Publications by authors named "John D Isaacs"

100Publications

Pharmacogenetics of TNF inhibitor response in rheumatoid arthritis utilizing the two-component disease activity score.

Pharmacogenomics 2020 Nov 30;21(16):1151-1156. Epub 2020 Oct 30.

NIHR Manchester Biomedical Research Center, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Center, Manchester, M13 9WL, UK.

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http://dx.doi.org/10.2217/pgs-2020-0043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649675PMC
November 2020

Basic Mechanisms of JAK Inhibition.

Mediterr J Rheumatol 2020 Jun 11;31(Suppl 1):100-104. Epub 2020 Jun 11.

Translational and Clinical Research Institute, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.31138/mjr.31.1.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361186PMC
June 2020

Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition: An early phase trial.

Medicine (Baltimore) 2020 Jun;99(26):e20458

Translational and Experimental Medicine Institute, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne.

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http://dx.doi.org/10.1097/MD.0000000000020458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328978PMC
June 2020

Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities.

Lancet Respir Med 2020 08 16;8(8):822-830. Epub 2020 Jun 16.

Centre for Inflammation and Tissue Repair, Division of Medicine, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(20)30267-8DOI Listing
August 2020

Smart battles: immunosuppression versus immunomodulation in the inflammatory RMDs.

Ann Rheum Dis 2020 08 11;79(8):991-993. Epub 2020 Jun 11.

Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2020-218019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392482PMC
August 2020

Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission.

Ther Adv Musculoskelet Dis 2020 11;12:1759720X20915322. Epub 2020 May 11.

Musculoskeletal Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1177/1759720X20915322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236396PMC
May 2020

In search of pathobiological endotypes: a systems approach to early rheumatoid arthritis.

Expert Rev Clin Immunol 2020 06 27;16(6):621-630. Epub 2020 May 27.

Translational and Clinical Research Institute, Newcastle University Medical School , Newcastle, UK.

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http://dx.doi.org/10.1080/1744666X.2020.1771183DOI Listing
June 2020

Correction to: Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents.

BioDrugs 2020 04;34(2):253

Institute of Cellular Medicine, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s40259-020-00410-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113198PMC
April 2020

Schrödinger's pipeline and the outsourcing of pharmaceutical innovation.

Drug Discov Today 2020 03 10;25(3):480-484. Epub 2019 Dec 10.

Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; NIHR Biomedical Research Centre at Newcastle University & Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/j.drudis.2019.11.015DOI Listing
March 2020

Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis.

J Transl Med 2019 11 14;17(1):375. Epub 2019 Nov 14.

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1186/s12967-019-2128-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857208PMC
November 2019

Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents.

BioDrugs 2020 Feb;34(1):27-37

Institute of Cellular Medicine, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s40259-019-00394-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042210PMC
February 2020

Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis.

Rheumatology (Oxford) 2020 06;59(6):1364-1371

University College Dublin School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1093/rheumatology/kez411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244777PMC
June 2020

Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study.

J Autoimmun 2019 12 4;105:102298. Epub 2019 Jul 4.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891251PMC
December 2019

"Living a normal life": a qualitative study of patients' views of medication withdrawal in rheumatoid arthritis.

BMC Rheumatol 2019 13;3. Epub 2019 Jun 13.

1Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH UK.

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http://dx.doi.org/10.1186/s41927-019-0070-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567658PMC
June 2019

Potential Pharmacologic Targets for the Prevention of Rheumatoid Arthritis.

Clin Ther 2019 07 10;41(7):1312-1322. Epub 2019 Jun 10.

Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom; Musculoskeletal Unit, Newcastle Upon Tyne Hospitals National Health Service (NHS) Foundation Trust, Newcastle Upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.clinthera.2019.04.020DOI Listing
July 2019

Routine musculoskeletal ultrasound findings impact diagnostic decisions maximally in autoantibody-seronegative early arthritis patients.

Rheumatology (Oxford) 2019 07;58(7):1268-1273

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/rheumatology/kez008DOI Listing
July 2019

Tolerising cellular therapies: what is their promise for autoimmune disease?

Ann Rheum Dis 2019 03 2;78(3):297-310. Epub 2018 Nov 2.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21402
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http://dx.doi.org/10.1136/annrheumdis-2018-214024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390030PMC
March 2019

Therapeutic tolerance in autoimmune disease.

Semin Arthritis Rheum 2018 12 28;48(3):558-562. Epub 2018 Sep 28.

Institute of Cellular Medicine, Newcastle University and Musculoskeletal Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00490172183059
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http://dx.doi.org/10.1016/j.semarthrit.2018.09.008DOI Listing
December 2018

Biologic refractory disease in rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Ann Rheum Dis 2018 10 6;77(10):1405-1412. Epub 2018 Jul 6.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2018-213378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161665PMC
October 2018

Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis.

Front Immunol 2018 9;9:755. Epub 2018 May 9.

Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.00755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968398PMC
June 2019

The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy.

J Allergy Clin Immunol 2018 01 5;141(1):445-448.e4. Epub 2017 Oct 5.

Institute of Cellular Medicine, Newcastle University and National Institute for Health Research, Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals, NHS Foundation Trust, and Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2017.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751729PMC
January 2018

Targeting of tolerogenic dendritic cells towards heat-shock proteins: a novel therapeutic strategy for autoimmune diseases?

Immunology 2018 01 18;153(1):51-59. Epub 2017 Sep 18.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/imm.12811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721256PMC
January 2018

Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?

Ann Rheum Dis 2018 02 1;77(2):175-187. Epub 2017 Aug 1.

Musculoskeletal Research Group and Arthritis Research UK Centre of Excellence in Rheumatoid Arthritis Pathogenesis, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2017-211555DOI Listing
February 2018

Synovial tissue research: a state-of-the-art review.

Nat Rev Rheumatol 2017 08 13;13(8):463-475. Epub 2017 Jul 13.

Department of Clinical Immunology &Rheumatology, Amsterdam Rheumatology and Immunology Centre, Academic Medical Centre, University of Amsterdam, Room F4-105, POBox 22700, 1100 DE, Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/nrrheum.2017.115DOI Listing
August 2017

Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions.

Chembiochem 2017 09 19;18(17):1688-1691. Epub 2017 Jul 19.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1002/cbic.201700214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708275PMC
September 2017

The predictive value of serum S100A9 and response to etanercept is not confirmed in a large UK rheumatoid arthritis cohort.

Rheumatology (Oxford) 2017 06;56(6):1019-1024

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, The University of Manchester.

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http://dx.doi.org/10.1093/rheumatology/kew387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445600PMC
June 2017

Immune reconstitution 20 years after treatment with alemtuzumab in a rheumatoid arthritis cohort: implications for lymphocyte depleting therapies.

Arthritis Res Ther 2016 12 20;18(1):302. Epub 2016 Dec 20.

Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1186/s13075-016-1188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170892PMC
December 2016

Patient and researcher perspectives on facilitating patient and public involvement in rheumatology research.

Musculoskeletal Care 2017 12 16;15(4):395-399. Epub 2016 Dec 16.

Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1002/msc.1171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808150PMC
December 2017

Let's not fool ourselves. In RA, the ACR/EULAR remission criteria are not perfect!

Ann Rheum Dis 2017 06 1;76(6):e12. Epub 2016 Dec 1.

Musculoskeletal Research Group, NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-210797DOI Listing
June 2017

Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.

Nat Rev Rheumatol 2016 12 27;12(12):731-742. Epub 2016 Oct 27.

Institute of Cellular Medicine, Faculty of Medical Sciences, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2016.175DOI Listing
December 2016

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.

Genome Biol 2016 11 1;17(1):212. Epub 2016 Nov 1.

Arthritis Research UK Centre for Genetics and Genomics, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1186/s13059-016-1078-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088679PMC
November 2016

Clinical trials of biosimilars should become more similar.

Ann Rheum Dis 2017 01 25;76(1):4-6. Epub 2016 Aug 25.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208113DOI Listing
January 2017

Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels.

Rheumatology (Oxford) 2016 Nov 25;55(11):2050-2055. Epub 2016 Aug 25.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kew299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088626PMC
November 2016

Components of treatment delay in rheumatoid arthritis differ according to autoantibody status: validation of a single-centre observation using national audit data.

Rheumatology (Oxford) 2016 Oct 3;55(10):1843-8. Epub 2016 Jul 3.

National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne.

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http://dx.doi.org/10.1093/rheumatology/kew261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034219PMC
October 2016

High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort.

Ann Rheum Dis 2017 Jan 31;76(1):208-213. Epub 2016 May 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264213PMC
January 2017

Drug breakthrough offers hope to arthritis sufferers: qualitative analysis of medical research in UK newspapers.

Health Expect 2017 04 4;20(2):309-320. Epub 2016 May 4.

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/hex.12460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354054PMC
April 2017

Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis.

Ann Rheum Dis 2017 Jan 26;76(1):227-234. Epub 2016 Apr 26.

Arthritis Research UK Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE), Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264217PMC
January 2017

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis.

Arthritis Rheumatol 2016 06 21;68(6):1353-60. Epub 2016 Apr 21.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, and Central Manchester NHS Trust, and Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/art.39590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914881PMC
June 2016

Cytokines in rheumatoid arthritis - shaping the immunological landscape.

Nat Rev Rheumatol 2016 Jan 10;12(1):63-8. Epub 2015 Dec 10.

NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Institute of Cellular Medicine, Newcastle University, William Leech Building, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2015.171DOI Listing
January 2016

Bcl-3 in CD4+ T Cell-Mediated Rheumatoid Arthritis Pathogenesis: Comment on the Article by Meguro et al.

Arthritis Rheumatol 2016 Mar;68(3):770-1

NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/art.39509DOI Listing
March 2016

Teaching examples for the design of experiments: geographical sensitivity and the self-fulfilling prophecy.

Pharm Stat 2016 Jan-Feb;15(1):90-2. Epub 2015 Nov 12.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/pst.1723DOI Listing
October 2016

Lost in space: design of experiments and scientific exploration in a Hogarth Universe.

Drug Discov Today 2015 Nov 23;20(11):1365-71. Epub 2015 Oct 23.

Centre for Medicines Research, GlaxoSmithKline, Stevenage, UK.

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http://dx.doi.org/10.1016/j.drudis.2015.09.015DOI Listing
November 2015

Decade in review-clinical rheumatology: 10 years of therapeutic advances in the rheumatic diseases.

Authors:
John D Isaacs

Nat Rev Rheumatol 2015 Nov 13;11(11):628-30. Epub 2015 Oct 13.

Newcastle University, Institute of Cellular Medicine, William Leech Building, Framlington Place, Newcastle-Upon-Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrrheum.2015.138DOI Listing
November 2015

Why is it hard to terminate failing projects in pharmaceutical R&D?

Nat Rev Drug Discov 2015 Oct 21;14(10):663-4. Epub 2015 Aug 21.

Institute of Cellular Medicine, Framlington Place, Newcastle University NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrd4725DOI Listing
October 2015

Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.

Arthritis Rheumatol 2015 May;67(8):2011-9

Darren Plant, PhD, Anne Barton, MBChB, PhD, FRCP: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, UK.

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(
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http://doi.wiley.com/10.1002/art.39169
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http://dx.doi.org/10.1002/art.39169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843946PMC
May 2015

Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.

JAMA 2015 Apr;313(16):1645-56

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, England2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manches.

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http://dx.doi.org/10.1001/jama.2015.3435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928097PMC
April 2015

Evaluation of the effect of tofacitinib on measured glomerular filtration rate in patients with active rheumatoid arthritis: results from a randomised controlled trial.

Arthritis Res Ther 2015 Apr 6;17:95. Epub 2015 Apr 6.

National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1186/s13075-015-0612-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445792PMC
April 2015

Rheumatoid arthritis: an evolutionary force in biologics.

Curr Pharm Des 2015 ;21(17):2170-8

NIHR Newcastle Biomedical Research Centre, Institute of Cellular Medicine, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.2174/1381612821666150310141827DOI Listing
May 2016

Progression-seeking bias and rational optimism in research and development.

Nat Rev Drug Discov 2015 Mar 6;14(3):219-21. Epub 2015 Feb 6.

Institute of Cellular Medicine, Newcastle University, Newcastle, NE2 4HH, UK.

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http://dx.doi.org/10.1038/nrd4320-c1DOI Listing
March 2015

Genotyping in rheumatoid arthritis: a game changer in clinical management?

Expert Rev Clin Immunol 2015 Mar 2;11(3):303-5. Epub 2015 Feb 2.

Institute of Cellular Medicine (Musculoskeletal Research Group), Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1586/1744666X.2015.1008454DOI Listing
March 2015

Seronegative rheumatoid arthritis: pathogenetic and therapeutic aspects.

Best Pract Res Clin Rheumatol 2014 Aug 18;28(4):651-9. Epub 2014 Nov 18.

NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK. Electronic address:

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http://dx.doi.org/10.1016/j.berh.2014.10.016DOI Listing
August 2014

Rheumatoid arthritis: from palliation to remission in two decades.

Clin Med (Lond) 2014 Dec;14 Suppl 6:s50-5

National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Trust and Newcastle University, Newcastle-upon-Tyne, UK

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http://dx.doi.org/10.7861/clinmedicine.14-6-s50DOI Listing
December 2014

Retrospective analysis of the role of serum vitamin D in early rheumatic disease.

Rheumatology (Oxford) 2015 Feb 17;54(2):374-5. Epub 2014 Nov 17.

National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/rheumatology/keu420DOI Listing
February 2015

R&D productivity rides again?

Pharm Stat 2015 Jan-Feb;14(1):1-3. Epub 2014 Oct 22.

Institute of Cellular Medicine, Newcastle University, UK.

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http://dx.doi.org/10.1002/pst.1653DOI Listing
September 2015

Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort.

Rheumatology (Oxford) 2015 Mar 10;54(3):494-9. Epub 2014 Sep 10.

Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science, Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne and Institute for Inflammation and Repair, University of Manchester, Manchester, UK. Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science, Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne and Institute for Inflammation and Repair, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/keu358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334684PMC
March 2015

A negative feedback loop mediated by STAT3 limits human Th17 responses.

J Immunol 2014 Aug 27;193(3):1142-50. Epub 2014 Jun 27.

Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom

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http://www.jimmunol.org/content/early/2014/06/27/jimmunol.13
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1302467
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http://dx.doi.org/10.4049/jimmunol.1302467DOI Listing
August 2014

Emerging immunotherapies for rheumatoid arthritis.

Hum Vaccin Immunother 2014 17;10(4):822-37. Epub 2014 Feb 17.

Institute of Cellular Medicine; Musculoskeletal Research Group; Newcastle University; Newcastle upon Tyne, Tyne & Wear UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896612PMC
http://dx.doi.org/10.4161/hv.27910DOI Listing
April 2016

Prospects for therapeutic tolerance in humans.

Curr Opin Rheumatol 2014 Mar;26(2):219-27

The National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, UK.

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http://dx.doi.org/10.1097/BOR.0000000000000029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640179PMC
March 2014

Treg cells in rheumatoid arthritis: an update.

Curr Rheumatol Rep 2013 Sep;15(9):352

Newcastle NIHR Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s11926-013-0352-0DOI Listing
September 2013

The role of biosimilars in the treatment of rheumatic diseases.

Ann Rheum Dis 2013 Mar 19;72(3):322-8. Epub 2012 Dec 19.

CC12 Department of Medicine, Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Chariteplatz 1, Berlin 10117, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2012-202715DOI Listing
March 2013

Adrenal steroidogenesis after B lymphocyte depletion therapy in new-onset Addison's disease.

J Clin Endocrinol Metab 2012 Oct 5;97(10):E1927-32. Epub 2012 Jul 5.

Newcastle University, Newccastle upon Tyne Hospitals National Health Service Foundation Trust, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-1680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462934PMC
October 2012

Immunity 12 years after alemtuzumab in RA: CD5⁺ B-cell depletion, thymus-dependent T-cell reconstitution and normal vaccine responses.

Rheumatology (Oxford) 2012 Aug 24;51(8):1397-406. Epub 2012 Mar 24.

Institute of Cellular Medicine, Musculoskeletal Research Group, 4th Floor Catherine Cookson Building, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1093/rheumatology/kes038DOI Listing
August 2012

Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up.

Arthritis Res Ther 2012 Feb 7;14(1):R30. Epub 2012 Feb 7.

Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1186/ar3734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392825PMC
February 2012

Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis.

Hum Mutat 2012 Apr 28;33(4):741-9. Epub 2012 Feb 28.

NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1002/humu.22031DOI Listing
April 2012