Johannes Betge

Multi-omics integration identifies a selective vulnerability of colorectal cancer subtypes to YM155.

Authors:

Tianzuo Zhan Verena Faehling Benedikt Rauscher Johannes Betge Matthias P Ebert Michael Boutros

Int J Cancer 2020 Nov 13. Epub 2020 Nov 13.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg University, Heidelberg, Germany.

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November 2020

Cancer-Associated Mutations in Normal Colorectal Mucosa Adjacent to Sporadic Neoplasia.

Authors:

Tianzuo Zhan Sebastian Belle Erica Valentini Simon Herrmann Thilo Miersch Moying Li Timo Gaiser Michael Boutros Matthias P Ebert Johannes Betge

Clin Transl Gastroenterol 2020 Jul;11(7):e00212

1Department Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 2German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; 3Central Interdisciplinary Endoscopy (ZIE), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 4Institute of Pathology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 5German Cancer Consortium (DKTK), Heidelberg, Germany.

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July 2020

Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer.

Sci Rep 2020 06 17;10(1):9778. Epub 2020 Jun 17.

Centre for Systems Medicine and Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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June 2020

Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma.

Authors:

Philip Weidner Michaela Söhn Torsten Schroeder Laura Helm Veronika Hauber Tobias Gutting Johannes Betge Christoph Röcken Florian N Rohrbacher Vijaya R Pattabiraman Jeffrey W Bode Rony Seger Daniel Saar Ariane Nunes-Alves Rebecca C Wade Matthias P A Ebert Elke Burgermeister

Oncogenesis 2020 Jun 10;9(6):59. Epub 2020 Jun 10.

Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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June 2020

Complete Remission of Metastatic HER2+ Oesophagogastric Junctional Adenocarcinoma under long-term Trastuzumab Treatment.

Authors:

Tobias Gutting Nadine Schulte Sebastian Belle Johannes Betge Nicolai Härtel Jürgen Wilke Jürgen Weers Matthias P Ebert Tianzuo Zhan

J Gastrointestin Liver Dis 2019 Dec 9;28(4):503-507. Epub 2019 Dec 9.

Department of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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December 2019

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A.

Authors:

Elke Burgermeister Francesca Battaglin Fagr Eladly Wen Wu Frank Herweck Nadine Schulte Johannes Betge Nicolai Härtel Jakob N Kather Cleo-Aron Weis Timo Gaiser Alexander Marx Christel Weiss Ralf Hofheinz Ian S Miller Fotios Loupakis Heinz-Josef Lenz Annette T Byrne Matthias P Ebert

EBioMedicine 2019 Jul 9;45:139-154. Epub 2019 Jul 9.

Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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July 2019

Detection of mutational patterns in cell-free DNA of colorectal cancer by custom amplicon sequencing.

Authors:

Simon Herrmann Tianzuo Zhan Johannes Betge Benedikt Rauscher Sebastian Belle Tobias Gutting Nadine Schulte Ralf Jesenofsky Nicolai Härtel Timo Gaiser Ralf-Dieter Hofheinz Matthias P Ebert Michael Boutros

Mol Oncol 2019 08 19;13(8):1669-1683. Epub 2019 Jul 19.

Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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August 2019

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer.

Authors:

Tianzuo Zhan Giulia Ambrosi Anna Maxi Wandmacher Benedikt Rauscher Johannes Betge Niklas Rindtorff Ragna S Häussler Isabel Hinsenkamp Leonhard Bamberg Bernd Hessling Karin Müller-Decker Gerrit Erdmann Elke Burgermeister Matthias P Ebert Michael Boutros

Nat Commun 2019 05 16;10(1):2197. Epub 2019 May 16.

Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, 69120, Heidelberg, Germany.

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May 2019

A multicenter open-label phase II trial to evaluate nivolumab and ipilimumab for 2nd line therapy in elderly patients with advanced esophageal squamous cell cancer (RAMONA).

Authors:

Nadja M Meindl-Beinker Johannes Betge Tobias Gutting Elke Burgermeister Sebastian Belle Tianzuo Zhan Nadine Schulte Martin Maenz Matthias P Ebert Nicolai Haertel

BMC Cancer 2019 Mar 14;19(1):231. Epub 2019 Mar 14.

Department of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

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March 2019

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy.

Nat Commun 2018 10 5;9(1):4112. Epub 2018 Oct 5.

Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D2, Ireland.

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October 2018

A multicenter phase 4 geriatric assessment directed trial to evaluate gemcitabine +/- nab-paclitaxel in elderly pancreatic cancer patients (GrantPax).

Authors:

Johannes Betge Jing Chi-Kern Nadine Schulte Sebastian Belle Tobias Gutting Elke Burgermeister Ralf Jesenofsky Martin Maenz Ulrich Wedding Matthias P Ebert Nicolai Haertel

BMC Cancer 2018 Jul 18;18(1):747. Epub 2018 Jul 18.

Department of Medicine II, Medical Faculty Mannheim, University Hospital Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

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July 2018

Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab.

J Clin Oncol 2018 07 24;36(20):2052-2060. Epub 2018 May 24.

Erik van Dijk, Hedde D. Biesma, Martijn Cordes, Maarten Neerincx, Paul P. Eijk, Henk M.W. Verheul, Nicole C.T. van Grieken, and Bauke Ylstra, Vrije Universiteit Medical Center; Gerrit A. Meijer, Netherlands Cancer Institute; Cornelis J.A. Punt, Academic Medical Center, Amsterdam; Miriam Koopman, University Medical Center Utrecht, Utrecht, the Netherlands; Dominiek Smeets and Diether Lambrechts, KU Leuven, Leuven, Belgium; Sudipto Das, Orna Bacon, Jochen H.M. Prehn, Bryan T. Hennessey, Darran P. O'Connor, and Annette T. Byrne, Royal College of Surgeons in Ireland; Verena Murphy, Cancer Trials Ireland; Anna Barat, Deborah A. McNamara, and Elaine W. Kay, Beaumont Hospital; Bozena Fender and William M. Gallagher, OncoMark Ltd; Rut Klinger and William M. Gallagher, University College Dublin, Dublin, United Kingdom; Johannes Betge, Timo Gaiser, and Matthias P.A. Ebert, University Hospital Mannheim, Mannheim, Germany; and Fotios Loupakis, Veneto Institute of Oncology IOV-IRCCS Padua, Italy.

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July 2018

CRISPR/Cas9 for cancer research and therapy.

Authors:

Tianzuo Zhan Niklas Rindtorff Johannes Betge Matthias P Ebert Michael Boutros

Semin Cancer Biol 2019 04 16;55:106-119. Epub 2018 Apr 16.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, and Heidelberg University, Department Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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April 2019

Epigenetic silencing of tumor suppressor candidate 3 confers adverse prognosis in early colorectal cancer.

Oncotarget 2017 Oct 15;8(49):84714-84728. Epub 2017 Sep 15.

Department of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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October 2017

Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer.

Oncotarget 2017 Jun;8(26):42949-42961

SomantiX BV, Utrecht, The Netherlands.

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June 2017

Tumor size, tumor location, and antitumor inflammatory response are associated with lymph node size in colorectal cancer patients.

Authors:

Ortrun Rössler Johannes Betge Lars Harbaum Karl Mrak Jörg Tschmelitsch Cord Langner

Mod Pathol 2017 06 24;30(6):897-904. Epub 2017 Feb 24.

Institute of Pathology, Medical University of Graz, Graz, Austria.

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June 2017

Lymph node retrieval in colorectal cancer: determining factors and prognostic significance.

Authors:

Johannes Betge Lars Harbaum Marion J Pollheimer Richard A Lindtner Peter Kornprat Matthias P Ebert Cord Langner

Int J Colorectal Dis 2017 Jul 16;32(7):991-998. Epub 2017 Feb 16.

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria.

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July 2017

Multiple behavioral factors are associated with occurrence of large, flat colorectal polyps.

Authors:

Tianzuo Zhan Felix Hahn Thomas Hielscher Asmé Bilge Jürgen Grüger Jürgen Weers Johannes Betge Timo Gaiser Georg Kähler Matthias P Ebert Sebastian Belle

Int J Colorectal Dis 2017 Apr 28;32(4):575-582. Epub 2016 Nov 28.

Department of Internal Medicine II, Medical Faculty Mannheim, Heidelberg University, Universitätsmedizin Mannheim, Theodor-Kutzer Ufer 1-3, D-68167, Mannheim, Germany.

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April 2017