John D Minna

John D Minna

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John D Minna

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Unbiased peptoid combinatorial cell screen identifies plectin protein as a potential biomarker for lung cancer stem cells.

Sci Rep 2019 Oct 18;9(1):14954. Epub 2019 Oct 18.

Department of Pharmacological & Pharmaceutical Sciences, University of Houston, 4849 Calhoun Rd, Houston, TX, 77204-5037, USA.

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http://dx.doi.org/10.1038/s41598-019-51004-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802198PMC
October 2019

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.

Mol Cell 2019 Sep 24. Epub 2019 Sep 24.

Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.08.028DOI Listing
September 2019

AIF: an acquired metabolic liability in lung cancer.

Cell Res 2019 Aug;29(8):607-608

Hamon Center for Therapeutic Oncology Research, Dallas, TX, USA.

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http://dx.doi.org/10.1038/s41422-019-0197-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796866PMC
August 2019

Systematic Analysis of Gene Expression in Lung Adenocarcinoma and Squamous Cell Carcinoma with a Case Study of and .

Cancers (Basel) 2019 Jun 25;11(6). Epub 2019 Jun 25.

Quantitative Biomedical Research Center, Department of Population and Data Sciences, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.

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http://dx.doi.org/10.3390/cancers11060886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627508PMC
June 2019

Small cell lung cancers made from scratch.

J Exp Med 2019 Mar 13;216(3):476-478. Epub 2019 Feb 13.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX

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http://dx.doi.org/10.1084/jem.20182216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400528PMC
March 2019

Checkpoint Inhibitor Pneumonitis: Too Clinically Serious For Benefit?

J Thorac Oncol 2019 03;14(3):332-335

Division of Hematology-Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.12.017DOI Listing
March 2019

Kub5-Hera Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers.

Clin Cancer Res 2018 12 14;24(24):6459-6470. Epub 2018 Aug 14.

Departments of Pharmacology and Radiation Oncology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-1118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295248PMC
December 2018

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism.

Cell Rep 2018 11;25(8):2223-2233.e6

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.10.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338450PMC
November 2018

Different Originating Cells Underlie Intertumoral Heterogeneity in Lung Neuroendocrine Tumors.

Cancer Discov 2018 10;8(10):1216-1218

Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-0979DOI Listing
October 2018

Retraction notice to "Sun exposure related methylation in malignant and non-malignant skin lesions" [Cancer Letters 245/1-2 (2007) 112-120].

Cancer Lett 2018 Sep;432:272

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas75390-8593, USA; Departments of Pathology, University of Texas Southwestern Medical Center, Dallas, TX75390, USA.

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http://dx.doi.org/10.1016/j.canlet.2018.07.010DOI Listing
September 2018

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.

Cell Metab 2018 09 28;28(3):369-382.e5. Epub 2018 Jun 28.

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics and Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125205PMC
September 2018

A quantitative method for assessing smoke associated molecular damage in lung cancers.

Transl Lung Cancer Res 2018 Aug;7(4):439-449

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.21037/tlcr.2018.07.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131178PMC
August 2018

Identifying a missing lineage driver in a subset of lung neuroendocrine tumors.

Genes Dev 2018 07;32(13-14):865-867

Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1101/gad.316943.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075039PMC
July 2018

LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer.

Oncotarget 2018 Jul 3;9(51):29601-29618. Epub 2018 Jul 3.

Greehey Children's Cancer Research Institute, UT Health Science Center at San Antonio, San Antonio, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.25642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049873PMC
July 2018

Diagnosis and management of pulmonary toxicity associated with cancer immunotherapy.

Lancet Respir Med 2018 06;6(6):472-478

Division of Hematology-Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30172-3DOI Listing
June 2018

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors.

Transl Oncol 2018 Apr 2;11(2):292-299. Epub 2018 Feb 2.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884185PMC
April 2018

Evaluating tumor-suppressor gene combinations.

Nat Genet 2018 04;50(4):480-482

Department of Internal Medicine, Division of Hematology-Oncology, University of Texas Southwestern, Dallas, TX, USA.

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http://dx.doi.org/10.1038/s41588-018-0095-yDOI Listing
April 2018

Small-cell lung cancer: what we know, what we need to know and the path forward.

Nat Rev Cancer 2017 12 27;17(12):725-737. Epub 2017 Oct 27.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75230-8593, USA.

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http://dx.doi.org/10.1038/nrc.2017.87DOI Listing
December 2017

Small-cell lung cancer: what we know, what we need to know and the path forward.

Nat Rev Cancer 2017 Nov 10;17(12):765. Epub 2017 Nov 10.

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http://dx.doi.org/10.1038/nrc.2017.106DOI Listing
November 2017

Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer.

J Am Soc Mass Spectrom 2017 10 27;28(10):2078-2089. Epub 2017 Jul 27.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1007/s13361-017-1706-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693617PMC
October 2017

Exosome mediated phenotypic changes in lung cancer pathophysiology.

Transl Cancer Res 2017 Aug;6(Suppl 6):S1040-S1042

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.

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http://tcr.amegroups.com/article/view/14924/12356
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http://dx.doi.org/10.21037/tcr.2017.07.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319955PMC
August 2017

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.

Cell Rep 2017 05;19(8):1669-1684

Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531293PMC
May 2017

Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays.

Cancer Cell 2017 02;31(2):225-239

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501076PMC
February 2017

Proportion of Never-Smoker Non-Small Cell Lung Cancer Patients at Three Diverse Institutions.

J Natl Cancer Inst 2017 01 28;109(7). Epub 2017 Jan 28.

Affiliations of authors: Department of Internal Medicine, Hematology/Oncology, Harold C. Simmons Comprehensive Cancer Center (LP, AM, JDM, JS), Department of Biostatistics (CA, AG), Hamon Center for Therapeutic Oncology Research (JDM, AFG), Department of Pharmacology (JDM), Department of Pathology (AFG), UT Southwestern, Dallas, TX; Department of Hematology/Oncology, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Nashville, TN (LH, DM); Parkland Memorial Hospital, Dallas, TX (JC).

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http://dx.doi.org/10.1093/jnci/djw295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279285PMC
January 2017

Developing New, Rational Therapies for Recalcitrant Small Cell Lung Cancer.

J Natl Cancer Inst 2016 10 31;108(10). Epub 2016 May 31.

Hamon Center of Therapeutic Oncology Research, Simmons Comprehensive Cancer Center (AFG, JDM) and Departments of Pathology (AFG), Internal Medicine, and Pharmacology (JDM), UT Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1093/jnci/djw119DOI Listing
October 2016

An Expression Signature as an Aid to the Histologic Classification of Non-Small Cell Lung Cancer.

Clin Cancer Res 2016 Oct 28;22(19):4880-4889. Epub 2016 Jun 28.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492382PMC
October 2016

Monitoring drug induced apoptosis and treatment sensitivity in non-small cell lung carcinoma using dielectrophoresis.

Biochim Biophys Acta 2016 09 2;1860(9):1877-83. Epub 2016 Jun 2.

Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2016.05.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544523PMC
September 2016

Developing EZH2-Targeted Therapy for Lung Cancer.

Cancer Discov 2016 09;6(9):949-52

Department of Internal Medicine and Simmons Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas. Hamon Center for Therapeutic Oncology Research and Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012289PMC
September 2016

Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells.

Proc Natl Acad Sci U S A 2016 09 12;113(39):E5702-10. Epub 2016 Sep 12.

Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://www.pnas.org/content/113/39/E5702.full.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047169PMC
http://dx.doi.org/10.1073/pnas.1606886113DOI Listing
September 2016

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs.

Cell Rep 2016 08 21;16(5):1259-1272. Epub 2016 Jul 21.

Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972690PMC
August 2016

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.

Cell Rep 2016 08 28;16(6):1614-1628. Epub 2016 Jul 28.

Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981512PMC
August 2016

Correction: "From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers".

J Thorac Oncol 2016 07;11(7):e88-9

Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; Departments of Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jtho.2016.04.003DOI Listing
July 2016

Opening a Chromatin Gate to Metastasis.

Cell 2016 07;166(2):275-276

Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)30802-9.pdf
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http://dx.doi.org/10.1016/j.cell.2016.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546407PMC
July 2016

Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis.

PLoS One 2015 5;10(8):e0134842. Epub 2015 Aug 5.

Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea; Institute of Lifestyle Medicine, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea; Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134842PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526668PMC
May 2016

Computational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer.

Bioinformatics 2016 05 10;32(9):1373-9. Epub 2016 Jan 10.

Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, TX, USA, Center for Systems and Synthetic Biology and Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.

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http://dx.doi.org/10.1093/bioinformatics/btw010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848405PMC
May 2016

Identification of lipid-phosphatidylserine (PS) as the target of unbiasedly selected cancer specific peptide-peptoid hybrid PPS1.

Oncotarget 2016 May;7(21):30678-90

Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA.

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http://dx.doi.org/10.18632/oncotarget.8929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058709PMC
May 2016

Selecting Reliable mRNA Expression Measurements Across Platforms Improves Downstream Analysis.

Cancer Inform 2016 10;15:81-9. Epub 2016 May 10.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.4137/CIN.S38590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863871PMC
May 2016

From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers.

J Thorac Oncol 2016 Mar 24;11(3):287-99. Epub 2015 Dec 24.

Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center and Departments of Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1016/j.jtho.2015.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809191PMC
March 2016

Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations.

Cancer Res 2016 Feb 16;76(3):675-85. Epub 2015 Dec 16.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer, Houston, Texas. Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738155PMC
February 2016

Quantitative Secretomic Analysis Identifies Extracellular Protein Factors That Modulate the Metastatic Phenotype of Non-Small Cell Lung Cancer.

J Proteome Res 2016 Feb 25;15(2):477-86. Epub 2016 Jan 25.

Department of Biochemistry and ‡Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, Pharmacology and Internal Medicine, University of Texas Southwestern Medical Center , Dallas, Texas 75235, United States.

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http://dx.doi.org/10.1021/acs.jproteome.5b00819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001500PMC
February 2016

Unbiased Selection of Peptide-Peptoid Hybrids Specific for Lung Cancer Compared to Normal Lung Epithelial Cells.

ACS Chem Biol 2015 Dec 28;10(12):2891-9. Epub 2015 Oct 28.

Advanced Imaging Research Center, ‡Simmons Comprehensive Cancer Center, §Hamon Center for Therapeutic Oncology Research, ∥Departments of Biochemistry, ⊥Pharmacology, #Internal Medicine, and ▽Surgery, University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd., Dallas, Texas 75390, United States.

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http://dx.doi.org/10.1021/acschembio.5b00592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774050PMC
December 2015

A systematic analysis reveals heterogeneous changes in the endocytic activities of cancer cells.

Cancer Res 2015 Nov 10;75(21):4640-50. Epub 2015 Sep 10.

Department of Cell Biology, UT Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802864PMC
November 2015

Elucidation of changes in molecular signalling leading to increased cellular transformation in oncogenically progressed human bronchial epithelial cells exposed to radiations of increasing LET.

Mutagenesis 2015 Sep 22;30(5):685-94. Epub 2015 May 22.

Department of Radiation Oncology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390-8593, USA

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http://dx.doi.org/10.1093/mutage/gev028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635632PMC
September 2015

On comparing heterogeneity across biomarkers.

Cytometry A 2015 Jun 25;87(6):558-67. Epub 2014 Nov 25.

Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1002/cyto.a.22599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442742PMC
June 2015

Small cell lung cancer: will recent progress lead to improved outcomes?

Clin Cancer Res 2015 May;21(10):2244-55

Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497796PMC
May 2015

Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5.

Mol Cancer Res 2015 Apr 8;13(4):784-94. Epub 2015 Jan 8.

The Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398612PMC
April 2015

Genetic mutation of p53 and suppression of the miR-17∼92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D Signaling.

Cancer Res 2015 Feb 17;75(4):666-75. Epub 2014 Dec 17.

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.

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http://cancerres.aacrjournals.org/content/75/4/666.full.pdf
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http://cancerres.aacrjournals.org/content/early/2014/12/17/0
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-14-1329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333022PMC
February 2015

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.

Proc Natl Acad Sci U S A 2014 Oct 29;111(41):14788-93. Epub 2014 Sep 29.

Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, and Pharmacology, Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235;

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http://dx.doi.org/10.1073/pnas.1410419111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205603PMC
October 2014

Ras transformation uncouples the kinesin-coordinated cellular nutrient response.

Proc Natl Acad Sci U S A 2014 Jul 7;111(29):10568-73. Epub 2014 Jul 7.

Department of Pharmacology and

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http://dx.doi.org/10.1073/pnas.1411016111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115560PMC
July 2014