John F Kadow

John F Kadow

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John F Kadow

John F Kadow

Publications by authors named "John F Kadow"

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A survey of core replacements in indole-based HIV-1 attachment inhibitors.

Bioorg Med Chem Lett 2019 Jun 28;29(11):1423-1429. Epub 2019 Mar 28.

Department of Discovery Chemistry and Molecular Technologies, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, United States.

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http://dx.doi.org/10.1016/j.bmcl.2019.03.018DOI Listing
June 2019

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.

Xenobiotica 2018 Dec 12;48(12):1215-1226. Epub 2017 Dec 12.

a Departments of Pharmaceutical Candidate Optimisation , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA and.

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http://dx.doi.org/10.1080/00498254.2017.1409915DOI Listing
December 2018

Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir.

J Med Chem 2018 01 22;61(1):62-80. Epub 2017 Dec 22.

Drug Product Science and Technology, Bristol-Myers Squibb , Reeds Lane, Moreton, Merseyside CH46 1QW, United Kingdom.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01337
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http://dx.doi.org/10.1021/acs.jmedchem.7b01337DOI Listing
January 2018

Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties.

Eur J Med Chem 2017 Oct 22;139:865-883. Epub 2017 Jul 22.

Department of Medicinal Chemistry, ViiV Healthcare, 36 East Industrial Road, Branford, CT 06405, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234173056
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http://dx.doi.org/10.1016/j.ejmech.2017.07.044DOI Listing
October 2017

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Bioorg Med Chem Lett 2017 08 11;27(15):3294-3300. Epub 2017 Jun 11.

Department of Discovery Chemistry and Molecular Technologies, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, United States.

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http://dx.doi.org/10.1016/j.bmcl.2017.06.024DOI Listing
August 2017

Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase.

Bioorg Med Chem Lett 2017 01 22;27(2):295-298. Epub 2016 Nov 22.

Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.

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http://dx.doi.org/10.1016/j.bmcl.2016.11.054DOI Listing
January 2017

Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.

Bioorg Med Chem Lett 2016 Feb 19;26(3):936-940. Epub 2015 Dec 19.

Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492, United States.

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http://dx.doi.org/10.1016/j.bmcl.2015.12.058DOI Listing
February 2016

Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action.

Proteins 2015 Feb 23;83(2):331-50. Epub 2014 Dec 23.

Computer Assisted Drug Design, Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut.

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http://dx.doi.org/10.1002/prot.24726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681349PMC
February 2015

Enabled clinical use of an HIV-1 attachment inhibitor through drug delivery.

Drug Discov Today 2014 Sep 13;19(9):1288-93. Epub 2014 Apr 13.

Discovery Chemistry, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S13596446140011
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http://dx.doi.org/10.1016/j.drudis.2014.03.025DOI Listing
September 2014

Identification of a novel series of potent HCV NS5B Site I inhibitors.

Bioorg Med Chem Lett 2014 Apr 28;24(8):1993-7. Epub 2014 Feb 28.

Research and Development, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X140017
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http://dx.doi.org/10.1016/j.bmcl.2014.02.047DOI Listing
April 2014

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

J Med Chem 2014 Mar 7;57(5):1855-79. Epub 2014 Jan 7.

Discovery Chemistry, ‡Molecular Discovery Technologies, Molecular Structure & Design, §Molecular Discovery Technologies, Protein Science, ∥Pharmaceutical Candidate Optimization, ⊥Discovery Virology, Disease Sciences and Biologics, #Leads Discovery and Optimization, ▽Materials Science, Drug Product Science and Technology, Bristol-Myers Squibb Research and Development , 5 Research Parkway, Wallingford, Connecticut 06492, United States.

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http://pubs.acs.org/doi/10.1021/jm4016894
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http://dx.doi.org/10.1021/jm4016894DOI Listing
March 2014

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 13. Synthesis and profiling of a novel amminium prodrug of the HIV-1 attachment inhibitor BMS-585248.

J Med Chem 2013 Feb 12;56(4):1670-6. Epub 2013 Feb 12.

Department of Medicinal Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.

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http://dx.doi.org/10.1021/jm301638aDOI Listing
February 2013

Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores.

Bioorg Med Chem Lett 2013 Jan 7;23(1):213-7. Epub 2012 Nov 7.

Research and Development, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.10.120DOI Listing
January 2013

Inhibitors of HIV-1 attachment. Part 11: the discovery and structure-activity relationships associated with 4,6-diazaindole cores.

Bioorg Med Chem Lett 2013 Jan 5;23(1):218-22. Epub 2012 Nov 5.

Research and Development, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.10.118DOI Listing
January 2013

AlMe(3)-promoted formation of amides from acids and amines.

Org Lett 2012 Jan 7;14(1):214-7. Epub 2011 Dec 7.

Bristol-Myers Squibb Company, Research and Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, USA.

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http://dx.doi.org/10.1021/ol203007sDOI Listing
January 2012

Maraviroc, a chemokine CCR5 receptor antagonist for the treatment of HIV infection and AIDS.

Curr Opin Investig Drugs 2007 Aug;8(8):669-81

Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.

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August 2007

Developments in antiviral drug design, discovery and development in 2004.

Curr Drug Targets Infect Disord 2005 Dec;5(4):307-400

Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA.

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December 2005

New dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Bioorg Med Chem Lett 2005 Nov;15(21):4774-9

Department of Oncology Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, NJ 08543-4000, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.07.027DOI Listing
November 2005

Synthesis and biological activity of macrocyclic taxane analogues.

Bioorg Med Chem Lett 2004 May;14(10):2555-8

Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5100, Wallingford, CT 06492-7660, USA.

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http://dx.doi.org/10.1016/j.bmcl.2004.02.086DOI Listing
May 2004

Dialkylaminoacetonitrile derivatives as amide synthons. A one-pot preparation of heteroaryl amides via a strategy of sequential SNAr substitution and oxidation.

J Org Chem 2004 Feb;69(4):1360-3

Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.

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http://dx.doi.org/10.1021/jo030233jDOI Listing
February 2004

Acetonitrile derivatives as carbonyl synthons. One-pot preparation of diheteroaryl ketones via a strategy of sequential SNAr substitution and oxidation.

J Org Chem 2004 Feb;69(4):1364-7

Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.

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http://dx.doi.org/10.1021/jo030234bDOI Listing
February 2004

The discovery of BMS-275183: an orally efficacious novel taxane.

Bioorg Med Chem 2003 Oct;11(20):4315-23

Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, PO Box 5100, Wallingford, CT 06492-7660, USA.

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http://dx.doi.org/10.1016/s0968-0896(03)00495-4DOI Listing
October 2003

Selective monoacylation of symmetrical diamines via prior complexation with boron.

Org Lett 2003 Sep;5(19):3399-402

Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.

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http://dx.doi.org/10.1021/ol0300773DOI Listing
September 2003

Inhibitors of the entry of HIV into host cells.

Curr Opin Drug Discov Devel 2003 Jul;6(4):451-61

Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Chemistry, 5 Research Parkway, Wallingford, CT 06492, USA.

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July 2003

The role of viruses in human cancer development and antiviral approaches for intervention.

Curr Opin Investig Drugs 2002 Nov;3(11):1574-9

Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA.

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November 2002

An effective procedure for the acylation of azaindoles at C-3.

J Org Chem 2002 Aug;67(17):6226-7

Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.

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http://dx.doi.org/10.1021/jo020135iDOI Listing
August 2002

A strategy for the synthesis of aryl alpha-ketoamides based upon the acylation of anions derived from cyanomethylamines followed by oxidative cleavage.

Org Lett 2002 Apr;4(7):1103-5

Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.

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http://dx.doi.org/10.1021/ol010297lDOI Listing
April 2002

A general method for the preparation of 4- and 6-azaindoles.

J Org Chem 2002 Apr;67(7):2345-7

Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.

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http://dx.doi.org/10.1021/jo0111614DOI Listing
April 2002