John E Ladbury

John E Ladbury

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John E Ladbury

John E Ladbury

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Intrinsic Thermodynamics of Protein-Ligand Binding by Isothermal Titration Calorimetry as Aid to Drug Design.

Methods Mol Biol 2019 ;1964:61-74

Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania.

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http://dx.doi.org/10.1007/978-1-4939-9179-2_5DOI Listing
August 2019

Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling.

Cancer Lett 2019 Aug 14;457:86-97. Epub 2019 May 14.

School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584941PMC
August 2019

H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing.

Nucleic Acids Res 2019 03;47(5):2666-2680

King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Division of Biological and Environmental Sciences and Engineering (BESE), Thuwal, 23955-6900,Saudi Arabia.

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https://academic.oup.com/nar/advance-article/doi/10.1093/nar
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http://dx.doi.org/10.1093/nar/gky1299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411929PMC
March 2019

Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry.

Chem Commun (Camb) 2018 Jul;54(57):7995-7998

Institute for Protein research, Osaka University, Yamadaoka 3-2, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1039/c8cc02718hDOI Listing
July 2018

Thermodynamic, kinetic, and structural parameterization of human carbonic anhydrase interactions toward enhanced inhibitor design.

Q Rev Biophys 2018 01;51:e10

Department of Biothermodynamics and Drug Design,Institute of Biotechnology, Life Sciences Center, Vilnius University,Saulėtekio 7, 10257 Vilnius,Lithuania.

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http://dx.doi.org/10.1017/S0033583518000082DOI Listing
January 2018

Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity.

Biochem J 2016 11 22;473(21):3837-3854. Epub 2016 Aug 22.

Institute for Protein Research, Osaka University, Yamadaoka 3-2, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1042/BCJ20160658DOI Listing
November 2016

Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.

J Biol Chem 2016 Mar 14;291(11):5623-33. Epub 2016 Jan 14.

From the Structural and Computational Biology and Molecular Biophysics Program, Department of Pharmacology, and Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030,

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http://www.jbc.org/content/291/11/5623.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.691303
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http://dx.doi.org/10.1074/jbc.M115.691303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786703PMC
March 2016

Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma.

Am J Cancer Res 2015 15;5(10):3135-48. Epub 2015 Sep 15.

School of Molecular and Cellular Biology, University of Leeds Leeds, LS2 9JT, UK ; Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center Unit 1000, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656736PMC
December 2015

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.

Nat Immunol 2015 Sep 13;16(9):970-9. Epub 2015 Jul 13.

1] Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [2] Department of Dermatology, University Hospital CHUV, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/ni.3211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776746PMC
September 2015

Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors.

Chem Sci 2015 Aug 3;6(8):4778-4783. Epub 2015 Jun 3.

Department of Chemistry , Rice University , 6100 Main St. , Houston , Texas , USA . Email:

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http://dx.doi.org/10.1039/c5sc01602aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667506PMC
August 2015

Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.

Nat Commun 2015 Jun 24;6:7354. Epub 2015 Jun 24.

1] Department of Biochemistry and Molecular Biology, University of Texas, M.D. Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] Center for Biomolecular Structure and Function, University of Texas, M.D. Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [3] School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1038/ncomms8354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491180PMC
June 2015

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.

Biochem J 2015 Mar;466(2):337-46

†Department of Biochemistry and Molecular Biology and Center for Biomolecular Structure and Function, The University of Texas MD Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston TX 77030, U.S.A.

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http://dx.doi.org/10.1042/BJ20140933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142613PMC
March 2015

A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans.

Dev Cell 2014 Dec;31(5):614-28

Department of Genetics, UT MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, Houston, TX 77030, USA; Center for Genetics and Genomics, UT MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261158PMC
December 2014

Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity.

PLoS One 2014 27;9(1):e86784. Epub 2014 Jan 27.

Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America ; Program in Genes & Development, The University of Texas Graduate School of Biomedical Science - Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086784PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903613PMC
September 2014

The toolbox is open, but who should pay for the job?

Nat Rev Drug Discov 2014 Jul;13(7):479-80

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1038/nrd4367DOI Listing
July 2014

(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus.

Structure 2014 Apr 27;22(4):515-525. Epub 2014 Feb 27.

Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, and Northeast Structural Genomics Consortium, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, U.S.A.

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http://dx.doi.org/10.1016/j.str.2014.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110948PMC
April 2014

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion.

Nat Struct Mol Biol 2014 Feb 19;21(2):180-8. Epub 2014 Jan 19.

1] Department of Biochemistry and Molecular Biology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA. [2] Center for Biomolecular Structure and Function, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA.

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http://www.nature.com/articles/nsmb.2752
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http://dx.doi.org/10.1038/nsmb.2752DOI Listing
February 2014

SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.

J Biol Chem 2013 Oct 9;288(41):29539-49. Epub 2013 Aug 9.

From the Cell Signalling Section, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M112.424846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795252PMC
October 2013

CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins.

Biochem J 2013 Aug;454(1):109-21

Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A.

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http://dx.doi.org/10.1042/BJ20130485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749870PMC
August 2013

Biophysical characterization of VEGF-aHt DNA aptamer interactions.

Int J Biol Macromol 2013 Jun 5;57:69-75. Epub 2013 Mar 5.

Department of Biology and Biochemistry, University of Houston, TX, USA.

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http://dx.doi.org/10.1016/j.ijbiomac.2013.02.016DOI Listing
June 2013

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.

Nat Struct Mol Biol 2013 May 14;20(5):620-7. Epub 2013 Apr 14.

Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059177PMC
http://dx.doi.org/10.1038/nsmb.2557DOI Listing
May 2013

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.

J Cell Biol 2013 Feb;200(4):493-504

Department of Biochemistry and Molecular Biology and Center for Biomolecular Structure and Function, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://www.jcb.org/lookup/doi/10.1083/jcb.201204106
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http://dx.doi.org/10.1083/jcb.201204106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575544PMC
February 2013

Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems.

J Am Chem Soc 2012 Jun 7;134(24):10138-45. Epub 2012 Jun 7.

Department of Chemistry, Rice University, Houston, Texas 77005, USA.

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http://pubs.acs.org/doi/10.1021/ja302284p
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http://dx.doi.org/10.1021/ja302284pDOI Listing
June 2012

Inhibition of basal FGF receptor signaling by dimeric Grb2.

Cell 2012 Jun;149(7):1514-24

Department of Biochemistry and Molecular Biology and Center for Biomolecular Structure and Function, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.cell.2012.04.033DOI Listing
June 2012

Noise in cellular signaling pathways: causes and effects.

Trends Biochem Sci 2012 May 15;37(5):173-8. Epub 2012 Feb 15.

Department of Biochemistry and Molecular Biology, Unit 1000, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.tibs.2012.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348409PMC
May 2012

Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid.

J Biol Chem 2012 Jan 18;287(1):736-47. Epub 2011 Nov 18.

Department of Immunology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1074/jbc.M111.238477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249128PMC
January 2012

Catalysis and regulation.

Curr Opin Struct Biol 2011 Dec;21(6):775-6

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http://dx.doi.org/10.1016/j.sbi.2011.10.007DOI Listing
December 2011

Extent of enthalpy-entropy compensation in protein-ligand interactions.

Protein Sci 2011 Sep 2;20(9):1607-18. Epub 2011 Aug 2.

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1002/pro.692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190155PMC
September 2011

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling.

Methods Enzymol 2011 ;488:147-83

Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1016/B978-0-12-381268-1.00007-0DOI Listing
May 2011

Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering.

J Biol Chem 2011 Feb 14;286(8):6685-96. Epub 2010 Dec 14.

Nuffield Department of Clinical Medicine and MRC Human Immunology Unit, The University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom.

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http://www.jbc.org/content/286/8/6685.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M110.182394
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http://dx.doi.org/10.1074/jbc.M110.182394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057841PMC
February 2011

H-NS forms a superhelical protein scaffold for DNA condensation.

Proc Natl Acad Sci U S A 2010 Sep 23;107(36):15728-32. Epub 2010 Aug 23.

Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center, Houston, 77030, USA.

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http://dx.doi.org/10.1073/pnas.1006966107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936596PMC
September 2010

Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design.

Authors:
John E Ladbury

Biochem Soc Trans 2010 Aug;38(4):888-93

Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1042/BST0380888DOI Listing
August 2010

T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation.

Biochem J 2010 May 27;428(3):429-37. Epub 2010 May 27.

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E6BT, UK.

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http://biochemj.org/lookup/doi/10.1042/BJ20091660
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http://dx.doi.org/10.1042/BJ20091660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888567PMC
May 2010

T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.

Immunity 2010 Apr 25;32(4):541-56. Epub 2010 Mar 25.

Cell Signaling Section, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge UK, CB2 1Q.

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http://dx.doi.org/10.1016/j.immuni.2010.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812847PMC
April 2010

The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Apr 31;66(Pt 4):421-5. Epub 2010 Mar 31.

Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, England.

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http://dx.doi.org/10.1107/S1744309110004574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852335PMC
April 2010

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function.

Cell Signal 2010 Jan 6;22(1):23-33. Epub 2009 Sep 6.

Department of Structural & Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.cellsig.2009.08.011DOI Listing
January 2010

Adding calorimetric data to decision making in lead discovery: a hot tip.

Nat Rev Drug Discov 2010 01 4;9(1):23-7. Epub 2009 Dec 4.

University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://www.nature.com/articles/nrd3054
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http://dx.doi.org/10.1038/nrd3054DOI Listing
January 2010

Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90.

J Mol Biol 2009 Oct 21;392(4):923-36. Epub 2009 Jul 21.

Institute of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.jmb.2009.07.041DOI Listing
October 2009

Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria.

Mol Microbiol 2009 Jul 8;73(2):165-79. Epub 2009 Jun 8.

Department of Structural and Molecular Biology, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2009.06754.xDOI Listing
July 2009

Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.

J Mol Biol 2009 Apr 4;387(5):1120-36. Epub 2009 Mar 4.

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.jmb.2009.02.061DOI Listing
April 2009

Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: implications for drug design.

Proteins 2008 Dec;73(4):929-40

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1002/prot.22119DOI Listing
December 2008

Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).

Biochem J 2008 Dec;416(2):189-99

Department of Biochemistry and Molecular Biology, Darwin Building, Gower Street, London WC1E6BT, UK.

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http://dx.doi.org/10.1042/BJ20080887DOI Listing
December 2008

The thermodynamics of protein-ligand interaction and solvation: insights for ligand design.

J Mol Biol 2008 Dec 9;384(4):1002-17. Epub 2008 Oct 9.

Institute of Structural and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1016/j.jmb.2008.09.073DOI Listing
December 2008

Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.

Nucleic Acids Res 2008 Sep 2;36(16):5139-51. Epub 2008 Aug 2.

Department of Biochemistry and Pharmaceutical Science Division, School of Biomedical and Health Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford St., London SE1 9NH, UK.

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http://dx.doi.org/10.1093/nar/gkn490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532732PMC
September 2008

The binding stoichiometry of CIN85 SH3 domain A and cbl-b.

Nat Struct Mol Biol 2008 Sep;15(9):890-1; author reply 891-2

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http://dx.doi.org/10.1038/nsmb0908-890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770232PMC
September 2008

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling.

Biochem J 2008 Jul;413(1):37-49

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1042/BJ20071594DOI Listing
July 2008

A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein.

J Mol Biol 2008 Mar 28;377(3):740-7. Epub 2007 Dec 28.

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360701669
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http://dx.doi.org/10.1016/j.jmb.2007.12.040DOI Listing
March 2008

Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation.

Biochem J 2008 Feb;410(1):205-11

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1042/BJ20070859DOI Listing
February 2008

Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation.

Proteins 2007 Jun;67(4):981-90

Department of Biochemistry and Molecular Biology, University College London, United Kingdom.

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http://dx.doi.org/10.1002/prot.21369DOI Listing
June 2007

Survey of the year 2005: literature on applications of isothermal titration calorimetry.

J Mol Recognit 2007 Jan-Feb;20(1):4-14

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1002/jmr.803DOI Listing
April 2007

Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction.

Authors:
John E Ladbury

Acta Crystallogr D Biol Crystallogr 2007 Jan 13;63(Pt 1):26-31. Epub 2006 Dec 13.

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, England.

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http://dx.doi.org/10.1107/S0907444906046373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483503PMC
January 2007

Redox-state-dependent complex formation between pseudoazurin and nitrite reductase.

J Am Chem Soc 2007 Jan;129(1):226-33

Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1021/ja0659830DOI Listing
January 2007

Partial filling multiple injection affinity capillary electrophoresis (PFMIACE) to estimate binding constants of receptors to ligands.

Talanta 2007 Jan 15;71(1):192-201. Epub 2006 May 15.

Department of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032-8202, USA.

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http://dx.doi.org/10.1016/j.talanta.2006.03.039DOI Listing
January 2007

Partial-filling affinity capillary electrophoresis techniques to probe the binding of glycopeptide antibiotics to D-Ala-D-Ala terminus peptides.

J Capill Electrophor Microchip Technol 2006 ;9(5-6):101-17

Department of Chemistry and Biochemistry, California State University, Los Angeles, CA 90032-8202, USA.

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December 2006

Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.

J Biol Chem 2006 Sep 27;281(39):29309-20. Epub 2006 Jun 27.

Nuffield Department of Clinical Medicine, The University of Oxford and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.

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http://www.jbc.org/content/281/39/29309.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M601314200
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http://dx.doi.org/10.1074/jbc.M601314200DOI Listing
September 2006

Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.

Structure 2006 Mar;14(3):415-26

Department of Biochemistry and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1016/j.str.2005.12.009DOI Listing
March 2006

Survey of the year 2004: literature on applications of isothermal titration calorimetry.

J Mol Recognit 2006 Jan-Feb;19(1):79-89

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1002/jmr.750DOI Listing
February 2006

Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors.

J Mol Biol 2005 Nov 27;353(5):1001-10. Epub 2005 Sep 27.

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.jmb.2005.09.024DOI Listing
November 2005

H-NS is a part of a thermally controlled mechanism for bacterial gene regulation.

Biochem J 2005 Oct;391(Pt 2):203-13

Department of Biochemistry and Molecular Biology, and Institute of Structural Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1042/BJ20050453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276917PMC
October 2005

A survey of the year 2003 literature on applications of isothermal titration calorimetry.

J Mol Recognit 2004 Nov-Dec;17(6):513-23

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1002/jmr.714DOI Listing
March 2005

Molecular recognition via coupled folding and binding in a TPR domain.

J Mol Biol 2005 Feb 18;346(3):717-32. Epub 2005 Jan 18.

Department of Biochemistry and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.jmb.2004.12.017DOI Listing
February 2005

Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.

EMBO J 2005 Jan 2;24(1):1-10. Epub 2004 Dec 2.

Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK.

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http://dx.doi.org/10.1038/sj.emboj.7600496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544909PMC
January 2005

Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice.

Protein Sci 2004 Dec;13(12):3115-26

Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106-4935, USA.

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http://dx.doi.org/10.1110/ps.04866404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287320PMC
December 2004

Application of isothermal titration calorimetry in the biological sciences: things are heating up!

Authors:
John E Ladbury

Biotechniques 2004 Dec;37(6):885-7

University College London, London, UK.

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https://www.future-science.com/doi/10.2144/04376TE01
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December 2004

Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity.

Biochemistry 2004 Nov;43(44):13910-25

Department of Biochemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106-4935, USA.

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http://dx.doi.org/10.1021/bi0491999DOI Listing
November 2004

The extended interface: measuring non-local effects in biomolecular interactions.

Curr Opin Struct Biol 2004 Oct;14(5):562-9

Department of Biochemistry and Molecular Biology, Institute for Structural Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.sbi.2004.08.001DOI Listing
October 2004

A survey of the year 2002 literature on applications of isothermal titration calorimetry.

J Mol Recognit 2003 Nov-Dec;16(6):383-91

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1002/jmr.648DOI Listing
September 2004

Heat capacity effects of water molecules and ions at a protein-DNA interface.

J Mol Biol 2004 Feb;336(4):829-42

Department of Biochemistry and Molecular Biology, Institute for Structural Molecular Biology, ISMB, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.jmb.2003.12.061DOI Listing
February 2004

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

J Biol Chem 2003 Oct 21;278(41):39735-46. Epub 2003 Jul 21.

Institute of Biochemistry II, University of Frankfurt Medical School, Theodor-Stern-Kai 7, Frankfurt 60590, Germany.

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http://dx.doi.org/10.1074/jbc.M304541200DOI Listing
October 2003

Specificity is complex and time consuming: mutual exclusivity in tyrosine kinase-mediated signaling.

Acc Chem Res 2003 Jun;36(6):410-6

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1021/ar020167sDOI Listing
June 2003

H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein.

J Mol Biol 2002 Dec;324(4):841-50

Department of Biochemistry and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/s0022-2836(02)01141-5DOI Listing
December 2002

Reversal of halophilicity in a protein-DNA interaction by limited mutation strategy.

Structure 2002 May;10(5):629-37

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1016/s0969-2126(02)00749-9DOI Listing
May 2002

Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains.

J Mol Biol 2002 May;319(1):87-106

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK

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http://dx.doi.org/10.1016/S0022-2836(02)00236-XDOI Listing
May 2002

The hidden thermodynamics of a zinc finger.

J Mol Biol 2002 Mar;316(4):969-89

Department of Biochemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4935, USA.

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http://dx.doi.org/10.1006/jmbi.2001.5335DOI Listing
March 2002