Publications by authors named "John E Dick"

100Publications

Human Aging Alters the Spatial Organization between CD34+ Hematopoietic Cells and Adipocytes in Bone Marrow.

Stem Cell Reports 2020 08 9;15(2):317-325. Epub 2020 Jul 9.

Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2020.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419665PMC
August 2020

Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal.

Cell Stem Cell 2019 11 17;25(5):639-653.e7. Epub 2019 Oct 17.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G0A3, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838675PMC
November 2019

High efficiency error suppression for accurate detection of low-frequency variants.

Nucleic Acids Res 2019 09;47(15):e87

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/nar/gkz474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735726PMC
September 2019

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia.

Cell Rep 2018 10;25(5):1109-1117.e5

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183159
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http://dx.doi.org/10.1016/j.celrep.2018.10.021DOI Listing
October 2018

Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression.

Exp Hematol 2019 01 22;69:27-36. Epub 2018 Oct 22.

Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X183086
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http://dx.doi.org/10.1016/j.exphem.2018.10.006DOI Listing
January 2019

Prediction of acute myeloid leukaemia risk in healthy individuals.

Nature 2018 07 9;559(7714):400-404. Epub 2018 Jul 9.

Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-018-0317-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485381PMC
July 2018

Global proteomics dataset of miR-126 overexpression in acute myeloid leukemia.

Data Brief 2016 Dec 24;9:57-61. Epub 2016 Aug 24.

Princess Margaret Cancer Centre, University Health Network, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada ON M5G 1L7.

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http://dx.doi.org/10.1016/j.dib.2016.07.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021708PMC
December 2016

An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers.

Cancer Res 2016 Mar 1;76(5):1214-24. Epub 2016 Feb 1.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Division of Medical Oncology and Hematology, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2743DOI Listing
March 2016

Molecular landscapes of human hematopoietic stem cells in health and leukemia.

Ann N Y Acad Sci 2016 04 11;1370(1):5-14. Epub 2015 Dec 11.

Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1111/nyas.12981DOI Listing
April 2016

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.

Cancer Cell 2015 Dec 25;28(6):715-729. Epub 2015 Nov 25.

Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(15)00382-7.pd
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http://linkinghub.elsevier.com/retrieve/pii/S153561081500382
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http://dx.doi.org/10.1016/j.ccell.2015.10.005DOI Listing
December 2015

CDK6 levels regulate quiescence exit in human hematopoietic stem cells.

Cell Stem Cell 2015 Mar 19;16(3):302-13. Epub 2015 Feb 19.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359055PMC
March 2015

Intercellular network structure and regulatory motifs in the human hematopoietic system.

Mol Syst Biol 2014 Jul 15;10:741. Epub 2014 Jul 15.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada The Donnelly Centre, University of Toronto, Toronto, ON, Canada Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada McEwen Centre for Regenerative Medicine, University of Health Network, Toronto, ON, Canada Heart & Stroke/Richard Lewar Centre of Excellence, Toronto, ON, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299490PMC
http://dx.doi.org/10.15252/msb.20145141DOI Listing
July 2014

Tumor archaeology: tracking leukemic evolution to its origins.

Authors:
John E Dick

Sci Transl Med 2014 May;6(238):238fs23

Princess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Ontario M5G2C1, Canada.

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http://dx.doi.org/10.1126/scitranslmed.3009168DOI Listing
May 2014

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

Nature 2014 Jun 28;510(7504):268-72. Epub 2014 Apr 28.

1] Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1038/nature13228DOI Listing
June 2014

Evolution of the cancer stem cell model.

Cell Stem Cell 2014 Mar;14(3):275-91

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada and Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.02.006DOI Listing
March 2014

Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion.

Cell Stem Cell 2014 Jan;14(1):94-106

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2013.11.021DOI Listing
January 2014

Self-renewal as a therapeutic target in human colorectal cancer.

Nat Med 2014 Jan 1;20(1):29-36. Epub 2013 Dec 1.

1] Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. [3] Department of Surgery, Toronto General Hospital, Toronto, Ontario, Canada. [4].

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http://dx.doi.org/10.1038/nm.3418DOI Listing
January 2014

The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment.

Nat Immunol 2013 Jul 26;14(7):756-63. Epub 2013 May 26.

Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ni.2615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961471PMC
July 2013

Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer.

Science 2013 Feb 13;339(6119):543-8. Epub 2012 Dec 13.

Campbell Family Institute, Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1126/science.1227670DOI Listing
February 2013

Attenuation of miR-126 activity expands HSC in vivo without exhaustion.

Cell Stem Cell 2012 Dec 8;11(6):799-811. Epub 2012 Nov 8.

Campbell Family Institute, Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.stem.2012.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517970PMC
December 2012

Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts.

J Exp Med 2012 Sep 3;209(10):1883-99. Epub 2012 Sep 3.

The Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1084/jem.20120502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457732PMC
September 2012

Molecular and functional characterization of early human hematopoiesis.

Ann N Y Acad Sci 2012 Aug;1266:68-71

Campbell Family Institute for Cancer Research/Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1749-6632.2012.06577.xDOI Listing
August 2012

ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21.

Cancer Cell 2012 Jun;21(6):777-92

Campbell Family Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.ccr.2012.04.036DOI Listing
June 2012

Hematopoiesis: a human perspective.

Cell Stem Cell 2012 Feb;10(2):120-36

Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research/Ontario Cancer Institute, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.1016/j.stem.2012.01.006DOI Listing
February 2012

Stem cell gene expression programs influence clinical outcome in human leukemia.

Nat Med 2011 Aug 28;17(9):1086-93. Epub 2011 Aug 28.

Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research, Ontario Cancer Institute, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://www.nature.com/articles/nm.2415
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http://dx.doi.org/10.1038/nm.2415DOI Listing
August 2011

Auger electron radioimmunotherapeutic agent specific for the CD123+/CD131- phenotype of the leukemia stem cell population.

J Nucl Med 2011 Sep 4;52(9):1465-73. Epub 2011 Aug 4.

Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2967/jnumed.111.087668DOI Listing
September 2011

Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.

Science 2011 Jul;333(6039):218-21

Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research/Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1126/science.1201219DOI Listing
July 2011

Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.

Nature 2011 Jan;469(7330):362-7

Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research/Ontario Cancer Institute, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1038/nature09733DOI Listing
January 2011

Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance.

Blood 2010 Dec 1;116(24):5268-79. Epub 2010 Sep 1.

Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2010-06-292300DOI Listing
December 2010

Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development.

Nat Immunol 2010 Jul 13;11(7):585-93. Epub 2010 Jun 13.

Department of Stem Cell and Developmental Biology, Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ni.1889DOI Listing
July 2010

Comparison of human cord blood engraftment between immunocompromised mouse strains.

Blood 2010 Jul 19;116(2):193-200. Epub 2010 Apr 19.

Department of Molecular Genetics, University of Toronto, University Health Network, 101 College St., Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2010-02-271841DOI Listing
July 2010

Engraftment of human hematopoietic stem cells is more efficient in female NOD/SCID/IL-2Rgc-null recipients.

Blood 2010 May 5;115(18):3704-7. Epub 2010 Mar 5.

Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research/Ontario Cancer Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2009-10-249326DOI Listing
May 2010

Bone marrow-derived human hematopoietic stem cells engraft NOD/SCID mice and traffic appropriately to an inflammatory stimulus in the joint.

J Rheumatol 2010 Mar 28;37(3):496-502. Epub 2010 Jan 28.

Arthritis Centre of Excellence and Toronto Western Hospital Research Institute, Division of Genetics and Development, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.090317DOI Listing
March 2010

The role of PLZF in human myeloid development.

Ann N Y Acad Sci 2009 Sep;1176:150-3

Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1749-6632.2009.04965.xDOI Listing
September 2009

PLZF is a regulator of homeostatic and cytokine-induced myeloid development.

Genes Dev 2009 Sep;23(17):2076-87

Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1101/gad.1788109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751973PMC
September 2009

Cancer stem cells in solid tumors: an overview.

Semin Radiat Oncol 2009 Apr;19(2):71-7

Department of General Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.semradonc.2008.11.001DOI Listing
April 2009

Looking ahead in cancer stem cell research.

Authors:
John E Dick

Nat Biotechnol 2009 Jan;27(1):44-6

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http://dx.doi.org/10.1038/nbt0109-44DOI Listing
January 2009

Stem cell concepts renew cancer research.

Authors:
John E Dick

Blood 2008 Dec;112(13):4793-807

Division of Cell and Molecular Biology, University Health Network, and Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2008-08-077941DOI Listing
December 2008

Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis.

Haematologica 2008 Nov 24;93(11):1617-26. Epub 2008 Sep 24.

The Hospital for Sick Children, Program in Cell Biology, Room 7129 Elm Wing, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

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http://dx.doi.org/10.3324/haematol.13359DOI Listing
November 2008

Comment on "Tumor growth need not be driven by rare cancer stem cells".

Science 2007 Dec;318(5857):1722; author reply 1722

Division of Cell and Molecular Biology, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1126/science.1149590DOI Listing
December 2007

Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.

Nat Immunol 2007 Dec 4;8(12):1313-23. Epub 2007 Nov 4.

Division of Cellular and Molecular Biology, University Health Network, Toronto, Ontario M5G2M9, Canada.

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http://search.proquest.com/openview/7a8e08fc3fa34e0cd33ae560
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http://dx.doi.org/10.1038/ni1527DOI Listing
December 2007

Reversible cell surface expression of CD38 on CD34-positive human hematopoietic repopulating cells.

Exp Hematol 2007 Sep 25;35(9):1429-36. Epub 2007 Jul 25.

Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.exphem.2007.05.017DOI Listing
September 2007

Modeling the initiation and progression of human acute leukemia in mice.

Science 2007 Apr;316(5824):600-4

Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada.

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http://dx.doi.org/10.1126/science.1139851DOI Listing
April 2007

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice.

Nature 2007 Jan 19;445(7123):106-10. Epub 2006 Nov 19.

Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada.

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http://www.nature.com/articles/nature05372
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http://dx.doi.org/10.1038/nature05372DOI Listing
January 2007

Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment.

Nat Immunol 2006 Nov 1;7(11):1225-33. Epub 2006 Oct 1.

Division of Cell and Molecular Biology, University Health Network, University of Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1038/ni1393DOI Listing
November 2006

Targeting of CD44 eradicates human acute myeloid leukemic stem cells.

Nat Med 2006 Oct 24;12(10):1167-74. Epub 2006 Sep 24.

Division of Cell and Molecular Biology, University Health Network Suite 8-355, Toronto Medical Discovery Tower, 101 College Street, Toronto, M5G 1L7, Canada.

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http://dx.doi.org/10.1038/nm1483DOI Listing
October 2006

Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin-CD34+CD38- population.

Blood 2007 Jan 21;109(2):543-5. Epub 2006 Sep 21.

Division of Cell and Molecular Biology, University Health Network, Department of Molecular and Medical Genetics, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2006-06-030270DOI Listing
January 2007

Biology of normal and acute myeloid leukemia stem cells.

Int J Hematol 2005 Dec;82(5):389-96

Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1532/IJH97.05144DOI Listing
December 2005