John A Cidlowski

John A Cidlowski

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John A Cidlowski

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Deletion of the Cardiomyocyte Glucocorticoid Receptor Leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart Failure.

J Am Heart Assoc 2019 Aug 17;8(15):e011012. Epub 2019 Jul 17.

Signal Transduction Laboratory National Institute of Environmental Health Sciences National Institutes of Health Department of Health and Human Services Research Triangle Park NC.

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http://dx.doi.org/10.1161/JAHA.118.011012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761632PMC
August 2019

β-Arrestin-1 inhibits glucocorticoid receptor turnover and alters glucocorticoid signaling.

J Biol Chem 2019 Jul 5;294(29):11225-11239. Epub 2019 Jun 5.

Signal Transduction Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709

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http://dx.doi.org/10.1074/jbc.RA118.007150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643030PMC
July 2019

Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice.

Sci Signal 2019 Apr 16;12(577). Epub 2019 Apr 16.

Signal Transduction Laboratory, NIEHS, NIH, DHHS, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1126/scisignal.aau9685DOI Listing
April 2019

Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation.

J Clin Invest 2019 Mar 18;129(3):1345-1358. Epub 2019 Feb 18.

Molecular Endocrinology Group, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1172/JCI123233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391099PMC
March 2019

Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis.

Mol Cancer Res 2018 11 10;16(11):1761-1772. Epub 2018 Jul 10.

Division of Hematology, Oncology, and Transplantation, Departments of Medicine and Pharmacology and The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-18-0410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214723PMC
November 2018

Glucocorticoid receptor isoform-specific regulation of development, circadian rhythm, and inflammation in mice.

FASEB J 2018 10 19;32(10):5258-5271. Epub 2018 Apr 19.

Signal Transduction Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1096/fj.201701153RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133704PMC
October 2018

Glucocorticoid Receptor Mutations and Hypersensitivity to Endogenous and Exogenous Glucocorticoids.

J Clin Endocrinol Metab 2018 10;103(10):3630-3639

National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1210/jc.2018-00352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179182PMC
October 2018

Glucocorticoid receptor signaling in the eye.

Steroids 2018 05 10;133:60-66. Epub 2017 Nov 10.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2017.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875721PMC
May 2018

Probing Dominant Negative Behavior of Glucocorticoid Receptor β through a Hybrid Structural and Biochemical Approach.

Mol Cell Biol 2018 04 29;38(8). Epub 2018 Mar 29.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

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http://dx.doi.org/10.1128/MCB.00453-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879464PMC
April 2018

Neonatal Genistein Exposure and Glucocorticoid Signaling in the Adult Mouse Uterus.

Environ Health Perspect 2018 04 5;126(4):047002. Epub 2018 Apr 5.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/EHP1575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071733PMC
April 2018

Mechanisms of Glucocorticoid Action During Development.

Curr Top Dev Biol 2017 16;125:147-170. Epub 2017 Jan 16.

Molecular Endocrinology Group, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.ctdb.2016.12.004DOI Listing
March 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Estrogen Deficiency Promotes Hepatic Steatosis via a Glucocorticoid Receptor-Dependent Mechanism in Mice.

Cell Rep 2018 03;22(10):2690-2701

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875726PMC
March 2018

Pharmacology of Corticosteroids for Diabetic Macular Edema.

Invest Ophthalmol Vis Sci 2018 01;59(1):1-12

Center for Advanced Vision Science, Department of Ophthalmology, Department of Pathology, Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States.

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http://dx.doi.org/10.1167/iovs.17-22259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961100PMC
January 2018

Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor.

Lab Invest 2017 11 31;97(11):1282-1295. Epub 2017 Jul 31.

Molecular Endocrinology Group, Signal Transduction Laboratory, National Institute of Environmental Health Sciences/NIH, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1038/labinvest.2017.76DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759773PMC
November 2017

Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells.

Endocrinology 2017 11;158(11):4076-4092

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.

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http://dx.doi.org/10.1210/en.2017-00361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695839PMC
November 2017

Glucocorticoids and Reproduction: Traffic Control on the Road to Reproduction.

Trends Endocrinol Metab 2017 06 6;28(6):399-415. Epub 2017 Mar 6.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2017.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438761PMC
June 2017

Immune regulation by glucocorticoids.

Nat Rev Immunol 2017 Apr 13;17(4):233-247. Epub 2017 Feb 13.

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1038/nri.2017.1DOI Listing
April 2017

Cross-talk between the glucocorticoid receptor and MyoD family inhibitor domain-containing protein provides a new mechanism for generating tissue-specific responses to glucocorticoids.

J Biol Chem 2017 04 21;292(14):5825-5844. Epub 2017 Feb 21.

From the Signal Transduction Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709

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http://dx.doi.org/10.1074/jbc.M116.758888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392576PMC
April 2017

Glucocorticoid action in human corneal epithelial cells establishes roles for corticosteroids in wound healing and barrier function of the eye.

Exp Eye Res 2016 11 4;152:10-33. Epub 2016 Sep 4.

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2016.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097880PMC
November 2016

Healthy glucocorticoid receptor N363S carriers dysregulate gene expression associated with metabolic syndrome.

Am J Physiol Endocrinol Metab 2016 10 6;311(4):E741-E748. Epub 2016 Sep 6.

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina; and

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http://www.physiology.org/doi/10.1152/ajpendo.00105.2016
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http://dx.doi.org/10.1152/ajpendo.00105.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241554PMC
October 2016

Neuroimmune mechanisms of stress: sex differences, developmental plasticity, and implications for pharmacotherapy of stress-related disease.

Stress 2015 15;18(4):367-80. Epub 2015 Jul 15.

d College of Dentistry and Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, The Ohio State University , Columbus , OH , USA.

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http://dx.doi.org/10.3109/10253890.2015.1053451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813310PMC
July 2016

Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice.

Endocrinology 2016 07 24;157(7):2759-71. Epub 2016 May 24.

Signal Transduction Laboratory (D.C.-T., J.A.C.), Comparative Medicine Branch (P.H.M.), and Cellular and Molecular Pathology Branch (J.F.F.), National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892; and McAllister Heart Institute (M.S.W.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514.

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http://dx.doi.org/10.1210/en.2015-1604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929548PMC
July 2016

Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.

Cancer Res 2016 Mar 29;76(6):1653-63. Epub 2016 Jan 29.

Division of Hematology, Oncology, and Transplantation, Departments of Medicine and Pharmacology and The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794366PMC
March 2016

Endogenous hepatic glucocorticoid receptor signaling coordinates sex-biased inflammatory gene expression.

FASEB J 2016 Feb 18;30(2):971-82. Epub 2015 Nov 18.

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

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http://dx.doi.org/10.1096/fj.15-278309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714552PMC
February 2016

Corticosteroids: Mechanisms of Action in Health and Disease.

Rheum Dis Clin North Am 2016 Feb;42(1):15-31, vii

Signal Transduction Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangular Park, 111 T. W. Alexander Drive, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rdc.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662771PMC
February 2016

Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization.

Proc Natl Acad Sci U S A 2015 Dec 23;112(49):15166-71. Epub 2015 Nov 23.

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709;

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http://dx.doi.org/10.1073/pnas.1508056112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679013PMC
December 2015

Human Glucocorticoid Receptor β Regulates Gluconeogenesis and Inflammation in Mouse Liver.

Mol Cell Biol 2015 Dec 28;36(5):714-30. Epub 2015 Dec 28.

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA

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http://dx.doi.org/10.1128/MCB.00908-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760220PMC
December 2015

Glucocorticoid signaling in the heart: A cardiomyocyte perspective.

J Steroid Biochem Mol Biol 2015 Sep 21;153:27-34. Epub 2015 Mar 21.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, P.O. Box 12233, MD F3-07, Research Triangle Park, North Carolina 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2015.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568128PMC
September 2015

Specificity and sensitivity of glucocorticoid signaling in health and disease.

Best Pract Res Clin Endocrinol Metab 2015 Aug 25;29(4):545-56. Epub 2015 Apr 25.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X150003
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http://dx.doi.org/10.1016/j.beem.2015.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549805PMC
August 2015

One hormone, two actions: anti- and pro-inflammatory effects of glucocorticoids.

Neuroimmunomodulation 2015 12;22(1-2):20-32. Epub 2014 Sep 12.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Department of Health and Human Services, Research Triangle Park, N.C., USA.

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https://www.karger.com/Article/FullText/362724
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http://dx.doi.org/10.1159/000362724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243162PMC
June 2015

Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells.

Environ Health Perspect 2015 Jan 19;123(1):80-7. Epub 2014 Aug 19.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.1408437
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http://dx.doi.org/10.1289/ehp.1408437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286279PMC
January 2015

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

Pharmacol Rev 2014 Oct;66(4):918-47

Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (A.C., P.M.S., C.J.L.); Collège de France and CNRS URA 2182, Institut Pasteur, Paris, France (J.-P.C.); Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington (W.A.C.); PIQUR Therapeutics AG, Basel, Switzerland (D.F.); Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, Louisiana (T.P.B.); Signal Transduction Laboratory, Molecular Endocrinology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina (J.A.C.); Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California (R.W.O.); Division of Neuroscience, School of Medicine, University of Dundee, Scotland, United Kingdom (J.A.P.); Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (R.R.N.); Institut de Genomique Fonctionelle, CNRS, Montpellier, France (J.-P.P.); Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina (T.P.K.); Department of Pharmacology, University of California, Irvine, California (F.J.E.); and Research Solutions SARL, Paris, France (M.S.).

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http://dx.doi.org/10.1124/pr.114.008862DOI Listing
October 2014

Deep sequencing identification of novel glucocorticoid-responsive miRNAs in apoptotic primary lymphocytes.

PLoS One 2013 24;8(10):e78316. Epub 2013 Oct 24.

Molecular Endocrinology Group, Laboratory of Signal Transduction, NIEHS, NIH, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078316PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824063PMC
June 2014

Sexually dimorphic actions of glucocorticoids: beyond chromosomes and sex hormones.

Ann N Y Acad Sci 2014 May 16;1317:1-6. Epub 2014 Apr 16.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, U. S. Department of Health and Human Services, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1111/nyas.12425DOI Listing
May 2014

Ion channels and apoptosis in cancer.

Philos Trans R Soc Lond B Biol Sci 2014 Mar 3;369(1638):20130104. Epub 2014 Feb 3.

The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, , Research Triangle Park, NC 27709, USA.

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http://rstb.royalsocietypublishing.org/cgi/doi/10.1098/rstb.
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http://dx.doi.org/10.1098/rstb.2013.0104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917358PMC
March 2014

Analysis of glucocorticoid receptors and their apoptotic response to dexamethasone in male murine B cells during development.

Endocrinology 2014 Feb 6;155(2):463-74. Epub 2013 Nov 6.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2013-1473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891935PMC
February 2014

Glutathione depletion regulates both extrinsic and intrinsic apoptotic signaling cascades independent from multidrug resistance protein 1.

Apoptosis 2014 Jan;19(1):117-34

Redox Biology Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.

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http://dx.doi.org/10.1007/s10495-013-0900-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966077PMC
January 2014

A role for glucocorticoids in stress-impaired reproduction: beyond the hypothalamus and pituitary.

Endocrinology 2013 Dec 24;154(12):4450-68. Epub 2013 Sep 24.

NIEHS/NIH, MD F3-07, P.O. Box 12233, Research Triangle Park, North Carolina 27709.

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http://dx.doi.org/10.1210/en.2013-1652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836069PMC
December 2013

HES1 is a master regulator of glucocorticoid receptor-dependent gene expression.

Sci Signal 2013 Dec 3;6(304):ra103. Epub 2013 Dec 3.

1Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2004389
Publisher Site
http://dx.doi.org/10.1126/scisignal.2004389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997072PMC
December 2013

The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease.

J Allergy Clin Immunol 2013 Nov 29;132(5):1033-44. Epub 2013 Sep 29.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC.

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http://dx.doi.org/10.1016/j.jaci.2013.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084612PMC
November 2013

Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease.

Proc Natl Acad Sci U S A 2013 Oct 30;110(42):17035-40. Epub 2013 Sep 30.

Laboratory of Signal Transduction, Comparative Medicine Branch, and Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709.

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http://dx.doi.org/10.1073/pnas.1302546110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801058PMC
October 2013

Global gene expression analysis in human uterine epithelial cells defines new targets of glucocorticoid and estradiol antagonism.

Biol Reprod 2013 Sep 27;89(3):66. Epub 2013 Sep 27.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1095/biolreprod.113.111054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435104PMC
September 2013

Glucocorticoid receptor signaling in health and disease.

Trends Pharmacol Sci 2013 Sep 14;34(9):518-30. Epub 2013 Aug 14.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T.W. Alexander Drive, MD F3-07, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.tips.2013.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951203PMC
September 2013

Exploring the molecular mechanisms of glucocorticoid receptor action from sensitivity to resistance.

Endocr Dev 2013 1;24:41-56. Epub 2013 Feb 1.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, N.C., USA.

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August 2013

Ligand-induced repression of the glucocorticoid receptor gene is mediated by an NCoR1 repression complex formed by long-range chromatin interactions with intragenic glucocorticoid response elements.

Mol Cell Biol 2013 May 19;33(9):1711-22. Epub 2013 Feb 19.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

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May 2013

Tissue-specific actions of glucocorticoids on apoptosis: a double-edged sword.

Cells 2013 Mar 26;2(2):202-23. Epub 2013 Mar 26.

Laboratory of Signal Transduction, National Institutes of Environmental Health Sciences, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972684PMC
March 2013

The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore.

Trends Endocrinol Metab 2013 Mar 8;24(3):109-19. Epub 2013 Jan 8.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667973PMC
March 2013

Estradiol antagonism of glucocorticoid-induced GILZ expression in human uterine epithelial cells and murine uterus.

Endocrinology 2013 Jan 26;154(1):499-510. Epub 2012 Nov 26.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529382PMC
January 2013

Glutathione efflux and cell death.

Antioxid Redox Signal 2012 Dec 16;17(12):1694-713. Epub 2012 Jul 16.

Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.

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December 2012

Dual role for glucocorticoids in cardiomyocyte hypertrophy and apoptosis.

Endocrinology 2012 Nov 18;153(11):5346-60. Epub 2012 Sep 18.

Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

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November 2012

Glucocorticoids regulate arrestin gene expression and redirect the signaling profile of G protein-coupled receptors.

Proc Natl Acad Sci U S A 2012 Oct 8;109(43):17591-6. Epub 2012 Oct 8.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1073/pnas.1209411109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491462PMC
October 2012

Proinflammatory actions of glucocorticoids: glucocorticoids and TNFα coregulate gene expression in vitro and in vivo.

Endocrinology 2012 Aug 6;153(8):3701-12. Epub 2012 Jun 6.

Laboratory of Signal Transduction, National Institutes of Environmental Health Sciences, 111 T. W. Alexander Drive, Research Triangle Park, North Carolina 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404340PMC
August 2012

Glucocorticoids regulate gene expression and repress cellular proliferation in human uterine leiomyoma cells.

Horm Cancer 2012 Jun;3(3):79-92

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772901PMC
June 2012

Life and death of lymphocytes: a volume regulation affair.

Cell Physiol Biochem 2011 16;28(6):1079-88. Epub 2011 Dec 16.

The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709179PMC
April 2012

Complex human glucocorticoid receptor dim mutations define glucocorticoid induced apoptotic resistance in bone cells.

Mol Endocrinol 2012 Feb 15;26(2):244-56. Epub 2011 Dec 15.

National Institute of Environmental Health Sciences/National Institutes of Health, Laboratory of Signal Transduction, Research Triangle Park, North Carolina 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275167PMC
February 2012

Osmotic stress resistance imparts acquired anti-apoptotic mechanisms in lymphocytes.

J Biol Chem 2012 Feb 6;287(9):6284-95. Epub 2012 Jan 6.

Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

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February 2012

Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome.

J Biol Chem 2011 Nov 22;286(44):38703-13. Epub 2011 Sep 22.

Department of Health and Human Services, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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November 2011

Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance.

Mol Endocrinol 2011 Jul 28;25(7):1087-99. Epub 2011 Apr 28.

Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1210/me.2010-0051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125093PMC
July 2011

Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids.

J Biol Chem 2011 Feb 13;286(5):3177-84. Epub 2010 Dec 13.

Laboratory of Signal Transduction, NIEHS, National Institutes of Heath, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

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February 2011

Lysine 419 targets human glucocorticoid receptor for proteasomal degradation.

Steroids 2010 Dec 7;75(12):1016-23. Epub 2010 Jul 7.

Department of Environmental & Molecular Toxicology, Campus Box 7633, North Carolina State University, Raleigh, NC 27695-7633, USA.

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http://dx.doi.org/10.1016/j.steroids.2010.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926287PMC
December 2010

Glucocorticoid signaling in cardiac disease.

Horm Mol Biol Clin Investig 2010 Dec;4(2):559-64

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December 2010

Glucocorticoids modulate microRNA expression and processing during lymphocyte apoptosis.

J Biol Chem 2010 Nov 16;285(47):36698-708. Epub 2010 Sep 16.

Molecular Endocrinology Group, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

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November 2010

Sexually dimorphic actions of glucocorticoids provide a link to inflammatory diseases with gender differences in prevalence.

Sci Signal 2010 Oct 12;3(143):ra74. Epub 2010 Oct 12.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, MD F3-07, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772900PMC
October 2010

Glucocorticoid-induced apoptosis of healthy and malignant lymphocytes.

Prog Brain Res 2010 ;182:1-30

Molecular Endocrinology Group, Laboratory of Signal Transduction, NIEHS, NIH, DHHS, Research Triangle Park, NC, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770454PMC
September 2010

Ouabain-induced perturbations in intracellular ionic homeostasis regulate death receptor-mediated apoptosis.

Apoptosis 2010 Jul;15(7):834-49

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1007/s10495-010-0494-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399447PMC
July 2010

Emerging roles of glucocorticoid receptor phosphorylation in modulating glucocorticoid hormone action in health and disease.

IUBMB Life 2009 Oct;61(10):979-86

Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

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October 2009

Mechanisms generating diversity in glucocorticoid receptor signaling.

Ann N Y Acad Sci 2009 Oct;1179:167-78

Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences (NIEHS)/NIH, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2009.04986.xDOI Listing
October 2009

Glucocorticoids and their actions in cells.

Authors:
John A Cidlowski

Retina 2009 Jun;29(6 Suppl):S21-3

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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June 2009

Molecular mechanisms regulating glucocorticoid sensitivity and resistance.

Mol Cell Endocrinol 2009 Mar 19;300(1-2):7-16. Epub 2008 Oct 19.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.mce.2008.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674248PMC
March 2009

Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis.

J Biol Chem 2008 Dec 21;283(52):36071-87. Epub 2008 Oct 21.

Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1074/jbc.M807061200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605975PMC
December 2008

Tissue-specific glucocorticoid action: a family affair.

Trends Endocrinol Metab 2008 Nov 19;19(9):331-9. Epub 2008 Sep 19.

Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720031PMC
November 2008

Apoptosis and cell volume regulation: the importance of ions and ion channels.

Adv Exp Med Biol 2004 ;559:189-203

National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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September 2008

An endogenous calcium-dependent, caspase-independent intranuclear degradation pathway in thymocyte nuclei: antagonism by physiological concentrations of K(+) ions.

Exp Cell Res 2008 Apr 16;314(6):1237-49. Epub 2008 Jan 16.

Laboratory of Signal Transduction, National Institute of Environmental Health Science, National Institute of Health, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692666PMC
April 2008

Cationic gradient reversal and cytoskeleton-independent volume regulatory pathways define an early stage of apoptosis.

J Biol Chem 2008 Mar 10;283(11):7219-29. Epub 2008 Jan 10.

Laboratory of Signal Transduction, National Institutes of Health Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1074/jbc.M707809200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680553PMC
March 2008

New approaches for determining apoptotic volume decrease in cells.

Methods Enzymol 2007 ;428:161-81

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, North Carolina, USA.

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November 2007

Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor.

Mol Cell Biol 2007 Oct 6;27(20):7143-60. Epub 2007 Aug 6.

Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168898PMC
October 2007

Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation.

J Biol Chem 2007 Oct 27;282(42):30452-65. Epub 2007 Aug 27.

Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1074/jbc.M703091200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267748PMC
October 2007

Molecular evidence for a link between the N363S glucocorticoid receptor polymorphism and altered gene expression.

J Clin Endocrinol Metab 2007 Aug 29;92(8):3268-77. Epub 2007 May 29.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, MD F3-07, Research Triangle Park, North Carolina 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692663PMC
August 2007

Cell shrinkage and monovalent cation fluxes: role in apoptosis.

Arch Biochem Biophys 2007 Jun 8;462(2):176-88. Epub 2007 Feb 8.

The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941616PMC
June 2007

Human glucocorticoid receptor beta binds RU-486 and is transcriptionally active.

Mol Cell Biol 2007 Mar 22;27(6):2266-82. Epub 2007 Jan 22.

Laboratory of Signal Transduciton, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1128/MCB.01439-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820503PMC
March 2007

Glucocorticoids regulate tristetraprolin synthesis and posttranscriptionally regulate tumor necrosis factor alpha inflammatory signaling.

Mol Cell Biol 2006 Dec 18;26(23):9126-35. Epub 2006 Sep 18.

Department of Health and Human Services, Laboratory of Signal Transduction, National Institute of Environmental Health Services, National Institutes of Health, Building 101, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1128/MCB.00679-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636823PMC
December 2006

Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification.

J Steroid Biochem Mol Biol 2006 Dec 27;102(1-5):11-21. Epub 2006 Oct 27.

Laboratory of Signal Transduction, Molecular Endocrinology Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2006.09.009DOI Listing
December 2006

International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors.

Pharmacol Rev 2006 Dec;58(4):782-97

Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

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December 2006