Johanne Tremblay

Johanne Tremblay

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Johanne Tremblay

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A catalog of genetic loci associated with kidney function from analyses of a million individuals.

Authors:
Matthias Wuttke Yong Li Man Li Karsten B Sieber Mary F Feitosa Mathias Gorski Adrienne Tin Lihua Wang Audrey Y Chu Anselm Hoppmann Holger Kirsten Ayush Giri Jin-Fang Chai Gardar Sveinbjornsson Bamidele O Tayo Teresa Nutile Christian Fuchsberger Jonathan Marten Massimiliano Cocca Sahar Ghasemi Yizhe Xu Katrin Horn Damia Noce Peter J van der Most Sanaz Sedaghat Zhi Yu Masato Akiyama Saima Afaq Tarunveer S Ahluwalia Peter Almgren Najaf Amin Johan Ärnlöv Stephan J L Bakker Nisha Bansal Daniela Baptista Sven Bergmann Mary L Biggs Ginevra Biino Michael Boehnke Eric Boerwinkle Mathilde Boissel Erwin P Bottinger Thibaud S Boutin Hermann Brenner Marco Brumat Ralph Burkhardt Adam S Butterworth Eric Campana Archie Campbell Harry Campbell Mickaël Canouil Robert J Carroll Eulalia Catamo John C Chambers Miao-Ling Chee Miao-Li Chee Xu Chen Ching-Yu Cheng Yurong Cheng Kaare Christensen Renata Cifkova Marina Ciullo Maria Pina Concas James P Cook Josef Coresh Tanguy Corre Cinzia Felicita Sala Daniele Cusi John Danesh E Warwick Daw Martin H de Borst Alessandro De Grandi Renée de Mutsert Aiko P J de Vries Frauke Degenhardt Graciela Delgado Ayse Demirkan Emanuele Di Angelantonio Katalin Dittrich Jasmin Divers Rajkumar Dorajoo Kai-Uwe Eckardt Georg Ehret Paul Elliott Karlhans Endlich Michele K Evans Janine F Felix Valencia Hui Xian Foo Oscar H Franco Andre Franke Barry I Freedman Sandra Freitag-Wolf Yechiel Friedlander Philippe Froguel Ron T Gansevoort He Gao Paolo Gasparini J Michael Gaziano Vilmantas Giedraitis Christian Gieger Giorgia Girotto Franco Giulianini Martin Gögele Scott D Gordon Daniel F Gudbjartsson Vilmundur Gudnason Toomas Haller Pavel Hamet Tamara B Harris Catharina A Hartman Caroline Hayward Jacklyn N Hellwege Chew-Kiat Heng Andrew A Hicks Edith Hofer Wei Huang Nina Hutri-Kähönen Shih-Jen Hwang M Arfan Ikram Olafur S Indridason Erik Ingelsson Marcus Ising Vincent W V Jaddoe Johanna Jakobsdottir Jost B Jonas Peter K Joshi Navya Shilpa Josyula Bettina Jung Mika Kähönen Yoichiro Kamatani Candace M Kammerer Masahiro Kanai Mika Kastarinen Shona M Kerr Chiea-Chuen Khor Wieland Kiess Marcus E Kleber Wolfgang Koenig Jaspal S Kooner Antje Körner Peter Kovacs Aldi T Kraja Alena Krajcoviechova Holly Kramer Bernhard K Krämer Florian Kronenberg Michiaki Kubo Brigitte Kühnel Mikko Kuokkanen Johanna Kuusisto Martina La Bianca Markku Laakso Leslie A Lange Carl D Langefeld Jeannette Jen-Mai Lee Benjamin Lehne Terho Lehtimäki Wolfgang Lieb Su-Chi Lim Lars Lind Cecilia M Lindgren Jun Liu Jianjun Liu Markus Loeffler Ruth J F Loos Susanne Lucae Mary Ann Lukas Leo-Pekka Lyytikäinen Reedik Mägi Patrik K E Magnusson Anubha Mahajan Nicholas G Martin Jade Martins Winfried März Deborah Mascalzoni Koichi Matsuda Christa Meisinger Thomas Meitinger Olle Melander Andres Metspalu Evgenia K Mikaelsdottir Yuri Milaneschi Kozeta Miliku Pashupati P Mishra Karen L Mohlke Nina Mononen Grant W Montgomery Dennis O Mook-Kanamori Josyf C Mychaleckyj Girish N Nadkarni Mike A Nalls Matthias Nauck Kjell Nikus Boting Ning Ilja M Nolte Raymond Noordam Jeffrey O'Connell Michelle L O'Donoghue Isleifur Olafsson Albertine J Oldehinkel Marju Orho-Melander Willem H Ouwehand Sandosh Padmanabhan Nicholette D Palmer Runolfur Palsson Brenda W J H Penninx Thomas Perls Markus Perola Mario Pirastu Nicola Pirastu Giorgio Pistis Anna I Podgornaia Ozren Polasek Belen Ponte David J Porteous Tanja Poulain Peter P Pramstaller Michael H Preuss Bram P Prins Michael A Province Ton J Rabelink Laura M Raffield Olli T Raitakari Dermot F Reilly Rainer Rettig Myriam Rheinberger Kenneth M Rice Paul M Ridker Fernando Rivadeneira Federica Rizzi David J Roberts Antonietta Robino Peter Rossing Igor Rudan Rico Rueedi Daniela Ruggiero Kathleen A Ryan Yasaman Saba Charumathi Sabanayagam Veikko Salomaa Erika Salvi Kai-Uwe Saum Helena Schmidt Reinhold Schmidt Ben Schöttker Christina-Alexandra Schulz Nicole Schupf Christian M Shaffer Yuan Shi Albert V Smith Blair H Smith Nicole Soranzo Cassandra N Spracklen Konstantin Strauch Heather M Stringham Michael Stumvoll Per O Svensson Silke Szymczak E-Shyong Tai Salman M Tajuddin Nicholas Y Q Tan Kent D Taylor Andrej Teren Yih-Chung Tham Joachim Thiery Chris H L Thio Hauke Thomsen Gudmar Thorleifsson Daniela Toniolo Anke Tönjes Johanne Tremblay Ioanna Tzoulaki André G Uitterlinden Simona Vaccargiu Rob M van Dam Pim van der Harst Cornelia M van Duijn Digna R Velez Edward Niek Verweij Suzanne Vogelezang Uwe Völker Peter Vollenweider Gerard Waeber Melanie Waldenberger Lars Wallentin Ya Xing Wang Chaolong Wang Dawn M Waterworth Wen Bin Wei Harvey White John B Whitfield Sarah H Wild James F Wilson Mary K Wojczynski Charlene Wong Tien-Yin Wong Liang Xu Qiong Yang Masayuki Yasuda Laura M Yerges-Armstrong Weihua Zhang Alan B Zonderman Jerome I Rotter Murielle Bochud Bruce M Psaty Veronique Vitart James G Wilson Abbas Dehghan Afshin Parsa Daniel I Chasman Kevin Ho Andrew P Morris Olivier Devuyst Shreeram Akilesh Sarah A Pendergrass Xueling Sim Carsten A Böger Yukinori Okada Todd L Edwards Harold Snieder Kari Stefansson Adriana M Hung Iris M Heid Markus Scholz Alexander Teumer Anna Köttgen Cristian Pattaro

Nat Genet 2019 06 31;51(6):957-972. Epub 2019 May 31.

Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.

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http://dx.doi.org/10.1038/s41588-019-0407-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698888PMC
June 2019

Artificial Intelligence and Machine Learning in Endocrinology and Metabolism: The Dawn of a New Era.

Front Endocrinol (Lausanne) 2019 28;10:185. Epub 2019 Mar 28.

Section on Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fendo.2019.00185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448412PMC
March 2019

COMMD5/HCaRG Hooks Endosomes on Cytoskeleton and Coordinates EGFR Trafficking.

Cell Rep 2018 Jul;24(3):670-684.e7

Centre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada; Département de Médecine, Université de Montréal, Montréal, QC H3T 1J4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.056DOI Listing
July 2018

HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma.

Oncotarget 2017 Sep 19;8(41):69559-69576. Epub 2017 May 19.

Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada, H2X 0A9.

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http://dx.doi.org/10.18632/oncotarget.18012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642500PMC
September 2017

PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study.

J Hypertens 2017 05;35 Suppl 1:S24-S32

aDepartment of Medicine, Gene Medicine Services bDepartment of Medicine cDepartment of Social and Preventive Medicine, Université de Montréal, CRCHUM dDepartment of Software Engineering and the Information Technology, École de Technologie Supérieure, Montreal, Quebec, Canada eThe George Institute for Global Health, University of Sydney, Sydney, New South Wales, Australia fHôpital Bichat, Claude Bernard, Université Paris 7, Paris, France gRoyal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1097/HJH.0000000000001241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377997PMC
May 2017

Artificial intelligence in medicine.

Metabolism 2017 Apr 11;69S:S36-S40. Epub 2017 Jan 11.

Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada, H2X 0A9; Department of Medicine, Université de Montréal, Montréal, Québec, Canada, H3T 3J7. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2017.01.011DOI Listing
April 2017

Foreword: From guest co-editors.

Metabolism 2017 04 11;69S:S2. Epub 2017 Jan 11.

Université de Montréal, Montréal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2017.01.016DOI Listing
April 2017

Response to Letter to the Editor entitled Oxidative Stress Participates in the Associations Between Serum Uric Acid and Albuminuria in Obesity.

Am J Hypertens 2017 03;30(3):e2-e3

Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic.

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http://dx.doi.org/10.1093/ajh/hpw198DOI Listing
March 2017

The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome.

Am J Hypertens 2016 12;29(12):1335-1342

Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague and Thomayer Hospital, Prague, Czech Republic.

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http://dx.doi.org/10.1093/ajh/hpw098DOI Listing
December 2016

Key Considerations and Methods in the Study of Gene-Environment Interactions.

Am J Hypertens 2016 08 1;29(8):891-9. Epub 2016 Apr 1.

CHUM Research Center, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1093/ajh/hpw021DOI Listing
August 2016

Estrogen and testosterone in concert with EFNB3 regulate vascular smooth muscle cell contractility and blood pressure.

Am J Physiol Heart Circ Physiol 2016 Apr 5;310(7):H861-72. Epub 2016 Feb 5.

Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada; Nephrology Service, CRCHUM, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1152/ajpheart.00873.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867358PMC
April 2016

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

Authors:
Alexander Teumer Adrienne Tin Rossella Sorice Mathias Gorski Nan Cher Yeo Audrey Y Chu Man Li Yong Li Vladan Mijatovic Yi-An Ko Daniel Taliun Alessandro Luciani Ming-Huei Chen Qiong Yang Meredith C Foster Matthias Olden Linda T Hiraki Bamidele O Tayo Christian Fuchsberger Aida Karina Dieffenbach Alan R Shuldiner Albert V Smith Allison M Zappa Antonio Lupo Barbara Kollerits Belen Ponte Bénédicte Stengel Bernhard K Krämer Bernhard Paulweber Braxton D Mitchell Caroline Hayward Catherine Helmer Christa Meisinger Christian Gieger Christian M Shaffer Christian Müller Claudia Langenberg Daniel Ackermann David Siscovick Eric Boerwinkle Florian Kronenberg Georg B Ehret Georg Homuth Gerard Waeber Gerjan Navis Giovanni Gambaro Giovanni Malerba Gudny Eiriksdottir Guo Li H Erich Wichmann Harald Grallert Henri Wallaschofski Henry Völzke Herrmann Brenner Holly Kramer I Mateo Leach Igor Rudan Hans L Hillege Jacques S Beckmann Jean Charles Lambert Jian'an Luan Jing Hua Zhao John Chalmers Josef Coresh Joshua C Denny Katja Butterbach Lenore J Launer Luigi Ferrucci Lyudmyla Kedenko Margot Haun Marie Metzger Mark Woodward Matthew J Hoffman Matthias Nauck Melanie Waldenberger Menno Pruijm Murielle Bochud Myriam Rheinberger Niek Verweij Nicholas J Wareham Nicole Endlich Nicole Soranzo Ozren Polasek Pim van der Harst Peter Paul Pramstaller Peter Vollenweider Philipp S Wild Ron T Gansevoort Rainer Rettig Reiner Biffar Robert J Carroll Ronit Katz Ruth J F Loos Shih-Jen Hwang Stefan Coassin Sven Bergmann Sylvia E Rosas Sylvia Stracke Tamara B Harris Tanguy Corre Tanja Zeller Thomas Illig Thor Aspelund Toshiko Tanaka Uwe Lendeckel Uwe Völker Vilmundur Gudnason Vincent Chouraki Wolfgang Koenig Zoltan Kutalik Jeffrey R O'Connell Afshin Parsa Iris M Heid Andrew D Paterson Ian H de Boer Olivier Devuyst Jozef Lazar Karlhans Endlich Katalin Susztak Johanne Tremblay Pavel Hamet Howard J Jacob Carsten A Böger Caroline S Fox Cristian Pattaro Anna Köttgen

Diabetes 2016 Mar 2;65(3):803-17. Epub 2015 Dec 2.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Renal Division, Medical Center, University of Freiburg, Freiburg, Germany

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http://diabetes.diabetesjournals.org/content/early/2015/11/2
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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db15
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http://dx.doi.org/10.2337/db15-1313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764151PMC
March 2016

ARMC5 mutations in a large French-Canadian family with cortisol-secreting β-adrenergic/vasopressin responsive bilateral macronodular adrenal hyperplasia.

Eur J Endocrinol 2016 Jan;174(1):85-96

Division of EndocrinologyDepartment of MedicineDivision of Medical GeneticsDepartment of Medicine, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, CanadaDepartment of PathologyCHUM, Montréal, Quebec, CanadaDepartment of PediatricsCentre de Recherche CHU Sainte-Justine, Université de Montréal, Montréal, Quebec, CanadaUnidade de SuprarrenalDisciplina de Endocrinologia e Metabologia, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil.

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http://dx.doi.org/10.1530/EJE-15-0642DOI Listing
January 2016

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Authors:
Cristian Pattaro Alexander Teumer Mathias Gorski Audrey Y Chu Man Li Vladan Mijatovic Maija Garnaas Adrienne Tin Rossella Sorice Yong Li Daniel Taliun Matthias Olden Meredith Foster Qiong Yang Ming-Huei Chen Tune H Pers Andrew D Johnson Yi-An Ko Christian Fuchsberger Bamidele Tayo Michael Nalls Mary F Feitosa Aaron Isaacs Abbas Dehghan Pio d'Adamo Adebowale Adeyemo Aida Karina Dieffenbach Alan B Zonderman Ilja M Nolte Peter J van der Most Alan F Wright Alan R Shuldiner Alanna C Morrison Albert Hofman Albert V Smith Albert W Dreisbach Andre Franke Andre G Uitterlinden Andres Metspalu Anke Tonjes Antonio Lupo Antonietta Robino Åsa Johansson Ayse Demirkan Barbara Kollerits Barry I Freedman Belen Ponte Ben A Oostra Bernhard Paulweber Bernhard K Krämer Braxton D Mitchell Brendan M Buckley Carmen A Peralta Caroline Hayward Catherine Helmer Charles N Rotimi Christian M Shaffer Christian Müller Cinzia Sala Cornelia M van Duijn Aude Saint-Pierre Daniel Ackermann Daniel Shriner Daniela Ruggiero Daniela Toniolo Yingchang Lu Daniele Cusi Darina Czamara David Ellinghaus David S Siscovick Douglas Ruderfer Christian Gieger Harald Grallert Elena Rochtchina Elizabeth J Atkinson Elizabeth G Holliday Eric Boerwinkle Erika Salvi Erwin P Bottinger Federico Murgia Fernando Rivadeneira Florian Ernst Florian Kronenberg Frank B Hu Gerjan J Navis Gary C Curhan George B Ehret Georg Homuth Stefan Coassin Gian-Andri Thun Giorgio Pistis Giovanni Gambaro Giovanni Malerba Grant W Montgomery Gudny Eiriksdottir Gunnar Jacobs Guo Li H-Erich Wichmann Harry Campbell Helena Schmidt Henri Wallaschofski Henry Völzke Hermann Brenner Heyo K Kroemer Holly Kramer Honghuang Lin I Mateo Leach Ian Ford Idris Guessous Igor Rudan Inga Prokopenko Ingrid Borecki Iris M Heid Ivana Kolcic Ivana Persico J Wouter Jukema James F Wilson Janine F Felix Jasmin Divers Jean-Charles Lambert Jeanette M Stafford Jean-Michel Gaspoz Jennifer A Smith Jessica D Faul Jie Jin Wang Jingzhong Ding Joel N Hirschhorn John Attia John B Whitfield John Chalmers Jorma Viikari Josef Coresh Joshua C Denny Juha Karjalainen Jyotika K Fernandes Karlhans Endlich Katja Butterbach Keith L Keene Kurt Lohman Laura Portas Lenore J Launer Leo-Pekka Lyytikäinen Loic Yengo Lude Franke Luigi Ferrucci Lynda M Rose Lyudmyla Kedenko Madhumathi Rao Maksim Struchalin Marcus E Kleber Margherita Cavalieri Margot Haun Marilyn C Cornelis Marina Ciullo Mario Pirastu Mariza de Andrade Mark A McEvoy Mark Woodward Martin Adam Massimiliano Cocca Matthias Nauck Medea Imboden Melanie Waldenberger Menno Pruijm Marie Metzger Michael Stumvoll Michele K Evans Michele M Sale Mika Kähönen Mladen Boban Murielle Bochud Myriam Rheinberger Niek Verweij Nabila Bouatia-Naji Nicholas G Martin Nick Hastie Nicole Probst-Hensch Nicole Soranzo Olivier Devuyst Olli Raitakari Omri Gottesman Oscar H Franco Ozren Polasek Paolo Gasparini Patricia B Munroe Paul M Ridker Paul Mitchell Paul Muntner Christa Meisinger Johannes H Smit Peter Kovacs Philipp S Wild Philippe Froguel Rainer Rettig Reedik Mägi Reiner Biffar Reinhold Schmidt Rita P S Middelberg Robert J Carroll Brenda W Penninx Rodney J Scott Ronit Katz Sanaz Sedaghat Sarah H Wild Sharon L R Kardia Sheila Ulivi Shih-Jen Hwang Stefan Enroth Stefan Kloiber Stella Trompet Benedicte Stengel Stephen J Hancock Stephen T Turner Sylvia E Rosas Sylvia Stracke Tamara B Harris Tanja Zeller Tatijana Zemunik Terho Lehtimäki Thomas Illig Thor Aspelund Tiit Nikopensius Tonu Esko Toshiko Tanaka Ulf Gyllensten Uwe Völker Valur Emilsson Veronique Vitart Ville Aalto Vilmundur Gudnason Vincent Chouraki Wei-Min Chen Wilmar Igl Winfried März Wolfgang Koenig Wolfgang Lieb Ruth J F Loos Yongmei Liu Harold Snieder Peter P Pramstaller Afshin Parsa Jeffrey R O'Connell Katalin Susztak Pavel Hamet Johanne Tremblay Ian H de Boer Carsten A Böger Wolfram Goessling Daniel I Chasman Anna Köttgen W H Linda Kao Caroline S Fox

Nat Commun 2016 Jan 21;7:10023. Epub 2016 Jan 21.

NHLBI's Framingham Heart Study and the Center for Population Studies, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.

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http://dx.doi.org/10.1038/ncomms10023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735748PMC
January 2016

Endothelial Gata5 transcription factor regulates blood pressure.

Nat Commun 2015 Nov 30;6:8835. Epub 2015 Nov 30.

Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H8M5.

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http://dx.doi.org/10.1038/ncomms9835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696516PMC
November 2015

Genomic determinants of triglyceride and cholesterol distribution into lipoprotein fractions in the rat.

PLoS One 2014 8;9(10):e109983. Epub 2014 Oct 8.

Institute of Biology and Medical Genetics, the First Faculty of Medicine, Charles University and the General Teaching Hospital, Prague, Czech Republic; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109983PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190321PMC
October 2015

Transcriptomic changes in Ca²⁺-depleted cells: Role of elevated intracellular [Na⁺]/[K⁺] ratio.

Cell Calcium 2015 Sep 30;58(3):317-24. Epub 2015 Jun 30.

Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) - Technopôle Angus, Montreal, PQ, Canada; Tomsk National Research University, Tomsk, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2015.06.009DOI Listing
September 2015

Transcriptomic changes triggered by hypoxia: evidence for HIF-1α-independent, [Na+]i/[K+]i-mediated, excitation-transcription coupling.

PLoS One 2014 6;9(11):e110597. Epub 2014 Nov 6.

Department of Biology, Moscow State University, Moscow, Russia; Department of Medicine, Centre de recherche, Centre hospitalier de l'Université de Montréal, Montreal, Quebec, Canada; Department of Medical Biology, Siberian State Medical University, Tomsk, Russia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110597PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222758PMC
July 2015

Genome-wide association study of kidney function decline in individuals of European descent.

Authors:
Mathias Gorski Adrienne Tin Maija Garnaas Gearoid M McMahon Audrey Y Chu Bamidele O Tayo Cristian Pattaro Alexander Teumer Daniel I Chasman John Chalmers Pavel Hamet Johanne Tremblay Marc Woodward Thor Aspelund Gudny Eiriksdottir Vilmundur Gudnason Tamara B Harris Lenore J Launer Albert V Smith Braxton D Mitchell Jeffrey R O'Connell Alan R Shuldiner Josef Coresh Man Li Paul Freudenberger Edith Hofer Helena Schmidt Reinhold Schmidt Elizabeth G Holliday Paul Mitchell Jie Jin Wang Ian H de Boer Guo Li David S Siscovick Zoltan Kutalik Tanguy Corre Peter Vollenweider Gérard Waeber Jayanta Gupta Peter A Kanetsky Shih-Jen Hwang Matthias Olden Qiong Yang Mariza de Andrade Elizabeth J Atkinson Sharon L R Kardia Stephen T Turner Jeanette M Stafford Jingzhong Ding Yongmei Liu Cristina Barlassina Daniele Cusi Erika Salvi Jan A Staessen Paul M Ridker Harald Grallert Christa Meisinger Martina Müller-Nurasyid Bernhard K Krämer Holly Kramer Sylvia E Rosas Ilja M Nolte Brenda W Penninx Harold Snieder M Fabiola Del Greco Andre Franke Ute Nöthlings Wolfgang Lieb Stephan J L Bakker Ron T Gansevoort Pim van der Harst Abbas Dehghan Oscar H Franco Albert Hofman Fernando Rivadeneira Sanaz Sedaghat André G Uitterlinden Stefan Coassin Margot Haun Barbara Kollerits Florian Kronenberg Bernhard Paulweber Nicole Aumann Karlhans Endlich Mike Pietzner Uwe Völker Rainer Rettig Vincent Chouraki Catherine Helmer Jean-Charles Lambert Marie Metzger Benedicte Stengel Terho Lehtimäki Leo-Pekka Lyytikäinen Olli Raitakari Andrew Johnson Afshin Parsa Murielle Bochud Iris M Heid Wolfram Goessling Anna Köttgen W H Linda Kao Caroline S Fox Carsten A Böger

Kidney Int 2015 May 10;87(5):1017-29. Epub 2014 Dec 10.

Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.

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https://lirias.kuleuven.be/bitstream/123456789/479606/1/15-1
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S008525381530090
Publisher Site
http://dx.doi.org/10.1038/ki.2014.361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425568PMC
May 2015

EPHB4 Protein Expression in Vascular Smooth Muscle Cells Regulates Their Contractility, and EPHB4 Deletion Leads to Hypotension in Mice.

J Biol Chem 2015 May 22;290(22):14235-44. Epub 2015 Apr 22.

From the Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec H2X 0A9, the Nephrology Service, CHUM, Montreal, Quebec H2L 4M1, Canada

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.621615
Publisher Site
http://dx.doi.org/10.1074/jbc.M114.621615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447992PMC
May 2015

Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals.

J Hypertens 2015 Apr;33(4):727-35; discussion 735

aCentre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Québec bSimon Fraser University British Columbia, Bumbay, British Columbia cCHU Ste-Justine, Université de Montréal, Montréal dMédecine génétique, Université Laval, Ste-Foy, Québec eCentre of Genomics and Policy, Faculty of Medicine, Department of Human Genetics, McGill University fEcogene-21 Clinical Research Center and Department of Medicine, Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1097/HJH.0000000000000475DOI Listing
April 2015

Biomarkers of vascular complications in type 2 diabetes.

Metabolism 2015 Mar 30;64(3 Suppl 1):S28-32. Epub 2014 Oct 30.

CHUM Research Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.metabol.2014.10.032DOI Listing
March 2015

Polygenic overlap between kidney function and large artery atherosclerotic stroke.

Stroke 2014 Dec 28;45(12):3508-13. Epub 2014 Oct 28.

From the School of Medicine and Public Health (E.G.H., J.S., M.M., J.A.) and School of Nursing and Midwifery (J.M.), University of Newcastle, Australia; Clinical Research Design, IT and Statistical Support Unit (E.G.H., C.O., J.A.), Hunter Medical Research Institute (J.M., R.J.S., C.L.), Newcastle, Australia; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (M.T., S.B., H.S.M.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (R.M., M.D.); Stroke Research Program, School of Medicine and Adelaide Center for Neuroscience Research, University of Adelaide, Australia (S.A.K.); Neurology Department, Gosford Hospital, Australia (J.S.); School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (G.J.H.); Neurology Department, Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); Division of Clinical Neurosciences, University of Edinburgh, UK (C.S.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK (P.M.R.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (J.C., W.H.L.K.); The University of Montreal Hospital Health Centre, Research Centre, University of Montreal, Montreal, Canada (P.H., J.T.); Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.) and Division of Biomedical Statistics and Informatics (M.d.A.), Mayo Clinic, Rochester, MN; Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Boston, MA (M.R.); Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria (R.S.); Division of Regulatory Systems and Risk Management, Department of Defense, Australia (P.A.C.); Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy (A.R.); Division of Nephrology, University of California San Francisco Scho

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December 2014

TGFBI (βIG-H3) is a diabetes-risk gene based on mouse and human genetic studies.

Hum Mol Genet 2014 Sep 11;23(17):4597-611. Epub 2014 Apr 11.

Centre de Recherche and Service de Néphrologie, Centre Hospitalier de L'Université de Montréal (CRCHUM), Montréal, QC, Canada,

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http://dx.doi.org/10.1093/hmg/ddu173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119410PMC
September 2014

Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) and kidney diseases: HCaRG accelerates tubular repair.

J Nephrol 2014 Aug 11;27(4):351-60. Epub 2014 Feb 11.

Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada,

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http://link.springer.com/10.1007/s40620-014-0054-3
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104007PMC
August 2014

ARMC5 mutations are a frequent cause of primary macronodular adrenal Hyperplasia.

J Clin Endocrinol Metab 2014 Aug 7;99(8):E1501-9. Epub 2014 Apr 7.

Unidade de Suprarrenal (G.A.A., A.M.L., M.Y.N., B.M.d.P.M., M.Q.A., M.A.A.P., B.B.M., M.C.B.V.F.), Disciplina de Endocrinologia e Metabologia, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403900, Brazil; Département de Médecine (J.T., P.H., I.B., A.L.), Centre Hospitalier de l'Université de Montréal, Montréal H2W 1T8, Canada; Departamento de Patologia (M.C.N.Z.), Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403900, Brazil; Departamento de Radiologia (G.C.G., M.d.S.R.), Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403900, Brazil; and Disciplina de Urologia, Departamento de Cirurgia (J.L.C.), Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403900, Brazil.

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http://dx.doi.org/10.1210/jc.2013-4237DOI Listing
August 2014

Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1.

PLoS Genet 2014 Feb 27;10(2):e1004146. Epub 2014 Feb 27.

Department of Medical Genetics, CHU Sainte-Justine Research Center, University of Montreal, Montreal, Canada ; Department of Anatomy and Cell Biology, McGill University, Montreal, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937211PMC
February 2014

Increased renal epithelial na channel expression and activity correlate with elevation of blood pressure in spontaneously hypertensive rats.

Hypertension 2013 Oct 19;62(4):731-7. Epub 2013 Aug 19.

CRCHUM - Technopôle Angus, 2901, Rachel est, Montreal, QC H1W 4A4, Canada.

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October 2013

Role of genomics on the path to personalized medicine.

Metabolism 2013 Jan 25;62 Suppl 1:S2-5. Epub 2012 Sep 25.

Research Centre, Centre hospitalier de l'Université de Montréal-Technopôle Angus, 2901 Rachel Street East, Room 314, H1W 4A4, Montreal, Quebec, Canada.

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January 2013

Imaging-based biomarkers: characterization of post-kawasaki vasculitis in infants and hypertension phenotype in rat model.

Int J Vasc Med 2012 14;2012:364145. Epub 2012 Jun 14.

Centre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montréal, QC, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418648PMC
August 2012

NKCC1 and hypertension: role in the regulation of vascular smooth muscle contractions and myogenic tone.

Ann Med 2012 Jun;44 Suppl 1:S111-8

Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM)-Technôpole Angus, and Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.

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http://www.tandfonline.com/doi/full/10.3109/07853890.2011.65
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June 2012

Possible role of Efnb1 protein, a ligand of Eph receptor tyrosine kinases, in modulating blood pressure.

J Biol Chem 2012 May 5;287(19):15557-69. Epub 2012 Mar 5.

Nephrology Department, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec H2L 4M1, Canada.

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http://dx.doi.org/10.1074/jbc.M112.340869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346120PMC
May 2012

Low efficiency of functional translation of ouabain-resistant α2-Na(+),K(+)-ATPase mRNA in C7-MDCK epithelial cells.

Can J Physiol Pharmacol 2012 Jan 21;90(1):83-8. Epub 2011 Dec 21.

Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM) - Technopôle Angus, 2901 Rachel East, Montreal, QC H1W 4A4, Canada.

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January 2012

HCaRG accelerates tubular repair after ischemic kidney injury.

J Am Soc Nephrol 2011 Nov 15;22(11):2077-89. Epub 2011 Sep 15.

Centre de Recherche, Centre Hospitalier de l’Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1681/ASN.2010121265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279999PMC
November 2011

Genetics of pain, opioids, and opioid responsiveness.

Metabolism 2010 Oct;59 Suppl 1:S5-8

Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM)-Technopôle Angus, Montreal, Quebec, Canada.

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October 2010

Aberrant G-protein coupled receptor expression in relation to adrenocortical overfunction.

Clin Endocrinol (Oxf) 2010 Jul 29;73(1):1-15. Epub 2009 Aug 29.

Division of Endocrinology, Department of Medicine, Centre de recherche du Centre hospitalier de l'Université de Montréal, Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1111/j.1365-2265.2009.03689.xDOI Listing
July 2010

GREBP, a cGMP-response element-binding protein repressing the transcription of natriuretic peptide receptor 1 (NPR1/GCA).

J Biol Chem 2010 Jul 5;285(27):20926-39. Epub 2010 May 5.

Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec H1W 4A4, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.061622
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898340PMC
July 2010

Decreased NKCC1 activity in erythrocytes from African Americans with hypertension and dyslipidemia.

Am J Hypertens 2010 Mar 31;23(3):321-6. Epub 2009 Dec 31.

Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM)-Technopôle Angus, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/ajh.2009.249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727424PMC
March 2010

NKCC1 and hypertension: a novel therapeutic target involved in the regulation of vascular tone and renal function.

Curr Opin Nephrol Hypertens 2010 Mar;19(2):163-8

Research Centre, Centre Hospitalier de l'Université de Montréal (CHUM)-Technôpole Angus and Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.

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March 2010

Central role of guanylyl cyclase in natriuretic peptide signaling in hypertension and metabolic syndrome.

Mol Cell Biochem 2010 Jan 25;334(1-2):53-65. Epub 2009 Nov 25.

Laboratory of Cellular Biology of Hypertension, Centre for Ecogenomic Models of Human Diseases, Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM), Technopôle Angus, 2901 rue Rachel est, bureau 314, Montreal, QC H1W 4A4, Canada.

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January 2010

Cardiotonic steroid-resistant alpha1-Na+,K+-ATPase rescues renal epithelial cells from the cytotoxic action of ouabain: evidence for a Nai+,Ki+ -independent mechanism.

Apoptosis 2010 Jan;15(1):55-62

Centre de Recherche, Centre Hospitalier de l'Université de Montréal, Technopôle Angus, 2901 Rachel Est, Montreal, QC H1W 4A4, Canada.

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January 2010

Death of ouabain-treated renal epithelial cells: evidence for p38 MAPK-mediated Na (i) (+) /K (i) (+) -independent signaling.

Apoptosis 2009 Nov;14(11):1266-73

Centre de recherche, Centre hospitalier de l'Université de Montréal, QC, Canada.

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November 2009

HCO3-dependent impact of Na+,K+,2Cl- cotransport in vascular smooth muscle excitation-contraction coupling.

Cell Physiol Biochem 2009 6;23(4-6):407-14. Epub 2009 May 6.

Research Centre, Centre hospitalier de l'Université de Montréal - Technopôle Angus, Montreal, Canada.

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http://dx.doi.org/10.1159/000218187DOI Listing
August 2009

Cardiac pathways distinguish two epistatic modules enacting BP quantitative trait loci and candidate gene analysis.

Hypertens Res 2009 Jul 22;32(7):631-7. Epub 2009 May 22.

Research Centre, Centre hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Québec, Canada.

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http://www.nature.com/articles/hr200970
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July 2009

Excitation-contraction coupling in resistance mesenteric arteries: evidence for NKCC1-mediated pathway.

Biochem Biophys Res Commun 2009 Feb 14;379(4):1080-3. Epub 2009 Jan 14.

Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM - Technopôle Angus), Montreal, PQ, Canada H1W 4A4.

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February 2009

Invitations for the Program: 6th International Congress of Pathophysiology, "Gene-environmental Interactions in Health and Diseases", Montréal, Québec, Canada, 27-30 June 2010.

Pathophysiology 2008 Dec 24;15(4):209. Epub 2008 Sep 24.

Laboratory of Abnormalities on Ion Transport, Department of Medicine, Centre Hospitalier de l'Universite de Montreal, 3850, rue Saint Urbain, Montreal, Quebec, H2W 1T7 Canada.

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December 2008

Impact of genetic and epigenetic factors from early life to later disease.

Metabolism 2008 Oct;57 Suppl 2:S27-31

Gene Medicine Service, Research Center, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada H1W 4A4.

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http://dx.doi.org/10.1016/j.metabol.2008.07.012DOI Listing
October 2008

Altered phosphorylation of RRXS*/T* motif in ouabain-treated renal epithelial cells is not mediated by inversion of the [Na](i)/[K+](i) ratio.

Cell Physiol Biochem 2008 23;21(4):315-24. Epub 2008 Apr 23.

Research Centre, Centre hospitalier de l'Université de Montréal (CHUM) - Technopôle - Angus, Montreal, Quebec, Canada.

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September 2008

Systematic, genome-wide, sex-specific linkage of cardiovascular traits in French Canadians.

Hypertension 2008 Apr 7;51(4):1156-62. Epub 2008 Feb 7.

Centre de Recherche, Centre Hospitalier de l'Université de Montréal-Technôpole Angus, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.105247DOI Listing
April 2008

Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genes.

Hum Mol Genet 2008 Feb 3;17(3):331-44. Epub 2007 Oct 3.

Centre de recherche, Centre hospitalier de l'Université de Montréal-Technopôle Angus, Montréal, Québec, Canada.

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http://dx.doi.org/10.1093/hmg/ddm277DOI Listing
February 2008

Pharmacogenomics of metabolic effects of rosiglitazone.

Pharmacogenomics 2008 Feb;9(2):141-55

Centre Hospitalier de l'Université de Montréal, Centre de Recherche, Technôpole Angus, 2901 Rachel East, Office 314, Montréal, Québec H1W 4A4, Canada.

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http://dx.doi.org/10.2217/14622416.9.2.141DOI Listing
February 2008

[Na]i -induced c-Fos expression is not mediated by activation of the 5' -promoter containing known transcriptional elements.

FEBS J 2007 Jul 12;274(14):3557-3567. Epub 2007 Jun 12.

 Centre de recherche, Centre hospitalier de l'Université de Montréal (CHUM) - Technopôle ANGUS, Montreal, PQ, Canada Department of Medicine, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2007.05885.xDOI Listing
July 2007

Sucrose feeding during pregnancy and lactation elicits distinct metabolic response in offspring of an inbred genetic model of metabolic syndrome.

Am J Physiol Endocrinol Metab 2007 May 9;292(5):E1318-24. Epub 2007 Jan 9.

Institute of Biology and Medical Genetics of the First Faculty of Medicine of Charles University and the General Teaching Hospital,Prague, Czech Republic.

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http://www.physiology.org/doi/10.1152/ajpendo.00526.2006
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May 2007

The Na(+)/K(+)-ATPase as [K(+)](o) sensor: Role in cardiovascular disease pathogenesis and augmented production of endogenous cardiotonic steroids.

Pathophysiology 2006 Dec 20;13(4):209-16. Epub 2006 Jul 20.

Centre de Recherche, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada.

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December 2006

Emergence of sex differences in prevalence of high systolic blood pressure: analysis of a longitudinal adolescent cohort.

Circulation 2006 Dec 4;114(24):2663-70. Epub 2006 Dec 4.

Departments of Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.624536DOI Listing
December 2006

Novel double-congenic strain reveals effects of spontaneously hypertensive rat chromosome 2 on specific lipoprotein subfractions and adiposity.

Physiol Genomics 2006 Oct 5;27(1):95-102. Epub 2006 Jul 5.

Institute of Biology and Medical Genetics of the First Faculty of Medicine of Charles University and the General Teaching Hospital, Prague, Czech Republic.

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http://www.physiology.org/doi/10.1152/physiolgenomics.00039.
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October 2006

Genetics of the sleep-wake cycle and its disorders.

Metabolism 2006 Oct;55(10 Suppl 2):S7-12

Centre de recherche du Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada H2W 1T7.

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http://dx.doi.org/10.1016/j.metabol.2006.07.006DOI Listing
October 2006

Whole genome expression profiling of glucose-dependent insulinotropic peptide (GIP)- and adrenocorticotropin-dependent adrenal hyperplasias reveals novel targets for the study of GIP-dependent Cushing's syndrome.

J Clin Endocrinol Metab 2006 Sep 13;91(9):3611-8. Epub 2006 Jun 13.

Department of Medicine, Hôtel-Dieu du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1210/jc.2006-0221DOI Listing
September 2006

Development of hypertension and kidney hypertrophy in transgenic mice overexpressing ARAP1 gene in the kidney.

Hypertension 2006 Sep 26;48(3):453-9. Epub 2006 Jun 26.

Research Centre, Centre hospitalier de l'Université de Montréal, Hôtel-Dieu, Pavillon Masson, 3850 Saint Urbain St, Montreal, Quebec, Canada H2W 1T8.

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September 2006

Expression of ACTH receptor pathway genes in glucose-dependent insulinotrophic peptide (GIP)-dependent Cushing's syndrome.

Clin Endocrinol (Oxf) 2006 Jan;64(1):29-36

Laboratory of Endocrine Pathophysiology, Research Centre, Hotel-Dieu du Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada.

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http://dx.doi.org/10.1111/j.1365-2265.2005.02411.xDOI Listing
January 2006

HCaRG increases renal cell migration by a TGF-alpha autocrine loop mechanism.

Am J Physiol Renal Physiol 2005 Dec 20;289(6):F1273-80. Epub 2005 Jul 20.

Laboratory of Cellular Biology of Hypertension, Centre Hospitalier de l'Université de Montréal, Quebec, Canada.

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http://dx.doi.org/10.1152/ajprenal.00103.2005DOI Listing
December 2005

Integrating genomics and transcriptomics with geo-ethnicity and the environment for the resolution of complex cardiovascular diseases.

Curr Opin Mol Ther 2005 Dec;7(6):583-7

Centre hospitalier de l'Université de Montreal (CHUM), Research Centre, Laboratory of Molecular Medicine, Montreal, Quebec, Canada.

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December 2005

Genetics and genomics of depression.

Metabolism 2005 May;54(5 Suppl 1):10-5

Département de médecine, Faculté de médecine, Université de Montréal, and Centre de recherche, Centre hospitalier de l'Université de Montréal (CHUM), Québec, Canada.

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May 2005

Dynamic genetic architecture of metabolic syndrome attributes in the rat.

Physiol Genomics 2005 Apr 22;21(2):243-52. Epub 2005 Feb 22.

Centre de Recherche, Centre Hospitalier de l'Université de Montréal, Montreal, Canada.

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http://dx.doi.org/10.1152/physiolgenomics.00230.2004DOI Listing
April 2005

Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells.

J Biol Chem 2005 Jan 19;280(1):832-9. Epub 2004 Oct 19.

Centre de recherche, Centre hospitalier de l'Université de Montréal, Montreal, Quebec H2W 1T7, Canada.

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http://dx.doi.org/10.1074/jbc.M411011200DOI Listing
January 2005

EphB6-null mutation results in compromised T cell function.

J Clin Invest 2004 Dec;114(12):1762-73

Laboratory of Immunology, Centre de Recherché, Notre Dame Hospital, Centre Hospitalier de l'Université de Montréal, Pavilion DeSève, 1560 Sherbrooke Street East, Montréal, Quebec H2L 4M1, Canada.

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http://dx.doi.org/10.1172/JCI21846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535066PMC
December 2004

Diet-induced obesity delays cardiovascular recovery from stress in spontaneously hypertensive rats.

Obes Res 2004 Dec;12(12):1951-8

Centre de Recherche, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.

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http://dx.doi.org/10.1038/oby.2004.245DOI Listing
December 2004

Cushing's syndrome variants secondary to aberrant hormone receptors.

Trends Endocrinol Metab 2004 Oct;15(8):375-82

Laboratories of Endocrine Pathophysiology, Cellular Biology of Hypertension, and Molecular Medicine, Department of Medicine, Hôtel-Dieu du Centre hospitalier de l'Université de Montréal (CHUM), Montréal H2W 1T8, Canada.

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http://dx.doi.org/10.1016/j.tem.2004.08.007DOI Listing
October 2004

Na+/K+ pump and endothelial cell survival: [Na+]i/[K+]i-independent necrosis triggered by ouabain, and protection against apoptosis mediated by elevation of [Na+]i.

Pflugers Arch 2004 Jun 7;448(3):335-45. Epub 2004 Apr 7.

Centre de recherche, Centre hospitalier de l'Université de Montréal, Hôtel-Dieu, 3850 rue St-Urbain, Montreal, Quebec, H2W 1T7, Canada.

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http://dx.doi.org/10.1007/s00424-004-1262-9DOI Listing
June 2004

Characterization of a cGMP-response element in the guanylyl cyclase/natriuretic peptide receptor A gene promoter.

Hypertension 2004 Jun 19;43(6):1270-8. Epub 2004 Apr 19.

Centre de recherche, Centre hospitalier de l'Université de Montréal-Hôtel-Dieu, Montréal, Québec, Canada.

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http://dx.doi.org/10.1161/01.HYP.0000126920.93207.53DOI Listing
June 2004

Rat model of familial combined hyperlipidemia as a result of comparative mapping.

Physiol Genomics 2004 Mar 12;17(1):38-47. Epub 2004 Mar 12.

Centre de recherche du Centre hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1152/physiolgenomics.00043.2003DOI Listing
March 2004

Genes of aging.

Metabolism 2003 Oct;52(10 Suppl 2):5-9

Centre de recherche, CHUM-Hôtel-Dieu, Université Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1016/s0026-0495(03)00294-4DOI Listing
October 2003

Segment of rat chromosome 20 regulates diet-induced augmentations in adiposity, glucose intolerance, and blood pressure.

Hypertension 2003 May 24;41(5):1047-55. Epub 2003 Mar 24.

Laboratory of Functional Genomics, Centre de recherche, CHUM Hôtel-Die, 3850 St Urbain St, Montréal, Québec H2W 1T7, Canada.

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https://www.ahajournals.org/doi/10.1161/01.HYP.0000064347.49
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May 2003

HCaRG is a novel regulator of renal epithelial cell growth and differentiation causing G2M arrest.

Am J Physiol Renal Physiol 2003 Apr 3;284(4):F753-62. Epub 2002 Dec 3.

Laboratory of Cellular Biology of Hypertension, Centre de Recherche, Centre Hospitalier de l'Université de Montréal, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1152/ajprenal.00252.2002DOI Listing
April 2003

Inhibition of Na+,K+-ATPase by ouabain triggers epithelial cell death independently of inversion of the [Na+]i/[K+]i ratio.

Biochem Biophys Res Commun 2003 Feb;301(3):735-44

Centre de recherche, Centre hospitalier de l'Université de Montréal, Hôtel-Dieu, PQ, Canada

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http://dx.doi.org/10.1016/s0006-291x(02)03002-4DOI Listing
February 2003

TA repeat variation, Npr1 expression, and blood pressure: impact of the Ace locus.

Hypertension 2003 Jan;41(1):16-24

Laboratory of Cellular Biology of Hypertension, Centre de recherche du Centre hospitalier de l'Université de Montréal-Hôtel-Dieu, , Montréal, Québec, Canada.

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http://dx.doi.org/10.1161/01.hyp.0000042664.75193.1bDOI Listing
January 2003

Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems.

J Mol Med (Berl) 2003 Jan 21;81(1):51-60. Epub 2002 Nov 21.

Centre de recherche, Centre hospitalier de l'Université de Montréal-Hôtel-Dieu, 3850 rue Saint-Urbain, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1007/s00109-002-0394-7DOI Listing
January 2003