Publications by authors named "Johannes Schulte"

100Publications

Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma.

Children (Basel) 2020 Oct 28;7(11). Epub 2020 Oct 28.

Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.

View Article and Find Full Text PDF
October 2020

Outcome of chronic granulomatous disease - Conventional treatment vs stem cell transplantation.

Pediatr Allergy Immunol 2020 Oct 28. Epub 2020 Oct 28.

Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Charité Universitätsmedizin -Berlin University Hospital Center, Berlin, Germany.

View Article and Find Full Text PDF
October 2020

Multiplexed Quantification of Four Neuroblastoma DNA Targets in a Single Droplet Digital PCR Reaction.

J Mol Diagn 2020 Aug 26. Epub 2020 Aug 26.

Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Neuroblastoma Research Group, Experimental and Clinical Research Center, Berlin, Germany.

View Article and Find Full Text PDF
August 2020

Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma.

Int J Mol Sci 2020 Jul 19;21(14). Epub 2020 Jul 19.

Institute of Molecular Medicine, Sect. Molecular Cell Biology, Martin Luther University Halle-Wittenberg, Charles Tanford Protein Center, 06120 Halle Saale, Germany.

View Article and Find Full Text PDF
July 2020

Lineage-restricted sympathoadrenal progenitors confer neuroblastoma origin and its tumorigenicity.

Oncotarget 2020 Jun 16;11(24):2357-2371. Epub 2020 Jun 16.

Department of Medical Oncology and Hematology, University Hospital Zürich, Zürich, Switzerland.

View Article and Find Full Text PDF
June 2020

Long-term small-fiber neuropathy and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation.

J Cancer Res Clin Oncol 2020 Aug 28;146(8):2143-2152. Epub 2020 Apr 28.

Department of Pediatric Oncology/Hematology and Stem Cell Transplantation, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany.

View Article and Find Full Text PDF
August 2020

N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma.

Sci Rep 2020 04 28;10(1):7157. Epub 2020 Apr 28.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

View Article and Find Full Text PDF
April 2020

Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells.

Mol Carcinog 2020 07 25;59(7):724-735. Epub 2020 Apr 25.

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

View Article and Find Full Text PDF
July 2020

Oncogenic drives tumorigenesis in cutaneous squamous cell carcinoma.

Life Sci Alliance 2020 06 20;3(6). Epub 2020 Apr 20.

Department of Medical Oncology and Hematology, University Hospital Zürich, Zürich, Switzerland

View Article and Find Full Text PDF
June 2020

Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4 CAR T Cell Efficacy.

Front Immunol 2020 31;11:531. Epub 2020 Mar 31.

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

View Article and Find Full Text PDF
March 2020

Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors.

Transl Oncol 2020 Feb 21;13(2):221-232. Epub 2019 Dec 21.

Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Experimental and Clinical Research Center (ECRC) of the Charité and the Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany; Deutsches Konsortium für Translationale Krebsforschung, Berlin, Germany; Berlin Institute of Health, Berlin, Germany. Electronic address:

View Article and Find Full Text PDF
February 2020

Donor selection in a pediatric stem cell transplantation cohort using PIRCHE and HLA-DPB1 typing.

Pediatr Blood Cancer 2020 03 18;67(3):e28127. Epub 2019 Dec 18.

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

View Article and Find Full Text PDF
March 2020

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing.

BMC Cancer 2019 Sep 9;19(1):895. Epub 2019 Sep 9.

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany.

View Article and Find Full Text PDF
September 2019

Haploidentical CD3 or α/β T-cell depleted HSCT in advanced stage sickle cell disease.

Bone Marrow Transplant 2019 11 14;54(11):1859-1867. Epub 2019 May 14.

Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Franz-Josef-Strauss-Allee 11, University Hospital of Regensburg, Regensburg, Germany.

View Article and Find Full Text PDF
November 2019

Transmission of chromosomally integrated human herpes virus-6A via haploidentical stem cell transplantation poses a risk for virus reactivation and associated complications.

Bone Marrow Transplant 2020 01 15;55(1):260-264. Epub 2019 Apr 15.

Department of Pediatric Hematology and Oncology, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

View Article and Find Full Text PDF
January 2020

Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma.

Cancer Lett 2019 03 4;445:24-33. Epub 2019 Jan 4.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany; German Consortium for Translational Cancer Research (DKTK), Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany. Electronic address:

View Article and Find Full Text PDF
March 2019

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article and Find Full Text PDF
July 2018

MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of , and .

Oncotarget 2018 Apr 6;9(26):18160-18179. Epub 2018 Apr 6.

Pediatric Research Group, Department of Clinical Medicine, Faculty of Health Science, The Arctic University of Norway - UiT, Tromsø NO-9037, Norway.

View Article and Find Full Text PDF
April 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article and Find Full Text PDF
March 2018

Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma.

Oncotarget 2018 Jan 18;9(2):2304-2319. Epub 2017 Dec 18.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Hematology/Oncology/Stem Cell Transplantation, Berlin, Germany.

View Article and Find Full Text PDF
January 2018

The Expanding World of N-MYC-Driven Tumors.

Cancer Discov 2018 02 22;8(2):150-163. Epub 2018 Jan 22.

Theodor Boveri Institute and Comprehensive Cancer Center Mainfranken, Biocenter, University of Würzburg, Würzburg, Germany.

View Article and Find Full Text PDF
February 2018

Life-threatening systemic rotavirus infection after vaccination in severe combined immunodeficiency (SCID).

Pediatr Allergy Immunol 2017 12 9;28(8):841-843. Epub 2017 Oct 9.

Department of Pediatric Oncology/Hematology/Stem Cell Transplantation, Charité-Universitätsmedizin Berlin, Berlin, Germany.

View Article and Find Full Text PDF
December 2017

Bromodomain and extraterminal protein inhibitors in pediatrics: A review of the literature.

Pediatr Blood Cancer 2017 05 30;64(5). Epub 2016 Nov 30.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

View Article and Find Full Text PDF
May 2017

Towards diagnostic application of non-coding RNAs in neuroblastoma.

Expert Rev Mol Diagn 2016 12 15;16(12):1307-1313. Epub 2016 Nov 15.

a Department of Pediatric Oncology and Hematology , University Children's Hospital Essen , Essen , Germany.

View Article and Find Full Text PDF
December 2016

Pharmaceutically inhibiting polo-like kinase 1 exerts a broad anti-tumour activity in retinoblastoma cell lines.

Clin Exp Ophthalmol 2017 Apr 10;45(3):288-296. Epub 2016 Nov 10.

Department of Pediatric Oncology and Hematology, University Hospital Essen, Essen, Germany.

View Article and Find Full Text PDF
April 2017

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

View Article and Find Full Text PDF
September 2016

Immune response modulation by Galectin-1 in a transgenic model of neuroblastoma.

Oncoimmunology 2016 May 18;5(5):e1131378. Epub 2016 Feb 18.

Pediatric Oncology and Hematology, University Children's Hospital Essen, University of Duisburg-Essen , Essen, Germany.

View Article and Find Full Text PDF
May 2016

Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum.

Cerebellum 2017 02;16(1):122-131

Center for Neuropathology, Ludwig-Maximilians-University, Feodor-Lynen-Strasse 23, D-81377, Munich, Germany.

View Article and Find Full Text PDF
February 2017

Lin28B and Let-7 in the Control of Sympathetic Neurogenesis and Neuroblastoma Development.

J Neurosci 2015 Dec;35(50):16531-44

Developmental Neurobiology, Max Planck Institute for Brain Research, 60438 Frankfurt am Main, Germany, Institute of Clinical Neuroanatomy, Goethe University of Frankfurt, 60590 Frankfurt am Main, Germany, Ernst Strüngmann Institute, 60528 Frankfurt am Main, Germany,

View Article and Find Full Text PDF
December 2015

Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.

Clin Cancer Res 2016 05 2;22(10):2470-81. Epub 2015 Dec 2.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany. German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Duesseldorf, Essen, Germany. Neuroblastoma Genomics, B087, German Cancer Research Center (DKFZ), Heidelberg, Germany. Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.

View Article and Find Full Text PDF
May 2016

The Lin28/let-7 axis is critical for myelination in the peripheral nervous system.

Nat Commun 2015 Oct 14;6:8584. Epub 2015 Oct 14.

Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Otto-Stern-Weg 7, 8093 Zurich, Switzerland.

View Article and Find Full Text PDF
October 2015

Neuroblastoma.

Crit Rev Oncog 2015 ;20(3-4):245-70

Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Berlin, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article and Find Full Text PDF
June 2016

Development of Port-Site Metastases Following Thoracoscopic Resection of a Neuroblastoma.

Pediatr Blood Cancer 2016 Jan 23;63(1):149-51. Epub 2015 Jul 23.

Department of Pediatric Hematology and Oncology, Kinderklinik III, Universitätsklinikum-Essen and the University of Duisburg-Essen, Essen, Germany.

View Article and Find Full Text PDF
January 2016

Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma.

Biomed Rep 2015 Jul 13;3(4):443-446. Epub 2015 May 13.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, D-45122 Essen, Germany ; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Duesseldorf, D-45122 Essen, Germany ; German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany ; Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, D-45147 Essen, Germany ; Centre for Medical Biotechnology, University Duisburg-Essen, D-45147 Essen, Germany.

View Article and Find Full Text PDF
July 2015

Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation.

Sci Signal 2015 Apr 28;8(374):ra40. Epub 2015 Apr 28.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

View Article and Find Full Text PDF
April 2015

IGF2BP1 harbors prognostic significance by gene gain and diverse expression in neuroblastoma.

J Clin Oncol 2015 Apr 9;33(11):1285-93. Epub 2015 Mar 9.

Jessica L. Bell, Raseswari Turlapati, and Stefan Hüttelmaier, Martin Luther University Halle-Wittenberg, Halle; Johannes H. Schulte, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, and University Children's Hospital Essen, Essen; Johannes H. Schulte, German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany; and Tao Liu, Children's Cancer Institute Australia for Medical Research and University of New South Wales, Randwick, New South Wales, Australia.

View Article and Find Full Text PDF
April 2015

Neoadjuvant/adjuvant treatment of high-risk retinoblastoma: a report from the German Retinoblastoma Referral Centre.

Br J Ophthalmol 2015 Jul 12;99(7):949-53. Epub 2015 Jan 12.

Department of Pediatric Oncology and Hematology, University Hospital Essen, Essen, Germany German Cancer Consortium (DKTK), Heidelberg, Germany Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany German Cancer Research Center (DKFZ), Heidelberg, Germany Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.

View Article and Find Full Text PDF
July 2015

Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells.

Oncotarget 2014 Nov;5(22):11180-92

Department of Pediatric Oncology and Hematology, University Children`s Hospital Essen, Essen, Germany. German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), Germany. Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.

View Article and Find Full Text PDF
November 2014

ALK pERKs up MYCN in neuroblastoma.

Sci Signal 2014 Oct 28;7(349):pe27. Epub 2014 Oct 28.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, 45122 Essen, Germany. German Cancer Consortium (DKTK), Partner Site Essen/Duesseldorf, 45122 Essen, Germany. Department of Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Hufelandstr.55, 45122 Essen, Germany. German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, 45122 Essen, Germany.

View Article and Find Full Text PDF
October 2014

Early targets of miR-34a in neuroblastoma.

Mol Cell Proteomics 2014 Aug 9;13(8):2114-31. Epub 2014 Jun 9.

From the ‡Centro di Ingegneria Genetica e Biotecnologie Avanzate (CEINGE), 80145 Naples, Italy; §Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II, 80131 Naples, Italy; ‖‖Centro di Medicina Trasfusionale, Azienda Ospedaliera Federico II, 80131 Naples, Italy

View Article and Find Full Text PDF
August 2014

The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia.

BMC Cancer 2013 Oct 2;13:452. Epub 2013 Oct 2.

Department of Pediatric Hematology-Oncology, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany.

View Article and Find Full Text PDF
October 2013

Chemoreduction improves eye retention in patients with retinoblastoma: a report from the German Retinoblastoma Reference Centre.

Br J Ophthalmol 2013 Oct 17;97(10):1277-83. Epub 2013 Jul 17.

Department of Paediatric Oncology and Haematology, University Hospital Essen, , Essen, Germany.

View Article and Find Full Text PDF
October 2013