Publications by authors named "John C Bell"

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Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms.
Cancer Res 2018 Feb 19;78(4):922-937. Epub 2017 Dec 19.
UCSF Helen Diller Family Comprehensive Cancer Center, Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, San Francisco, California.

Multi-modal Potentiation of Oncolytic Virotherapy by Vanadium Compounds.
Mol Ther 2018 Jan 24;26(1):56-69. Epub 2017 Oct 24.
Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, ON, Canada. Electronic address:

Rapid Generation of Multiple Loci-Engineered Marker-free Poxvirus and Characterization of a Clinical-Grade Oncolytic Vaccinia Virus.
Mol Ther Methods Clin Dev 2017 Dec 30;7:112-122. Epub 2017 Sep 30.
UPMC Hillman Cancer Center and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.



Complement inhibition prevents oncolytic vaccinia virus neutralization in immune humans and cynomolgus macaques.
Mol Ther 2015 Jun 25;23(6):1066-1076. Epub 2015 Mar 25.
Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Surgery, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.




Maraba MG1 virus enhances natural killer cell function via conventional dendritic cells to reduce postoperative metastatic disease.
Mol Ther 2014 Jul 3;22(7):1320-1332. Epub 2014 Apr 3.
Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Surgery, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:


Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure.
Circulation 2014 Apr 24;129(13):1397-406. Epub 2014 Jan 24.
Cardiovascular Division and Lillehei Heart Institute (H.W., X.X., J.F., D.K., X.L., X.H., R.J.B., Y.C.) and Pulmonary Division (P.B.), University of Minnesota Medical School, Minneapolis; Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L.); Institute of Molecular Medicine, Peking University, Beijing, China (X.H.); Ottawa Hospital Research Institute, Ottawa, ON, Canada (T.J.F., J.C.B.); and Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China (H.L.).

Smac mimetics and innate immune stimuli synergize to promote tumor death.
Nat Biotechnol 2014 Feb 26;32(2):182-90. Epub 2014 Jan 26.
1] Solange Gauthier Karsh Molecular Genetics Laboratory, Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada. [2] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

Perioperative influenza vaccination reduces postoperative metastatic disease by reversing surgery-induced dysfunction in natural killer cells.
Clin Cancer Res 2013 Sep 23;19(18):5104-15. Epub 2013 Jul 23.
Authors' Affiliations: Centre for Innovative Cancer Research, Ottawa Hospital Research Institute; Departments of Cellular and Molecular Medicine, Biochemistry, Microbiology, and Immunology, and Surgery, University of Ottawa, Ottawa, Canada; Department of Neurosurgery, The Second Hospital of Shandong University, Shandong, China; Targeted & Biological Therapies Group, Leeds Institute of Cancer Studies and Pathology, Leeds, United Kingdom; Department of Medical Laboratory Technology, University of Tabuk, Tabuk; and College of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia.

Oncolytic and immunotherapeutic vaccinia induces antibody-mediated complement-dependent cancer cell lysis in humans.
Sci Transl Med 2013 May;5(185):185ra63
Pusan National University and Medical Research Institute, Pusan National University, 1-10 Ami-Dong, Seo-Gu, Busan 602-739, South Korea.

HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy.
Mol Ther 2013 Apr 8;21(4):887-94. Epub 2013 Jan 8.
McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.





Perioperative management of patients undergoing cytoreductive surgery combined with heated intraperitoneal chemotherapy for peritoneal surface malignancy: a multi-institutional experience.
Ann Surg Oncol 2012 Dec 18;19(13):4244-51. Epub 2012 Jul 18.
National Centre for Pseudomyxoma Surgery, Basingstoke and North Hampshire Hospitals NHS Foundation Trust, Basingstoke, UK.


ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic.
Mol Ther 2012 Jun 24;20(6):1148-57. Epub 2012 Jan 24.
Department of Biochemistry, Microbiology & Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada.










Evidence for differential viral oncolytic efficacy in an in vitro model of epithelial ovarian cancer metastasis.
Mol Ther Oncolytics 2015 23;2:15013. Epub 2015 Sep 23.
Translational Ovarian Cancer Research Program, London Regional Cancer Program, London, Ontario, Canada; Department of Anatomy & Cell Biology, Western University, London, Ontario, Canada; Department of Oncology, Western University, London, Ontario, Canada; Department of Obstetrics & Gynaecology, Western University, London, Ontario, Canada.




N-Myc expression enhances the oncolytic effects of vesicular stomatitis virus in human neuroblastoma cells.
Mol Ther Oncolytics 2016 16;3:16005. Epub 2016 Mar 16.
Department of Oncology, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, Alberta, Canada; Department of Surgery, Alberta Children's Hospital, Research Institute for Child and Maternal Health, Calgary, Alberta, Canada.

Complement inhibition enables tumor delivery of LCMV glycoprotein pseudotyped viruses in the presence of antiviral antibodies.
Mol Ther Oncolytics 2016 16;3:16027. Epub 2016 Nov 16.
Center for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.


Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation.
Oncoimmunology 2017 31;6(4):e1285992. Epub 2017 Jan 31.
National Center for Tumor Diseases Heidelberg, Department of Translational Oncology, German Cancer Research Center, Heidelberg, Germany.



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