Johannes Attems

Johannes Attems

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Johannes Attems

Publications by authors named "Johannes Attems"

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Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls.

Acta Neuropathol 2019 Nov 28. Epub 2019 Nov 28.

Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, N2 4HH, UK.

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http://dx.doi.org/10.1007/s00401-019-02105-wDOI Listing
November 2019

Discovery of autism/intellectual disability somatic mutations in Alzheimer's brains: mutated ADNP cytoskeletal impairments and repair as a case study.

Mol Psychiatry 2019 Oct 30. Epub 2019 Oct 30.

The First Lily and Avraham Gildor Chair for the Investigation of Growth Factors; The Elton Laboratory for Neuroendocrinology; Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neuroscience and Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv, 69978, Israel.

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http://dx.doi.org/10.1038/s41380-019-0563-5DOI Listing
October 2019

Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies - current issues and future directions.

J Neurochem 2019 Sep 23;150(5):467-474. Epub 2019 Apr 23.

Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1111/jnc.14698DOI Listing
September 2019

Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders.

Brain Pathol 2019 07 29;29(4):544-557. Epub 2019 Jan 29.

NIHR Biomedical Research Centre Newcastle, Biomedical Research Building, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/bpa.12697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767514PMC
July 2019

Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.

Cell Rep 2019 Jul;28(1):65-77.e6

Department of Experimental Neurodegeneration, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center, Waldweg 33, Göttingen 37073, Germany; Institute of Neuroscience, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK; Max Planck Institute of Experimental Medicine, Hermann Rein Street 3, Göttingen 37075, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.009DOI Listing
July 2019

Neurodegenerative Diseases and Ageing.

Subcell Biochem 2019;91:75-106

Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/978-981-13-3681-2_4DOI Listing
June 2019

Neuropathological Changes in Dementia With Lewy Bodies and the Cingulate Island Sign.

J Neuropathol Exp Neurol 2019 May 24. Epub 2019 May 24.

NIHR Biomedical Research Centre Newcastle, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/jnen/nlz047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640897PMC
May 2019

Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration.

BMJ Case Rep 2019 Mar 7;12(3). Epub 2019 Mar 7.

Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.

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http://dx.doi.org/10.1136/bcr-2018-228305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424260PMC
March 2019

Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.

Brain Pathol 2019 01 17;29(1):63-74. Epub 2018 Oct 17.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore.

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http://dx.doi.org/10.1111/bpa.12631DOI Listing
January 2019

A new visual rating scale for Ioflupane imaging in Lewy body disease.

Neuroimage Clin 2018 20;20:823-829. Epub 2018 Sep 20.

Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom.

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http://dx.doi.org/10.1016/j.nicl.2018.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169248PMC
January 2019

Dementia with Lewy bodies: an update and outlook.

Mol Neurodegener 2019 01 21;14(1). Epub 2019 Jan 21.

Institute of Neuroscience, The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1186/s13024-019-0306-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341685PMC
January 2019

Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease.

Alzheimers Dement 2018 12 13;14(12):1632-1639. Epub 2018 Aug 13.

Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jalz.2018.06.3056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544509PMC
December 2018

Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study.

Dement Geriatr Cogn Disord 2017 27;44(5-6):283-293. Epub 2018 Jan 27.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1159/000484437DOI Listing
September 2018

Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?

Alzheimers Dement 2018 08 7;14(8):1022-1037. Epub 2018 Apr 7.

Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.02.017DOI Listing
August 2018

Neuropathology and biochemistry of early onset familial Alzheimer's disease caused by presenilin-1 missense mutation Thr116Asn.

J Neural Transm (Vienna) 2018 06 5;125(6):965-976. Epub 2018 Feb 5.

Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1007/s00702-018-1850-zDOI Listing
June 2018

Improving the identification of dementia with Lewy bodies in the context of an Alzheimer's-type dementia.

Alzheimers Res Ther 2018 03 1;10(1):27. Epub 2018 Mar 1.

Institute of Neuroscience, Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1186/s13195-018-0356-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831205PMC
March 2018

Proteomics for synaptic markers of cognitive decline in neurodegenerative diseases.

Brain 2018 02;141(2):329-331

Institute of Clinical Neurobiology, Vienna, Austria.

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http://dx.doi.org/10.1093/brain/awx360DOI Listing
February 2018

Regional levels of physiological α-synuclein are directly associated with Lewy body pathology.

Acta Neuropathol 2018 01 13;135(1):153-154. Epub 2017 Nov 13.

Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1007/s00401-017-1787-6DOI Listing
January 2018

Interactions of pathological proteins in neurodegenerative diseases.

Acta Neuropathol 2017 08 11;134(2):187-205. Epub 2017 Apr 11.

Departement Neurowetenschappen, Katholieke Universiteit Leuven, Herestraat 49, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00401-017-1709-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508034PMC
August 2017

The multi-morbid old brain.

Authors:
Johannes Attems

Acta Neuropathol 2017 08;134(2):169-170

Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1007/s00401-017-1723-9DOI Listing
August 2017

TDP-43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing.

Brain Pathol 2017 07 24;27(4):472-479. Epub 2016 Aug 24.

Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.

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http://dx.doi.org/10.1111/bpa.12424DOI Listing
July 2017

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

J Neuropathol Exp Neurol 2017 Jul;76(7):605-619

Institute of Neurology, Medical University of Vienna, Vienna, Austria; Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania; and Department of Biostatistics and Epidemiology; and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida; Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois; Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland; University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California; Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France; Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain; Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia; Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain; Department of Medicine, Imperial College London, London, UK; IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California; Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil; Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuropathology, John Radcliffe Hospital, Oxford, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland; Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic; Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic; Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia; Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky; Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil; Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil; Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan; Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Neuroscience, Katholieke Universiteit-Leuven; and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium; Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK; and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1093/jnen/nlx041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251511PMC
July 2017

Neuronal Loss and Α-Synuclein Pathology in the Superior Colliculus and Its Relationship to Visual Hallucinations in Dementia with Lewy Bodies.

Am J Geriatr Psychiatry 2017 Jun 10;25(6):595-604. Epub 2017 Jan 10.

Ageing Research Laboratories, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10647481173000
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http://dx.doi.org/10.1016/j.jagp.2017.01.005DOI Listing
June 2017

Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts.

J Neural Transm (Vienna) 2017 06 6;124(6):671-683. Epub 2017 Mar 6.

Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1007/s00702-017-1702-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446847PMC
June 2017

Common Impact of Chronic Kidney Disease and Brain Microhemorrhages on Cerebral Aβ Pathology in SHRSP.

Brain Pathol 2017 03 30;27(2):169-180. Epub 2016 May 30.

German Center for Neurodegenerative Diseases (DZNE), Leipziger Strasse 44, Magdeburg, 39120, Germany.

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http://dx.doi.org/10.1111/bpa.12384DOI Listing
March 2017

Specific patterns of neuronal loss in the pulvinar nucleus in dementia with lewy bodies.

Mov Disord 2017 03 6;32(3):414-422. Epub 2017 Jan 6.

Institute of Neuroscience, Ageing Research Laboratories, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.

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http://doi.wiley.com/10.1002/mds.26887
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http://dx.doi.org/10.1002/mds.26887DOI Listing
March 2017

Reply: Atherosclerosis and vascular cognitive impairment neuropathological guideline.

Brain 2017 02 21;140(2):e13. Epub 2016 Dec 21.

Dementia Research Group, School of Clinical Sciences, Faculty of Health Sciences, University of Bristol, Level 1, Learning & Research, Southmead Hospital, Bristol, BS10 5NB, UK

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http://dx.doi.org/10.1093/brain/aww305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841058PMC
February 2017

Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

Neurology 2017 Jan 9;88(3):276-283. Epub 2016 Dec 9.

From the Institute of Neuroscience (A.J.T., J.A., S.J.C., I.M., D.B., D.J.L.), Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne; Department of Psychiatry (J.T.O.), University of Cambridge School of Clinical Medicine; Department of Neurology (R.W.), Barts Health NHS Trust, Royal London Hospital; North Essex Partnership University NHS Foundation Trust (L.L., Z.W.), Epping; and Division of Psychiatry (Z.W.), University College London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000003512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272795PMC
January 2017

Alzheimer's disease pathology in synucleinopathies.

Authors:
Johannes Attems

Lancet Neurol 2017 01;16(1):22-23

Institute of Neuroscience, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(16)30282-4DOI Listing
January 2017

Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.

Alzheimers Dement 2016 11 22;12(11):1149-1158. Epub 2016 May 22.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2016.04.005DOI Listing
November 2016

Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment.

Brain 2016 11;139(11):2957-2969

Dementia Research Group, School of Clinical Sciences, Faculty of Health Sciences, University of Bristol, Learning and Research Level 1, Southmead Hospital, Bristol, BS10 5NB, UK.

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http://dx.doi.org/10.1093/brain/aww214DOI Listing
November 2016

Extended post-mortem delay times should not be viewed as a deterrent to the scientific investigation of human brain tissue: a study from the Brains for Dementia Research Network Neuropathology Study Group, UK.

Acta Neuropathol 2016 11 15;132(5):753-755. Epub 2016 Sep 15.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Salford Royal Hospital, University of Manchester, Salford, Manchester, M6 8HD, UK.

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http://dx.doi.org/10.1007/s00401-016-1617-2DOI Listing
November 2016

Is the time ripe for new diagnostic criteria of cognitive impairment due to cerebrovascular disease? Consensus report of the International Congress on Vascular Dementia working group.

BMC Med 2016 Nov 3;14(1):162. Epub 2016 Nov 3.

Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology and Medicine, Charing Cross Hospital, St Dunstan's Road, W6 8RP, London, UK.

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http://dx.doi.org/10.1186/s12916-016-0719-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093932PMC
November 2016

Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia.

J Alzheimers Dis 2016 ;50(1):101-10

Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.3233/JAD-150707DOI Listing
October 2016

The Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells.

J Diabetes Res 2016 28;2016:1964634. Epub 2015 Dec 28.

Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.1155/2016/1964634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707345PMC
October 2016

Anatomic Connections of the Subgenual Cingulate Region.

Neurosurgery 2016 Sep;79(3):465-72

*Department of Neurosurgery, King's College Hospital, London, United Kingdom; ‡Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom; §Department of Neurological Surgery, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain; ¶Natbrainlab, Department of Neuroimaging, Institute of Psychiatry, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1227/NEU.0000000000001315DOI Listing
September 2016

Olfaction and Aging: A Mini-Review.

Gerontology 2015 9;61(6):485-90. Epub 2015 May 9.

Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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https://www.karger.com/Article/FullText/381619
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http://dx.doi.org/10.1159/000381619DOI Listing
August 2016

Unfolded protein response is activated in Lewy body dementias.

Neuropathol Appl Neurobiol 2016 06 17;42(4):352-65. Epub 2015 Aug 17.

Department of Neurobiology, Care Sciences and Society, Division for Neurogeriatrics, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1111/nan.12260DOI Listing
June 2016

Dementia in Parkinson's disease is associated with enhanced mitochondrial complex I deficiency.

Mov Disord 2016 Mar 8;31(3):352-9. Epub 2016 Feb 8.

Wolfson Center for Age-Related Diseases, King's College London, Guy's Campus, London, United Kingdom.

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http://dx.doi.org/10.1002/mds.26513DOI Listing
March 2016

An isoform-specific role of FynT tyrosine kinase in Alzheimer's disease.

J Neurochem 2016 Feb 10;136(3):637-50. Epub 2015 Dec 10.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore.

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http://dx.doi.org/10.1111/jnc.13429DOI Listing
February 2016

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Acta Neuropathol 2016 Jan 10;131(1):87-102. Epub 2015 Dec 10.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-015-1509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879001PMC
January 2016

Facial Onset Sensory and Motor Neuronopathy: Further Evidence for a TDP-43 Proteinopathy.

Case Rep Neurol 2015 Jan-Apr;7(1):95-100. Epub 2015 Apr 23.

Department of Neurology, Walton Centre NHS Foundation Trust, Liverpool, UK.

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https://www.karger.com/Article/FullText/381944
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http://dx.doi.org/10.1159/000381944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448067PMC
September 2015

Cortical tau load is associated with white matter hyperintensities.

Acta Neuropathol Commun 2015 Sep 30;3:60. Epub 2015 Sep 30.

Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1186/s40478-015-0240-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589169PMC
September 2015

Frontotemporal lobar degeneration FTLD-tau: preclinical lesions, vascular, and Alzheimer-related co-pathologies.

J Neural Transm (Vienna) 2015 Jul 4;122(7):1007-18. Epub 2015 Jan 4.

Laboratory of Neuropathology, Institute of Pathology, Center for Clinical Research, Ulm University, Ulm, Germany,

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http://dx.doi.org/10.1007/s00702-014-1360-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6655426PMC
July 2015

Spreading of amyloid, tau, and microvascular pathology in Alzheimer's disease: findings from neuropathological and neuroimaging studies.

J Alzheimers Dis 2014 ;42 Suppl 4:S421-9

Michael Ewers, Institute for Stroke and Dementia Research, Clinic of the University of Munich, Ludwig Maximilian University Munich, Munich, Germany.

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http://dx.doi.org/10.3233/JAD-141461DOI Listing
June 2015

Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes.

Acta Neuropathol 2015 May 11;129(5):729-48. Epub 2015 Mar 11.

Institute of Neuroscience and Institute for Ageing, Newcastle University, Campus for Ageing and Vitality, NE4 5PL, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s00401-015-1406-3DOI Listing
May 2015

Stage-specific changes in neurogenic and glial markers in Alzheimer's disease.

Biol Psychiatry 2015 Apr 9;77(8):711-9. Epub 2014 Jun 9.

Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2014.05.021DOI Listing
April 2015

Challenges of multimorbidity of the aging brain: a critical update.

J Neural Transm (Vienna) 2015 Apr 5;122(4):505-21. Epub 2014 Aug 5.

Institute of Clinical Neurobiology, Kenyongasse 18, 1070, Vienna, Austria,

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http://dx.doi.org/10.1007/s00702-014-1288-xDOI Listing
April 2015

Spreading pathologies precede cognitive decline in Alzheimer's disease.

Biol Psychiatry 2015 Apr;77(8):678-9

Wolfson Centre for Age-Related Diseases, King's College London, London.

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http://dx.doi.org/10.1016/j.biopsych.2015.02.001DOI Listing
April 2015

Clinicians' ability to diagnose dementia with Lewy bodies is not affected by β-amyloid load.

Neurology 2015 Feb 31;84(5):496-9. Epub 2014 Dec 31.

From the Division of Neurology V and Neuropathology (P.T.), IRCCS Foundation, Carlo Besta Neurologic Institute, Milan, Italy; Institute for Aging and Health (J.A., A.T., A.B., E.J., D.J.L., R.H.P., L.R., L.W., I.G.M.), Wolfson Research Center, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, UK; and Division of Neurology and Neurophysiology (M.O.), Azienda Ospedaliera di Busto Arsizio, Presidio di Tradate, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000001204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336072PMC
February 2015

The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.

J Neurosci 2015 Jan;35(4):1659-74

Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Institute for Cell and Molecular Bioscience, and

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http://dx.doi.org/10.1523/JNEUROSCI.2925-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308607PMC
January 2015

White matter connections of the supplementary motor area in humans.

J Neurol Neurosurg Psychiatry 2014 Dec 16;85(12):1377-85. Epub 2014 Apr 16.

Natbrainlab, Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, Institute of Psychiatry, London, UK.

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http://dx.doi.org/10.1136/jnnp-2013-307492DOI Listing
December 2014

Quantitative neuropathological assessment to investigate cerebral multi-morbidity.

Alzheimers Res Ther 2014 28;6(9):85. Epub 2014 Nov 28.

Department of Pathology, Division of Neuropathology, University of Kentucky, 800 Limestone Street, Lexington, KY 40536-0230 USA.

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http://dx.doi.org/10.1186/s13195-014-0085-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247208PMC
December 2014

A platelet protein biochip rapidly detects an Alzheimer's disease-specific phenotype.

Acta Neuropathol 2014 Nov 24;128(5):665-77. Epub 2014 Sep 24.

Center of Physiology and Pharmacology, Institute of Physiology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s00401-014-1341-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201753PMC
November 2014

The overlap between vascular disease and Alzheimer's disease--lessons from pathology.

BMC Med 2014 Nov 11;12:206. Epub 2014 Nov 11.

Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1186/s12916-014-0206-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226890PMC
November 2014

High-level ERBB2 gene amplification is associated with a particularly short time-to-metastasis, but results in a high rate of complete response once trastuzumab-based therapy is offered in the metastatic setting.

Int J Cancer 2014 Jul 28;135(1):224-31. Epub 2014 Jan 28.

Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria; Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/ijc.28660DOI Listing
July 2014

Frontotemporal dementia and its subtypes: a genome-wide association study.

Authors:
Raffaele Ferrari Dena G Hernandez Michael A Nalls Jonathan D Rohrer Adaikalavan Ramasamy John B J Kwok Carol Dobson-Stone William S Brooks Peter R Schofield Glenda M Halliday John R Hodges Olivier Piguet Lauren Bartley Elizabeth Thompson Eric Haan Isabel Hernández Agustín Ruiz Mercè Boada Barbara Borroni Alessandro Padovani Carlos Cruchaga Nigel J Cairns Luisa Benussi Giuliano Binetti Roberta Ghidoni Gianluigi Forloni Daniela Galimberti Chiara Fenoglio Maria Serpente Elio Scarpini Jordi Clarimón Alberto Lleó Rafael Blesa Maria Landqvist Waldö Karin Nilsson Christer Nilsson Ian R A Mackenzie Ging-Yuek R Hsiung David M A Mann Jordan Grafman Christopher M Morris Johannes Attems Timothy D Griffiths Ian G McKeith Alan J Thomas P Pietrini Edward D Huey Eric M Wassermann Atik Baborie Evelyn Jaros Michael C Tierney Pau Pastor Cristina Razquin Sara Ortega-Cubero Elena Alonso Robert Perneczky Janine Diehl-Schmid Panagiotis Alexopoulos Alexander Kurz Innocenzo Rainero Elisa Rubino Lorenzo Pinessi Ekaterina Rogaeva Peter St George-Hyslop Giacomina Rossi Fabrizio Tagliavini Giorgio Giaccone James B Rowe Johannes C M Schlachetzki James Uphill John Collinge Simon Mead Adrian Danek Vivianna M Van Deerlin Murray Grossman John Q Trojanowski Julie van der Zee William Deschamps Tim Van Langenhove Marc Cruts Christine Van Broeckhoven Stefano F Cappa Isabelle Le Ber Didier Hannequin Véronique Golfier Martine Vercelletto Alexis Brice Benedetta Nacmias Sandro Sorbi Silvia Bagnoli Irene Piaceri Jørgen E Nielsen Lena E Hjermind Matthias Riemenschneider Manuel Mayhaus Bernd Ibach Gilles Gasparoni Sabrina Pichler Wei Gu Martin N Rossor Nick C Fox Jason D Warren Maria Grazia Spillantini Huw R Morris Patrizia Rizzu Peter Heutink Julie S Snowden Sara Rollinson Anna Richardson Alexander Gerhard Amalia C Bruni Raffaele Maletta Francesca Frangipane Chiara Cupidi Livia Bernardi Maria Anfossi Maura Gallo Maria Elena Conidi Nicoletta Smirne Rosa Rademakers Matt Baker Dennis W Dickson Neill R Graff-Radford Ronald C Petersen David Knopman Keith A Josephs Bradley F Boeve Joseph E Parisi William W Seeley Bruce L Miller Anna M Karydas Howard Rosen John C van Swieten Elise G P Dopper Harro Seelaar Yolande A L Pijnenburg Philip Scheltens Giancarlo Logroscino Rosa Capozzo Valeria Novelli Annibale A Puca Massimo Franceschi Alfredo Postiglione Graziella Milan Paolo Sorrentino Mark Kristiansen Huei-Hsin Chiang Caroline Graff Florence Pasquier Adeline Rollin Vincent Deramecourt Florence Lebert Dimitrios Kapogiannis Luigi Ferrucci Stuart Pickering-Brown Andrew B Singleton John Hardy Parastoo Momeni

Lancet Neurol 2014 Jul;13(7):686-99

Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, Texas, USA.

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http://dx.doi.org/10.1016/S1474-4422(14)70065-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112126PMC
July 2014

Olfactory bulb involvement in neurodegenerative diseases.

Acta Neuropathol 2014 Apr 20;127(4):459-75. Epub 2014 Feb 20.

Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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April 2014

Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma.

Ann Clin Transl Neurol 2014 Feb 9;1(2):124-9. Epub 2014 Jan 9.

Department of Neurology, Otto-von-Guericke University Magdeburg, Germany ; German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Germany.

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http://dx.doi.org/10.1002/acn3.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212487PMC
February 2014

Amyloid and tau: neither chicken nor egg but two partners in crime!

Acta Neuropathol 2013 Oct 18;126(4):619-21. Epub 2013 Aug 18.

Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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http://link.springer.com/10.1007/s00401-013-1167-9
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October 2013