John C Atherton

John C Atherton

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John C Atherton

John C Atherton

Publications by authors named "John C Atherton"

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Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy.

J Clin Pathol 2016 11 17;69(11):968-973. Epub 2016 May 17.

NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the University of Nottingham, School of Medicine, University of Nottingham, Nottingham, UK.

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http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2016-203641
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http://dx.doi.org/10.1136/jclinpath-2016-203641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136723PMC
November 2016

3-Dimensional Patient-Derived Lung Cancer Assays Reveal Resistance to Standards-of-Care Promoted by Stromal Cells but Sensitivity to Histone Deacetylase Inhibitors.

Mol Cancer Ther 2016 04 12;15(4):753-63. Epub 2016 Feb 12.

Ex Vivo Cancer Pharmacology Centre of Excellence, Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0598DOI Listing
April 2016

Helicobacter pylori-Mediated Protection from Allergy Is Associated with IL-10-Secreting Peripheral Blood Regulatory T Cells.

Front Immunol 2016 7;7:71. Epub 2016 Mar 7.

Nottingham Digestive Diseases Biomedical Research Unit, Queen's Medical Centre, Nottingham University Hospitals, Nottingham, UK; Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.3389/fimmu.2016.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779884PMC
March 2016

Correction for Ferreira et al., A Novel Method for Genotyping the Helicobacter pylori vacA Intermediate Region Directly in Gastric Biopsy Specimens.

J Clin Microbiol 2016 Feb;54(2):507

IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal Medical Faculty of the University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1128/JCM.03173-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733184PMC
February 2016

Expression of the Helicobacter pylori virulence factor vacuolating cytotoxin A (vacA) is influenced by a potential stem-loop structure in the 5' untranslated region of the transcript.

Mol Microbiol 2015 Dec 10;98(5):831-46. Epub 2015 Sep 10.

Nottingham Digestive Diseases Biomedical Research Unit, School of Medicine, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1111/mmi.13160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843948PMC
December 2015

Reply to "Helicobacter pylori vacA as marker for gastric cancer and gastroduodenal diseases: one but not the only factor".

J Clin Microbiol 2014 Dec;52(12):4452

Nottingham Digestive Diseases Biomedical Research Unit, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom.

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http://jcm.asm.org/cgi/doi/10.1128/JCM.02667-14
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http://dx.doi.org/10.1128/JCM.02667-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313328PMC
December 2014

CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa.

Gut 2014 Oct 16;63(10):1550-9. Epub 2014 Jan 16.

Nottingham Digestive Diseases Biomedical Research Unit, School of Medicine, The University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1136/gutjnl-2013-306253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173663PMC
October 2014

Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: a matched case-control study.

J Clin Microbiol 2014 Aug 11;52(8):2984-9. Epub 2014 Jun 11.

Nottingham Digestive Diseases Biomedical Research Unit, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom, and Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom.

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http://dx.doi.org/10.1128/JCM.00551-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136171PMC
August 2014

A novel method for genotyping the Helicobacter pylori vacA intermediate region directly in gastric biopsy specimens.

J Clin Microbiol 2012 Dec 3;50(12):3983-9. Epub 2012 Oct 3.

IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1128/JCM.02087-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502994PMC
December 2012

Helicobacter pylori dupA is polymorphic, and its active form induces proinflammatory cytokine secretion by mononuclear cells.

J Infect Dis 2010 Jul;202(2):261-9

Nottingham Digestive Diseases Centre Biomedical Research Unit, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.

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https://academic.oup.com/jid/article-lookup/doi/10.1086/6535
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http://dx.doi.org/10.1086/653587DOI Listing
July 2010

In Helicobacter pylori, LuxS is a key enzyme in cysteine provision through a reverse transsulfuration pathway.

J Bacteriol 2010 Mar 8;192(5):1184-92. Epub 2010 Jan 8.

Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.

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http://jb.asm.org/cgi/doi/10.1128/JB.01372-09
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http://dx.doi.org/10.1128/JB.01372-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820867PMC
March 2010

Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes.

Infect Immun 2010 Feb 16;78(2):845-53. Epub 2009 Nov 16.

Immunoregulation Laboratory, Department of Nephrology and Transplantation, 5th Floor Thomas Guy House, Guy's Hospital Campus, King's College London School of Medicine at Guy's, London SE1 9RT, United Kingdom.

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http://dx.doi.org/10.1128/IAI.00524-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812220PMC
February 2010

Coadaptation of Helicobacter pylori and humans: ancient history, modern implications.

J Clin Invest 2009 Sep;119(9):2475-87

Nottingham Digestive Diseases Centre Biomedical Research Unit and Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom.

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http://dx.doi.org/10.1172/JCI38605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735910PMC
September 2009

The effect of the human gut-signalling hormone, norepinephrine, on the growth of the gastric pathogen Helicobacter pylori.

Helicobacter 2009 Jun;14(3):223-30

Institute of Infections, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1111/j.1523-5378.2009.00682.xDOI Listing
June 2009

A study of Helicobacter pylori-associated gastritis patterns in Iraq and their association with strain virulence.

Saudi J Gastroenterol 2009 Apr;15(2):125-7

Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.4103/1319-3767.48971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702972PMC
April 2009

The clinical utility and diagnostic yield of routine gastric biopsies in the investigation of iron deficiency anemia: a case-control study.

Am J Gastroenterol 2008 Nov 4;103(11):2883-9. Epub 2008 Sep 4.

Department of Cellular Pathology, Nottingham University Hospitals and NHS Trust and University of Nottingham, Queen's Medical Centre Campus, Nottingham, United Kingdom.

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http://www.nature.com/doifinder/10.1111/j.1572-0241.2008.021
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http://dx.doi.org/10.1111/j.1572-0241.2008.02121.xDOI Listing
November 2008

Helicobacter pylori-induced inhibition of vascular endothelial cell functions: a role for VacA-dependent nitric oxide reduction.

Am J Physiol Heart Circ Physiol 2008 Oct 25;295(4):H1403-13. Epub 2008 Jul 25.

School of Biotechnology, Dublin City University, Dublin, Ireland.

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http://dx.doi.org/10.1152/ajpheart.00240.2008DOI Listing
October 2008

Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cells.

Am J Physiol Gastrointest Liver Physiol 2008 Sep 3;295(3):G431-41. Epub 2008 Jul 3.

Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown St., Liverpool L69 3BX, UK.

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http://dx.doi.org/10.1152/ajpgi.90283.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536790PMC
September 2008

Differences in Helicobacter pylori CagA tyrosine phosphorylation motif patterns between western and East Asian strains, and influences on interleukin-8 secretion.

J Med Microbiol 2008 Sep;57(Pt 9):1062-7

Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.

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http://jmm.microbiologyresearch.org/content/journal/jmm/10.1
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http://dx.doi.org/10.1099/jmm.0.2008/001818-0DOI Listing
September 2008

Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H. pylori-associated disease.

J Clin Microbiol 2008 May 19;46(5):1774-9. Epub 2008 Mar 19.

Institute of Infection, Immunity, and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom.

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http://dx.doi.org/10.1128/JCM.01737-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395113PMC
May 2008

Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families.

Clin Cancer Res 2008 Apr;14(7):2227-35

Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University Park and Wolfson Digestive Diseases Centre, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-07-2022DOI Listing
April 2008

The highly repetitive region of the Helicobacter pylori CagY protein comprises tandem arrays of an alpha-helical repeat module.

J Mol Biol 2008 Mar 31;377(3):956-71. Epub 2008 Jan 31.

Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.

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http://dx.doi.org/10.1016/j.jmb.2008.01.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581425PMC
March 2008

Functional association between the Helicobacter pylori virulence factors VacA and CagA.

J Med Microbiol 2008 Feb;57(Pt 2):145-50

Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.

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http://dx.doi.org/10.1099/jmm.0.47465-0DOI Listing
February 2008

The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases.

Authors:
John C Atherton

Annu Rev Pathol 2006 ;1:63-96

Wolfson Digestive Diseases Centre and Institute of Infections, Immunity, and Inflammation, University of Nottingham, Nottingham NG7 2UH, United Kingdom.

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http://www.annualreviews.org/doi/10.1146/annurev.pathol.1.11
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http://dx.doi.org/10.1146/annurev.pathol.1.110304.100125DOI Listing
December 2007

The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America.

Clin Infect Dis 2007 Nov 21;45(9):1204-6. Epub 2007 Sep 21.

Wolfson Digestive Diseases Centre, Queen's Medical Centre, Nottingham, United Kingdom.

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http://dx.doi.org/10.1086/522177DOI Listing
November 2007

A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer.

Gastroenterology 2007 Sep 3;133(3):926-36. Epub 2007 Jul 3.

Wolfson Digestive Diseases Centre and Institute of Infection, Immunity and Inflammation, University of Nottingham, Nottingham, England.

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http://linkinghub.elsevier.com/retrieve/pii/S001650850701288
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http://dx.doi.org/10.1053/j.gastro.2007.06.056DOI Listing
September 2007

Heterogeneity in the activity of Mexican Helicobacter pylori strains in gastric epithelial cells and its association with diversity in the cagA gene.

Infect Immun 2007 Jul 16;75(7):3445-54. Epub 2007 Apr 16.

Unidad de Investigación Medica en Enfermedades Infecciosas y Parasitarias, Hospital de Pediatría, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtemoc 330, Mexico, DF CP 06725, Mexico.

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http://dx.doi.org/10.1128/IAI.01951-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1932923PMC
July 2007

The inflammatory and immune response to Helicobacter pylori infection.

Best Pract Res Clin Gastroenterol 2007 ;21(2):237-59

Wolfson Digestive Diseases Centre, University of Nottingham, C Floor, South Block, Queen's Medical Centre Campus, Nottingham University Hospital NHS Trust, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1016/j.bpg.2007.01.001DOI Listing
May 2007

Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner.

J Biol Chem 2006 Nov 21;281(46):34888-96. Epub 2006 Sep 21.

Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Portugal, and the Laboratory of Experimental Cancerology, Ghent University Hospital, Belgium.

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http://dx.doi.org/10.1074/jbc.M607067200DOI Listing
November 2006

Paired cysteine residues are required for high levels of the Helicobacter pylori autotransporter VacA.

Microbiology 2006 May;152(Pt 5):1319-25

Wolfson Digestive Diseases Centre, University of Nottingham, Queen's Medical Centre, Clifton Boulevard, Nottingham NG7 2UH, UK.

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http://mic.microbiologyresearch.org/content/journal/micro/10
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http://dx.doi.org/10.1099/mic.0.28548-0DOI Listing
May 2006

Can peptic ulcers be healed with 7 days of proton-pump-inhibitor-based triple therapy?

Authors:
John C Atherton

Nat Clin Pract Gastroenterol Hepatol 2005 Aug;2(8):346-7

Wolfson Digestive Diseases Centre and University of Nottingham, Nottingham, UK.

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http://www.nature.com/articles/ncpgasthep0235
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http://dx.doi.org/10.1038/ncpgasthep0235DOI Listing
August 2005

All subtypes of the cytotoxin VacA adsorb to the surface of Helicobacter pylori post-secretion.

J Med Microbiol 2005 Jul;54(Pt 7):621-30

Institute of Infection, Immunity, and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham NG7 2RH, UK.

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http://dx.doi.org/10.1099/jmm.0.45946-0DOI Listing
July 2005

Tyrosine phosphorylation of CagA from Chinese Helicobacter pylori isolates in AGS gastric epithelial cells.

J Clin Microbiol 2005 Feb;43(2):786-90

Division of Gastroenterology, The Affiliated Hospital Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.

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http://jcm.asm.org/cgi/doi/10.1128/JCM.43.2.786-790.2005
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http://dx.doi.org/10.1128/JCM.43.2.786-790.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548088PMC
February 2005

Simple method for determination of the number of Helicobacter pylori CagA variable-region EPIYA tyrosine phosphorylation motifs by PCR.

J Clin Microbiol 2005 Feb;43(2):791-5

Institute of Infection, Immunity, and Inflammation, C Floor West Block, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1128/JCM.43.2.791-795.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548073PMC
February 2005

Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach.

J Bacteriol 2004 Aug;186(15):5182-5

Wolfson Digestive Diseases Centre, University Hospital, Nottingham NG7 2UH, United Kingdom.

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http://dx.doi.org/10.1128/JB.186.15.5182-5185.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC451639PMC
August 2004

Brefeldin A enhances Helicobacter pylori vacuolating cytotoxin-induced vacuolation of epithelial cells.

FEMS Microbiol Lett 2004 Aug;237(1):163-70

Institute of Infection, Immunity and Inflammation, and the Wolfson Digestive Diseases Centre, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1016/j.femsle.2004.06.031DOI Listing
August 2004

Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori.

Gastroenterology 2004 Aug;127(2):514-23

Institute of Infection, Immunity and Inflammation, and the Wolfson Digestive Diseases Centre, University of Nottingham, Queen's Medical Centre, England.

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http://dx.doi.org/10.1053/j.gastro.2004.06.006DOI Listing
August 2004

Helicobacter pylori persistence: biology and disease.

J Clin Invest 2004 Feb;113(3):321-33

Department of Medicine, New York University School of Medicine, and New York Harbor Veterans Affairs Medical Center, New York 10016, USA.

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http://www.jci.org/articles/view/20925
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http://dx.doi.org/10.1172/JCI20925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC324548PMC
February 2004

Mastic gum has no effect on Helicobacter pylori load in vivo.

J Antimicrob Chemother 2003 Sep 29;52(3):522-3. Epub 2003 Jul 29.

Division of Gastroenterology, University Hospital, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1093/jac/dkg366DOI Listing
September 2003

cagA and vacA genotype of Helicobacter pylori associated with gastric diseases in Xi'an area.

World J Gastroenterol 2003 Aug;9(8):1762-6

Department of Gastroenterology, First Hospital, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China. xhy1202@ sohu.com

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611539PMC
http://dx.doi.org/10.3748/wjg.v9.i8.1762DOI Listing
August 2003

Determinants of non-toxicity in the gastric pathogen Helicobacter pylori.

J Biol Chem 2003 Jul 8;278(29):26734-41. Epub 2003 May 8.

Division of Gastroenterology and Institute of Infections, Immunity and Inflammation, University of Nottingham, C Floor, West Block, Queen's Medical Centre, Clifton Boulevard, Nottingham NG7 2UH, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M304071200
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http://dx.doi.org/10.1074/jbc.M304071200DOI Listing
July 2003

Helicobacter pylori supernatants cause epithelial cytoskeletal disruption that is bacterial strain and epithelial cell line dependent but not toxin VacA dependent.

Infect Immun 2003 Jun;71(6):3623-7

Division of Gastroenterology and Institution of Infections, Immunity and Inflammation, University of Nottingham, University Hospital, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155751PMC
http://dx.doi.org/10.1128/iai.71.6.3623-3627.2003DOI Listing
June 2003

Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation.

Gastroenterology 2003 Jun;124(7):1846-54

Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1016/s0016-5085(03)00397-4DOI Listing
June 2003