John Eikelboom

John Eikelboom

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Gastroenterology 2020 01 5;158(1):285-286. Epub 2019 Nov 5.

Population Health Research Institute, McMaster University and, Hamilton Health Sciences, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2019.10.032DOI Listing
January 2020

Reply to GASTRO-D-19-,01448, GASTRO-D-19-01576, GASTRO-D-19-02060, and GASTRO-D-19-02139.

Gastroenterology 2020 Jan 6. Epub 2020 Jan 6.

Population Health Research Institute, McMaster University and Hamilton Health Sciences, David Brailey Research Bldg., Hamilton General Hospital, 237 Barton St. E., Hamilton, ON L8L 2X2, Canada.

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http://dx.doi.org/10.1053/j.gastro.2019.12.023DOI Listing
January 2020

Lower versus Standard INR Targets in Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Thromb Haemost 2020 Jan 15. Epub 2020 Jan 15.

Division of Cardiac Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0039-3401823DOI Listing
January 2020

Fifty years of research on antithrombotic therapy: Achievements and disappointments.

Eur J Intern Med 2019 Dec 1;70:1-7. Epub 2019 Nov 1.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; Population Health Research Institute, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2019.10.023DOI Listing
December 2019

Diabetes Mellitus Is Associated With Increased Risk of Ischemic Stroke in Patients With and Without Coronary Artery Disease.

Stroke 2019 Dec 6;50(12):3347-3354. Epub 2019 Nov 6.

From the Department of Cardiology (K.K.W.O., C.G., P.G.T., T.T., H.E.B., M. Maeng), Aarhus University Hospital, Denmark.

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http://dx.doi.org/10.1161/STROKEAHA.119.026099DOI Listing
December 2019

Applying contemporary antithrombotic therapy in the secondary prevention of chronic atherosclerotic cardiovascular disease.

Am Heart J 2019 Dec 23;218:100-109. Epub 2019 Oct 23.

Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ahj.2019.09.006DOI Listing
December 2019

How Did We Get Here?: A Historical Review and Critical Analysis of Anticoagulation Therapy Following Mechanical Valve Replacement.

Circulation 2019 Dec 2;140(23):1933-1942. Epub 2019 Dec 2.

Population Health Research Institute, Hamilton, Canada (S.M., I.H.J., E.P.B.-C., G.R.M., J.W.E., R.P.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.041105DOI Listing
December 2019

Selection Bias, Orthopaedic Style: Knowing What We Don't Know About Aspirin.

J Bone Joint Surg Am 2019 Dec 31. Epub 2019 Dec 31.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.2106/JBJS.19.01135DOI Listing
December 2019

Andexanet alfa for reversal of factor Xa inhibitors: a critical review of the evidence.

Future Cardiol 2019 Nov 31;15(6):395-404. Epub 2019 Oct 31.

Division of Hematology & Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON, L8S 4L8, Canada.

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http://dx.doi.org/10.2217/fca-2019-0038DOI Listing
November 2019

External applicability of the COMPASS trial: the Western Denmark Heart Registry.

Eur Heart J Cardiovasc Pharmacother 2019 Oct;5(4):192-199

Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK Aarhus, Denmark.

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http://dx.doi.org/10.1093/ehjcvp/pvz013DOI Listing
October 2019

Bleeding and New Cancer Diagnosis in Patients With Atherosclerosis.

Circulation 2019 Oct 12;140(18):1451-1459. Epub 2019 Sep 12.

Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada (J.W.E., S.J.C., J.B., O.S., S.S.A., R.G.H., P.M., S.Y.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.041949DOI Listing
October 2019

Dabigatran Reversal With Idarucizumab in Patients With Renal Impairment.

J Am Coll Cardiol 2019 Oct;74(14):1760-1768

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2019.07.070DOI Listing
October 2019

Major Bleeding in Patients With Coronary or Peripheral Artery Disease Treated With Rivaroxaban Plus Aspirin.

J Am Coll Cardiol 2019 Sep;74(12):1519-1528

Hamilton Health Sciences, Hamilton, Ontario, Canada; McMaster University, Hamilton, Ontario, Canada; Population Health Research Institute, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2019.07.065DOI Listing
September 2019

How can the results of the COMPASS trial benefit patients with coronary or peripheral artery disease in Poland?

Kardiol Pol 2019 Aug 30;77(7-8):661-669. Epub 2019 May 30.

Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada

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http://dx.doi.org/10.33963/KP.14855DOI Listing
August 2019

Pulmonary embolism: update on diagnosis and management.

Med J Aust 2019 Jul 19;211(2):82-87. Epub 2019 Jun 19.

University of Western Australia, Perth, WA.

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http://dx.doi.org/10.5694/mja2.50233DOI Listing
July 2019

Rivaroxaban Plus Aspirin Versus Aspirin in Relation to Vascular Risk in the COMPASS Trial.

J Am Coll Cardiol 2019 Jul;73(25):3271-3280

Department of Medicine, Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2019.02.079DOI Listing
July 2019

Individual Treatment Effect Estimation of 2 Doses of Dabigatran on Stroke and Major Bleeding in Atrial Fibrillation.

Circulation 2019 Jun 3;139(25):2846-2856. Epub 2019 May 3.

Department of Vascular Medicine, University Medical Center Utrecht, The Netherlands (M.C.S.-S., J.v.d.L., J.A.N.D., F.L.J.V.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035266DOI Listing
June 2019

Monitoring Emerging Data From the COMPASS Trial of an Antithrombotic Agent.

J Am Coll Cardiol 2019 Jun;73(21):2769-2772

Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin.

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http://dx.doi.org/10.1016/j.jacc.2019.03.479DOI Listing
June 2019

Deep vein thrombosis: update on diagnosis and management.

Med J Aust 2019 06 2;210(11):516-524. Epub 2019 Jun 2.

University of Western Australia, Perth, WA.

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http://dx.doi.org/10.5694/mja2.50201DOI Listing
June 2019

Stroke prevention in AF: Of Asians and non-Asians.

Eur Heart J 2019 May;40(19):1528-1530

Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.

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http://dx.doi.org/10.1093/eurheartj/ehy776DOI Listing
May 2019

Reversal of the antiplatelet effect of ticagrelor by simulated platelet transfusion.

Transfusion 2019 May 25;59(5):1850-1856. Epub 2019 Feb 25.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

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http://dx.doi.org/10.1111/trf.15219DOI Listing
May 2019

How I manage anticoagulant therapy in older individuals with atrial fibrillation or venous thromboembolism.

Blood 2019 05 29;133(21):2269-2278. Epub 2019 Mar 29.

Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada; Population Health Research Institute, Hamilton, ON, Canada; and Department of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1182/blood-2019-01-846048DOI Listing
May 2019

Rivaroxaban Plus Aspirin in Patients With Vascular Disease and Renal Dysfunction: From the COMPASS Trial.

J Am Coll Cardiol 2019 May;73(18):2243-2250

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Population Health Research Institute, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2019.02.048DOI Listing
May 2019

Reply: Rivaroxaban Plus Aspirin After CABG: More Evidence Is Needed.

J Am Coll Cardiol 2019 May;73(18):2360

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http://dx.doi.org/10.1016/j.jacc.2019.03.022DOI Listing
May 2019

Reduction in Mortality following Elective Major Hip and Knee Surgery: A Systematic Review and Meta-Analysis.

Thromb Haemost 2019 Apr 30;119(4):668-674. Epub 2019 Jan 30.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0039-1677732DOI Listing
April 2019

Management of Patients with Asymptomatic and Symptomatic Carotid Artery Disease: Update on Anti-Thrombotic Therapy.

Thromb Haemost 2019 Apr 31;119(4):576-585. Epub 2019 Jan 31.

I Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1055/s-0039-1678527DOI Listing
April 2019

Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors.

N Engl J Med 2019 04 7;380(14):1326-1335. Epub 2019 Feb 7.

From the Population Health Research Institute (S.J.C., J.W.E., D.M.S., E.Z., B.M., S.A., J.N.) and the Department of Medicine (M. Crowther), McMaster University, Hamilton, ON, and the University of Calgary, Calgary, AB (A.M.D.) - all in Canada; Harvard Medical School (C.M.G.) and Brigham and Women's Hospital (D.J.P.) - both in Boston; Portola Pharmaceuticals, South San Francisco, CA (J.T.C., J.H.L., P.Y., M.D.B., G.L., P.B.C., S.G., J.L., S.S.); University of Leuven, Leuven, Belgium (P.V.); Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand (J.S.), and Grenoble-Alpes University Hospital, Grenoble (P.A.) - both in France; Academic Medical Center, Amsterdam (S.M.); Guy's and St. Thomas' Hospitals, King's College London, London (A.T.C.); University Hospital Carl Gustav Carus Dresden, Dresden, Germany (J.B.-W.); Instituto de Investigación Hospital Universitario La Paz, Madrid (J.L.-S.); Sarasota Memorial Hospital, Sarasota, FL (M. Concha); and Seton Dell Medical School Stroke Institute, Austin, TX (T.J.M.).

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http://dx.doi.org/10.1056/NEJMoa1814051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699827PMC
April 2019

The FAST-MI 2005-2010-2015 registries in the light of the COMPASS trial: The COMPASS criteria applied to a post-MI population.

Int J Cardiol 2019 Mar 3;278:7-13. Epub 2018 Dec 3.

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP), Department of Cardiology, Paris, France; Université Paris-Descartes, Paris, France.

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http://dx.doi.org/10.1016/j.ijcard.2018.11.138DOI Listing
March 2019

NOACs only for those who cannot tolerate a VKA: where is the evidence?

Acta Cardiol 2019 Feb 23;74(1):17-20. Epub 2018 Feb 23.

a Department of Medicine , McMaster University , Hamilton , Canada.

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http://dx.doi.org/10.1080/00015385.2018.1442780DOI Listing
February 2019

The association between blood donor sex and age and transfusion recipient mortality: an exploratory analysis.

Transfusion 2019 02 10;59(2):482-491. Epub 2018 Nov 10.

McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada.

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http://doi.wiley.com/10.1111/trf.15011
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http://dx.doi.org/10.1111/trf.15011DOI Listing
February 2019

Antiplatelet Therapy versus Anticoagulation after Surgical Bioprosthetic Aortic Valve Replacement: A Systematic Review and Meta-Analysis.

Thromb Haemost 2019 Feb 7;119(2):328-339. Epub 2019 Jan 7.

Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0038-1676816DOI Listing
February 2019

Stroke Outcomes in the COMPASS Trial.

Circulation 2019 02;139(9):1134-1145

McMaster University/Population Health Research Institute, Hamilton, Canada (M.S., R.G.H., S.J.C., J.B., O.S., K.K.H.N., L.C., S.Y., J.W.E.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035864DOI Listing
February 2019

Synergy of Dual Pathway Inhibition in Chronic Cardiovascular Disease.

Circ Res 2019 02;124(3):416-425

McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada (J.I.W., J.W.A.E.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313141DOI Listing
February 2019

Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.

N Engl J Med 2019 02;380(8):720-728

From the Department of Hematology and Medical Oncology, Taussig Cancer Institute and Case Comprehensive Cancer Center, Cleveland Clinic, Cleveland (A.A.K.); the Department of Medicine, Memorial Sloan Kettering Cancer Center (G.A.S., E.M.O.), and Weill Cornell Medical College (G.A.S., E.M.O.), New York; the Thrombosis Research Institute and University College London, London (A.K.K.); University of Texas M.D. Anderson Cancer Center, Houston (S.V.-R.), and U.S. Oncology Research-Texas Oncology, Tyler (H.A.Y.) - both in Texas; the Department of Medicine, Charité Universitätsmedizin Berlin, Berlin (H.R.); the Division of Hematology-Oncology, University of California Davis School of Medicine, Sacramento (T.W.), and the Keck School of Medicine, University of Southern California, Los Angeles (H.A.L.); the Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore (M.B.S.); the University of Washington School of Medicine (D.A.G., N.M.K., G.H.L.), Advanced Cancer Research Group (N.M.K.), and Fred Hutchinson Cancer Research Center (G.H.L.), Seattle; Penn State Cancer Institute, Milton S. Hershey Medical Center, Hershey, PA (C.P.B.); the Department of Cancer Pharmacology, Levine Cancer Institute, Atrium Health, Charlotte, NC (J.N.P.); Janssen Scientific Affairs, Titusville (P.W., P.B., S.K.), and Janssen Research and Development, Raritan (U.V.) - both in New Jersey; the Department of Medicine, McMaster University, Hamilton, ON, Canada (J.E.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (R.M.); and the Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston (K.A.B.).

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http://www.nejm.org/doi/10.1056/NEJMoa1814630
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http://dx.doi.org/10.1056/NEJMoa1814630DOI Listing
February 2019

Blood Disorders in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review.

JACC Cardiovasc Interv 2019 01;12(1):1-11

Department of Cardiology, Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2018.09.041DOI Listing
January 2019

Rivaroxaban, Aspirin, or Both to Prevent Early Coronary Bypass Graft Occlusion: The COMPASS-CABG Study.

J Am Coll Cardiol 2019 01;73(2):121-130

Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183906
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http://dx.doi.org/10.1016/j.jacc.2018.10.048DOI Listing
January 2019

Patients with Peripheral Artery Disease in the COMPASS Trial.

Eur J Vasc Endovasc Surg 2018 12 10;56(6):772-773. Epub 2018 Sep 10.

Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejvs.2018.08.010DOI Listing
December 2018

Anticoagulant-Related Nephropathy.

J Am Soc Nephrol 2018 12 12;29(12):2787-2793. Epub 2018 Nov 12.

Division of Nephrology, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, Ohio; and

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http://dx.doi.org/10.1681/ASN.2018070741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287865PMC
December 2018

In Vitro Reversal of the Anti-Aggregant Effect of Ticagrelor Using Untreated Platelets.

Thromb Haemost 2018 Nov 17;118(11):1895-1901. Epub 2018 Oct 17.

Population Health Research Institute, Hamilton, Ontario, Canada.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673381
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http://dx.doi.org/10.1055/s-0038-1673381DOI Listing
November 2018

Low-dose rivaroxaban plus aspirin for the prevention of cardiovascular events: an evaluation of COMPASS.

Future Cardiol 2018 11 12;14(6):443-453. Epub 2018 Nov 12.

Department of Medicine, McMaster University, Hamilton, ON, L8S 4K1, Canada.

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https://www.futuremedicine.com/doi/10.2217/fca-2018-0059
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http://dx.doi.org/10.2217/fca-2018-0059DOI Listing
November 2018

Impact of cost on use of non-vitamin K antagonists in atrial fibrillation patients in Ontario, Canada.

J Thromb Thrombolysis 2018 Oct;46(3):310-315

Population Health Research Institute, Hamilton, ON, Canada.

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http://dx.doi.org/10.1007/s11239-018-1692-4DOI Listing
October 2018

Quantifying immature platelets as markers of increased platelet production after coronary artery bypass grafting surgery.

Eur J Haematol 2018 Sep 27;101(3):362-367. Epub 2018 Jul 27.

Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/ejh.13109DOI Listing
September 2018

Rivaroxaban with or without aspirin for prevention of cardiovascular disease.

Coron Artery Dis 2018 08;29(5):361-365

Department of Medicine, Division of Hematology and Thromboembolism, Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada.

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http://Insights.ovid.com/crossref?an=00019501-201808000-0000
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http://dx.doi.org/10.1097/MCA.0000000000000605DOI Listing
August 2018

Direct Oral Anticoagulants and Myocardial Infarction: The Dust Is Settling.

J Am Coll Cardiol 2018 07;72(1):27-28

McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2018.04.037DOI Listing
July 2018

Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation.

J Am Coll Cardiol 2018 07 9;72(3):255-267. Epub 2018 Jul 9.

Sidney Kimmel Medical College at Thomas Jefferson University and Lankenau and Bryn Mawr Hospitals, Philadelphia, Pennsylvania. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183482
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http://dx.doi.org/10.1016/j.jacc.2018.04.063DOI Listing
July 2018

Reduced-Intensity Anticoagulation for Mechanical Aortic Valve Prostheses.

J Am Coll Cardiol 2018 06;71(24):2727-2730

Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2018.04.018DOI Listing
June 2018

Efficacy and safety of dabigatran compared with warfarin in patients with atrial fibrillation in relation to renal function over time-A RE-LY trial analysis.

Am Heart J 2018 04 5;198:169-177. Epub 2018 Jan 5.

Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.ahj.2017.10.015DOI Listing
April 2018

The value of novel oral anticoagulants in rural Australia.

Med J Aust 2018 01;208(1):15-16

Population Health Research Institute, Hamilton, ON, Canada.

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http://dx.doi.org/10.5694/mja17.00592DOI Listing
January 2018

Rivaroxaban in Stable Cardiovascular Disease.

N Engl J Med 2018 01;378(4):397-398

Population Health Research Institute, Hamilton, ON, Canada

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http://dx.doi.org/10.1056/NEJMc1714934DOI Listing
January 2018

Aortic valve replacement in younger patients.

Eur Heart J 2017 12;38(45):3378-3381

Population Health Research Institute, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1093/eurheartj/ehx367DOI Listing
December 2017

A Test in Context: D-Dimer.

J Am Coll Cardiol 2017 Nov;70(19):2411-2420

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2017.09.024DOI Listing
November 2017

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease.

N Engl J Med 2017 10 27;377(14):1319-1330. Epub 2017 Aug 27.

From the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON (J.W.E., S.J.C., J.B., R.G.H., O.S., E.M.L., S.S.A., D.L., S.Y.), and Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, QC (G.R.D.) - both in Canada; Estudios Clínicos Latino América and Instituto Cardiovascular de Rosario, Rosario, Argentina (R.D.); Amphia Ziekenhuis and Werkgroep Cardiologische Centra Nederland (WCN), Utrecht, the Netherlands (M.A.); Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W.); Osaka International Cancer Institute, Osaka, Japan (M.H.); Instituto Dante Pazzanese de Cardiologia (A.A.), and Hospital do Coração (L.S.P.), São Paulo; University of Washington Medical Center (K.R.H.B.) and University of Washington (J.P.), Seattle; Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston (D.L.B.); FuWai Hospital, Beijing (J.Z., Y.L.); National Association of Hospital Cardiologists Research Center (ANMCO), Florence, Italy (A.P.M.); Research Institute, Fundación Oftalmológica de Santander (FOSCAL)-Bucaramanga, Bucaramanga, Colombia (P.L.-J.); National University of Ireland, Galway (M.O.); Thrombosis Research Institute and University College London, London (A.K.K.), Centre for Cardiovascular Science, University of Edinburgh, Edinburgh (K.A.A.F.), and University of Glasgow, Glasgow (T.J.G.) - all in the United Kingdom; Collegium Medicum Jagiellonian University, Krakow, Poland (T.J.G); Institute of Cardiology, Kiev, Ukraine (A.N.P.); University of Würzburg and University Hospital, Würzburg (G.E., S.S.), and Bayer, Leverkusen (N.C.B., F.M., E.C.) - all in Germany; Semmelweis University, Budapest, Hungary (M.K.); Karolinska Institutet, Stockholm (L.R.); National Research Center for Preventative Medicine, Moscow (N.P.); University of Philippines, Manila (A.L.D.); Universidad de La Frontera, Temuco, Chile (F.L.); University of Cape Town, Cape Town, South Africa (P.J.C.); University of Aalborg, Copenhagen (C.T.-P.); University of Leuven, Leuven, Belgium (P.B.V.); University of Medicine and Pharmacology, Carol Davila University and Emergency Hospital, Bucharest, Romania (D.V.); Catholic University of Korea, Seoul, South Korea (J.-H.K.); Monash University, Melbourne, VIC, Australia (A.M.T.); Lady Davis Carmel Medical Center, Haifa, Israel (B.S.L.); Facultad de Ciencias de la Salud Eugenio Espejo-Universidad Tecnológica Equinoccial, Quito, Ecuador (C.F.); Universiti Teknologi Mara, Selangor, Malaysia (K.Y.); Université Paris Diderot, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris (P.G.S.); and Turku University Central Hospital and Turku University, Turku, Finland (K.P.M.).

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http://dx.doi.org/10.1056/NEJMoa1709118DOI Listing
October 2017

Assessing renal function in patients receiving DOACs: Cockcroft-Gault versus estimated glomerular filtration rate.

Thromb Res 2017 09 25;157:165-166. Epub 2017 Jul 25.

Population Health Research Institute, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada; McMaster Thrombosis Clinic, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2017.07.020DOI Listing
September 2017

Idarucizumab for Dabigatran Reversal - Full Cohort Analysis.

N Engl J Med 2017 08 11;377(5):431-441. Epub 2017 Jul 11.

From Thomas Jefferson University, Philadelphia (C.V.P.); Boehringer Ingelheim, Ridgefield, CT (P.A.R., R.D., B.W.); Boehringer Ingelheim, Biberach (J.R., S.G., J.S.), Boehringer Ingelheim, Ingelheim am Rhein (J.K.), Klinikum Frankfurt Höchst, Frankfurt (T.S.), and Heidelberg University Hospital, Heidelberg (T.S.) - all in Germany; McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada (J.W.E., J.I.W.); Feinberg School of Medicine, Northwestern University, Chicago (R.A.B.); Leiden University Medical Center, Leiden (M.V.H.), and Tergooi Hospital, Hilversum (P.W.K.) - both in the Netherlands; Boston University School of Medicine, Boston (E.M.H.); Tuen Mun Hospital, Hong Kong (C.-W.K.); Duke University School of Medicine, Durham, NC (J.H.L.); Middlemore Hospital (G.R.) and the University of Auckland (L.Y.) - both in Auckland, New Zealand; Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence (F.W.S.); and KU Leuven, Center for Molecular and Vascular Biology, Leuven, Belgium (P.V.).

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http://dx.doi.org/10.1056/NEJMoa1707278DOI Listing
August 2017

In Reply.

Anesthesiology 2017 08;127(2):401-402

McMaster University and Population Health Research Institute, Hamilton, Ontario, Canada (J.W.E.).

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http://dx.doi.org/10.1097/ALN.0000000000001729DOI Listing
August 2017

Growth-differentiation factor 15 and risk of major bleeding in atrial fibrillation: Insights from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial.

Am Heart J 2017 Aug 6;190:94-103. Epub 2017 Jun 6.

Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.ahj.2017.06.001DOI Listing
August 2017

Platelet Transfusion for Ticagrelor Reversal.

Circ Cardiovasc Interv 2017 08;10(8)

From the Population Health Research Institute (P.K., J.W.E.); Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada (N.C., J.W.E.); and Hamilton Health Science Corporation and McMaster University, Ontario, Canada (P.K., N.C., J.W.E.).

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.117.005579DOI Listing
August 2017

Bleeding impacting mortality after noncardiac surgery: a protocol to establish diagnostic criteria, estimate prognostic importance, and develop and validate a prediction guide in an international prospective cohort study.

CMAJ Open 2017 Aug;5(3):E594-E603

Affiliations: Lilibeth Caberto Kidney Clinical Research Unit (Roshanov, Garg), London Health Sciences Centre, London, Ont.; Department of Medicine (Eikelboom, Tandon, Borges, Kearon, Panju, Sheth, Mizera, Ribas, Devereaux), Department of Surgery (Lamy, Whitlock, de Beer, Winemaker, Pinthus, Simunovic), Department of Health Research Methods, Evidence, and Impact (Lamy, Guyatt, Le Manach, Thabane, Simunovic, Devereaux), Department of Pathology and Molecular Medicine (Crowther, Kavsak), Department of Anesthesia (Spence, VanHelder, Le Manach), Thrombosis and Atherosclerosis Research Institute (Kearon) and School of Nursing (McGillion), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; Population Health Research Institute (Eikelboom, Borges, Lamy, Whitlock, Spence, McGillion, Le Manach, Devereaux), Hamilton, Ont.; Department of Anaesthesia and Perioperative Medicine (Biccard), Groote Schuur Hospital, Observatory, South Africa, and University of Cape Town, South Africa; Department of Intensive Care and Perioperative Medicine (Szczeklik), Jagiellonian University Medical College, Krakow, Poland; Institute for Clinical Evaluative Sciences at Western (Garg), London, Ont.; Faculty of Health and Life Sciences (McGillion), Coventry University, Coventry, United Kingdom; Department of Outcomes Research (Sessler), Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio.; Biostatistics Unit (Thabane), St. Joseph's Healthcare, Hamilton, Ont.

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http://dx.doi.org/10.9778/cmajo.20160106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963363PMC
August 2017

Trends in Perioperative Venous Thromboembolism Associated with Major Noncardiac Surgery.

TH Open 2017 Jul;1(2):e82-e91

Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1055/s-0037-1605360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146393PMC
July 2017

Resuming warfarin after intracranial hemorrhage in patients with AF was linked to reduced mortality.

Ann Intern Med 2017 06;166(12):JC70

McMaster UniversityHamilton, Ontario, Canada.

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http://dx.doi.org/10.7326/ACPJC-2017-166-12-070DOI Listing
June 2017

Laboratory Monitoring of Non-Vitamin K Antagonist Oral Anticoagulant Use in Patients With Atrial Fibrillation: A Review.

JAMA Cardiol 2017 05;2(5):566-574

Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada3Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada4Hamilton Health Sciences, Hamilton, Ontario, Canada6Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1001/jamacardio.2017.0364DOI Listing
May 2017

Anticoagulation for Mechanical Heart Valves: Will Oral Factor Xa Inhibitors Be Effective?

Arterioscler Thromb Vasc Biol 2017 05;37(5):743-745

From the Thrombosis and Atherosclerosis Research Institute, David Braley Research Institute, Hamilton, Canada (N.C.C., J.I.W., J.W.E.); and Department of Medicine, McMaster University, Hamilton, Canada (N.C.C., J.I.W., J.W.E.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309223DOI Listing
May 2017