John C Cambier

John C Cambier

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John C Cambier

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Non-Antibody-Secreting Functions of B Cells and Their Contribution to Autoimmune Disease.

Annu Rev Cell Dev Biol 2019 Oct 18;35:337-356. Epub 2019 Mar 18.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA; email:

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062518DOI Listing
October 2019

Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy.

Front Immunol 2018 6;9:665. Epub 2018 Apr 6.

Department of Immunology and Microbiology, University of Colorado Denver School of Medicine, Aurora, CO, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897502PMC
June 2019

A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation.

J Immunol 2019 Jun 10;202(12):3381-3393. Epub 2019 May 10.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045

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http://dx.doi.org/10.4049/jimmunol.1801394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548689PMC
June 2019

Protective role of B cells in sterile particulate-induced lung injury.

JCI Insight 2019 May 16;5. Epub 2019 May 16.

Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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http://dx.doi.org/10.1172/jci.insight.125494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629102PMC
May 2019

Soluble Antigen Arrays for Selective Desensitization of Insulin-Reactive B Cells.

Mol Pharm 2019 04 25;16(4):1563-1572. Epub 2019 Feb 25.

Department of Chemistry , University of Kansas , 1251 Wescoe Hall Drive , Lawrence , Kansas 66045 , United States.

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http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b01250
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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01250DOI Listing
April 2019

Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.

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http://dx.doi.org/10.1172/jci.insight.123384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413793PMC
February 2019

Silencing of high-affinity insulin-reactive B lymphocytes by anergy and impact of the NOD genetic background in mice.

Diabetologia 2018 12 25;61(12):2621-2632. Epub 2018 Sep 25.

Department of Immunology and Microbiology, University of Colorado School of Medicine, P18-8100, RC1 North, 12800 East 19th Avenue, Aurora, CO, 80045-2537, USA.

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http://dx.doi.org/10.1007/s00125-018-4730-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219930PMC
December 2018

B Cell-Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses.

J Immunol 2018 11 3;201(9):2641-2653. Epub 2018 Oct 3.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045; and

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1701405
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http://dx.doi.org/10.4049/jimmunol.1701405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497520PMC
November 2018

Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients.

J Autoimmun 2018 05 9;89:82-89. Epub 2017 Dec 9.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902436PMC
May 2018

Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.

Diabetes 2018 04 17;67(4):697-703. Epub 2018 Jan 17.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO

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http://dx.doi.org/10.2337/db17-0937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860860PMC
April 2018

High-efficiency RNA-based reprogramming of human primary fibroblasts.

Nat Commun 2018 02 21;9(1):745. Epub 2018 Feb 21.

Department of Dermatology, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 East 17th Avenue, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1038/s41467-018-03190-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821705PMC
February 2018

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

PLoS Pathog 2018 01 3;14(1):e1006829. Epub 2018 Jan 3.

Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1006829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770077PMC
January 2018

B cells in type 1 diabetes mellitus and diabetic kidney disease.

Nat Rev Nephrol 2017 Oct;13(11):712-720

Department of Immunology and Microbiology, University of Colorado School of Medicine, 12800 E 19th Avenue, RC1 North, P18-8100, Aurora, Colorado 80045-2537, USA.

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http://www.nature.com/doifinder/10.1038/nrneph.2017.138
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http://dx.doi.org/10.1038/nrneph.2017.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733025PMC
October 2017

Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway.

J Exp Med 2017 04 24;214(4):931-941. Epub 2017 Mar 24.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045

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http://dx.doi.org/10.1084/jem.20160972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379973PMC
April 2017

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function.

J Vis Exp 2017 02 16(120). Epub 2017 Feb 16.

Department of Immunology and Microbiology, University of Colorado School of Medicine; Department of Biomedical Research, National Jewish Health;

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http://dx.doi.org/10.3791/55382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409333PMC
February 2017

Targeting B cells in treatment of autoimmunity.

Curr Opin Immunol 2016 12 5;43:39-45. Epub 2016 Oct 5.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Denver, CO, USA; Department of Biomedical Research, National Jewish Health, Denver, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127449PMC
December 2016

Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines.

J Immunol 2016 08 29;197(4):1221-30. Epub 2016 Jun 29.

Department of Biomedical Research, National Jewish Health, Denver, CO 80206; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045; and Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206

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http://dx.doi.org/10.4049/jimmunol.1501565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974487PMC
August 2016

Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells.

J Exp Med 2016 05 25;213(5):751-69. Epub 2016 Apr 25.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045 Department of Biomedical Research, National Jewish Health, Denver, CO 80206

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http://dx.doi.org/10.1084/jem.20150537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854724PMC
May 2016

γδ T Cells Shape Preimmune Peripheral B Cell Populations.

J Immunol 2016 Jan 18;196(1):217-31. Epub 2015 Nov 18.

Department of Biomedical Research, National Jewish Health, Denver, CO 80206; Department of Immunology and Microbiology, University of Colorado Health Sciences Center, Aurora, CO 80045;

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http://dx.doi.org/10.4049/jimmunol.1501064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684964PMC
January 2016

Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination.

J Immunol 2015 Dec 23;195(11):5461-5471. Epub 2015 Oct 23.

Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045.

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http://dx.doi.org/10.4049/jimmunol.1501375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655169PMC
December 2015

Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling.

Immunol Rev 2015 Nov;268(1):66-73

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1111/imr.12336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621791PMC
November 2015

B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens.

J Autoimmun 2015 Aug 4;62:45-54. Epub 2015 Jul 4.

Department of Immunology and Microbiology, University of Colorado School of Medicine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2015.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529775PMC
August 2015

Role of B lymphocytes in the pathogenesis of type 1 diabetes.

Curr Diab Rep 2014 ;14(11):543

Department of Immunology and Microbiology, University of Colorado School of Medicine, 12800 E 19th Avenue, P18-8100, Mail Stop 8333, RC1 N, Aurora, CO, 80045-2537, USA,

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http://dx.doi.org/10.1007/s11892-014-0543-8DOI Listing
June 2015

γδ T cells affect IL-4 production and B-cell tolerance.

Proc Natl Acad Sci U S A 2015 Jan 22;112(1):E39-48. Epub 2014 Dec 22.

Department of Biomedical Research, National Jewish Health, Denver, CO 80206; Department of Immunology & Microbiology, University of Colorado Health Sciences Center, Aurora, CO 80045;

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http://dx.doi.org/10.1073/pnas.1415107111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291655PMC
January 2015

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.

Cell 2014 Dec;159(7):1549-62

ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.11.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520319PMC
December 2014

B cells and type 1 diabetes ...in mice and men.

Immunol Lett 2014 Aug 25;160(2):128-32. Epub 2014 Jan 25.

University of Colorado Denver and National Jewish Health, Denver, CO, United States; Department of Immunology, National Jewish Health, Rm 803A, Goodman Building, 1400 Jackson Street, Denver, CO 80206, United States. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2014.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526342PMC
August 2014

B lymphocyte antigen receptor signaling: initiation, amplification, and regulation.

F1000Prime Rep 2013 Oct 1;5:40. Epub 2013 Oct 1.

Integrated Department of Immunology, University of Colorado School of Medicine & National Jewish Health 1400 Jackson St, Denver, CO 80206.

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http://dx.doi.org/10.12703/P5-40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790562PMC
October 2013

Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells.

Curr Opin Immunol 2013 Jun 15;25(3):313-20. Epub 2013 May 15.

Institut Pasteur, Département d'Immunologie, Centre d'Immunologie Humaine, Paris, France.

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http://dx.doi.org/10.1016/j.coi.2013.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732051PMC
June 2013

Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways.

Authors:
John C Cambier

J Clin Invest 2013 May 24;123(5):1928-31. Epub 2013 Apr 24.

Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, Colorado, USA.

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http://dx.doi.org/10.1172/JCI69289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635745PMC
May 2013

COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype.

Immunol Res 2013 Mar;55(1-3):48-57

Department of Immunology, University of Colorado School of Medicine, National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.1007/s12026-012-8347-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919062PMC
March 2013

Integrated immunology in Colorado.

Immunol Res 2013 Mar;55(1-3):1-2

Integrated Department of Immunology, National Jewish Health, Denver, CO 80220, USA.

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http://dx.doi.org/10.1007/s12026-012-8376-5DOI Listing
March 2013

STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration.

J Immunol 2013 Mar 1;190(6):2835-43. Epub 2013 Feb 1.

Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.4049/jimmunol.1201788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593745PMC
March 2013

B cell maintenance and function in aging.

Semin Immunol 2012 Oct 4;24(5):342-9. Epub 2012 May 4.

Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.1016/j.smim.2012.04.004DOI Listing
October 2012

Retention of anergy and inhibition of antibody responses during acute γ herpesvirus 68 infection.

J Immunol 2012 Sep 17;189(6):2965-74. Epub 2012 Aug 17.

Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.4049/jimmunol.1201407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436999PMC
September 2012

B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity.

Science 2012 Jun 3;336(6085):1178-81. Epub 2012 May 3.

Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1126/science.1213368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777391PMC
June 2012

SMIP-016 in action: CD37 as a death receptor.

Cancer Cell 2012 May;21(5):597-8

Department of Immunology, University of Colorado School of Medicine and National Jewish Health Denver, Denver, CO 80206, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.04.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363110PMC
May 2012

The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling.

Immunol Lett 2012 Mar 24;143(1):122-30. Epub 2012 Feb 24.

Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO 80206, United States.

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http://dx.doi.org/10.1016/j.imlet.2012.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314150PMC
March 2012

VISA is required for B cell expression of TLR7.

J Immunol 2012 Jan 21;188(1):248-58. Epub 2011 Nov 21.

Integrated Department of Immunology, University of Colorado School of Medicine, Denver, CO 80206, USA.

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http://dx.doi.org/10.4049/jimmunol.1100918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244560PMC
January 2012

Differential STIM1 expression in T and B cell subsets suggests a role in determining antigen receptor signal amplitude.

Mol Immunol 2011 Sep 12;48(15-16):1851-8. Epub 2011 Jun 12.

Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.1016/j.molimm.2011.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163766PMC
September 2011

A dose-dependent role for EBF1 in repressing non-B-cell-specific genes.

Eur J Immunol 2011 Jun 9;41(6):1787-93. Epub 2011 May 9.

Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.1002/eji.201041137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127254PMC
June 2011

B cell depletion therapy exacerbates murine primary biliary cirrhosis.

Hepatology 2011 Feb 28;53(2):527-35. Epub 2010 Dec 28.

Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA.

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http://dx.doi.org/10.1002/hep.24044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058242PMC
February 2011

CD23-mediated cell signaling in human B cells differs from signaling in cells of the monocytic lineage.

Clin Immunol 2010 Dec;137(3):330-6

Department of Pediatric Immunology Research, Children's Mercy Hospital and Clinics, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1016/j.clim.2010.08.005DOI Listing
December 2010

The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms.

FEBS Lett 2010 Dec 28;584(24):4878-82. Epub 2010 Sep 28.

Integrated Department of Immunology, University of Colorado School of Medicine, Denver CO 80206, USA.

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http://doi.wiley.com/10.1016/j.febslet.2010.09.029
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http://dx.doi.org/10.1016/j.febslet.2010.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998577PMC
December 2010

Cellular reactive oxygen species inhibit MPYS induction of IFNβ.

PLoS One 2010 Dec 10;5(12):e15142. Epub 2010 Dec 10.

Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, Colorado, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015142PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000824PMC
December 2010

Molecular underpinning of B-cell anergy.

Immunol Rev 2010 Sep;237(1):249-63

Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2010.00936.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968701PMC
September 2010

B cell activation versus anergy; the antigen receptor as a molecular switch.

Immunol Lett 2010 Jan 4;128(1):6-7. Epub 2009 Oct 4.

Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Medical and Research Center, 1400 Jackson Street, K803 Denver, CO 80206, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01652478090023
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http://dx.doi.org/10.1016/j.imlet.2009.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815188PMC
January 2010

Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetes.

Curr Opin Endocrinol Diabetes Obes 2009 Aug;16(4):293-8

University of Colorado Denver and National Jewish Health, 1400 Jackson Street, Denver, Colorado 80206, USA.

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https://insights.ovid.com/crossref?an=01266029-200908000-000
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http://dx.doi.org/10.1097/MED.0b013e32832e06a7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968699PMC
August 2009

TLR4-mediated signaling induces MMP9-dependent cleavage of B cell surface CD23.

J Immunol 2009 Aug 27;183(4):2585-92. Epub 2009 Jul 27.

Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.4049/jimmunol.0803660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914506PMC
August 2009

Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells.

Proc Natl Acad Sci U S A 2009 Apr 30;106(15):6262-7. Epub 2009 Mar 30.

Department of Medicine, Section of Rheumatology, and The Knapp Center for Lupus Research, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.0812922106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662959PMC
April 2009

FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation.

Blood 2009 Feb 12;113(7):1464-73. Epub 2008 Sep 12.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2008-02-138651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644074PMC
February 2009

B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice.

J Immunol 2008 Sep;181(5):2961-72

Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865432PMC
http://dx.doi.org/10.4049/jimmunol.181.5.2961DOI Listing
September 2008

MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals.

Mol Cell Biol 2008 Aug 16;28(16):5014-26. Epub 2008 Jun 16.

Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Medical and Research Center, Denver, CO 80206, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00640-08
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http://dx.doi.org/10.1128/MCB.00640-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519703PMC
August 2008

Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging.

Proc Natl Acad Sci U S A 2008 Aug 12;105(33):11898-902. Epub 2008 Aug 12.

Department of Immunology, University of Colorado, Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.1073/pnas.0805498105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515225PMC
August 2008

MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death.

Immunol Lett 2008 Mar 26;116(2):184-94. Epub 2007 Dec 26.

Department of Immunology, University of Colorado at Denver and Health Sciences Center and National Jewish Medical and Research Center, Denver, CO 80206, United States.

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http://dx.doi.org/10.1016/j.imlet.2007.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424217PMC
March 2008

Cutting edge: Complement (C3d)-linked antigens break B cell anergy.

J Immunol 2007 Sep;179(5):2695-9

Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Denver, CO 802602, USA.

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http://dx.doi.org/10.4049/jimmunol.179.5.2695DOI Listing
September 2007

Multiple paths to loss of anergy and gain of autoimmunity.

Autoimmunity 2007 Sep;40(6):418-24

Integrated Department of Immunology, University of Colorado Health Science Center, National Jewish Medical Research Center, Denver, CO 80206, USA.

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September 2007

B-cell anergy: from transgenic models to naturally occurring anergic B cells?

Nat Rev Immunol 2007 Aug 20;7(8):633-43. Epub 2007 Jul 20.

Department of Immunology, University of Colorado Health Science Center and National Jewish Medical Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714009PMC
August 2007

Ig allotypic inclusion does not prevent B cell development or response.

J Immunol 2007 Jul;179(2):1049-57

Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA.

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July 2007

Modulation of MHC class II signal transduction by CD19.

Adv Exp Med Biol 2007 ;596:139-48

The Burnham Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

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April 2007

Cutting Edge: Acute and chronic exposure of immature B cells to antigen leads to impaired homing and SHIP1-dependent reduction in stromal cell-derived factor-1 responsiveness.

J Immunol 2007 Mar;178(6):3353-7

Integrated Department of Immunology, University of Colorado Health Sciences Center and National Jewish Medical and Research Center, Denver, CO 80206, USA.

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March 2007

Identification of anergic B cells within a wild-type repertoire.

Immunity 2006 Dec;25(6):953-62

Integrated Department of Immunology, University of Colorado Health Sciences Center and National Jewish Medical Research Center, Denver, Colorado 80206, USA.

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http://dx.doi.org/10.1016/j.immuni.2006.10.017DOI Listing
December 2006

B cell receptor signaling in human systemic lupus erythematosus.

Curr Opin Rheumatol 2006 Sep;18(5):451-5

Integrated Department of Immunology, University of Colorado Health Sciences Center and National Jewish Medical Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

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http://dx.doi.org/10.1097/01.bor.0000240353.99808.5fDOI Listing
September 2006

Silencing of autoreactive B cells by anergy: a fresh perspective.

Curr Opin Immunol 2006 Jun 17;18(3):292-7. Epub 2006 Apr 17.

Integrated Department of Immunology, University of Colorado Health Science Center and National Jewish Medical Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

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June 2006

Alteration of the Fc gamma RIIa dimer interface affects receptor signaling but not ligand binding.

J Immunol 2006 Jun;176(12):7489-94

The Macfarlane Burnet Institute for Medical Research and Public Health Limited, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.4049/jimmunol.176.12.7489DOI Listing
June 2006

Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling.

Nat Immunol 2005 Nov 2;6(11):1160-7. Epub 2005 Oct 2.

Integrated Department of Immunology, University of Colorado Health Sciences Center and National Jewish Medical and Research Center, Denver, Colorado 80206, USA.

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http://www.nature.com/articles/ni1256
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November 2005

Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway.

J Immunol 2005 Mar;174(6):3264-72

Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80220, USA.

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March 2005

Ageing, autoimmunity and arthritis: senescence of the B cell compartment - implications for humoral immunity.

Arthritis Res Ther 2004 10;6(4):131-9. Epub 2004 May 10.

Integrated Department of Immunology, University of Colorado Health Sciences Center and National Jewish Medical and Research Center, Denver, Colorado, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC464870PMC
February 2005

Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.

J Biol Chem 2004 Dec 28;279(50):51931-8. Epub 2004 Sep 28.

Laboratoire d'Immunologie Cellulaire et Clinique, INSERM U255, Institut de Recherches Biomédicales des Cordeliers, 75006 Paris, France.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M410261200
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December 2004

Src-family kinases in B-cell development and signaling.

Oncogene 2004 Oct;23(48):8001-6

Integrated Department of Immunology, University of Colorado Health Sciences Center and National Jewish Medical research Center, 1400 Jackson Street, Denver, CO 80206, USA.

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http://www.nature.com/articles/1208075
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October 2004

Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck.

Immunity 2004 Sep;21(3):443-53

Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver 80206, USA.

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September 2004

Promotion of B cell immune responses via an alum-induced myeloid cell population.

Science 2004 Jun;304(5678):1808-10

Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA.

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June 2004

Autonomous SHIP-dependent FcgammaR signaling in pre-B cells leads to inhibition of cell migration and induction of cell death.

Immunol Lett 2004 Mar;92(1-2):75-81

Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA.

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March 2004

Cognate B cell signaling via MHC class II: differential regulation of B cell antigen receptor and MHC class II/Ig-alpha beta signaling by CD22.

J Immunol 2004 Jan;172(1):195-201

Integrated Department of Immunology, University of Colorado Health Sciences Center and National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

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January 2004

B lymphocyte activation during cognate interactions with CD4+ T lymphocytes: molecular dynamics and immunologic consequences.

Semin Immunol 2003 Dec;15(6):325-9

Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA.

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December 2003

Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.

Nat Immunol 2003 Oct 31;4(10):974-81. Epub 2003 Aug 31.

Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA.

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October 2003

The unique antigen receptor signaling phenotype of B-1 cells is influenced by locale but induced by antigen.

J Immunol 2002 Aug;169(4):1735-43

Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado School of Medicine, Denver, CO 80206, USA.

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August 2002

Ligation of human CD4 interferes with antigen-induced activation of primary T cells.

Immunol Lett 2002 Jun;82(1-2):131-9

Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA.

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June 2002

Transmodulation of BCR signaling by transduction-incompetent antigen receptors: implications for impaired signaling in anergic B cells.

J Immunol 2002 May;168(9):4344-51

Integrated Department of Immunology, University of Colorado Health Sciences Center, and National Jewish Medical and Research Center, Denver, CO 80206, USA.

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http://dx.doi.org/10.4049/jimmunol.168.9.4344DOI Listing
May 2002

Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling.

J Immunol 2002 May;168(9):4430-9

Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA.

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May 2002

Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire.

J Immunol 2002 May;168(10):5014-23

Integrated Department of Immunology, University of Colorado Health Science Center and National Jewish Medical and Research Center, 1400 Jackson Street, RM K1004, Denver, CO 80206.

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May 2002

B cell antigen receptor signaling: roles in cell development and disease.

Science 2002 May;296(5573):1641-2

Integrated Department of Immunology, University of Colorado Health Sciences Center, and National Jewish Medical Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1071546
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May 2002

Introduction: multifaceted roles of lipids and their catabolites in immune cell signaling.

Semin Immunol 2002 Feb;14(1):1-6

Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA.

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February 2002