Publications by authors named "John D Lambris"

100Publications

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement.

Elife 2020 09 10;9. Epub 2020 Sep 10.

The Laboratory of Molecular Medicine, Department of Clinical Immunology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.7554/eLife.60908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511233PMC
September 2020

Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy.

Periodontol 2000 2020 10;84(1):14-34

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/prd.12331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457922PMC
October 2020

Author Correction: Complement as a target in COVID-19?

Nat Rev Immunol 2020 07;20(7):448

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41577-020-0366-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290154PMC
July 2020

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101.

Clin Immunol 2020 06 29;215:108450. Epub 2020 Apr 29.

Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; University Vita Salute San Raffaele, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2020.108450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189192PMC
June 2020

Complement as a target in COVID-19?

Nat Rev Immunol 2020 06 23;20(6):343-344. Epub 2020 Apr 23.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41577-020-0320-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187144PMC
June 2020

Editorial: Therapeutic Modulation of the Complement System: Clinical Indications and Emerging Drug Leads.

Front Immunol 2019 9;10:3029. Epub 2020 Jan 9.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.03029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964234PMC
January 2020

Therapeutic targeting of the complement system.

Nat Rev Drug Discov 2019 Dec 9. Epub 2019 Dec 9.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41573-019-0055-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346643PMC
December 2019

Complement activation on neutrophils initiates endothelial adhesion and extravasation.

Mol Immunol 2019 10 19;114:629-642. Epub 2019 Sep 19.

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA; John Cochran VA Medical Center, Saint Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2019.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815348PMC
October 2019

Clinical promise of next-generation complement therapeutics.

Nat Rev Drug Discov 2019 09 19;18(9):707-729. Epub 2019 Jul 19.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41573-019-0031-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340853PMC
September 2019

Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells.

Haematologica 2020 31;105(2):e57-e60. Epub 2020 Jan 31.

Sanquin Research, Department of Immunopathology, Amsterdam and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

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http://dx.doi.org/10.3324/haematol.2019.216028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012486PMC
January 2020

The Challenges and Promise of Complement Therapeutics for Ocular Diseases.

Front Immunol 2019 15;10:1007. Epub 2019 May 15.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Stellar Chance Laboratories, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529562PMC
September 2020

Corrigendum: Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction.

Front Immunol 2019 3;10:994. Epub 2019 May 3.

Institute for Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509637PMC
May 2019

New insights into the immune functions of complement.

Nat Rev Immunol 2019 08;19(8):503-516

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41577-019-0168-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667284PMC
August 2019

Complementing the Cancer-Immunity Cycle.

Front Immunol 2019 12;10:774. Epub 2019 Apr 12.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473060PMC
August 2020

Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction.

Front Immunol 2019 21;10:543. Epub 2019 Mar 21.

Institute for Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany.

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00543
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http://dx.doi.org/10.3389/fimmu.2019.00543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437067PMC
September 2020

Complement-Dependent Mechanisms and Interventions in Periodontal Disease.

Front Immunol 2019 12;10:406. Epub 2019 Mar 12.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422998PMC
September 2020

Taming hemodialysis-induced inflammation: Are complement C3 inhibitors a viable option?

Clin Immunol 2019 01 22;198:102-105. Epub 2018 Nov 22.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366512PMC
January 2019

Reduced Terminal Complement Complex Formation in Mice Manifests in Low Bone Mass and Impaired Fracture Healing.

Am J Pathol 2019 01 17;189(1):147-161. Epub 2018 Oct 17.

Institute of Orthopedic Research and Biomechanics, Ulm University Medical Center, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.09.011DOI Listing
January 2019

Complement C5a-Mediated TAM-ing of Antitumor Immunity Drives Squamous Carcinogenesis.

Cancer Cell 2018 10;34(4):531-533

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.09.005DOI Listing
October 2018

Short Leucine-Rich Proteoglycans Modulate Complement Activity and Increase Killing of the Respiratory Pathogen .

J Immunol 2018 11 28;201(9):2721-2730. Epub 2018 Sep 28.

Division of Medical Protein Chemistry, Lund University, 21428 Malmö, Sweden;

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http://dx.doi.org/10.4049/jimmunol.1800734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200642PMC
November 2018

Expanding Complement Therapeutics for the Treatment of Paroxysmal Nocturnal Hemoglobinuria.

Semin Hematol 2018 07 14;55(3):167-175. Epub 2018 Feb 14.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060635PMC
July 2018

Novel Immunoassay for Complement Activation by PF4/Heparin Complexes.

Thromb Haemost 2018 Aug 30;118(8):1484-1487. Epub 2018 Jun 30.

Division of Hematology, Duke University Medical Center, Duke University, Durham, North Carolina, United States.

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http://dx.doi.org/10.1055/s-0038-1660858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288012PMC
August 2018

New Analogs of the Complement C3 Inhibitor Compstatin with Increased Solubility and Improved Pharmacokinetic Profile.

J Med Chem 2018 Jul 3;61(14):6153-6162. Epub 2018 Jul 3.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b00560
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http://dx.doi.org/10.1021/acs.jmedchem.8b00560DOI Listing
July 2018

Innate immune responses to trauma.

Nat Immunol 2018 04 5;19(4):327-341. Epub 2018 Mar 5.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/s41590-018-0064-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027646PMC
April 2018

The Complement System Is Critical in Maintaining Retinal Integrity during Aging.

Front Aging Neurosci 2018 15;10:15. Epub 2018 Feb 15.

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Harvard University, Boston, MA, United States.

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http://dx.doi.org/10.3389/fnagi.2018.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818470PMC
February 2018

Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation.

Front Immunol 2017 23;8:1586. Epub 2017 Nov 23.

Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States.

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http://dx.doi.org/10.3389/fimmu.2017.01586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703703PMC
November 2017

The renaissance of complement therapeutics.

Nat Rev Nephrol 2018 Jan 4;14(1):26-47. Epub 2017 Dec 4.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 401 Stellar Chance, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://www.nature.com/doifinder/10.1038/nrneph.2017.156
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http://dx.doi.org/10.1038/nrneph.2017.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805379PMC
January 2018

Novel mechanisms and functions of complement.

Nat Immunol 2017 Nov;18(12):1288-1298

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://www.nature.com/articles/ni.3858
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http://dx.doi.org/10.1038/ni.3858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706779PMC
November 2017

Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen .

J Immunol 2017 12 30;199(11):3828-3839. Epub 2017 Oct 30.

Department of Translational Medicine, Medical Protein Chemistry, Lund University, Skåne County Council, Malmö 20502, Sweden;

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http://dx.doi.org/10.4049/jimmunol.1700426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698128PMC
December 2017

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair.

Sci Rep 2017 10 25;7(1):14061. Epub 2017 Oct 25.

Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, University of Ulm, D-89081, Ulm, Germany.

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http://dx.doi.org/10.1038/s41598-017-14444-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656620PMC
October 2017

Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4.

Proc Natl Acad Sci U S A 2017 10 26;114(41):10948-10953. Epub 2017 Sep 26.

Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1707364114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642699PMC
October 2017

Complement in cancer: untangling an intricate relationship.

Nat Rev Immunol 2018 01 18;18(1):5-18. Epub 2017 Sep 18.

Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania 19104, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nri.2017.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816344PMC
January 2018

disturbs host-commensal homeostasis by changing complement function.

J Oral Microbiol 2017 30;9(1):1340085. Epub 2017 Jun 30.

Department of Microbiology, School of Dental Medicine; University of Pennsylvania, PA, USA.

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http://dx.doi.org/10.1080/20002297.2017.1340085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508361PMC
June 2017

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.

Nat Struct Mol Biol 2017 Aug 3;24(8):643-651. Epub 2017 Jul 3.

Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/nsmb.3427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773341PMC
August 2017

Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII.

Acta Biomater 2017 08 30;58:158-167. Epub 2017 May 30.

Centre of Molecular Inflammation Research, and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Clinic of Surgery, Centre for Obesity, St. Olavs University Hospital, Trondheim, Norway; Central Norway Regional Health Authority, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2017.05.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607061PMC
August 2017

Complement component C3aR constitutes a novel regulator for chick eye morphogenesis.

Dev Biol 2017 08 30;428(1):88-100. Epub 2017 May 30.

Department of Biology, Miami University and Center for Visual Sciences at Miami University (CVSMU), Oxford, OH 45056, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2017.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726978PMC
August 2017

Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery.

Trends Immunol 2017 06 14;38(6):383-394. Epub 2017 Apr 14.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447467PMC
June 2017

Structural Implications for the Formation and Function of the Complement Effector Protein iC3b.

J Immunol 2017 04 3;198(8):3326-3335. Epub 2017 Mar 3.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; and

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http://dx.doi.org/10.4049/jimmunol.1601864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478675PMC
April 2017

Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis.

Am J Physiol Renal Physiol 2017 03 4;312(3):F516-F532. Epub 2017 Jan 4.

Division of Nephrology, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia;

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http://dx.doi.org/10.1152/ajprenal.00604.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374314PMC
March 2017

Method development and validation for the quantitation of the complement inhibitor Cp40 in human and cynomolgus monkey plasma by UPLC-ESI-MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Jan 6;1041-1042:19-26. Epub 2016 Dec 6.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2016.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241290PMC
January 2017

Complement inhibition enables tumor delivery of LCMV glycoprotein pseudotyped viruses in the presence of antiviral antibodies.

Mol Ther Oncolytics 2016 16;3:16027. Epub 2016 Nov 16.

Center for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1038/mto.2016.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111574PMC
November 2016

More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation.

Immunol Rev 2016 11;274(1):233-244

Perelman School of Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/imr.12467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119927PMC
November 2016

Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense.

Immunol Rev 2016 11;274(1):33-58

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://doi.wiley.com/10.1111/imr.12500
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http://dx.doi.org/10.1111/imr.12500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427221PMC
November 2016

Preformed mediators of defense-Gatekeepers enter the spotlight.

Immunol Rev 2016 11;274(1):5-8

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/imr.12497DOI Listing
November 2016

Protection of host cells by complement regulators.

Immunol Rev 2016 11;274(1):152-171

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/imr.12475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432642PMC
November 2016

Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia.

Clin Immunol 2016 Oct 18;171:32-35. Epub 2016 Aug 18.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, United States. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330307PMC
October 2016

High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity.

Mol Cancer Res 2016 10 17;14(10):953-965. Epub 2016 Aug 17.

Department of Genetics, Case Western Reserve University, Cleveland, Ohio. Pacific Northwest Research Institute, Seattle, Washington.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330314PMC
October 2016

Complement therapeutics.

Semin Immunol 2016 06;28(3):205-7

Perelman School of Medicine, University of Pennsylvania, 401 Stellar Chance, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2016.07.001DOI Listing
June 2016

Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration.

J Immunol 2016 09 10;197(6):2500-8. Epub 2016 Aug 10.

Graduate Program in Bioinformatics, Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093; Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093; Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093; and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.4049/jimmunol.1600628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038987PMC
September 2016

From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage.

Immunobiology 2016 10 16;221(10):1046-57. Epub 2016 Jun 16.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.imbio.2016.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987232PMC
October 2016

New milestones ahead in complement-targeted therapy.

Semin Immunol 2016 06 16;28(3):208-22. Epub 2016 Jun 16.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2016.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404743PMC
June 2016

Complement in disease: a defence system turning offensive.

Nat Rev Nephrol 2016 07 23;12(7):383-401. Epub 2016 May 23.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 401 Stellar Chance, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://www.nature.com/articles/nrneph.2016.70
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http://dx.doi.org/10.1038/nrneph.2016.70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974115PMC
July 2016

Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood.

J Immunol 2016 06 25;196(11):4671-4680. Epub 2016 Apr 25.

Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.

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http://dx.doi.org/10.4049/jimmunol.1600040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888774PMC
June 2016

Control of the collective migration of enteric neural crest cells by the Complement anaphylatoxin C3a and N-cadherin.

Dev Biol 2016 06 1;414(1):85-99. Epub 2016 Apr 1.

Institut Curie/CNRS UMR144, Paris, France; Université Paris Est, Faculté de médecine, Créteil 94000, France; INSERM, U955, Team 6, Créteil, 94000, France. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2016.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937886PMC
June 2016

Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application.

Semin Immunol 2016 06 24;28(3):285-91. Epub 2016 Mar 24.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.smim.2016.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987193PMC
June 2016

Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.

EMBO J 2016 05 24;35(10):1133-49. Epub 2016 Mar 24.

Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science Utrecht University, Utrecht, The Netherlands

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http://dx.doi.org/10.15252/embj.201593673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868954PMC
May 2016

Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex.

J Infect Dis 2016 07 14;214(1):140-50. Epub 2016 Mar 14.

Department of Immunology K. G. Jebsen IRC, University of Oslo Research Laboratory, Nordland Hospital Bodø Faculty of Health Sciences K. G. Jebsen TREC, University of Tromsø Center of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1093/infdis/jiw100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907417PMC
July 2016

A 'rule of 3' to revive Greek science, research and innovation.

Nat Immunol 2015 Dec;16(12):1206-8

Department of Pathology &Laboratory Medicine, the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ni.3322DOI Listing
December 2015

Using an in vitro xenoantibody-mediated complement-dependent cytotoxicity model to evaluate the complement inhibitory activity of the peptidic C3 inhibitor Cp40.

Clin Immunol 2016 Jan 6;162:37-44. Epub 2015 Nov 6.

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, China; Key Laboratory of Organ Transplantation, Ministry of Public Health, Wuhan, China. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784679PMC
January 2016

A Phase-Variable Surface Layer from the Gut Symbiont Bacteroides thetaiotaomicron.

mBio 2015 Sep 29;6(5):e01339-15. Epub 2015 Sep 29.

Department of Bioengineering and Therapeutic Sciences and California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California, USA

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http://dx.doi.org/10.1128/mBio.01339-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611039PMC
September 2015

Applying complement therapeutics to rare diseases.

Clin Immunol 2015 Dec 1;161(2):225-40. Epub 2015 Sep 1.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658209PMC
December 2015

Regulation of Instant Blood Mediated Inflammatory Reaction (IBMIR) in Pancreatic Islet Xeno-Transplantation: Points for Therapeutic Interventions.

Adv Exp Med Biol 2015 ;865:171-88

Department of Clinical Pathobiochemistry, Medical Faculty, Technische Universität Dresden, Fetscherstrasse 74, Dresden, 01307, Germany,

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http://dx.doi.org/10.1007/978-3-319-18603-0_11DOI Listing
December 2015

Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches.

Adv Exp Med Biol 2015 ;865:57-74

Department of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA,

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http://dx.doi.org/10.1007/978-3-319-18603-0_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562417PMC
December 2015

Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18.

Thromb Haemost 2015 Nov 13;114(6):1207-17. Epub 2015 Aug 13.

Bo Nilsson, Dept. of Immunology, Genetics and Pathology (IGP), Rudbeck Laboratory C5:3, Uppsala University, SE-751 85 Uppsala, Sweden, Tel.: +46 70 9423977, Fax: +46 18 553149, E-mail:

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http://dx.doi.org/10.1160/TH15-02-0162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784683PMC
November 2015

Therapeutic control of complement activation at the level of the central component C3.

Immunobiology 2016 06 10;221(6):740-6. Epub 2015 Jun 10.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1016/j.imbio.2015.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675703PMC
June 2016

Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria.

Blood 2015 Aug 16;126(7):891-4. Epub 2015 Jun 16.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA;

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http://dx.doi.org/10.1182/blood-2015-02-625871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536542PMC
August 2015

Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy.

Immunobiology 2015 Aug 5;220(8):993-8. Epub 2015 May 5.

Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Division of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.imbio.2015.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510458PMC
August 2015