Johannes H Schulte

Johannes H Schulte

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Johannes H Schulte

Johannes H Schulte

Publications by authors named "Johannes H Schulte"

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CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing.

BMC Cancer 2019 Sep 9;19(1):895. Epub 2019 Sep 9.

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://dx.doi.org/10.1186/s12885-019-6131-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732842PMC
September 2019

HLA-haploidentical hematopoietic stem cell transplantation in pediatric patients with hemoglobinopathies: current practice and new approaches.

Bone Marrow Transplant 2019 Aug;54(Suppl 2):743-748

Dept. of Pediatric Oncology & Hematology, Charité University Medicine, Augustenburger Platz 1, Berlin, 13353, Germany.

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http://dx.doi.org/10.1038/s41409-019-0598-xDOI Listing
August 2019

Haploidentical CD3 or α/β T-cell depleted HSCT in advanced stage sickle cell disease.

Bone Marrow Transplant 2019 May 14. Epub 2019 May 14.

Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Franz-Josef-Strauss-Allee 11, University Hospital of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1038/s41409-019-0550-0DOI Listing
May 2019

Transmission of chromosomally integrated human herpes virus-6A via haploidentical stem cell transplantation poses a risk for virus reactivation and associated complications.

Bone Marrow Transplant 2019 Apr 15. Epub 2019 Apr 15.

Department of Pediatric Hematology and Oncology, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://dx.doi.org/10.1038/s41409-019-0530-4DOI Listing
April 2019

Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma.

Cancer Lett 2019 Mar 4;445:24-33. Epub 2019 Jan 4.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany; German Consortium for Translational Cancer Research (DKTK), Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.12.012DOI Listing
March 2019

The Expanding World of N-MYC-Driven Tumors.

Cancer Discov 2018 02 22;8(2):150-163. Epub 2018 Jan 22.

Theodor Boveri Institute and Comprehensive Cancer Center Mainfranken, Biocenter, University of Würzburg, Würzburg, Germany.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-17-0273DOI Listing
February 2018

Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma.

Oncotarget 2018 Jan 18;9(2):2304-2319. Epub 2017 Dec 18.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Hematology/Oncology/Stem Cell Transplantation, Berlin, Germany.

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http://dx.doi.org/10.18632/oncotarget.23409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788641PMC
January 2018

Life-threatening systemic rotavirus infection after vaccination in severe combined immunodeficiency (SCID).

Pediatr Allergy Immunol 2017 12 9;28(8):841-843. Epub 2017 Oct 9.

Department of Pediatric Oncology/Hematology/Stem Cell Transplantation, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1111/pai.12771DOI Listing
December 2017

Pharmaceutically inhibiting polo-like kinase 1 exerts a broad anti-tumour activity in retinoblastoma cell lines.

Clin Exp Ophthalmol 2017 Apr 10;45(3):288-296. Epub 2016 Nov 10.

Department of Pediatric Oncology and Hematology, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1111/ceo.12838DOI Listing
April 2017

Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum.

Cerebellum 2017 02;16(1):122-131

Center for Neuropathology, Ludwig-Maximilians-University, Feodor-Lynen-Strasse 23, D-81377, Munich, Germany.

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http://dx.doi.org/10.1007/s12311-016-0774-0DOI Listing
February 2017

Towards diagnostic application of non-coding RNAs in neuroblastoma.

Expert Rev Mol Diagn 2016 12 15;16(12):1307-1313. Epub 2016 Nov 15.

a Department of Pediatric Oncology and Hematology , University Children's Hospital Essen , Essen , Germany.

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http://dx.doi.org/10.1080/14737159.2016.1256207DOI Listing
December 2016

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.06.009DOI Listing
September 2016

Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.

Clin Cancer Res 2016 05 2;22(10):2470-81. Epub 2015 Dec 2.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany. German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Duesseldorf, Essen, Germany. Neuroblastoma Genomics, B087, German Cancer Research Center (DKFZ), Heidelberg, Germany. Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1449DOI Listing
May 2016

Immune response modulation by Galectin-1 in a transgenic model of neuroblastoma.

Oncoimmunology 2016 May 18;5(5):e1131378. Epub 2016 Feb 18.

Pediatric Oncology and Hematology, University Children's Hospital Essen, University of Duisburg-Essen , Essen, Germany.

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http://dx.doi.org/10.1080/2162402X.2015.1131378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910755PMC
May 2016

Development of Port-Site Metastases Following Thoracoscopic Resection of a Neuroblastoma.

Pediatr Blood Cancer 2016 Jan 23;63(1):149-51. Epub 2015 Jul 23.

Department of Pediatric Hematology and Oncology, Kinderklinik III, Universitätsklinikum-Essen and the University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1002/pbc.25677DOI Listing
January 2016

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

Cancer Res 2015 Dec 15;75(23):5143-54. Epub 2015 Oct 15.

Children's Cancer Institute Australia, Randwick, Sydney, New South Wales, Australia. School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Randwick, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0423DOI Listing
December 2015

The Lin28/let-7 axis is critical for myelination in the peripheral nervous system.

Nat Commun 2015 Oct 14;6:8584. Epub 2015 Oct 14.

Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Otto-Stern-Weg 7, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/ncomms9584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634210PMC
October 2015

Mutational dynamics between primary and relapse neuroblastomas.

Nat Genet 2015 Aug 29;47(8):872-7. Epub 2015 Jun 29.

1] Pediatric Oncology and Hematology, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany. [2] Pediatric Oncology and Hematology, Charité University Medicine, Berlin, Germany. [3] German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://search.proquest.com/openview/bef3fe020af3cd6708016aba
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http://dx.doi.org/10.1038/ng.3349DOI Listing
August 2015

Neoadjuvant/adjuvant treatment of high-risk retinoblastoma: a report from the German Retinoblastoma Referral Centre.

Br J Ophthalmol 2015 Jul 12;99(7):949-53. Epub 2015 Jan 12.

Department of Pediatric Oncology and Hematology, University Hospital Essen, Essen, Germany German Cancer Consortium (DKTK), Heidelberg, Germany Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany German Cancer Research Center (DKFZ), Heidelberg, Germany Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1136/bjophthalmol-2014-306222DOI Listing
July 2015

Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma.

Biomed Rep 2015 Jul 13;3(4):443-446. Epub 2015 May 13.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, D-45122 Essen, Germany ; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Duesseldorf, D-45122 Essen, Germany ; German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany ; Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, D-45147 Essen, Germany ; Centre for Medical Biotechnology, University Duisburg-Essen, D-45147 Essen, Germany.

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http://dx.doi.org/10.3892/br.2015.463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486810PMC
July 2015

MiR-34a deficiency accelerates medulloblastoma formation in vivo.

Int J Cancer 2015 May 25;136(10):2293-303. Epub 2014 Nov 25.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Hufelandstr. 55 45147, Essen, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.29294DOI Listing
May 2015

IGF2BP1 harbors prognostic significance by gene gain and diverse expression in neuroblastoma.

J Clin Oncol 2015 Apr 9;33(11):1285-93. Epub 2015 Mar 9.

Jessica L. Bell, Raseswari Turlapati, and Stefan Hüttelmaier, Martin Luther University Halle-Wittenberg, Halle; Johannes H. Schulte, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, and University Children's Hospital Essen, Essen; Johannes H. Schulte, German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany; and Tao Liu, Children's Cancer Institute Australia for Medical Research and University of New South Wales, Randwick, New South Wales, Australia.

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http://dx.doi.org/10.1200/JCO.2014.55.9880DOI Listing
April 2015

Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation.

Sci Signal 2015 Apr 28;8(374):ra40. Epub 2015 Apr 28.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1126/scisignal.2005769DOI Listing
April 2015

miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin.

Int J Cancer 2015 Mar 5;136(6):1308-20. Epub 2014 Aug 5.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Germany.

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http://dx.doi.org/10.1002/ijc.29091DOI Listing
March 2015

Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells.

Oncotarget 2014 Nov;5(22):11180-92

Department of Pediatric Oncology and Hematology, University Children`s Hospital Essen, Essen, Germany. German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), Germany. Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294349PMC
http://dx.doi.org/10.18632/oncotarget.2611DOI Listing
November 2014

ALK pERKs up MYCN in neuroblastoma.

Sci Signal 2014 Oct 28;7(349):pe27. Epub 2014 Oct 28.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, 45122 Essen, Germany. German Cancer Consortium (DKTK), Partner Site Essen/Duesseldorf, 45122 Essen, Germany. Department of Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Hufelandstr.55, 45122 Essen, Germany. German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, 45122 Essen, Germany.

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http://dx.doi.org/10.1126/scisignal.2005940DOI Listing
October 2014

Early targets of miR-34a in neuroblastoma.

Mol Cell Proteomics 2014 Aug 9;13(8):2114-31. Epub 2014 Jun 9.

From the ‡Centro di Ingegneria Genetica e Biotecnologie Avanzate (CEINGE), 80145 Naples, Italy; §Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II, 80131 Naples, Italy; ‖‖Centro di Medicina Trasfusionale, Azienda Ospedaliera Federico II, 80131 Naples, Italy

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http://dx.doi.org/10.1074/mcp.M113.035808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125741PMC
August 2014

Long-term follow-up of pediatric patients receiving total body irradiation before hematopoietic stem cell transplantation and post-transplant survival of >2 years.

Pediatr Blood Cancer 2013 Nov 24;60(11):1792-7. Epub 2013 Jul 24.

Department of Pediatric Hematology-Oncology, Pediatrics III, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1002/pbc.24702DOI Listing
November 2013

Chemoreduction improves eye retention in patients with retinoblastoma: a report from the German Retinoblastoma Reference Centre.

Br J Ophthalmol 2013 Oct 17;97(10):1277-83. Epub 2013 Jul 17.

Department of Paediatric Oncology and Haematology, University Hospital Essen, , Essen, Germany.

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http://dx.doi.org/10.1136/bjophthalmol-2013-303452DOI Listing
October 2013

MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A.

Int J Cancer 2013 Sep 7;133(5):1064-73. Epub 2013 Mar 7.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1002/ijc.28091DOI Listing
September 2013

Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells.

Int J Cancer 2013 Aug 16;133(4):908-19. Epub 2013 Mar 16.

Department of Pediatric Oncology and Hematology, University Hospital Essen, Germany.

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http://doi.wiley.com/10.1002/ijc.28096
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http://dx.doi.org/10.1002/ijc.28096DOI Listing
August 2013

Identifying transcriptional miRNA biomarkers by integrating high-throughput sequencing and real-time PCR data.

Methods 2013 Jan 23;59(1):154-63. Epub 2012 Oct 23.

Bioinformatics, Computer Science XI, TU Dortmund, Germany; Collaborative Research Center (SFB) 876, TU Dortmund, Germany.

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http://dx.doi.org/10.1016/j.ymeth.2012.10.005DOI Listing
January 2013

Polo-like kinase 1 is a therapeutic target in high-risk neuroblastoma.

Clin Cancer Res 2011 Feb 17;17(4):731-41. Epub 2010 Dec 17.

Children's Hospital, Department of Pediatric Oncology and Hematology and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-10-1129DOI Listing
February 2011

A small kiss of death for cancer.

Nat Med 2010 Oct;16(10):1079-81

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http://dx.doi.org/10.1038/nm1010-1079DOI Listing
October 2010

Reanalysis of neuroblastoma expression profiling data using improved methodology and extended follow-up increases validity of outcome prediction.

Cancer Lett 2009 Sep 5;282(1):55-62. Epub 2009 Apr 5.

Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Hufelandstrasse 55, Essen, Germany.

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http://dx.doi.org/10.1016/j.canlet.2009.02.052DOI Listing
September 2009

MicroRNAs in the pathogenesis of neuroblastoma.

Cancer Lett 2009 Feb 17;274(1):10-5. Epub 2008 Jul 17.

Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany.

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http://dx.doi.org/10.1016/j.canlet.2008.06.010DOI Listing
February 2009

Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells.

Cancer Lett 2008 Nov 11;271(1):56-63. Epub 2008 Jul 11.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1016/j.canlet.2008.05.039DOI Listing
November 2008

Translating expression profiling into a clinically feasible test to predict neuroblastoma outcome.

Clin Cancer Res 2007 Mar;13(5):1459-65

Division of Hematology and Oncology, University Children's Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2032DOI Listing
March 2007