John C Panetta

John C Panetta

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John C Panetta

John C Panetta

Publications by authors named "John C Panetta"

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Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice.

Drug Metab Dispos 2018 07 19;46(7):1014-1022. Epub 2018 Apr 19.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, (S.G., J.C.P., J.K.R., E.G.S.); and Cancer and Developmental Biology Track, University of Tennessee Health Science Center, Memphis, Tennessee (S.G.)

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http://dx.doi.org/10.1124/dmd.117.078360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992966PMC
July 2018

Genetics of pleiotropic effects of dexamethasone.

Pharmacogenet Genomics 2017 08;27(8):294-302

Departments of aPharmaceutical Sciences bBiostatistics cOncology dComprehensive Cancer Center, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523978PMC
August 2017

Pharmacokinetics, immunogenicity, and safety of weekly dosing of brentuximab vedotin in pediatric patients with Hodgkin lymphoma.

Cancer Chemother Pharmacol 2016 Dec 11;78(6):1217-1223. Epub 2016 Nov 11.

Pharmaceutical Sciences, St. Jude Children's Research Hospital, The University of Tennessee Health Science Center, Memphis, TN, USA.

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http://dx.doi.org/10.1007/s00280-016-3180-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206991PMC
December 2016

Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia.

Cancer Chemother Pharmacol 2016 Nov 13;78(5):1051-1058. Epub 2016 Oct 13.

Department of Haematology, Christian Medical College, Vellore, Tamilnadu, 632004, India.

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http://dx.doi.org/10.1007/s00280-016-3166-8DOI Listing
November 2016

Prophylactic Trimethoprim-Sulfamethoxazole Does Not Affect Pharmacokinetics or Pharmacodynamics of Methotrexate.

J Pediatr Hematol Oncol 2016 08;38(6):449-52

Departments of *Pharmaceutical Sciences §Oncology †Biostatistics, St Jude Children's Research Hospital, Memphis, TN ‡Department of Pediatric Oncology, Skejby Hospital, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1097/MPH.0000000000000606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955728PMC
August 2016

Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant.

Drug Metab Dispos 2016 07 6;44(7):1116-22. Epub 2016 Apr 6.

Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children's Research Hospital, Memphis, Tennessee

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.115.068676
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http://dx.doi.org/10.1124/dmd.115.068676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931885PMC
July 2016

Sorafenib metabolism, transport, and enterohepatic recycling: physiologically based modeling and simulation in mice.

Cancer Chemother Pharmacol 2016 05 6;77(5):1039-52. Epub 2016 Apr 6.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s00280-016-3018-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846505PMC
May 2016

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death.

Sci Rep 2015 Nov 18;5:16488. Epub 2015 Nov 18.

Departments of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105.

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http://dx.doi.org/10.1038/srep16488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649703PMC
November 2015

Phase I study of the safety and pharmacokinetics of plerixafor in children undergoing a second allogeneic hematopoietic stem cell transplantation for relapsed or refractory leukemia.

Biol Blood Marrow Transplant 2014 Aug 23;20(8):1224-8. Epub 2014 Apr 23.

Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

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http://dx.doi.org/10.1016/j.bbmt.2014.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631218PMC
August 2014

Mathematical modeling of folate metabolism.

Wiley Interdiscip Rev Syst Biol Med 2013 Sep-Oct;5(5):603-13. Epub 2013 May 22.

Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1002/wsbm.1227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745816PMC
March 2014

Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.

J Clin Oncol 2014 Mar 18;32(9):949-59. Epub 2014 Feb 18.

All authors: St Jude Children's Research Hospital; and Deepa Bhojwani, Jun J. Yang, Hiroto Inaba, Jeffrey E. Rubnitz, Monika L. Metzger, Scott C. Howard, Raul C. Ribeiro, Sima Jeha, John T. Sandlund, and Ching-Hon Pui, University of Tennessee Health Sciences Center, College of Medicine, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2013.53.0808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948096PMC
March 2014

Hypersensitivity reaction to high-dose methotrexate and successful rechallenge in a pediatric patient with osteosarcoma.

Pediatr Blood Cancer 2014 Feb 19;61(2):373-5. Epub 2013 Aug 19.

Pharmaceutical Department, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.24741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267721PMC
February 2014

Formalizing an integrative, multidisciplinary cancer therapy discovery workflow.

Cancer Res 2013 Oct 16;73(20):6111-7. Epub 2013 Aug 16.

Authors' Affiliations: University of Texas Medical School at Houston, Houston, Texas; Center of Cancer Systems Biology, Steward Research & Specialty Projects Corp., St. Elizabeth's Medical Center, Tufts University School of Medicine; Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, Massachusetts; Department of Mathematics, Dartmouth College, Hanover, New Hampshire; St. Jude Children's Research Hospital, Memphis, Tennessee; Hospital for Sick Children, Toronto, Ontario, Canada; Children's Cancer Institute Australia, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia; and Metronomics Global Health Initiative, Marseille, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040396PMC
October 2013

Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments.

Cancer Chemother Pharmacol 2013 Aug 13;72(2):369-78. Epub 2013 Jun 13.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.

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http://dx.doi.org/10.1007/s00280-013-2206-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719000PMC
August 2013

Phase I study of the tolerability and pharmacokinetics of palifermin in children undergoing allogeneic hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2012 Aug 25;18(8):1309-14. Epub 2012 Apr 25.

Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.bbmt.2012.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539307PMC
August 2012

Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells.

PLoS Comput Biol 2010 Dec 2;6(12):e1001019. Epub 2010 Dec 2.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1001019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996318PMC
December 2010

Genetic predictors of interindividual variability in hepatic CYP3A4 expression.

J Pharmacol Exp Ther 2010 Mar 24;332(3):1088-99. Epub 2009 Nov 24.

Department of Pharmaceutical Sciences, 262 Danny Thomas Place, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://jpet.aspetjournals.org/content/332/3/1088.full.pdf
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.109.16080
Publisher Site
http://dx.doi.org/10.1124/jpet.109.160804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835441PMC
March 2010

Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastoma.

Clin Cancer Res 2010 Feb 26;16(3):1049-57. Epub 2010 Jan 26.

Department of Clinical Pharmacy and Pharmaceutical Sciences, University of Tennessee, TN, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818675PMC
February 2010

Application of a highly specific and sensitive fluorescent HPLC method for topotecan lactone in whole blood.

Biomed Chromatogr 2009 Jul;23(7):707-13

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital (SJCRH), Memphis, Tennessee 38105, USA.

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http://doi.wiley.com/10.1002/bmc.1173
Publisher Site
http://dx.doi.org/10.1002/bmc.1173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914494PMC
July 2009

Asparaginase may influence dexamethasone pharmacokinetics in acute lymphoblastic leukemia.

J Clin Oncol 2008 Apr;26(12):1932-9

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, 332 N Lauderdale, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1200/JCO.2007.13.8404DOI Listing
April 2008

Using pharmacokinetic and pharmacodynamic modeling and simulation to evaluate importance of schedule in topotecan therapy for pediatric neuroblastoma.

Clin Cancer Res 2008 Jan;14(1):318-25

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1243DOI Listing
January 2008

Population pharmacokinetic analysis of topotecan in pediatric cancer patients.

Clin Cancer Res 2007 Nov;13(22 Pt 1):6703-11

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1376DOI Listing
November 2007

Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420.

Clin Cancer Res 2007 Mar;13(5):1511-5

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2372DOI Listing
March 2007

Topotecan central nervous system penetration is altered by a tyrosine kinase inhibitor.

Cancer Res 2006 Dec;66(23):11305-13

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0929DOI Listing
December 2006

Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo.

Cancer Res 2006 May;66(9):4802-7

Departments of Pharmaceutical Sciences, Hematology-Oncology, and Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2915DOI Listing
May 2006

Development and validation of limited sampling models for topotecan lactone pharmacokinetic studies in children.

Cancer Chemother Pharmacol 2006 Apr 27;57(4):475-82. Epub 2005 Jul 27.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1007/s00280-005-0062-zDOI Listing
April 2006

Using plasma topotecan pharmacokinetics to estimate topotecan exposure in cerebrospinal fluid of children with medulloblastoma.

Neuro Oncol 2006 Apr 3;8(2):89-95. Epub 2006 Feb 3.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis TN 38105-2794, USA.

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http://dx.doi.org/10.1215/15228517-2005-004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1871944PMC
April 2006

Population pharmacokinetic studies in pediatrics: issues in design and analysis.

AAPS J 2005 Oct 5;7(2):E475-87. Epub 2005 Oct 5.

Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1208/aapsj070248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750985PMC
October 2005

Development of a pharmacokinetic limited sampling model for temozolomide and its active metabolite MTIC.

Cancer Chemother Pharmacol 2005 May 26;55(5):433-8. Epub 2005 Jan 26.

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1007/s00280-004-0896-9DOI Listing
May 2005

Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.

J Clin Invest 2005 Jan;115(1):110-7

Hematological Malignancies Program, and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://www.jci.org/articles/view/22477
Publisher Site
http://dx.doi.org/10.1172/JCI22477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539195PMC
January 2005

Mrp4 confers resistance to topotecan and protects the brain from chemotherapy.

Mol Cell Biol 2004 Sep;24(17):7612-21

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1128/MCB.24.17.7612-7621.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC506999PMC
September 2004

Interferon-gamma pharmacokinetics and pharmacodynamics in patients with colorectal cancer.

Cancer Chemother Pharmacol 2004 Mar 28;53(3):253-60. Epub 2003 Nov 28.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1007/s00280-003-0723-8DOI Listing
March 2004

Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors.

Cancer Chemother Pharmacol 2003 Dec 16;52(6):435-41. Epub 2003 Sep 16.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1007/s00280-003-0670-4DOI Listing
December 2003

Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- mice.

Mol Pharmacol 2003 Aug;64(2):456-65

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1124/mol.64.2.456DOI Listing
August 2003

Pharmacokinetics and pharmacodynamics of oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia.

J Clin Oncol 2003 Apr;21(7):1340-6

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, and College of Pharmacy, The University of Tennessee, Memphis 38105, USA.

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http://dx.doi.org/10.1200/JCO.2003.06.083DOI Listing
April 2003