton Giuseppe Tosto Christophe Tzourio Sven J van der Lee Cornelia M van Duijn Badri Vardarajan Weixin Wang Ellen Wijsman Richard K Wilson Daniela Witten Kim C Worley Xiaoling Zhang Celine Bellenguez Jean-Charles Lambert Mitja I Kurki Aarno Palotie Mark Daly Eric Boerwinkle Kathryn L Lunetta Anita L Destefano Josée Dupuis Eden R Martin Gerard D Schellenberg Sudha Seshadri Adam C Naj Myriam Fornage Lindsay A Farrer

Mol Psychiatry 2018 Aug 14. Epub 2018 Aug 14.

Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41380-018-0112-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375806PMC
August 2018

Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk Variants.

Front Neurosci 2018 27;12:592. Epub 2018 Aug 27.

Biomedical Genetics, Department of Medicine, Boston University School of Medicine, Boston University, Boston, MA, United States.

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https://www.frontiersin.org/article/10.3389/fnins.2018.00592
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http://dx.doi.org/10.3389/fnins.2018.00592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119822PMC
August 2018

Aerobic Exercise Supplemented With Muscular Endurance Training Improves Onset of Blood Lactate Accumulation.

J Strength Cond Res 2018 May;32(5):1376-1382

Department of Health and Exercise Science, The University of Oklahoma, Norman, Oklahoma.

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http://dx.doi.org/10.1519/JSC.0000000000001981DOI Listing
May 2018

A variant Sp1 (R218Q) transcription factor might enhance HbF expression in β -thalassaemia homozygotes.

Br J Haematol 2018 03 27;180(5):755-757. Epub 2017 Feb 27.

Departments of Medicine, Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1111/bjh.14445DOI Listing
March 2018

A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression.

Blood Cells Mol Dis 2018 03 29;69:1-9. Epub 2017 Nov 29.

Department of Medicine, Section of Hematology-Oncology, Boston University School of Medicine, Boston, MA 02118, USA; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783741PMC
March 2018

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity.

Chem Res Toxicol 2018 03 14;31(3):165-167. Epub 2018 Feb 14.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , Liverpool L69 3GE , England.

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http://dx.doi.org/10.1021/acs.chemrestox.8b00030DOI Listing
March 2018

β-Lactam hypersensitivity involves expansion of circulating and skin-resident T22 cells.

J Allergy Clin Immunol 2018 Jan 20;141(1):235-249.e8. Epub 2017 Feb 20.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.01.020DOI Listing
January 2018

Dapsone and Nitroso Dapsone Activation of Naı̈ve T-Cells from Healthy Donors.

Chem Res Toxicol 2017 12 31;30(12):2174-2186. Epub 2017 Oct 31.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Liverpool L69 3GE, United Kingdom.

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http://pubs.acs.org/doi/10.1021/acs.chemrestox.7b00263
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http://dx.doi.org/10.1021/acs.chemrestox.7b00263DOI Listing
December 2017

Venous thromboembolism related to cytomegalovirus infection: A case report and literature review.

Medicine (Baltimore) 2017 Dec;96(51):e9336

Department of Infectious Diseases, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.

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http://dx.doi.org/10.1097/MD.0000000000009336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758214PMC
December 2017

Complete sequences of 4 viral hemorrhagic septicemia virus IVb isolates and their virulence in northern pike fry.

Dis Aquat Organ 2017 11;126(3):211-227

Aquatic Animal Health Program, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.3354/dao03171DOI Listing
November 2017

Genetic determinants of HbF in Saudi Arabian and African Benin haplotype sickle cell anemia.

Am J Hematol 2017 09 19;92(9):E555-E557. Epub 2017 Jul 19.

Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, 02118.

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http://dx.doi.org/10.1002/ajh.24822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546992PMC
September 2017

Eight Weeks of High-Volume Resistance Training Improves Onset of Blood Lactate in Trained Individuals.

J Strength Cond Res 2017 Aug;31(8):2176-2182

Department of Health and Exercise Science, University of Oklahoma, Norman, Oklahoma.

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http://dx.doi.org/10.1519/JSC.0000000000001686DOI Listing
August 2017

The effect of empiric antimicrobial treatment duration on detection of bacterial DNA in sterile surgical specimens.

PLoS One 2017 7;12(2):e0171074. Epub 2017 Feb 7.

Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171074PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295705PMC
August 2017

A rare case of aerococcus urinae infective endocarditis.

J Community Hosp Intern Med Perspect 2017 Mar 6;7(2):126-129. Epub 2017 Jun 6.

Department of Internal Medicine, Division of Infectious Disease, OSF Saint Francis Medical Center, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.

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http://dx.doi.org/10.1080/20009666.2017.1314072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473194PMC
March 2017

From the Cover: Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury.

Toxicol Sci 2017 02 1;155(2):420-431. Epub 2016 Nov 1.

MRC Centre for Drug Safety Science, Department of Clinical and Molecular Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3GE, England;

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http://dx.doi.org/10.1093/toxsci/kfw218DOI Listing
February 2017

Impact of preoperative screening for rectal colonization with fluoroquinolone-resistant enteric bacteria on the incidence of sepsis following transrectal ultrasound guided prostate biopsy.

Res Rep Urol 2017 24;9:37-41. Epub 2017 Feb 24.

Department of Urology, Cooper University Hospital; Department of Surgery, Cooper University School of Medicine, Camden, NJ, USA.

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http://dx.doi.org/10.2147/RRU.S117206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338954PMC
February 2017

Overcoming our nature and nurture.

Can Pharm J (Ott) 2017 Jan-Feb;150(1):5-7. Epub 2016 Dec 6.

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http://dx.doi.org/10.1177/1715163516682438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330427PMC
December 2016

Postoperative Adjuvant Lapatinib and Concurrent Chemoradiotherapy Followed by Maintenance Lapatinib Monotherapy in High-Risk Patients With Resected Squamous Cell Carcinoma of the Head and Neck: A Phase III, Randomized, Double-Blind, Placebo-Controlled Study.

J Clin Oncol 2015 Dec 2;33(35):4202-9. Epub 2015 Nov 2.

Kevin Harrington, Institute of Cancer Research and Royal Marsden Hospital, London; Hisham Mehanna, Institute of Head and Neck Studies and Education, University of Birmingham, Birmingham; Natalie Franklin and John Farrell, GlaxoSmithKline, Uxbridge, United Kingdom; Stephane Temam and Jean Bourhis, Institut Gustave- Roussy, Villejuif; Ida D'Onofrio, Hôpital Forcilles, Paris, France; Anil D'Cruz, Tata Memorial Hospital, Mumbai; Minish Jain, Ruby Hall Clinic-Cancer Centre, Pune, India; Georgy Manikhas, St Petersburg City Oncology Dispensary, St Petersburg, Russia; Zsuzsanna Horvath, Szent Imre University Teaching Hospital Budapest, Budapest, Hungary; Yan Sun, Beijing Cancer Hospital, Beijing, China; Stefan Dietzsch, Hospital and Policlinic for Radiation Therapy and Radio-oncology, Leipzig, Germany; Pavol Dubinsky, East Slovakia Cancer Institute, Kosice, Slovakia; Petra Holeckova, Institute of Radiation Oncology, Hospital Na Bulovce, and 1st Medical Faculty of Charles University, Prague, Czech Republic; Iman El-Hariry, Synta Pharmaceutical, Lexington, MA; Paul Wissel and Mayur Amonkar, Novartis Pharmaceuticals, East Hanover, NJ; Catherine Ellis and Sergio Santillana, GlaxoSmithKline, Philadelphia, PA; and Nigel Biswas-Baldwin, Philippe Legenne, Thelma Netherway, Jing Wang-Silvanto, and Nazma Ahmed, Novartis Pharma AG, Basel, Switzerland.

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http://dx.doi.org/10.1200/JCO.2015.61.4370DOI Listing
December 2015

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation.

AIDS 2015 Nov;29(18):2385-95

aMRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology bDepartment of Chemistry, University of Liverpool, Liverpool, England cLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, USA dDrug Metabolism and Pharmacokinetics, GlaxoSmithKline, Hertfordshire, England.

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http://dx.doi.org/10.1097/QAD.0000000000000867DOI Listing
November 2015

Experiences of Irish general practice trainees who participate in 4-month rotations in Malawi and Australia.

Educ Prim Care 2015 Nov;26(6):388-94

a South Eastern General Practice Training Scheme , Waterford Regional Hospital , Waterford , Ireland.

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http://dx.doi.org/10.1080/14739879.2015.1101868DOI Listing
November 2015

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury.

Hepatology 2015 Sep 23;62(3):887-99. Epub 2015 Jul 23.

MRC Center for Drug Safety Science, Department of Molecular and Clinical Pharmacology, The University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1002/hep.27912DOI Listing
September 2015

Culture negative empyema in a critically ill child: an opportunity for rapid molecular diagnostics.

BMC Anesthesiol 2014 22;14:107. Epub 2014 Nov 22.

Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Research Service, 10701 East Blvd, Cleveland, Ohio 44106 USA ; Department of Medicine, Case Western Reserve University, Cleveland, OH USA ; Departments of Pharmacology and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH USA.

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http://dx.doi.org/10.1186/1471-2253-14-107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258007PMC
July 2015

Salvage microbiology: opportunities and challenges in the detection of bacterial pathogens following initiation of antimicrobial treatment.

Expert Rev Mol Diagn 2015 Mar 19;15(3):349-60. Epub 2014 Dec 19.

Department of Medicine, Division of Infectious Disease, University of Illinois College of Medicine, 723 N.E. Glen Oak Ave. Peoria, IL 61603, USA.

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http://dx.doi.org/10.1586/14737159.2015.989216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654419PMC
March 2015

Partial mitigation of gold nanoparticle interactions with human lymphocytes by surface functionalization with a 'mixed matrix'.

Nanomedicine (Lond) 2014 Nov;9(16):2467-79

Department of Molecular & Clinical Pharmacology, University of Liverpool, UK.

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http://dx.doi.org/10.2217/nnm.14.38DOI Listing
November 2014

Low concentrations of contaminants in an invasive cyprinid, the rudd, in a Great Lakes Area of Concern.

Bull Environ Contam Toxicol 2014 Nov 28;93(5):567-73. Epub 2014 Jun 28.

Department of Environmental and Forest Biology, College of Environmental Science and Forestry, State University of New York, 1 Forestry Drive, Syracuse, NY, 13210, USA,

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http://dx.doi.org/10.1007/s00128-014-1325-3DOI Listing
November 2014

Acute respiratory distress caused by Neosartorya udagawae.

Med Mycol Case Rep 2014 Oct 24;6:1-5. Epub 2014 Jul 24.

Bacterial Foodborne Pathogens and Mycology, National Center for Agricultural Utilization Research, US Department of Agriculture, 1815 North University Street, Peoria, IL 61604, USA.

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http://dx.doi.org/10.1016/j.mmcr.2014.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216325PMC
October 2014

Identification of occult Fusobacterium nucleatum central nervous system infection by use of PCR-electrospray ionization mass spectrometry.

J Clin Microbiol 2014 Sep 25;52(9):3462-4. Epub 2014 Jun 25.

Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Departments of Pharmacology, Microbiology and Molecular Biology, Case Western Reserve University, Cleveland, Ohio, USA

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http://jcm.asm.org/content/early/2014/06/24/JCM.01082-14.ful
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http://jcm.asm.org/content/52/9/3462.full.pdf
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http://jcm.asm.org/lookup/doi/10.1128/JCM.01082-14
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http://dx.doi.org/10.1128/JCM.01082-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313185PMC
September 2014

Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways.

Neurobiol Aging 2014 Jun 19;35(6):1510.e7-18. Epub 2013 Dec 19.

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961547PMC
June 2014

Ureaplasma parvum prosthetic joint infection detected by PCR.

J Clin Microbiol 2014 Jun 26;52(6):2248-50. Epub 2014 Mar 26.

Divisions of Clinical Microbiology and Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1128/JCM.00432-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042745PMC
June 2014

Direct detection of indirect transmission of Streptobacillus moniliformis rat bite fever infection.

J Clin Microbiol 2014 Jun 9;52(6):2259-61. Epub 2014 Apr 9.

Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Research Service, Cleveland, Ohio, USA Case Western Reserve University, Departments of Medicine, Pharmacology and Molecular Microbiology, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1128/JCM.00259-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042756PMC
June 2014

"Salvage microbiology": detection of bacteria directly from clinical specimens following initiation of antimicrobial treatment.

PLoS One 2013 25;8(6):e66349. Epub 2013 Jun 25.

University of Illinois School of Medicine, Department of Medicine, Peoria, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066349PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692526PMC
February 2014

HLA restriction of carbamazepine-specific T-Cell clones from an HLA-A*31:01-positive hypersensitive patient.

Chem Res Toxicol 2014 Feb 31;27(2):175-7. Epub 2014 Jan 31.

Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.

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http://dx.doi.org/10.1021/tx400460wDOI Listing
February 2014

Temperature cycling improves in vivo recovery of cold-stored human platelets in a mouse model of transfusion.

Transfusion 2013 Jun 24;53(6):1178-86. Epub 2012 Sep 24.

Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20852-1448, USA.

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http://dx.doi.org/10.1111/j.1537-2995.2012.03896.xDOI Listing
June 2013

β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis.

Chem Res Toxicol 2013 Jun 23;26(6):963-75. Epub 2013 May 23.

MRC Centre for Drug Safety Science, Department of Pharmacology, The University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3GE, England.

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http://dx.doi.org/10.1021/tx400124mDOI Listing
June 2013

T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms.

Chem Res Toxicol 2013 May 12;26(5):759-66. Epub 2013 Apr 12.

MRC Centre for Drug Safety Science, Department of Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.

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http://dx.doi.org/10.1021/tx400060pDOI Listing
May 2013

IL-8 release from human neutrophils cultured with pro-haptenic chemical sensitizers.

Chem Res Toxicol 2012 Oct 12;25(10):2054-6. Epub 2012 Sep 12.

MRC Centre for Drug Safety Science, Department of Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.

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http://dx.doi.org/10.1021/tx300350sDOI Listing
October 2012

Characterization of the antigen specificity of T-cell clones from piperacillin-hypersensitive patients with cystic fibrosis.

J Pharmacol Exp Ther 2012 Jun 27;341(3):597-610. Epub 2012 Feb 27.

Medical Research Council Centre for Drug Safety Science, Department of Pharmacology, Sherrington Building, Ashton Street, University of Liverpool, Liverpool, L69 3GE, United Kingdom.

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http://dx.doi.org/10.1124/jpet.111.190900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362878PMC
June 2012

Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients.

J Pharmacol Exp Ther 2011 Sep 16;338(3):841-9. Epub 2011 Jun 16.

Medical Research Council Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1124/jpet.111.183871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164351PMC
September 2011

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.

J Allergy Clin Immunol 2011 Jun 26;127(6):1543-51.e3. Epub 2011 Feb 26.

MRC Centre for Drug Safety Science, Department of Pharmacology, University of Liverpool, Liverpool, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S009167491100063
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http://dx.doi.org/10.1016/j.jaci.2010.12.1119DOI Listing
June 2011

Trimethoprim stimulates T-cells through metabolism-dependent and -independent pathways.

Chem Res Toxicol 2011 Jun 3;24(6):791-3. Epub 2011 May 3.

MRC Centre for Drug Safety Science, Department of Pharmacology, University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, England.

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http://dx.doi.org/10.1021/tx2001256DOI Listing
June 2011

Reform requires resilience: a holistic model for success.

Healthc Financ Manage 2010 Jul;64(7):54-61

KPMG Healthcare, Chicago, USA.

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July 2010

Medication-related admissions in older people: a cross-sectional, observational study.

Drugs Aging 2009 ;26(11):951-61

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.2165/11316750-000000000-00000DOI Listing
January 2010

Metabolic and chemical origins of cross-reactive immunological reactions to arylamine benzenesulfonamides: T-cell responses to hydroxylamine and nitroso derivatives.

Chem Res Toxicol 2010 Jan;23(1):184-92

MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics,The University of Liverpool, Liverpool L69 3GE, United Kingdom.

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http://pubs.acs.org/doi/abs/10.1021/tx900329b
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http://dx.doi.org/10.1021/tx900329bDOI Listing
January 2010

Ethanol oxidation: kinetics of the alpha-hydroxyethyl radical + O2 reaction.

J Phys Chem A 2009 Aug;113(31):8923-33

Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1021/jp903210aDOI Listing
August 2009

Extension of general practice training from three to four years: experiences of a vocational training programme in Southern Ireland.

Educ Prim Care 2009 May;20(3):167-72

HSE South East GP Training Programme, Waterford, Ireland.

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May 2009

Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base in the mouse.

Toxicol Lett 2009 Mar 24;185(3):153-9. Epub 2008 Dec 24.

MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, The Sherrington Building, Ashton Street, The University of Liverpool, Liverpool L69 3GE, UK.

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http://dx.doi.org/10.1016/j.toxlet.2008.12.008DOI Listing
March 2009

Orthotic aided training of the paretic upper limb in chronic stroke: results of a phase 1 trial.

NeuroRehabilitation 2007 ;22(2):99-103

Saebo, Inc., Charlotte, NC, USA.

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October 2007

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling.

J Immunol 2007 May;178(9):5533-42

Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom.

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May 2007

Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity.

J Allergy Clin Immunol 2007 Apr 22;119(4):973-81. Epub 2007 Feb 22.

Department of Pharmacology, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1016/j.jaci.2006.12.617DOI Listing
April 2007

Activation of human dendritic cells by p-phenylenediamine.

J Pharmacol Exp Ther 2007 Feb 15;320(2):885-92. Epub 2006 Nov 15.

Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, L69 3GE, UK.

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http://dx.doi.org/10.1124/jpet.106.113803DOI Listing
February 2007

Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia.

Clin Infect Dis 2006 Sep 14;43(5):593-8. Epub 2006 Jul 14.

Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1086/506356DOI Listing
September 2006

Multifactor-dimensionality reduction versus family-based association tests in detecting susceptibility loci in discordant sib-pair studies.

BMC Genet 2005 Dec 30;6 Suppl 1:S146. Epub 2005 Dec 30.

Genetics Program, Department of Medicine, School of Medicine, Boston University, Boston, MA, USA.

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http://dx.doi.org/10.1186/1471-2156-6-S1-S146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866789PMC
December 2005

Genome-wide linkage analysis for alcohol dependence: a comparison between single-nucleotide polymorphism and microsatellite marker assays.

BMC Genet 2005 Dec 30;6 Suppl 1:S8. Epub 2005 Dec 30.

Genetics Program, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.

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http://dx.doi.org/10.1186/1471-2156-6-S1-S8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866701PMC
December 2005

Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis.

Blood 2005 Jul 22;106(1):372-5. Epub 2005 Mar 22.

Center for Human Genetics, Department of Pediatrics, Boston University School of Medicine, 715 Albany St, W408, Boston, MA 02118, USA.

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http://dx.doi.org/10.1182/blood-2005-02-0548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895132PMC
July 2005

Characterization of the T-cell response in a patient with phenindione hypersensitivity.

J Pharmacol Exp Ther 2005 Jun 2;313(3):1058-65. Epub 2005 Mar 2.

Department of Pharmacology, The University of Liverpool, England.

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http://dx.doi.org/10.1124/jpet.105.083758DOI Listing
June 2005

Broad-range (pan) Salmonella and Salmonella serotype typhi-specific real-time PCR assays: potential tools for the clinical microbiologist.

Am J Clin Pathol 2005 Mar;123(3):339-45

Department of Infectious Diseases, University of, Illinois/OSF Infectious Diseases, Peoria, IL, USA.

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http://dx.doi.org/10.1309/DP0H-Y5UT-10HQ-W9YMDOI Listing
March 2005

Isolated gastric varices occurring 5 years after chemotherapy for splenic lymphoma.

Ann Intern Med 2004 Jun;140(12):1062-3

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June 2004

Empirically derived phenotypic subgroups - qualitative and quantitative trait analyses.

BMC Genet 2003 Dec 31;4 Suppl 1:S15. Epub 2003 Dec 31.

Genetics Program, Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1186/1471-2156-4-S1-S15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866449PMC
December 2003

Search for genetic factors predisposing to atherogenic dyslipidemia.

BMC Genet 2003 Dec 31;4 Suppl 1:S100. Epub 2003 Dec 31.

Genetics Program, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1186/1471-2156-4-S1-S100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866438PMC
December 2003

Characterization of drug-specific T cells in lamotrigine hypersensitivity.

J Allergy Clin Immunol 2003 Jun;111(6):1393-403

Department of Pharmacology and Therapeutics, Sherrington Building, Ashton Street, The University of Liverpool, PO Box 147, Liverpool L69 3GE, England.

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June 2003

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation.

Mol Pharmacol 2002 Sep;62(3):628-37

Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, United Kingdom.

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September 2002