John E Pimanda

John E Pimanda

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John E Pimanda

Publications by authors named "John E Pimanda"

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Transcriptional networks in acute myeloid leukemia.

Genes Chromosomes Cancer 2019 Dec 16;58(12):859-874. Epub 2019 Aug 16.

School of Medical Sciences, Faculty of Medicine, UNSW Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/gcc.22794DOI Listing
December 2019

Shared roles for and in murine platelet production and function.

Blood 2019 Sep 12;134(10):826-835. Epub 2019 Jul 12.

Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1182/blood.2019896175DOI Listing
September 2019

Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing.

JNCI Cancer Spectr 2019 Jun 16;3(2):pkz012. Epub 2019 Apr 16.

Prince of Wales Clinical School and Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1093/jncics/pkz012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649856PMC
June 2019

A novel role for in primitive erythropoiesis.

Development 2018 10 11;145(19). Epub 2018 Oct 11.

Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia

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http://dx.doi.org/10.1242/dev.162990DOI Listing
October 2018

Disruption of a -35 kb Enhancer Impairs CTCF Binding and Expression in Colorectal Cells.

Clin Cancer Res 2018 09 13;24(18):4602-4611. Epub 2018 Jun 13.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, UNSW Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3678DOI Listing
September 2018

Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method.

Bioinformatics 2017 Sep;33(17):2622-2630

Department of Radiology, Center for Bioinformatics and Systems Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1093/bioinformatics/btx280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860060PMC
September 2017

Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif.

Cell Rep 2016 12;17(11):2865-2872

Prince of Wales Clinical School and Lowy Cancer Research Center, UNSW Australia, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.055DOI Listing
December 2016

Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr.

Mol Cell Biol 2016 Apr 31;36(8):1222-36. Epub 2016 Mar 31.

Adult Cancer Program, Prince of Wales Clinical School, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia Department of Haematology, Prince of Wales Hospital, Sydney, NSW, Australia

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http://dx.doi.org/10.1128/MCB.01035-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836279PMC
April 2016

PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

Proc Natl Acad Sci U S A 2016 Apr 4;113(16):E2306-15. Epub 2016 Apr 4.

Lowy Cancer Research Centre, University of New South Wales (UNSW) Australia, Sydney, NSW 2052, Australia; The Prince of Wales Clinical School, UNSW Australia, Sydney, NSW 2052, Australia; Department of Haematology, The Prince of Wales Hospital, Sydney, NSW 2032, Australia

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http://dx.doi.org/10.1073/pnas.1518244113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843430PMC
April 2016

Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes.

Nature 2016 Apr;532(7598):259-63

Prince of Wales Clinical School and Lowy Cancer Research Centre, UNSW Australia, Sydney 2052, Australia.

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http://dx.doi.org/10.1038/nature17437DOI Listing
April 2016

Clinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers.

Int J Cancer 2016 Feb 28;138(3):525-32. Epub 2015 Jan 28.

Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales (UNSW) Medicine Department, Sydney, New South Wales, 2052, Australia.

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http://dx.doi.org/10.1002/ijc.29431DOI Listing
February 2016

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a.

Genes Dev 2016 Jan;30(1):78-91

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia;

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http://dx.doi.org/10.1101/gad.268425.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701980PMC
January 2016

OncoCis: annotation of cis-regulatory mutations in cancer.

Genome Biol 2014 ;15(10):485

Prince of Wales Clinical School and Lowy Cancer Research Centre, UNSW, Australia, Sydney 2052, Australia.

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http://dx.doi.org/10.1186/s13059-014-0485-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224696PMC
October 2015

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.

J Exp Med 2015 Sep 24;212(10):1551-69. Epub 2015 Aug 24.

Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0XY, England, UK Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1TN, England, UK

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http://jem.rupress.org/content/212/10/1551.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20141661
Publisher Site
http://dx.doi.org/10.1084/jem.20141661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577832PMC
September 2015

CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations.

Oncotarget 2015 Aug;6(23):19661-70

Prostate Cancer Research Center (PCRC), Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637312PMC
http://dx.doi.org/10.18632/oncotarget.3875DOI Listing
August 2015

Systematic Screening of Promoter Regions Pinpoints Functional Cis-Regulatory Mutations in a Cutaneous Melanoma Genome.

Mol Cancer Res 2015 Aug 16;13(8):1218-26. Epub 2015 Jun 16.

Prince of Wales Clinical School, University of New South Wales Australia, Sydney, Australia. Lowy Cancer Research Centre, University of New South Wales Australia, Sydney, Australia.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0146DOI Listing
August 2015

SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development.

Mol Cell Biol 2015 Jun 13;35(12):2165-72. Epub 2015 Apr 13.

Lowy Cancer Research Centre and the Prince of Wales Clinical School, The University of New South Wales, Sydney, NSW, Australia Department of Haematology, Prince of Wales Hospital, Sydney, NSW, Australia

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http://dx.doi.org/10.1128/MCB.00239-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438244PMC
June 2015

High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.

Stem Cell Res 2015 May 18;14(3):307-22. Epub 2015 Feb 18.

Howard Hughes Medical Institute, USA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA; Joslin Diabetes Center, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18735061150002
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http://dx.doi.org/10.1016/j.scr.2015.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439311PMC
May 2015

Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis.

Biol Open 2015 May 15;4(7):819-29. Epub 2015 May 15.

Lowy Cancer Research Centre and the Prince of Wales Clinical School, UNSW Australia, Sydney, NSW 2052, Australia Department of Haematology, Prince of Wales Hospital, Sydney, NSW 2031, Australia

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http://dx.doi.org/10.1242/bio.011494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571086PMC
May 2015

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells.

Blood 2015 Jan 21;125(2):273-83. Epub 2014 Oct 21.

Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, and the.

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http://dx.doi.org/10.1182/blood-2014-05-576470DOI Listing
January 2015

Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.

Epigenetics 2014 Aug 16;9(8):1092-100. Epub 2014 May 16.

Adult Cancer Program; Lowy Cancer Research Centre and Prince of Wales Clinical School; Sydney, NSW Australia.

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http://dx.doi.org/10.4161/epi.29222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164494PMC
August 2014

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Cancer Cell 2014 Jun 15;25(6):794-808. Epub 2014 May 15.

Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.036DOI Listing
June 2014

Reassembly of nucleosomes at the MLH1 promoter initiates resilencing following decitabine exposure.

PLoS Genet 2013 25;9(7):e1003636. Epub 2013 Jul 25.

Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1371/journal.pgen.1003636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723495PMC
January 2014

BloodChIP: a database of comparative genome-wide transcription factor binding profiles in human blood cells.

Nucleic Acids Res 2014 Jan 31;42(Database issue):D172-7. Epub 2013 Oct 31.

Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1093/nar/gkt1036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964976PMC
January 2014

Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target.

Cancer Res 2013 Nov 7;73(22):6548-53. Epub 2013 Nov 7.

Authors' Affiliations: Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Hospital, University of New South Wales (UNSW) Medicine; Translational Cancer Research Network, University of New South Wales (UNSW), Sydney, Australia; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University; and Department of Pathology, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1994DOI Listing
November 2013

Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence.

Dev Biol 2013 Jul 23;379(2):258-69. Epub 2013 Apr 23.

Department of Bioengineering, Rice University, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.ydbio.2013.04.016DOI Listing
July 2013

Cell signalling pathways that mediate haematopoietic stem cell specification.

Int J Biochem Cell Biol 2012 Dec 17;44(12):2175-84. Epub 2012 Sep 17.

Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.biocel.2012.09.007DOI Listing
December 2012

Signal analysis for genome-wide maps of histone modifications measured by ChIP-seq.

Bioinformatics 2012 Apr 17;28(8):1062-9. Epub 2012 Feb 17.

Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1093/bioinformatics/bts085DOI Listing
April 2012

Pdgfrα and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells.

Stem Cell Res 2012 Mar 8;8(2):165-79. Epub 2011 Oct 8.

Differentiation and Transcription Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia.

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http://dx.doi.org/10.1016/j.scr.2011.09.007DOI Listing
March 2012

Gene regulatory networks governing haematopoietic stem cell development and identity.

Int J Dev Biol 2010 ;54(6-7):1201-11

Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1387/ijdb.093038jpDOI Listing
February 2011

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.

Arterioscler Thromb Vasc Biol 2010 Mar 17;30(3):536-45. Epub 2009 Dec 17.

Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia.

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http://dx.doi.org/10.1161/ATVBAHA.109.193821DOI Listing
March 2010

The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.

Proc Natl Acad Sci U S A 2007 Jan 9;104(3):840-5. Epub 2007 Jan 9.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0607196104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783401PMC
January 2007

A common origin of the 4143insA ADAMTS13 mutation.

Thromb Haemost 2006 Jul;96(1):3-6

University Medical Center Hamburg-Eppendorf, Department of Pediatric Hematology and Oncology, Martinistrasse 52, D-20246 Hamburg, Germany.

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http://dx.doi.org/10.1160/TH05-12-0817DOI Listing
July 2006

Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer.

Blood 2006 Jun 16;107(12):4737-45. Epub 2006 Feb 16.

Department of Hematology, Cambridge Institute of Medical Research, University of Cambridge, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1182/blood-2005-12-4929DOI Listing
June 2006

The proto-oncogene ERG in megakaryoblastic leukemias.

Cancer Res 2005 Sep;65(17):7596-602

Department of Pediatric Hematology-Oncology, Safra Children's Hospital and Hematology Institute, Sheba Cancer Research Center, Sheba Medical Center, Tel-Hashomer, Israel.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0147DOI Listing
September 2005

Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice.

J Biol Chem 2004 May 23;279(20):21439-48. Epub 2004 Feb 23.

Centre for Vascular Research, University of New South Wales and the Department of Haematology, The Prince of Wales Hospital, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1074/jbc.M313560200DOI Listing
May 2004

Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13.

Blood 2004 Jan 25;103(2):627-9. Epub 2003 Sep 25.

Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1182/blood-2003-04-1346DOI Listing
January 2004

Novel and emerging therapies in cardiology and haematology.

Curr Drug Targets Cardiovasc Haematol Disord 2003 Jun;3(2):101-23

Centre for Vascular Research, The University of New South Wales, and Department of Haematology, The Prince of Wales Hospital, Sydney, Australia.

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June 2003

A perspective on the measurement of ADAMTS13 in thrombotic thrombocytopaenic purpura.

Eur J Haematol 2003 Apr;70(4):257-62

The University of New South Wales and The Department of Haematology, The Prince of Wales Hospital, Sydney, Australia.

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http://dx.doi.org/10.1034/j.1600-0609.2003.00057.xDOI Listing
April 2003

The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974.

Blood 2002 Oct;100(8):2832-8

Centre for Thrombosis and Vascular Research and Cytokine Research Unit, School of Medical Sciences, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, Australia.

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http://dx.doi.org/10.1182/blood-2002-03-0770DOI Listing
October 2002