Publications by authors named "John B Davis"

44 Publications

TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.

Authors:
Hazel Hall-Roberts Devika Agarwal Juliane Obst Thomas B Smith Jimena Monzón-Sandoval Elena Di Daniel Caleb Webber William S James Emma Mead John B Davis Sally A Cowley

Alzheimers Res Ther 2020 11 16;12(1):151. Epub 2020 Nov 16.

James Martin Stem Cell Facility, Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.

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November 2020

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors.

Authors:
Sohaib Nizami Kanisa Arunasalam Jack Green James Cook Catherine B Lawrence Tryfon Zarganes-Tzitzikas John B Davis Elena Di Daniel David Brough

Immunology 2021 Jan 30;162(1):84-91. Epub 2020 Oct 30.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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January 2021

TargetDB: A target information aggregation tool and tractability predictor.

Authors:
Stephane De Cesco John B Davis Paul E Brennan

PLoS One 2020 2;15(9):e0232644. Epub 2020 Sep 2.

Nuffield Department of Medicine, ARUK Oxford Drug Discovery Institute, Target Discovery Institute, University of Oxford, Oxford, United-Kingdom.

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October 2020

A polycyclic aromatic hydrocarbon-enriched environmental chemical mixture enhances AhR, antiapoptotic signaling and a proliferative phenotype in breast cancer cells.

Authors:
Larisa M Gearhart-Serna John B Davis Mohit Kumar Jolly Nishad Jayasundara Scott J Sauer Richard T Di Giulio Gayathri R Devi

Carcinogenesis 2020 Dec;41(12):1648-1659

Department of Surgery, Division of Surgical Sciences, Durham, NC, USA.

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December 2020

A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6.

Authors:
Richard S Priestley Jonathan Cheung Emma J Murphy Matthias T Ehebauer John B Davis Elena Di Daniel

J Pharmacol Toxicol Methods 2019 Jan - Feb;95:47-55. Epub 2018 Nov 23.

Alzheimer's Research UK Oxford Drug Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK. Electronic address:

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March 2019

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Authors:
Karen Horsburgh Joanna M Wardlaw Tom van Agtmael Stuart M Allan Mike L J Ashford Philip M Bath Rosalind Brown Jason Berwick M Zameel Cader Roxana O Carare John B Davis Jessica Duncombe Tracy D Farr Jill H Fowler Jozien Goense Alessandra Granata Catherine N Hall Atticus H Hainsworth Adam Harvey Cheryl A Hawkes Anne Joutel Rajesh N Kalaria Patrick G Kehoe Catherine B Lawrence Andy Lockhart Seth Love Malcolm R Macleod I Mhairi Macrae Hugh S Markus Chris McCabe Barry W McColl Paul J Meakin Alyson Miller Maiken Nedergaard Michael O'Sullivan Terry J Quinn Rikesh Rajani Lisa M Saksida Colin Smith Kenneth J Smith Rhian M Touyz Rebecca C Trueman Tao Wang Anna Williams Steven C R Williams Lorraine M Work

Clin Sci (Lond) 2018 04 30;132(8):851-868. Epub 2018 Apr 30.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.

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April 2018

A standardized clinical evaluation of phenotypic diversity in diabetic polyneuropathy.

Authors:
Joachim Scholz James P Rathmell William S David David A Chad Alithia C Broderick Stephen G Perros Naomi S Shin Jenna L Wells John B Davis Charles J DiMaggio Shuang Wang Simon N Tate

Pain 2016 10;157(10):2297-2308

Convergence Pharmaceuticals, Cambridge, United Kingdom.

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October 2016

Person-centered health care: capabilities and identity.

Authors:
John B Davis

Am J Bioeth 2013 ;13(8):61-2

Department of Economics, Marquette University, Milwaukee, WI 53201-1881,USA.

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November 2013

Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.

Authors:
Vasiliki Michaki Francesc X Guix Krist'l Vennekens Sebastian Munck Colin Dingwall John B Davis Danyelle M Townsend Kenneth D Tew Fabian Feiguin Bart De Strooper Carlos G Dotti Tina Wahle

J Biol Chem 2012 Jan 15;287(2):1100-11. Epub 2011 Nov 15.

Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, KU Leuven, 3000 Leuven, Belgium.

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January 2012

Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease.

Authors:
Lauren Broom Lilia Marinova-Mutafchieva Mona Sadeghian John B Davis Andrew D Medhurst David T Dexter

Free Radic Biol Med 2011 Mar 23;50(5):633-40. Epub 2010 Dec 23.

Parkinson's Disease Research Group, Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK.

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March 2011

Xenon reduces activation of transient receptor potential vanilloid type 1 (TRPV1) in rat dorsal root ganglion cells and in human TRPV1-expressing HEK293 cells.

Authors:
John P M White Guy Calcott Agnes Jenes Mahmuda Hossein Cleoper C Paule Peter Santha John B Davis Daqing Ma Andrew S C Rice Istvan Nagy

Life Sci 2011 Jan 4;88(3-4):141-9. Epub 2010 Nov 4.

Anaesthetics, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369, Fulham Road, London, SW10 9NH, United Kingdom.

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January 2011

A key role for gp130 expressed on peripheral sensory nerves in pathological pain.

Authors:
Manfred Andratsch Norbert Mair Cristina E Constantin Nadja Scherbakov Camilla Benetti Serena Quarta Christian Vogl Claudia A Sailer Nurcan Uceyler Johannes Brockhaus Rudolf Martini Claudia Sommer Hanns Ulrich Zeilhofer Werner Müller Rohini Kuner John B Davis Stefan Rose-John Michaela Kress

J Neurosci 2009 Oct;29(43):13473-83

Department of Physiology and Medical Physics, Division of Physiology, Innsbruck Medical University, Innsbruck, Austria.

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October 2009

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson's disease.

Authors:
Lilia Marinova-Mutafchieva Mona Sadeghian Lauren Broom John B Davis Andrew D Medhurst David T Dexter

J Neurochem 2009 Aug 22;110(3):966-75. Epub 2009 Jun 22.

Parkinson's Disease Research Group, Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London, UK.

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August 2009

Autoradiographical imaging of PPARgamma agonist effects on PBR/TSPO binding in TASTPM mice.

Authors:
Jennifer C Roberts Sarah L Friel Shilina Roman Marion Perren Alex Harper John B Davis Jill C Richardson David Virley Andrew D Medhurst

Exp Neurol 2009 Apr;216(2):459-70

Neuroscience Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Avenue, Harlow, Essex, CM19 5AW, UK.

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April 2009

The discovery and early validation of novel plasma biomarkers in mild-to-moderate Alzheimer's disease patients responding to treatment with rosiglitazone.

Authors:
Emma L Akuffo John B Davis Steven M Fox Israel S Gloger David Hosford Emma E Kinsey Neil A Jones Christina M Nock Allen D Roses Ann M Saunders J Mark Skehel Marjorie A Smith Paul Cutler

Biomarkers 2008 Sep;13(6):618-36

GlaxoSmithKline, New Frontiers Science Park, Harlow, UK.

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September 2008

Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.

Authors:
Susan M Westaway Mervyn Thompson Harshad K Rami Geoffrey Stemp Leontine S Trouw Darren J Mitchell Jon T Seal Stephen J Medhurst Sarah C Lappin James Biggs James Wright Sandra Arpino Jeffrey C Jerman Jennifer E Cryan Vicky Holland Kim Y Winborn Tanya Coleman Alexander J Stevens John B Davis Martin J Gunthorpe

Bioorg Med Chem Lett 2008 Oct 31;18(20):5609-13. Epub 2008 Aug 31.

Neurology CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.

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October 2008

Perspectives of Alzheimer's disease treatments.

Authors:
John B Davis C Bountra J Richardson

Handb Clin Neurol 2008 ;89:273-90

Neurology and GI CEDD, GlaxoSmithKline R&D Ltd, Harlow, UK.

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December 2010

Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model.

Authors:
Cristina E Constantin Norbert Mair Claudia A Sailer Manfred Andratsch Zhen-Zhong Xu Michael J F Blumer Nadja Scherbakov John B Davis Horst Bluethmann Ru-Rong Ji Michaela Kress

J Neurosci 2008 May;28(19):5072-81

Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University, 6020 Innsbruck, Austria.

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May 2008

Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium-derived factor: Two novel biomarkers of Alzheimer's disease in human plasma.

Authors:
Paul Cutler Emma L Akuffo Wanda M Bodnar Deborah M Briggs John B Davis Christine M Debouck Steven M Fox Rachel A Gibson Darren A Gormley Joanna D Holbrook A Jacqueline Hunter Emma E Kinsey Rabinder Prinjha Jill C Richardson Allen D Roses Marjorie A Smith Nikos Tsokanas David R Willé Wen Wu John W Yates Israel S Gloger

Proteomics Clin Appl 2008 Apr 7;2(4):467-77. Epub 2008 Mar 7.

GlaxoSmithKline, New Frontiers Science Park, Harlow, UK.

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April 2008

The individual in mainstream health economics: a case of Persona Non-grata.

Authors:
John B Davis Robert McMaster

Health Care Anal 2007 Sep 5;15(3):195-210. Epub 2007 Apr 5.

University of Amsterdam and Marquette University, Milwaukee, Wisconsin, USA,

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September 2007

Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.

Authors:
Martin J Gunthorpe Sara Luis Hannan Darren Smart Jeffrey C Jerman Sandra Arpino Graham D Smith Stephen Brough Jim Wright Julie Egerton Sarah C Lappin Vicky A Holland Kim Winborn Mervyn Thompson Harshad K Rami Andrew Randall John B Davis

J Pharmacol Exp Ther 2007 Jun 28;321(3):1183-92. Epub 2007 Mar 28.

Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, Essex, UK.

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June 2007

GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models.

Authors:
Andrew D Medhurst Alan R Atkins Isabel J Beresford Kim Brackenborough Michael A Briggs Andrew R Calver Jackie Cilia Jane E Cluderay Barry Crook John B Davis Rebecca K Davis Robert P Davis Lee A Dawson Andrew G Foley Jane Gartlon M Isabel Gonzalez Teresa Heslop Warren D Hirst Carol Jennings Declan N C Jones Laurent P Lacroix Abbe Martyn Sandrine Ociepka Alison Ray Ciaran M Regan Jennifer C Roberts Joanne Schogger Eric Southam Tania O Stean Brenda K Trail Neil Upton Graham Wadsworth Jeffrey A Wald Trevor White Jason Witherington Marie L Woolley Angela Worby David M Wilson

J Pharmacol Exp Ther 2007 Jun 27;321(3):1032-45. Epub 2007 Feb 27.

Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Ave., Harlow, Essex, CM19 5AW, UK.

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June 2007

Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats.

Authors:
Andrew D Medhurst Michael A Briggs Gordon Bruton Andrew R Calver Iain Chessell Barry Crook John B Davis Robert P Davis Andrew G Foley Teresa Heslop Warren D Hirst Stephen J Medhurst Sandrine Ociepka Alison Ray Ciaran M Regan Becky Sargent Joanne Schogger Tania O Stean Brenda K Trail Neil Upton Trevor White Barry Orlek David M Wilson

Biochem Pharmacol 2007 Apr 7;73(8):1182-94. Epub 2007 Jan 7.

Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK.

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April 2007

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.

Authors:
Ishrut Hussain Julie Hawkins David Harrison Christopher Hille Gareth Wayne Leanne Cutler Tania Buck Daryl Walter Emmanuel Demont Colin Howes Alan Naylor Philip Jeffrey Maria I Gonzalez Colin Dingwall Anton Michel Sally Redshaw John B Davis

J Neurochem 2007 Feb;100(3):802-9

Neurology and GastroIntestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline Research & Development Ltd, Harlow, Essex, UK.

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February 2007

P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro.

Authors:
Stephen D Skaper Laura Facci Ainsley A Culbert Nicholas A Evans Iain Chessell John B Davis Jill C Richardson

Glia 2006 Aug;54(3):234-42

Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, New Frontiers Science Park, Third Avenue, Harlow CM19 5AW, Essex, United Kingdom.

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August 2006

N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1.

Authors:
Susan M Westaway Ying-Kit Chung John B Davis Vicky Holland Jeffrey C Jerman Stephen J Medhurst Harshad K Rami Geoffrey Stemp Alexander J Stevens Mervyn Thompson Kim Y Winborn James Wright

Bioorg Med Chem Lett 2006 Sep 27;16(17):4533-6. Epub 2006 Jun 27.

Neurology and GI Center of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, UK.

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September 2006

Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.

Authors:
Harshad K Rami Mervyn Thompson Geoffrey Stemp Steve Fell Jeffrey C Jerman Alexander J Stevens Darren Smart Becky Sargent Dominic Sanderson Andrew D Randall Martin J Gunthorpe John B Davis

Bioorg Med Chem Lett 2006 Jun 31;16(12):3287-91. Epub 2006 Mar 31.

Neurology and GI CEDD, New Frontiers Science Park, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK.

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June 2006

Vanilloid receptor 1 expression in human tooth pulp in relation to caries and pain.

Authors:
Claire R Morgan Helen D Rodd Nick Clayton John B Davis Fiona M Boissonade

J Orofac Pain 2005 ;19(3):248-60

School of Clinical Dentistry, University of Sheffield, Sheffield, South Yorkshire S10 2TA, United Kingdom.

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November 2005

Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain.

Authors:
Preethi Gopinath Elaine Wan Anita Holdcroft Paul Facer John B Davis Graham D Smith Chas Bountra Praveen Anand

BMC Womens Health 2005 Mar 8;5(1). Epub 2005 Mar 8.

Peripheral Neuropathy Unit, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK.

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March 2005

Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice.

Authors:
Weifang Rong Kirk Hillsley John B Davis Gareth Hicks Wendy J Winchester David Grundy

J Physiol 2004 Nov 26;560(Pt 3):867-81. Epub 2004 Aug 26.

Department of Biomedical Science, University of Sheffield, Alfred Danny Building, Western Bank, Sheffield S10 2TN, UK.

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November 2004