Publications by authors named "John D Gordan"

34Publications

Systemic Therapy for Advanced Hepatocellular Carcinoma: ASCO Guideline.

Authors:
John D Gordan Erin B Kennedy Ghassan K Abou-Alfa Muhammad Shaalan Beg Steven T Brower Terence P Gade Laura Goff Shilpi Gupta Jennifer Guy William P Harris Renuka Iyer Ishmael Jaiyesimi Minaxi Jhawer Asha Karippot Ahmed O Kaseb R Kate Kelley Jennifer J Knox Jeremy Kortmansky Andrea Leaf William M Remak Rachna T Shroff Davendra P S Sohal Tamar H Taddei Neeta K Venepalli Andrea Wilson Andrew X Zhu Michal G Rose

J Clin Oncol 2020 Dec 16;38(36):4317-4345. Epub 2020 Nov 16.

Yale Cancer Center and VA Connecticut Healthcare System, West Haven, CT.

View Article and Find Full Text PDF
December 2020

Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells.

Authors:
Garry L Coles Sandra Cristea James T Webber Rebecca S Levin Steven M Moss Andy He Jaya Sangodkar Yeonjoo C Hwang Julia Arand Alexandros P Drainas Nancie A Mooney Janos Demeter Jessica N Spradlin Brandon Mauch Vicky Le Yan Ting Shue Julie H Ko Myung Chang Lee Christina Kong Daniel K Nomura Michael Ohlmeyer Danielle L Swaney Nevan J Krogan Peter K Jackson Goutham Narla John D Gordan Kevan M Shokat Julien Sage

Cancer Cell 2020 Jul 11;38(1):129-143.e7. Epub 2020 Jun 11.

Department of Pediatrics, Stanford University, 265 Campus Drive, Stanford, CA 94305-5457, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address:

View Article and Find Full Text PDF
July 2020

A Multicenter Randomized Three-Arm Phase II Study of (1) Everolimus, (2) Estrogen Deprivation Therapy (EDT) with Leuprolide + Letrozole, and (3) Everolimus + EDT in Patients with Unresectable Fibrolamellar Carcinoma.

Authors:
Imane El Dika Robert J Mayer Alan P Venook Marinela Capanu Michael P LaQuaglia Rachel Kobos Allison F O'Neill Joanne F Chou Michele Ly Celina Ang Eileen M O'Reilly John D Gordan Ghassan K Abou-Alfa

Oncologist 2020 Nov 26;25(11):925-e1603. Epub 2020 May 26.

Memorial Sloan Kettering Cancer Center, New York, New York, USA.

View Article and Find Full Text PDF
November 2020

Checkpoint Inhibitors for the Treatment of Advanced Hepatocellular Carcinoma.

Authors:
Laura A Huppert John D Gordan Robin Kate Kelley

Clin Liver Dis (Hoboken) 2020 Feb 26;15(2):53-58. Epub 2020 Mar 26.

UCSF Helen Diller Family Comprehensive Cancer Center University of California San Francisco San Francisco CA.

View Article and Find Full Text PDF
February 2020

Phase II Multicenter, Open-Label Study of Oral ENMD-2076 for the Treatment of Patients with Advanced Fibrolamellar Carcinoma.

Authors:
Ghassan K Abou-Alfa Robert Mayer Alan P Venook Allison F O'Neill Muhammad S Beg Michael LaQuaglia Peter T Kingham Rachel Kobos Olca Basturk Cameron Brennan Adam Yopp James J Harding Stephen Leong John Crown Emir Hoti Gregory Leonard Michele Ly Mikaela Bradley Emily Valentino David Markowitz Alexander Zukiwski Ken Ren John D Gordan

Oncologist 2020 Dec 10;25(12):e1837-e1845. Epub 2020 Mar 10.

University of California San Francisco, San Francisco, California, USA.

View Article and Find Full Text PDF
December 2020

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.

Authors:
Mary McMahon Adrian Contreras Mikael Holm Tamayo Uechi Craig M Forester Xiaming Pang Cody Jackson Meredith E Calvert Bin Chen David A Quigley John M Luk R Kate Kelley John D Gordan Ryan M Gill Scott C Blanchard Davide Ruggero

Elife 2019 09 3;8. Epub 2019 Sep 3.

Helen Diller Family Comprehensive Cancer Center, Department of Urology, University of California, San Francisco, San Francisco, United States.

View Article and Find Full Text PDF
September 2019

Nivolumab in patients with advanced hepatocellular carcinoma and Child-Pugh class B cirrhosis: Safety and clinical outcomes in a retrospective case series.

Authors:
Swetha Kambhampati Kelly E Bauer Paige M Bracci Bridget P Keenan Spencer C Behr John D Gordan Robin K Kelley

Cancer 2019 09 2;125(18):3234-3241. Epub 2019 Jun 2.

Division of Hematology and Oncology, Department of Medicine, University of California at San Francisco Medical Center, San Francisco, California.

View Article and Find Full Text PDF
September 2019

KRAS inhibition produces a driver-limited state revealing collateral dependencies.

Authors:
Kevin Lou Veronica Steri Alex Y Ge Y Christina Hwang Christopher H Yogodzinski Arielle R Shkedi Alex L M Choi Dominique C Mitchell Danielle L Swaney Byron Hann John D Gordan Kevan M Shokat Luke A Gilbert

Sci Signal 2019 05 28;12(583). Epub 2019 May 28.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.

View Article and Find Full Text PDF
May 2019

Road map for fibrolamellar carcinoma: progress and goals of a diversified approach.

Authors:
Edward R Kastenhuber John Craig Jon Ramsey Kevin M Sullivan Julien Sage Sofia de Oliveira Kimberly J Riehle John D Scott John D Gordan Nabeel Bardeesy Ghassan K Abou-Alfa

J Hepatocell Carcinoma 2019 31;6:41-48. Epub 2019 Jan 31.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA,

View Article and Find Full Text PDF
January 2019

Translation control of the immune checkpoint in cancer and its therapeutic targeting.

Authors:
Yichen Xu Mauro Poggio Hyun Yong Jin Zhen Shi Craig M Forester Ying Wang Craig R Stumpf Lingru Xue Emily Devericks Lomon So Hao G Nguyen Alice Griselin John D Gordan Sarah E Umetsu Siegfried H Reich Stephen T Worland Saurabh Asthana Maria Barna Kevin R Webster John T Cunningham Davide Ruggero

Nat Med 2019 02 14;25(2):301-311. Epub 2019 Jan 14.

Department of Urology, University of California, San Francisco, San Francisco, CA, USA.

View Article and Find Full Text PDF
February 2019

Overexpression-mediated activation of MET in the Golgi promotes HER3/ERBB3 phosphorylation.

Authors:
Nicole Michael Frazier Toni Brand John D Gordan Jennifer Grandis Natalia Jura

Oncogene 2019 03 2;38(11):1936-1950. Epub 2018 Nov 2.

Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94158, USA.

View Article and Find Full Text PDF
March 2019

Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma.

Authors:
Xinhua Song Xianqiong Liu Haichuan Wang Jingxiao Wang Yu Qiao Antonio Cigliano Kirsten Utpatel Silvia Ribback Maria G Pilo Marina Serra John D Gordan Li Che Shanshan Zhang Antonio Cossu Alberto Porcu Rosa M Pascale Frank Dombrowski Hongbo Hu Diego F Calvisi Matthias Evert Xin Chen

Clin Cancer Res 2019 01 3;25(1):403-413. Epub 2018 Jul 3.

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.

View Article and Find Full Text PDF
January 2019

Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer.

Authors:
Hayley J Donnella James T Webber Rebecca S Levin Roman Camarda Olga Momcilovic Nora Bayani Khyati N Shah James E Korkola Kevan M Shokat Andrei Goga John D Gordan Sourav Bandyopadhyay

Nat Chem Biol 2018 08 25;14(8):768-777. Epub 2018 Jun 25.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.

View Article and Find Full Text PDF
August 2018

Hybrid Capture-Based Tumor Sequencing and Copy Number Analysis to Confirm Origin of Metachronous Metastases in Mutant Cholangiocarcinoma Harboring a Novel Fusion.

Authors:
Huat C Lim Meagan Montesion Thomas Botton Eric A Collisson Sarah E Umetsu Spencer C Behr John D Gordan Phil J Stephens Robin K Kelley

Oncologist 2018 09 5;23(9):998-1003. Epub 2018 Apr 5.

Department of Medicine, University of California, San Francisco, San Francisco, California, USA

View Article and Find Full Text PDF
September 2018

Sampling strategies to capture single-cell heterogeneity.

Authors:
Satwik Rajaram Louise E Heinrich John D Gordan Jayant Avva Kathy M Bonness Agnieszka K Witkiewicz James S Malter Chloe E Atreya Robert S Warren Lani F Wu Steven J Altschuler

Nat Methods 2017 Oct 4;14(10):967-970. Epub 2017 Sep 4.

Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA.

View Article and Find Full Text PDF
October 2017

An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases.

Authors:
Anatoly Urisman Rebecca S Levin John D Gordan James T Webber Hilda Hernandez Yasushi Ishihama Kevan M Shokat Alma L Burlingame

Mol Cell Proteomics 2017 02 11;16(2):265-277. Epub 2016 Dec 11.

§Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California.

View Article and Find Full Text PDF
February 2017

Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib.

Authors:
Rowan E Miller Rachel Brough Ilirjana Bajrami Chris T Williamson Simon McDade James Campbell Asha Kigozi Rumana Rafiq Helen Pemberton Rachel Natrajan Josephine Joel Holly Astley Claire Mahoney Jonathan D Moore Chris Torrance John D Gordan James T Webber Rebecca S Levin Kevan M Shokat Sourav Bandyopadhyay Christopher J Lord Alan Ashworth

Mol Cancer Ther 2016 07 30;15(7):1472-84. Epub 2016 Jun 30.

The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom. Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

View Article and Find Full Text PDF
July 2016

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.

Authors:
Supriya K Saha John D Gordan Benjamin P Kleinstiver Phuong Vu Mortada S Najem Jia-Chi Yeo Lei Shi Yasutaka Kato Rebecca S Levin James T Webber Leah J Damon Regina K Egan Patricia Greninger Ultan McDermott Mathew J Garnett Roger L Jenkins Kimberly M Rieger-Christ Travis B Sullivan Aram F Hezel Andrew S Liss Yusuke Mizukami Lipika Goyal Cristina R Ferrone Andrew X Zhu J Keith Joung Kevan M Shokat Cyril H Benes Nabeel Bardeesy

Cancer Discov 2016 07 26;6(7):727-39. Epub 2016 May 26.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.

View Article and Find Full Text PDF
July 2016

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.

Authors:
Kimberley J Evason Macrina T Francisco Vladislava Juric Sanjeev Balakrishnan Maria Del Pilar Lopez Pazmino John D Gordan Sanjay Kakar Jan Spitsbergen Andrei Goga Didier Y R Stainier

PLoS Genet 2015 Jul 2;11(7):e1005305. Epub 2015 Jul 2.

Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Diabetes Center, Institute for Regeneration Medicine and the Liver Center, University of California, San Francisco, San Francisco, California, United States of America.

View Article and Find Full Text PDF
July 2015

Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.

Authors:
Maria M Martins Alicia Y Zhou Alexandra Corella Dai Horiuchi Christina Yau Taha Rakhshandehroo John D Gordan Rebecca S Levin Jeff Johnson John Jascur Mike Shales Antonio Sorrentino Jaime Cheah Paul A Clemons Alykhan F Shamji Stuart L Schreiber Nevan J Krogan Kevan M Shokat Frank McCormick Andrei Goga Sourav Bandyopadhyay

Cancer Discov 2015 02 12;5(2):154-67. Epub 2014 Dec 12.

University of California, San Francisco, San Francisco, California.

View Article and Find Full Text PDF
February 2015

Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors.

Authors:
Martin L Sos Rebecca S Levin John D Gordan Juan A Oses-Prieto James T Webber Megan Salt Byron Hann Alma L Burlingame Frank McCormick Sourav Bandyopadhyay Kevan M Shokat

Cell Rep 2014 Aug 7;8(4):1037-48. Epub 2014 Aug 7.

Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

View Article and Find Full Text PDF
August 2014

Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets.

Authors:
Vijay R Dondeti Bradley Wubbenhorst Priti Lal John D Gordan Kurt D'Andrea Edward F Attiyeh M Celeste Simon Katherine L Nathanson

Cancer Res 2012 Jan 17;72(1):112-21. Epub 2011 Nov 17.

Department of Medicine, Abramson Family Cancer Research Institute, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

View Article and Find Full Text PDF
January 2012

"And what other medications are you taking?".

Authors:
John D Gordan Wen-Yee Chay R Kate Kelley Andrew H Ko Su-Pin Choo Alan P Venook

J Clin Oncol 2011 Apr 18;29(11):e288-91. Epub 2011 Jan 18.

Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, USA.

View Article and Find Full Text PDF
April 2011

HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses.

Authors:
Jessica A Bertout Amar J Majmundar John D Gordan Jennifer C Lam Dara Ditsworth Brian Keith Eric J Brown Katherine L Nathanson M Celeste Simon

Proc Natl Acad Sci U S A 2009 Aug 12;106(34):14391-6. Epub 2009 Aug 12.

Abramson Family Cancer Research Institute, Abramson Cancer Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article and Find Full Text PDF
August 2009

HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma.

Authors:
John D Gordan Priti Lal Vijay R Dondeti Richard Letrero Krishna N Parekh C Elisa Oquendo Roger A Greenberg Keith T Flaherty W Kimryn Rathmell Brian Keith M Celeste Simon Katherine L Nathanson

Cancer Cell 2008 Dec;14(6):435-46

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article and Find Full Text PDF
December 2008

Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism.

Authors:
Regina M Young Shang-Jui Wang John D Gordan Xinjun Ji Stephen A Liebhaber M Celeste Simon

J Biol Chem 2008 Jun 22;283(24):16309-19. Epub 2008 Apr 22.

Abramson Family Cancer Research Institute, Departments of Genetics and Medicine, University of Pennsylvania School of Medicine, and Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia Pennsylvania 19104, USA.

View Article and Find Full Text PDF
June 2008

HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation.

Authors:
John D Gordan Craig B Thompson M Celeste Simon

Cancer Cell 2007 Aug;12(2):108-13

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article and Find Full Text PDF
August 2007

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis.

Authors:
Julian J Lum Thi Bui Michaela Gruber John D Gordan Ralph J DeBerardinis Kelly L Covello M Celeste Simon Craig B Thompson

Genes Dev 2007 May 16;21(9):1037-49. Epub 2007 Apr 16.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article and Find Full Text PDF
May 2007

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.

Authors:
John D Gordan Jessica A Bertout Cheng-Jun Hu J Alan Diehl M Celeste Simon

Cancer Cell 2007 Apr;11(4):335-47

Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

View Article and Find Full Text PDF
April 2007

Hypoxia-inducible factors: central regulators of the tumor phenotype.

Authors:
John D Gordan M Celeste Simon

Curr Opin Genet Dev 2007 Feb 8;17(1):71-7. Epub 2007 Jan 8.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, PA, USA.

View Article and Find Full Text PDF
February 2007

Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest.

Authors:
Fang Zhang Robert B Hamanaka Ekaterina Bobrovnikova-Marjon John D Gordan Mu-Shui Dai Hua Lu M Celeste Simon J Alan Diehl

J Biol Chem 2006 Oct 7;281(40):30036-45. Epub 2006 Aug 7.

Leonard and Madlyn Abramson Family Cancer Research Institute and Howard Hughes Medical Institute, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania 19104, USA.

View Article and Find Full Text PDF
October 2006

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

Authors:
Kelly L Covello James Kehler Hongwei Yu John D Gordan Andrew M Arsham Cheng-Jun Hu Patricia A Labosky M Celeste Simon Brian Keith

Genes Dev 2006 Mar;20(5):557-70

Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article and Find Full Text PDF
March 2006

ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation.

Authors:
Hongyan Wang Fiona E McCann John D Gordan Xiang Wu Monika Raab Talat H Malik Daniel M Davis Christopher E Rudd

J Exp Med 2004 Oct 11;200(8):1063-74. Epub 2004 Oct 11.

Molecular Immunology Section, Department of Immunology, Imperial College London, Hammersmith Campus, London W12 ONN, England, UK.

View Article and Find Full Text PDF
October 2004

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.

Authors:
Sara B Cullinan John D Gordan Jianping Jin J Wade Harper J Alan Diehl

Mol Cell Biol 2004 Oct;24(19):8477-86

The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, Department of Cancer Biology, University of Pennsylvania Cancer Center, 454 BRB II/III, 421 Curie Blvd., Philadelphia, PA 19104, USA.

View Article and Find Full Text PDF
October 2004