Johannes P T M van Leeuwen

Johannes P T M van Leeuwen

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Johannes P T M van Leeuwen

Johannes P T M van Leeuwen

Publications by authors named "Johannes P T M van Leeuwen"

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A follistatin-based molecule increases muscle and bone mass without affecting the red blood cell count in mice.

FASEB J 2019 May 13;33(5):6001-6010. Epub 2019 Feb 13.

Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1096/fj.201801969RRDOI Listing
May 2019

Understanding age-induced cortical porosity in women: Is a negative BMU balance in quiescent osteons a major contributor?

Bone 2018 12 18;117:70-82. Epub 2018 Sep 18.

Clinical Cell Biology, Vejle Hospital - Lillebaelt Hospital, Department of Regional Health Research, University of Southern Denmark, Vejle, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2018.09.011DOI Listing
December 2018

Zika virus infection perturbs osteoblast function.

Sci Rep 2018 Nov 19;8(1):16975. Epub 2018 Nov 19.

Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.

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http://www.nature.com/articles/s41598-018-35422-3
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http://dx.doi.org/10.1038/s41598-018-35422-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242880PMC
November 2018

NELL-1, HMGB1, and CCN2 Enhance Migration and Vasculogenesis, But Not Osteogenic Differentiation Compared to BMP2.

Tissue Eng Part A 2018 02 13;24(3-4):207-218. Epub 2017 Dec 13.

3 Department of Oral and Maxillofacial Surgery, Erasmus MC , Rotterdam, The Netherlands .

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http://dx.doi.org/10.1089/ten.TEA.2016.0537DOI Listing
February 2018

Hydroxychloroquine affects bone resorption both in vitro and in vivo.

J Cell Physiol 2018 Feb 3;233(2):1424-1433. Epub 2017 Aug 3.

Division of Clinical Immunology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/jcp.26028DOI Listing
February 2018

Hydroxychloroquine decreases human MSC-derived osteoblast differentiation and mineralization in vitro.

J Cell Mol Med 2018 02 3;22(2):873-882. Epub 2017 Oct 3.

Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/jcmm.13373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783866PMC
February 2018

Vitamin D endocrinology of bone mineralization.

Mol Cell Endocrinol 2017 09 9;453:46-51. Epub 2017 Jun 9.

Department of Research and Education, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.06.008DOI Listing
September 2017

Novel Compound Heterozygous Mutations in the CYP27B1 Gene Lead to Pseudovitamin D-Deficient Rickets.

Calcif Tissue Int 2016 09 1;99(3):326-31. Epub 2016 Jul 1.

Department of Internal Medicine, Erasmus MC, Po. Box 2040, 3000 CA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00223-016-0165-zDOI Listing
September 2016

25-Hydroxyvitamin D and osteoarthritis: A meta-analysis including new data.

Semin Arthritis Rheum 2016 Apr 29;45(5):539-46. Epub 2015 Oct 29.

Departments of Internal Medicine, Genetic Laboratory, Erasmus Medical Center, Room Ee579b, PO Box 1738, Rotterdam 3000 DR, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2015.09.010DOI Listing
April 2016

Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway.

Proc Natl Acad Sci U S A 2015 Oct 29;112(41):12711-6. Epub 2015 Sep 29.

Department of Internal Medicine, Erasmus MC, 3015 CN Rotterdam, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1501597112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611615PMC
October 2015

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.

Bone 2015 Mar 18;72:14-22. Epub 2014 Nov 18.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2014.11.004DOI Listing
March 2015

UV exposure inhibits intestinal tumor growth and progression to malignancy in intestine-specific Apc mutant mice kept on low vitamin D diet.

Int J Cancer 2015 Jan 5;136(2):271-7. Epub 2014 Jun 5.

Department of Dermatology, Leiden University Medical Center, 2333, ZC Leiden, The Netherlands.

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http://dx.doi.org/10.1002/ijc.29002DOI Listing
January 2015

Cancer and bone: a complex complex.

Arch Biochem Biophys 2014 Nov 18;561:159-66. Epub 2014 Jul 18.

Department of Internal Medicine, Erasmus MC Rotterdam, Room Ee585c, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.abb.2014.07.013DOI Listing
November 2014

Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling.

Endocrinology 2014 Nov 25;155(11):4287-95. Epub 2014 Jul 25.

Department of Internal Medicine (P.J.D.D., M.V.D.V., B.C.J.V.D.E., J.M.M.G., A.-J.V.D.L., J.P.T.M.V.L.), Erasmus MC, Postbus 2040, 3000 CA Rotterdam, The Netherlands; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center (Y.S.) and Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030; and Department of Metabolism and Aging (R.G.S.), The Scripps Research Institute Florida, Jupiter, Florida 33458.

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http://dx.doi.org/10.1210/en.2013-2055DOI Listing
November 2014

Ghrelin and bone.

Biofactors 2014 Jan-Feb;40(1):41-8. Epub 2013 Jun 27.

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/biof.1120DOI Listing
October 2014

Vitamin D and gene networks in human osteoblasts.

Front Physiol 2014 9;5:137. Epub 2014 Apr 9.

Department of Internal Medicine, Bone and Calcium Metabolism Erasmus MC, Rotterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2014.00137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988399PMC
June 2014

Vitamin D endocrine system and osteoblasts.

Bonekey Rep 2014 5;3:493. Epub 2014 Feb 5.

Department of Internal Medicine, Erasmus MC , Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/bonekey.2013.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944124PMC
May 2014

Oxygen-induced transcriptional dynamics in human osteoblasts are most prominent at the onset of mineralization.

J Cell Physiol 2013 Sep;228(9):1863-72

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/jcp.24348DOI Listing
September 2013

Effect of calcium and cholecalciferol supplementation on several parameters of calcium status in plasma and urine of captive Asian (Elephas maximus) and African elephants (Loxodonta africana).

J Zoo Wildl Med 2013 Sep;44(3):529-40

Faculty of Veterinary Medicine, Department of Equine Sciences, Medicine Section, University of Utrecht, Postbus 80163, 3508TD Utrecht, The Netherlands.

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http://dx.doi.org/10.1638/2010-0123R4.1DOI Listing
September 2013

Bioinformatics-based selection of a model cell type for in vitro biomaterial testing.

Biomaterials 2013 Jul 28;34(22):5552-61. Epub 2013 Apr 28.

Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, Enschede 7500 AE, The Netherlands.

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http://dx.doi.org/10.1016/j.biomaterials.2013.04.001DOI Listing
July 2013

A small molecule approach to engineering vascularized tissue.

Biomaterials 2013 Apr 29;34(12):3053-63. Epub 2013 Jan 29.

MIRA Institute for Biomedical Technology and Technical Medicine, Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands.

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http://dx.doi.org/10.1016/j.biomaterials.2012.12.037DOI Listing
April 2013

An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects.

Endocrinology 2012 Aug 14;153(8):3593-602. Epub 2012 Jun 14.

Department of Internal Medicine, Erasmus University Medical Center's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1210/en.2012-1277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393325PMC
August 2012

Diverse effects of cyclic AMP variants on osteogenic and adipogenic differentiation of human mesenchymal stromal cells.

Tissue Eng Part A 2012 Jul 2;18(13-14):1431-42. Epub 2012 Jul 2.

Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands.

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http://dx.doi.org/10.1089/ten.TEA.2011.0484DOI Listing
July 2012

A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells.

Biomaterials 2012 Apr 29;33(11):3205-15. Epub 2012 Jan 29.

Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S01429612120003
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http://dx.doi.org/10.1016/j.biomaterials.2012.01.020DOI Listing
April 2012

Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells.

J Mol Cell Cardiol 2011 Nov 28;51(5):862-71. Epub 2011 Jul 28.

Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 50, NL-3015 GE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2011.07.020DOI Listing
November 2011

Unraveling the human bone microenvironment beyond the classical extracellular matrix proteins: a human bone protein library.

J Proteome Res 2011 Oct 21;10(10):4725-33. Epub 2011 Sep 21.

Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1021/pr200522nDOI Listing
October 2011

Pro-osteogenic trophic effects by PKA activation in human mesenchymal stromal cells.

Biomaterials 2011 Sep 31;32(26):6089-98. Epub 2011 May 31.

University of Twente, MIRA Institute for Biomedical Engineering and Technical Medicine, Drienerlolaan 5, 7500 AE Enschede, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S014296121100516
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http://dx.doi.org/10.1016/j.biomaterials.2011.05.010DOI Listing
September 2011

GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release.

J Bone Miner Res 2011 Sep;26(9):2045-51

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/jbmr.435DOI Listing
September 2011

Preliminary validation of assays to measure parameters of calcium metabolism in captive Asian and African elephants in western Europe.

J Vet Diagn Invest 2011 May;23(3):504-10

University of Utrecht, Department of Equine Sciences, Medicine Section, Utrecht, The Netherlands.

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http://dx.doi.org/10.1177/1040638711403411DOI Listing
May 2011

Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis.

Arthritis Res Ther 2010 5;12(5):R182. Epub 2010 Oct 5.

Department of Orthopaedics, Erasmus MC, University Medical Center, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/ar3148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991014PMC
March 2011

Stimulation of osteogenic differentiation in human osteoprogenitor cells by pulsed electromagnetic fields: an in vitro study.

BMC Musculoskelet Disord 2010 Aug 23;11:188. Epub 2010 Aug 23.

Department of Orthopaedics, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/1471-2474-11-188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936347PMC
August 2010

Estrogen modulates iodoacetate-induced gene expression in bovine cartilage explants.

J Orthop Res 2010 May;28(5):607-15

Department of Orthopaedics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/jor.21042DOI Listing
May 2010

A new concept underlying stem cell lineage skewing that explains the detrimental effects of thiazolidinediones on bone.

Stem Cells 2010 May;28(5):916-27

Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 50, NL-3015 GE Rotterdam, The Netherlands.

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http://doi.wiley.com/10.1002/stem.405
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http://dx.doi.org/10.1002/stem.405DOI Listing
May 2010

Stretch-induced inhibition of Wnt/beta-catenin signaling in mineralizing osteoblasts.

J Orthop Res 2010 Mar;28(3):390-6

Department of Orthopaedics, Erasmus University Medical Centre, Room Ee 1614, P.O. Box 2040, 3000 CA Rotterdam, the Netherlands.

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http://dx.doi.org/10.1002/jor.20991DOI Listing
March 2010

Klotho prevents renal calcium loss.

J Am Soc Nephrol 2009 Nov 27;20(11):2371-9. Epub 2009 Aug 27.

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, , 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1681/ASN.2008121273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799169PMC
November 2009

Vitamin D status, bone mineral density, and the development of radiographic osteoarthritis of the knee: The Rotterdam Study.

J Clin Rheumatol 2009 Aug;15(5):230-7

Departments of Internal Medicine, Erasmus Medical Center, Rotterdam 3000 DR, The Netherlands.

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http://dx.doi.org/10.1097/RHU.0b013e3181b08f20DOI Listing
August 2009

Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation.

Br J Nutr 2009 Jun 27;101(11):1597-606. Epub 2009 Apr 27.

Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1017/S0007114509338842DOI Listing
June 2009

Bone resorption inhibitor alendronate normalizes the reduced bone thickness of TRPV5(-/-) mice.

J Bone Miner Res 2008 Nov;23(11):1815-24

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1359/jbmr.080613DOI Listing
November 2008

Iodothyronine deiodinase enzyme activities in bone.

Bone 2008 Jul 4;43(1):126-134. Epub 2008 Apr 4.

Molecular Endocrinology Group, Division of Medicine and Medical Research Council (MRC) Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2008.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681075PMC
July 2008

Evidence for multiple peroxisome proliferator-activated receptor gamma transcripts in bone: fine-tuning by hormonal regulation and mRNA stability.

FEBS Lett 2008 May 22;582(11):1618-24. Epub 2008 Apr 22.

Department of Internal Medicine, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2008.04.012DOI Listing
May 2008

Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.

Am J Physiol Renal Physiol 2006 Dec 16;291(6):F1177-83. Epub 2006 May 16.

Department of Physiology, Nijmegen Centre for Molecualr Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1152/ajprenal.00038.2006DOI Listing
December 2006

The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist.

FASEB J 2006 Oct;20(12):2171-3

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101, Nijmegen, NL-6500 HB, The Netherlands.

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http://dx.doi.org/10.1096/fj.05-5515fjeDOI Listing
October 2006

Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice.

J Am Soc Nephrol 2005 Nov 7;16(11):3188-95. Epub 2005 Sep 7.

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1681/ASN.2005060632DOI Listing
November 2005

Identification of acid-sensing ion channels in bone.

Biochem Biophys Res Commun 2005 Nov;337(1):349-54

Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bbrc.2005.09.054DOI Listing
November 2005

Coordinated control of renal Ca(2+) transport proteins by parathyroid hormone.

Kidney Int 2005 Oct;68(4):1708-21

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/j.1523-1755.2005.00587.xDOI Listing
October 2005

Mechanism and function of high vitamin D receptor levels in genetic hypercalciuric stone-forming rats.

J Bone Miner Res 2005 Mar 29;20(3):447-54. Epub 2004 Nov 29.

Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1359/JBMR.041120DOI Listing
March 2005

Genetics and biology of vitamin D receptor polymorphisms.

Gene 2004 Sep;338(2):143-56

Genetic Laboratory, Room Ee575, Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 50, PO Box 1738, NL-3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.gene.2004.05.014DOI Listing
September 2004

Accelerated bone aging in the trichothiodystrophy mouse model.

J Gerontol A Biol Sci Med Sci 2003 Nov;58(11):969

Department of Cell Biology & Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/gerona/58.11.b969DOI Listing
November 2003

Regulation of the epithelial Ca2+ channels in small intestine as studied by quantitative mRNA detection.

Am J Physiol Gastrointest Liver Physiol 2003 Jul 5;285(1):G78-85. Epub 2003 Mar 5.

Department of Cell Physiology, Niujmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, P. O. Box 9101, NL-6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1152/ajpgi.00036.2003DOI Listing
July 2003

The importance of oestrogens in males.

Clin Endocrinol (Oxf) 2003 May;58(5):529-42

Department of Internal Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1046/j.1365-2265.2003.01669.xDOI Listing
May 2003

Detection of noncollagenous bone proteins in methylmethacrylate-embedded human bone sections.

Methods Mol Med 2003 ;80:249-58

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1385/1-59259-366-6:249DOI Listing
May 2003

A cross-sectional study on biochemical parameters of bone turnover and vitamin d metabolites in healthy dutch children and young adults.

Horm Res 2002 ;57(5-6):170-9

Department of Pediatrics, Subdivision Endocrinology, Sophia Children's Hospital Rotterdam, The Netherlands.

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http://dx.doi.org/10.1159/000058378DOI Listing
October 2002