John C Marshall

John C Marshall

UNVERIFIED PROFILE

Are you John C Marshall?   Register this Author

Register author
John C Marshall

John C Marshall

Publications by authors named "John C Marshall"

Are you John C Marshall?   Register this Author

100Publications

4390Reads

33Profile Views

A Core Outcome Set for Critical Care Ventilation Trials.

Crit Care Med 2019 Oct;47(10):1324-1331

Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Northern Ireland, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000003904DOI Listing
October 2019

Response to Letter to the Editor (Mangioni et al).

J Crit Care 2019 Aug 20;52:269. Epub 2019 Mar 20.

Department of Critical Care Medicine, Queen's University, Kingston, Ontario, Canada; Kingston Health Sciences Center, Queen's University, Kingston, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcrc.2019.03.004DOI Listing
August 2019

The Role of Endotoxin in Septic Shock-Reply.

JAMA 2019 03;321(9):903

Cooper University Hospital, Cooper Medical School of Rowan University, Camden, New Jersey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2018.20882DOI Listing
March 2019

Validation of diagnostic gene sets to identify critically ill patients with sepsis.

J Crit Care 2019 Feb 1;49:92-98. Epub 2018 Nov 1.

Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada; Kingston Health Sciences Center, Queen's University, Kingston, ON, Canada.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08839441183114
Publisher Site
http://dx.doi.org/10.1016/j.jcrc.2018.10.028DOI Listing
February 2019

Insights Into a "Negative" ICU Trial Derived From Gene Expression Profiling.

Crit Care Med 2019 Feb 26. Epub 2019 Feb 26.

Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000003693DOI Listing
February 2019

Estimating testosterone concentrations in adolescent girls: Comparison of two direct immunoassays to liquid chromatography-tandem mass spectrometry.

Steroids 2018 12 12;140:62-69. Epub 2018 Sep 12.

Center for Research in Reproduction, University of Virginia School of Medicine, Charlottesville, VA, USA; Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0039128X183016
Publisher Site
http://dx.doi.org/10.1016/j.steroids.2018.09.001DOI Listing
December 2018

Six subphenotypes in septic shock: Latent class analysis of the PROWESS Shock study.

J Crit Care 2018 10 8;47:70-79. Epub 2018 Jun 8.

Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02140, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcrc.2018.06.012DOI Listing
October 2018

The changing face of critical care: Task force on tropical diseases.

J Crit Care 2018 08 27;46:105. Epub 2017 Dec 27.

Division of Critical Care, Houston Methodist Hospital, 6565 Fannin St, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcrc.2017.12.019DOI Listing
August 2018

Multiple Organ Dysfunction: The Defining Syndrome of Sepsis.

Surg Infect (Larchmt) 2018 Feb/Mar;19(2):184-190. Epub 2018 Jan 23.

Departments of Surgery and Critical Care Medicine, St. Michael's Hospital, University of Toronto , Toronto, Ontario, Canada .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/sur.2017.298DOI Listing
August 2018

Heat-shock protein-90 prolongs septic neutrophil survival by protecting c-Src kinase and caspase-8 from proteasomal degradation.

J Leukoc Biol 2018 05 2;103(5):933-944. Epub 2018 Feb 2.

The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/JLB.4A0816-354RDOI Listing
May 2018

7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial.

Trials 2018 Feb 17;19(1):111. Epub 2018 Feb 17.

Departments of Medicine and Critical Care Medicine, Sunnybrook Health Sciences Center, Adjunct Scientist, Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-018-2474-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816399PMC
February 2018

Permissive hypotension during shock resuscitation: equipoise in all patients?

Intensive Care Med 2018 01 27;44(1):87-90. Epub 2017 May 27.

Department of Critical Care Medicine, Sunnybrook Health Sciences Centre and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00134-017-4849-2
Publisher Site
http://dx.doi.org/10.1007/s00134-017-4849-2DOI Listing
January 2018

Progesterone Suppression of Luteinizing Hormone Pulse Frequency in Adolescent Girls With Hyperandrogenism: Effects of Metformin.

J Clin Endocrinol Metab 2018 01;103(1):263-270

The Center for Research in Reproduction, University of Virginia Health System, Charlottesville, Virginia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2017-02068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761484PMC
January 2018

Sepsis Definitions: A Work in Progress.

Authors:
John C Marshall

Crit Care Clin 2018 Jan 5;34(1):1-14. Epub 2017 Oct 5.

Departments of Surgery and Critical Care Medicine, St. Michael's Hospital, 4th Floor Bond Wing, Room 4-007, 30 Bond Street, Toronto, ON M5B 1W8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccc.2017.08.004DOI Listing
January 2018

S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study.

Scand J Trauma Resusc Emerg Med 2017 Nov 25;25(1):114. Epub 2017 Nov 25.

Institut de recherches cliniques de Montréal, Université de Montréal, Montréal, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13049-017-0455-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702249PMC
November 2017

The intensive care medicine research agenda on septic shock.

Intensive Care Med 2017 Sep 12;43(9):1294-1305. Epub 2017 May 12.

Division of Medicine, Bloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00134-017-4821-1DOI Listing
September 2017

Steroids Redux: Targeting the Mineralocorticoid Axis in Sepsis.

Authors:
John C Marshall

Crit Care Med 2017 09;45(9):1582-1583

Departments of Surgery and Critical Care Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000002511DOI Listing
September 2017

The longest stalk: preserved pituitary function after regression of a giant prolactinoma.

Pituitary 2017 08;20(4):485-487

University of Virginia Health System, Charlottesville, VA, 22908, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11102-017-0796-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844470PMC
August 2017

Leveraging Transcriptomics to Disentangle Sepsis Heterogeneity.

Am J Respir Crit Care Med 2017 08;196(3):258-260

3 St. Michael's Hospital University of Toronto Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201701-0143EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549869PMC
August 2017

Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients: A Pilot Randomized Clinical Trial and Meta-Analysis.

Crit Care Med 2017 Jul;45(7):1121-1129

1Department of Medicine, McMaster University, Hamilton, ON, Canada.2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.3Department of Critical Care, University of Dammam, Dammam, Saudi Arabia.4Discipline of Acute Care Medicine, University of Adelaide, Adelaide, SA, Australia.5Department of Surgery and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.6Departments of Anesthesia, Pain Management and Perioperative Medicine and Critical Care Medicine, Dalhousie University, Halifax, NS, Canada.7Department of Critical Care, Queens University, Kingston, ON, Canada.8Department of Medicine (Critical Care), University of Ottawa, Ottawa, ON, Canada.9Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.10Departments of Medicine, Anesthesiology and Critical Care, Université Laval, Quebec City, QC, Canada.11Biostatistics Unit, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.12Intensive Care Department, King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.13The George Institute for Global Health and Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia.14Department of Medicine, University of Toronto, Toronto, ON, Canada.15Department of Internal Medicine, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000002461DOI Listing
July 2017

Development of a zebrafish sepsis model for high-throughput drug discovery.

Mol Med 2017 07 7;23:134-148. Epub 2017 Jun 7.

Zebrafish Centre for Advanced Drug Discovery, St. Michael's Hospital, 209 Victoria St, Toronto, Ontario, Canada M5B 1T8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2119/molmed.2016.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522968PMC
July 2017

Increased Adrenal Androgens in Overweight Peripubertal Girls.

J Endocr Soc 2017 May 12;1(5):538-552. Epub 2017 Apr 12.

Division of Endocrinology, Department of Internal Medicine, Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia 22908.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/js.2017-00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686668PMC
May 2017

Development of an intensive care unit resource assessment survey for the care of critically ill patients in resource-limited settings.

J Crit Care 2017 04 5;38:172-176. Epub 2016 Nov 5.

Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcrc.2016.11.002DOI Listing
April 2017

A path to precision in the ICU.

Crit Care 2017 04 3;21(1):79. Epub 2017 Apr 3.

Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-017-1653-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376689PMC
April 2017

Re-evaluating the Inhibition of Stress Erosions (REVISE): a protocol for pilot randomized controlled trial.

Ann Saudi Med 2016 Nov-Dec;36(6):427-433

Dr. Waleed Alhazzani, Critical Care Medicine, McMaster University,, 50 Charlton Avenue East,, Hamilton, Ontario,, L8N 4A6, Canada, T: +1905-522-1155 ext 32800, F: +1905-521-6068 ORCID: http://orcid.org/0000-0001-8076-9626.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5144/0256-4947.2016.427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074211PMC
March 2017

Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit.

Crit Care Med 2017 Mar;45(3):386-394

1Department of Anesthesiology and Intensive Care, Uniklinikum Jena, Jena, Germany. 2Department of Anaesthesia, Intensive Care and Acute Poisioning, Pomeranian Medical University, Szczecin, Poland. 3Department of Medicine, Medical College of Wisconsin, Milwaukee, WI. 4Department of Critical Care, Care Institute of Medical Sciences, Ahmedabad, India. 5Department of Intensive Care Medicine, University Medical Center, Hamburg Eppendorf, Germany. 6Center for Trauma and Critical Care, George Washington University Hospital, Washington, DC. 7Interdepartmental Division of Critical Care Medicine, Department of Surgery, University of Toronto, St. Michael's Hospital, Toronto, ON, Canada. 8Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00003246-201703000-0000
Publisher Site
http://dx.doi.org/10.1097/CCM.0000000000002189DOI Listing
March 2017

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

Crit Care Med 2017 Mar;45(3):486-552

1St. George's Hospital London, England, United Kingdom. 2New York University School of Medicine New York, NY. 3McMaster University Hamilton, Ontario, Canada. 4Brown University School of Medicine Providence, RI. 5Instituto di Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore, Rome, Italy. 6Vall d'Hebron University Hospital Barcelona, Spain. 7University of Manitoba Winnipeg, Manitoba, Canada. 8Emory University Hospital Atlanta, GA. 9Hadassah Hebrew University Medical Center Jerusalem, Israel. 10Sunnybrook Health Sciences Centre Toronto, Ontario, Canada. 11University of Pittsburgh Critical Care Medicine CRISMA Laboratory Pittsburgh, PA. 12Hospital Raymond Poincare Garches, France. 13Saint Thomas Hospital London, England, United Kingdom. 14University College London Hospitals London, England, United Kingdom. 15Vanderbilt University Medical Center Nashville, TN. 16Service de Reanimation Medicale Paris, France. 17CHIREC Hospitals Braine L'Alleud, Belgium. 18Western Hospital Victoria, Australia. 19Keio University School of Medicine, Tokyo, Japan. 20Vivantes-Klinikum Neukölln, Berlin, Germany. 21Karl Heusner Memorial Hospital Belize Healthcare Partners Belize City, Belize. 22Cooper Health System Camden, NJ. 23University of Mississippi Medical Center Jackson, MS. 24Jupiter Hospital Thane, India. 25Rush University Medical Center Chicago, IL. 26ASAN Medical Center University of Ulsan College of Medicine Seoul, South Korea. 27Hospital de Clinicas de Porto Alegre Porto Alegre, Brazil. 28Federal University of Sao Paulo Sao Paulo, Brazil. 29Regions Hospital St. Paul, MN. 30Saint Michael's Hospital Toronto, Ontario, Canada. 31Washington University School of Medicine St. Louis, MO. 32Ottawa Hospital Ottawa, Ontario, Canada. 33Nepean Hospital, University of Sydney Penrith, New South Wales, Australia. 34Mount Sinai Hospital Toronto, Ontario, Canada. 35UCINC, Centro Hospitalar de Lisboa Central, Lisbon, Portugal. 36University of New South Wales, Sydney, New South Wales, Australia. 37Università dellla Magna Graecia Catanzaro, Italy. 38Fujita Health University School of Medicine, Toyoake, Aich, Japan. 39Rigshospitalet Copenhagen, Denmark. 40Università Sapienza, Rome, Italy. 41Christiana Care Health Services Newark, DE. 42University of Pittsburgh School of Medicine Pittsburgh, PA. 43Stanford University School of Medicine Stanford, CA. 44Kaust Medical Services Thuwal, Saudi Arabia. 45University of Kansas Medical Center Kansas City, KS. 46Wolfson Institute of Biomedical Research London, England, United Kingdom. 47Massachusetts General Hospital Boston, MA. 48California Pacific Medical Center San Francisco, CA. 49University of Amsterdam Amsterdam, Netherlands. 50Erasmé University Hospital Brussels, Belgium. 51University of Amsterdam, Amsterdam, Netherlands. 52Houston Methodist Hospital, Houston, TX.

View Article

Download full-text PDF

Source
https://www.sccm.org/Documents/SSC-Guidelines.pdf
Web Search
http://link.springer.com/content/pdf/10.1007%2Fs00134-017-46
Web Search
http://www.esicm.org/upload/SSC%20guidelines%202012.pdf
Web Search
http://dx.doi.org/10.1097/CCM.0000000000002255DOI Listing
March 2017

Conservative fluid management or deresuscitation for patients with sepsis or acute respiratory distress syndrome following the resuscitation phase of critical illness: a systematic review and meta-analysis.

Intensive Care Med 2017 Feb 12;43(2):155-170. Epub 2016 Oct 12.

Interdepartmental Division of Critical Care, University of Toronto, 585 University Avenue, PMB 11-123, Toronto, ON, M5G 2N2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00134-016-4573-3DOI Listing
February 2017

Global Collaboration in Acute Care Clinical Research: Opportunities, Challenges, and Needs.

Authors:
John C Marshall

Crit Care Med 2017 Feb;45(2):311-320

1Interdepartmental Division of Critical Care Medicine, Department of Surgery, University of Toronto, Toronto, ON, Canada. 2Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. 3International Forum for Acute Care Trialists (InFACT).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000002211DOI Listing
February 2017

Patient and Organizational Factors Associated With Delays in Antimicrobial Therapy for Septic Shock.

Crit Care Med 2016 Dec;44(12):2145-2153

1Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.2Department of Emergency Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.3Critical Care Medicine, Prairie Mountain Health, Brandon, MB, Canada.4Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.5Critical Care Medicine, Richmond General Hospital, Richmond, BC, Canada.6Critical Care Medicine, Royal Columbian Hospital, New Westminster, BC, Canada.7Critical Care Medicine, Jewish General Hospital, Montreal, QC, Canada.8Critical Care Medicine and Department of Medicine, Winnipeg Regional Health Authority, Winnipeg, MB, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000001868DOI Listing
December 2016

The authors reply.

Crit Care Med 2016 10;44(10):e1006-7

Departement of Critical Care and Research Center of Hôpital du Sacré-Coeur de Montréal, Montreal, Québec, Canada;Department of Critical Care Medicine, St. Michael's Hospital and Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000001979DOI Listing
October 2016

Polycystic Ovary Syndrome.

N Engl J Med 2016 10;375(14):1398-1399

University of Virginia School of Medicine, Charlottesville, VA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1610000DOI Listing
October 2016

Sepsis-3: What is the Meaning of a Definition?

Authors:
John C Marshall

Crit Care Med 2016 08;44(8):1459-60

Departments of Surgery and Critical Care Medicine, Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000001983DOI Listing
August 2016

CLINICAL PRACTICE. Polycystic Ovary Syndrome.

N Engl J Med 2016 Jul;375(1):54-64

From the Center for Research in Reproduction and the Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMcp1514916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301909PMC
July 2016

Stress ulcer prophylaxis in critical illness: a Canadian survey.

Can J Anaesth 2016 Jun 24;63(6):718-24. Epub 2016 Feb 24.

Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Health Sciences Center, Room 2C11, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12630-016-0612-3DOI Listing
June 2016

The Richmond Agitation-Sedation Scale Should Not Be Used to Evaluate Neurologic Function.

Crit Care Med 2016 06;44(6):e450

Department of Intensive Care, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium; Department of Intensive Care Medicine, University Hospital Bern (Inselspital), Bern, Switzerland; Unidade de Cuidados Intensivos Neurocríticos, Hospital de São José, Centro Hospitalarde Lisboa Central, Lisbon, Portugal; Department of Anesthesiology and Intensive Care, Uniklinikum Jena, Jena, Germany; Department of Intensive Care, St. Michael's Hospital, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000001597DOI Listing
June 2016

Epithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts.

Cell Biosci 2016 16;6:43. Epub 2016 Jun 16.

SickKids Research Institute, Program in Physiology and Experimental Medicine, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 9th floor, 686 Bay Street, Toronto, ON M5G 0A4 Canada ; Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8 Canada ; Institute of Medical Science, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8 Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13578-016-0105-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910355PMC
June 2016

One-Year Outcomes in Caregivers of Critically Ill Patients.

N Engl J Med 2016 May;374(19):1831-41

From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1511160DOI Listing
May 2016

Determinants of Citation Impact in Large Clinical Trials in Critical Care: The Role of Investigator-Led Clinical Trials Groups.

Crit Care Med 2016 Apr;44(4):663-70

1Keenan Research Centre at the Li Ka Shing Knowledge Institute and the Department of Critical Care Medicine, St. Michael's Hospital, and the Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada. 2Faculty of Medicine, Queen's University, Kingston, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000001466DOI Listing
April 2016

Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure.

J Intensive Care 2016 31;4:24. Epub 2016 Mar 31.

CRISMA Center, Department of Critical Care Medicine, McGowan Institute for Regnerative Medicine, Clinical and Translational Science Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, PA USA ; Department of Health Policy and Management, McGowan Institute for Regnerative Medicine, Clinical and Translational Science Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, PA USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40560-016-0151-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815117PMC
April 2016

A Transcriptomic Biomarker to Quantify Systemic Inflammation in Sepsis - A Prospective Multicenter Phase II Diagnostic Study.

EBioMedicine 2016 Apr 8;6:114-125. Epub 2016 Mar 8.

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Erlanger Allee 101, 07646 Jena, Germany; Center for Sepsis Control & Care, Jena University Hospital, Erlanger Allee 101, 07646 Jena, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2016.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856796PMC
April 2016

DIAGNOSTIC UTILITY OF DIFFERENT BLOOD COMPONENTS IN GENE EXPRESSION ANALYSIS OF SEPSIS.

Shock 2016 Mar;45(3):292-8

*Departments of Medicine and Critical Care Medicine, Queen's University, Kingston †Critical Illness and Injury Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital ‡Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SHK.0000000000000511DOI Listing
March 2016

Endotoxemia Following Multiple Trauma: Risk Factors and Prognostic Implications.

Crit Care Med 2016 Feb;44(2):335-41

1Department of Medicine, Centre de Recherche de l'Hôpital du Sacré-Coeur, University of Montreal, Montreal, QC, Canada. 2Department of Medicine, Niagara Health System, St Catherine's, McMaster University, Hamilton, ON, Canada. 3Department of Critical Care, St. Michael's Hospital, Toronto, ON, Canada. 4Department of Clinical Biochemistry, St. Michael's Hospital and the Keenan Research Centre for Biomedical Science, University of Toronto, Toronto, ON, Canada. 5Department of Critical Care, St. Michael's Hospital and the Keenan Research Centre for Biomedical Science, University of Toronto, Toronto, ON, Canada. 6Departamento de Anestesiología y Reanimación, Gregorio Marañon Hospital, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000001404DOI Listing
February 2016

Fluid strategies and outcomes in patients with acute respiratory distress syndrome, systemic inflammatory response syndrome and sepsis: a protocol for a systematic review and meta-analysis.

Syst Rev 2015 Nov 12;4:162. Epub 2015 Nov 12.

Interdepartmental Division of Critical Care, University of Toronto, Toronto General Hospital, 585 University Avenue, PMB 11-123, Toronto, Ontario, M5G 2N2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13643-015-0150-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643493PMC
November 2015

Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome.

Endocr Rev 2015 Oct;36(5):487-525

Department of Obstetrics and Gynecology (D.A.D.), David Geffen School of Medicine at UCLA, Los Angeles, California 90095; Division of Pediatric Endocrinology (S.E.O.), Children's Hospital of New York-Presbyterian, Columbia University College of Physicians and Surgeons, New York, New York 10032; Department of Physiology (E.S.-V.), Karolinska Institutet, 171 77 Stockholm, Sweden; Center for Research in Reproduction and Division of Endocrinology (J.C.M.), Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22903; Division of Reproductive Medicine (J.S.L.), Department of Obstetrics and Gynecology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; and Department of Obstetrics and Gynecology (R.S.L.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/er.2015-1018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591526PMC
October 2015

Talactoferrin in Severe Sepsis: Results From the Phase II/III Oral tAlactoferrin in Severe sepsIS Trial.

Crit Care Med 2015 Sep;43(9):1832-8

1Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium. 2Department of Surgery, Interdepartmental Division of Critical Care Medicine, University of Toronto, St. Michael's Hospital, Toronto, ON, Canada. 3Department of Medicine, Cooper University Hospital and Cooper Medical School of Rowan University, Camden, NJ. 4Discovery Laboratories, Warrington, PA. 5Pulmonary Critical Care and Sleep Section, Department of Medicine, Baylor College of Medicine, Houston, TX. 6Warren Alpert Medical School at Brown University, Rhode Island Hospital, Providence, RI. 7Bloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom. 8Agennix, Princeton, NJ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000001090DOI Listing
September 2015

Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation.

Shock 2015 Aug;44(2):157-65

Department of Surgery, University of Toronto, and the Keenan Research Centre for Biomedical Science of St Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/shockjournal/2015/08000/Oxidati
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/SHK.0000000000000392DOI Listing
August 2015

Blood pressure targets for vasopressor therapy: a systematic review.

Shock 2015 Jun;43(6):530-9

*Department of Anaesthesia, Division of Critical Care, McMaster University; and †Departments of Medicine, and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario; ‡Centre Hospitalier Universitaire de Québec Research Center, Population Health and Optimal Health Practices, Division of Critical Care Medicine, Department of Anesthesiology, Department of Medicine, Université Laval, Québec, Québec; and §Department of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada; ∥Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; ¶Department of Anesthesiology, University of Ottawa, and **Department of Pharmacy, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada; ††Département de Réanimation Médicale et de Médecine Hyperbare, Centre Hospitalier Universitaire Angers, Angers, France; ‡‡Centre Hospitalier Universitaire de Québec Research Center, Population Health and Optimal Health Practices, Division of Critical Care Medicine, Department of Anesthesiology, Université Laval, Québec, Québec; §§Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton; and ∥∥Li Ka Shing Knowledge Institute, St. Michaels Hospital, University of Toronto, Toronto, Ontario; and ¶¶Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Département de médicine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.

View Article

Download full-text PDF

Source
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/SHK.0000000000000348DOI Listing
June 2015

Understanding the global burden of pediatric sepsis.

Authors:
John C Marshall

Am J Respir Crit Care Med 2015 May;191(10):1096-8

1 St. Michael's Hospital University of Toronto Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201503-0594EDDOI Listing
May 2015

Age of transfused blood in critically ill adults.

N Engl J Med 2015 Apr 17;372(15):1410-8. Epub 2015 Mar 17.

From Centre Hospitalier Universitaire (CHU) Sainte-Justine, Université de Montréal (J.L., L.C.) and Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal (P.C.H.), Ottawa Hospital Research Institute, University of Ottawa, Ottawa (D.A.F., A.T., L.M., E.S., D.V.), McMaster University, Hamilton, ON (D.J.C., M.A.B.), University of Toronto, Toronto (J.C.M., J.C.), and Centre de Recherche du CHU de Québec, Université Laval, Quebec, QC (A.F.T.) - all in Canada; University of Edinburgh (T.S.W.) and NHS Blood and Transplant-Oxford University Hospitals NHS Trust, University of Oxford, Oxford (S.J.S., H.C.) - both in the United Kingdom; Université de Franche-Comté, Besançon (G.C., P.T.) and Établissement Français du Sang, La Plaine St. Denis (P.T., L.B.) - both in France; and Sanquin Blood Supply, Amsterdam (L.W.), Amphia Hospital, Breda and Oosterhout (N.J.M.), and TIAS School for Business and Society-Tilburg University, Tilburg (N.J.M.) - all in the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1500704DOI Listing
April 2015

Pre-B cell colony enhancing factor induces Nampt-dependent translocation of the insulin receptor out of lipid microdomains in A549 lung epithelial cells.

Am J Physiol Endocrinol Metab 2015 Feb 16;308(4):E324-33. Epub 2014 Dec 16.

Department of Surgery, Department of Critical Care Medicine, and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and the Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpendo.00006.2014DOI Listing
February 2015

Low-dose corticosteroid treatment in septic shock: a propensity-matching study.

Crit Care Med 2014 Nov;42(11):2333-41

1Section of Critical Care Medicine, University of Manitoba, Winnipeg, MB, Canada. 2Department of Anesthesia, University of Manitoba, Winnipeg, MB, Canada. 3Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada. 4Departments of Medical Microbiology and Pharmacology/Therapeutics, University of Manitoba, Winnipeg, MB, Canada. 5The Center for Health Evaluation and Outcome Sciences and Department of Medicine (PD), St Paul's Hospital and University of British Columbia, Vancouver, BC, Canada. 6Department of Surgery and Critical Care Medicine, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michaels Hospital, The University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000000518DOI Listing
November 2014

Bridging lipid metabolism and innate host defense.

Sci Transl Med 2014 Oct;6(258):258fs41

Department of Critical Care Medicine and the Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada. Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.3010501DOI Listing
October 2014

Blunted day-night changes in luteinizing hormone pulse frequency in girls with obesity: the potential role of hyperandrogenemia.

J Clin Endocrinol Metab 2014 Aug 29;99(8):2887-96. Epub 2014 Apr 29.

The Center for Research in Reproduction (J.S.C., J.P.B., C.B.S., J.C.M., C.R.M.), Division of Endocrinology, Departments of Medicine (J.S.C., J.P.B., J.C.M., C.R.M.) and Pediatrics (C.B.S.), and Department of Public Health Sciences (J.T.P.), University of Virginia Health System, Charlottesville, Virginia 22908; and Division of Reproductive Endocrinology and Infertility (R.J.C.), Department of Reproductive Medicine, University of California, San Diego, San Diego, California 92103.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2013-3258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121026PMC
August 2014

Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome.

BMC Infect Dis 2014 Jul 29;14:420. Epub 2014 Jul 29.

Department of Critical Care Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2334-14-420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122779PMC
July 2014

Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit.

Lancet Respir Med 2014 May 14;2(5):380-6. Epub 2014 Apr 14.

Department of Anaesthesiology and Intensive Care and Centre for Sepsis Care and Control, Jena University Hospital, Jena, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(14)70061-XDOI Listing
May 2014

How outcomes are defined in clinical trials of mechanically ventilated adults and children.

Am J Respir Crit Care Med 2014 Apr;189(8):886-93

1 Centre for Infection and Immunity and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201309-1645PPDOI Listing
April 2014

Why have clinical trials in sepsis failed?

Authors:
John C Marshall

Trends Mol Med 2014 Apr 24;20(4):195-203. Epub 2014 Feb 24.

The Departments of Surgery and Critical Care Medicine, and the Keenan Research Centre for Biomedical Science, St Michael's Hospital, 4th Floor Bond Wing, Room 4-007, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada; The Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2014.01.007DOI Listing
April 2014

Activated neutrophils induce epithelial cell apoptosis through oxidant-dependent tyrosine dephosphorylation of caspase-8.

Am J Pathol 2014 Apr 28;184(4):1030-1040. Epub 2014 Feb 28.

Keenan Research Centre of the Li Ka Shing Knowledge Institute, Tortonto, Ontario, Canada; Department of Critical Care Medicine, St. Michael's Hospital, Tortonto, Ontario, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Surgery, St. Michael's Hospital, Tortonto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2013.12.031DOI Listing
April 2014

Perioperative cardiovascular system failure in South Asians undergoing cardiopulmonary bypass is associated with prolonged inflammation and increased Toll-like receptor signaling in inflammatory monocytes.

J Surg Res 2014 Mar 7;187(1):43-52. Epub 2013 Oct 7.

Department of Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute at St. Michael's Hospital, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00224804130090
Publisher Site
http://dx.doi.org/10.1016/j.jss.2013.09.035DOI Listing
March 2014

The PIRO (predisposition, insult, response, organ dysfunction) model: toward a staging system for acute illness.

Authors:
John C Marshall

Virulence 2014 Jan 1;5(1):27-35. Epub 2013 Nov 1.

Departments of Surgery and Critical Care Medicine; University of Toronto; Toronto, ON Canada; The Keenan Research Centre of the Li Ka Shing Knowledge Institute; St. Michael's Hospital; University of Toronto; Toronto, ON Canada; The Interdepartmental Division of Critical Care Medicine; University of Toronto; Toronto, ON Canada.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/abs/10.4161/viru.26908
Publisher Site
http://dx.doi.org/10.4161/viru.26908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916380PMC
January 2014