John Brognard

John Brognard

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John Brognard

John Brognard

Publications by authors named "John Brognard"

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36Publications

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Combing the Cancer Genome for Novel Kinase Drivers and New Therapeutic Targets.

Cancers (Basel) 2019 Dec 7;11(12). Epub 2019 Dec 7.

Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

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http://dx.doi.org/10.3390/cancers11121972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966563PMC
December 2019

Orange is the new black: Kinases are the new master regulators of tumor suppression.

IUBMB Life 2019 06 11;71(6):738-748. Epub 2018 Dec 11.

Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iub.1981
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http://dx.doi.org/10.1002/iub.1981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563145PMC
June 2019

Shipping Out MEK Inhibitor Resistance with SHP2 Inhibitors.

Cancer Discov 2018 10;8(10):1210-1212

Signaling Networks in Cancer Section, Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0915DOI Listing
October 2018

Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases.

Sci Signal 2018 04 17;11(526). Epub 2018 Apr 17.

Signalling Networks in Cancer Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1126/scisignal.aan6776DOI Listing
April 2018

Survival of Head and Neck Cancer Cells Relies upon LZK Kinase-Mediated Stabilization of Mutant p53.

Cancer Res 2017 09 31;77(18):4961-4972. Epub 2017 Jul 31.

Signalling Networks in Cancer Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0267DOI Listing
September 2017

Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor.

Trends Pharmacol Sci 2017 05 8;38(5):438-447. Epub 2017 Mar 8.

Laboratory of Cell and Developmental Signaling, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Cancer Research UK Manchester Institute, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403564PMC
May 2017

Using large-scale genomics data to identify driver mutations in lung cancer: methods and challenges.

Pharmacogenomics 2015 31;16(10):1149-60. Epub 2015 Jul 31.

RNA Biology Group & Computational Biology Support Team, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.2217/pgs.15.60DOI Listing
June 2016

Transcriptional Repressor DAXX Promotes Prostate Cancer Tumorigenicity via Suppression of Autophagy.

J Biol Chem 2015 Jun 22;290(25):15406-20. Epub 2015 Apr 22.

From the Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 and

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http://dx.doi.org/10.1074/jbc.M115.658765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505457PMC
June 2015

Reply: To PMID 23666743.

Arthritis Rheumatol 2014 Jan;66(1):229-30

Hôpital Femme Mère Enfant, Hospices Civils de Lyon and Université de Lyon, Lyon, France.

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http://dx.doi.org/10.1002/art.38234DOI Listing
January 2014

Druggable drivers of lung cancer.

Oncotarget 2013 Sep;4(9):1334-5

Signalling Networks in Cancer Group, Cancer Research UK Manchester Institute and The University of Manchester, Manchester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824536PMC
http://dx.doi.org/10.18632/oncotarget.1223DOI Listing
September 2013

Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer.

Proc Natl Acad Sci U S A 2013 Jul 8;110(30):12426-31. Epub 2013 Jul 8.

Signalling Networks in Cancer Group, Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1305207110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725071PMC
July 2013

Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase.

Cancer Res 2011 Apr 12;71(8):3152-61. Epub 2011 Apr 12.

Signalling Networks in Cancer Group, Cancer Research UK, Paterson Institute for Cancer Research, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078168PMC
April 2011

Protein kinase signaling networks in cancer.

Curr Opin Genet Dev 2011 Feb 29;21(1):4-11. Epub 2010 Nov 29.

Signalling Networks in Cancer Group, Cancer Research UK, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S0959437X1000190
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http://dx.doi.org/10.1016/j.gde.2010.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038181PMC
February 2011

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.

Mol Cell 2009 Aug;35(4):442-53

Department of Pharmacology, Case Comprehensive Caner Center, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Wood Building W343A, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736145PMC
August 2009

Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.

J Biol Chem 2009 May 26;284(22):15215-23. Epub 2009 Mar 26.

Department of Pharmacology and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093-0721, USA.

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http://newtonlab.ucsd.edu/documents/Brognardetal.2009.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M901468200
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http://dx.doi.org/10.1074/jbc.M901468200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685702PMC
May 2009

PHLiPPing the switch on Akt and protein kinase C signaling.

Trends Endocrinol Metab 2008 Aug 27;19(6):223-30. Epub 2008 May 27.

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-0721, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S104327600800081
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http://dx.doi.org/10.1016/j.tem.2008.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963565PMC
August 2008

The phosphatase PHLPP controls the cellular levels of protein kinase C.

J Biol Chem 2008 Mar 27;283(10):6300-11. Epub 2007 Dec 27.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M707319200
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http://dx.doi.org/10.1074/jbc.M707319200DOI Listing
March 2008

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.

Mol Cell 2007 Mar;25(6):917-31

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650700117
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http://dx.doi.org/10.1016/j.molcel.2007.02.017DOI Listing
March 2007

Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells.

Carcinogenesis 2005 Jul 24;26(7):1182-95. Epub 2005 Mar 24.

Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20889, USA.

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http://dx.doi.org/10.1093/carcin/bgi072DOI Listing
July 2005

Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo.

Chest 2004 May;125(5 Suppl):101S-2S

Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889-5105, USA.

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http://dx.doi.org/10.1378/chest.125.5_suppl.101sDOI Listing
May 2004

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

J Am Chem Soc 2003 Feb;125(5):1144-5

Drug Discovery Program, Department of Neurology, Georgetown University, 3900 Reservoir Road, NW, Washington, DC 20007, USA.

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http://dx.doi.org/10.1021/ja0285159DOI Listing
February 2003

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.

J Clin Invest 2003 Jan;111(1):81-90

Cancer Therapeutics Branch, Cell and Cancer Biology Branch, National Cancer Institute, Bethesda, Maryland 20889, USA.

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http://dx.doi.org/10.1172/JCI16147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151834PMC
January 2003