Publications by authors named "Johann Hitzler"

64Publications

Quantitative MRI outcomes in child and adolescent leukemia survivors: Evidence for global alterations in gray and white matter.

Neuroimage Clin 2020 Sep 15;28:102428. Epub 2020 Sep 15.

Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada; Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2020.102428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522853PMC
September 2020

Pathologic Features of Down Syndrome Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML0431.

Arch Pathol Lab Med 2020 04 20;144(4):466-472. Epub 2019 Aug 20.

From the Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (Drs Mast, Mosse, Jones, and Head); the Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit (Dr Taub); the Department of Biostatistics, University of Southern California, Monrovia (Dr Alonzo and Mr Wang); the Division of Hematology/Oncology/Bone Marrow Transplantation, Children's Mercy Hospital, Kansas City, Missouri (Dr Gamis); the Pathology and Laboratory Medicine Service, VA Tennessee Valley Healthcare System, Nashville (Dr Mosse); the Department of Pediatrics, University of New Mexico, Albuquerque (Dr Mathew); the Division of Hematology-Oncology, IWK Health Centre, Halifax, Nova Scotia, Canada (Dr Berman); the Departments of Oncology (Dr Campana and Ms Coustan-Smith) and Pathology (Dr Raimondi), St. Jude Children's Research Hospital, Memphis, Tennessee; the Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, The National University Cancer Institute, NUH Medical Centre, Singapore (Dr Campana and Ms Coustan-Smith); the Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis (Dr Hirsch); the Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada (Dr Hitzler); and the Division of Hematology/Oncology, The Hospital for Sick Children Developmental and Stem Cell Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada (Dr Hitzler). Dr Mast now has a joint appointment at the Pathology and Laboratory Medicine Service, VA Tennessee Valley Healthcare System, Nashville. Dr Mathew is currently at the Department of Pediatrics, Presbyterian Health Services, Albuquerque, New Mexico. Dr Berman is currently at the Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. Dr Jones is currently at Pathgroup Labs, Nashville, Tennessee. Dr Campana is no longer at the Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee. Ms Coustan-Smith is no longer at the Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.5858/arpa.2018-0526-OADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031019PMC
April 2020

Unusual lymphoid malignancy and treatment response in two children with Down syndrome.

Pediatr Blood Cancer 2019 09 28;66(9):e27822. Epub 2019 May 28.

Division of Hematology/Oncology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.27822
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http://dx.doi.org/10.1002/pbc.27822DOI Listing
September 2019

Need for new thinking: Treatment of relapsed leukemia in children with Down syndrome.

Pediatr Blood Cancer 2019 06 5;66(6):e27644. Epub 2019 Feb 5.

Division of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.27644DOI Listing
June 2019

Gemtuzumab ozogamicin in acute myeloid leukemia: act 2, with perhaps more to come.

Haematologica 2019 01;104(1):7-9

Division of Hematology University of Washington Medical Center and Clinical Research Division Fred Hutchinson Cancer Research Center Seattle, WA, USA.

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http://dx.doi.org/10.3324/haematol.2018.205948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312009PMC
January 2019

Value of flow cytometric analysis of peripheral blood samples in children diagnosed with acute lymphoblastic leukemia.

Pediatr Blood Cancer 2018 Jan 2;65(1). Epub 2017 Aug 2.

Division of Hematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26738DOI Listing
January 2018

Brain structure, working memory and response inhibition in childhood leukemia survivors.

Brain Behav 2017 02 29;7(2):e00621. Epub 2016 Dec 29.

Physiology and Experimental Medicine The Hospital for Sick Children Research Institute Toronto ON Canada; Mouse Imaging Centre (MICe) The Hospital for Sick Children Toronto ON Canada; Ontario Institute for Cancer Research Toronto ON Canada; Department of Medical Biophysics The University of Toronto Toronto ON Canada.

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http://dx.doi.org/10.1002/brb3.621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318374PMC
February 2017

Detection of a clone-specific GATA1 mutation to monitor treatment response and involvement of a monozygotic twin in myeloid leukemia of Down syndrome.

Pediatr Blood Cancer 2017 08 11;64(8). Epub 2017 Jan 11.

Division of Hematology/Oncology, The Hospital for Sick Children, University of Toronto,, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26439DOI Listing
August 2017

Clinical presentation and risk factors of serious infections in children with Down syndrome treated for acute lymphoblastic leukemia.

Pediatr Blood Cancer 2016 11 11;63(11):1949-53. Epub 2016 Jul 11.

Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/pbc.26127DOI Listing
November 2016

Frequency and outcome of pediatric acute lymphoblastic leukemia with ZNF384 gene rearrangements including a novel translocation resulting in an ARID1B/ZNF384 gene fusion.

Pediatr Blood Cancer 2016 11 8;63(11):1915-21. Epub 2016 Jul 8.

Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26116DOI Listing
November 2016

Minimal Residual Disease and Childhood Leukemia: Standard of Care Recommendations From the Pediatric Oncology Group of Ontario MRD Working Group.

Pediatr Blood Cancer 2016 Jun 23;63(6):973-82. Epub 2016 Feb 23.

Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.25939DOI Listing
June 2016

Early Complications of Hyperleukocytosis and Leukapheresis in Childhood Acute Leukemias.

J Pediatr Hematol Oncol 2016 Mar;38(2):111-7

*Leukemia/Lymphoma Section, Department of Pediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada †Pediatric Department, Pediatric Oncology/Hematology Division, Tawam Hospital, Al Ain, United Arab Emirates.

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http://dx.doi.org/10.1097/MPH.0000000000000490DOI Listing
March 2016

Neurocognitive Late Effects of Chemotherapy in Survivors of Acute Lymphoblastic Leukemia: Focus on Methotrexate.

J Can Acad Child Adolesc Psychiatry 2015 4;24(1):25-32. Epub 2015 Mar 4.

Psychiatry Department, The Hospital for Sick Children, Toronto, Ontario ; Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357331PMC
September 2015

Pre-Morbid Developmental Vulnerabilities in Children With Newly Diagnosed Acute Lymphoblastic Leukemia (ALL).

Pediatr Blood Cancer 2015 Dec 25;62(12):2183-8. Epub 2015 Aug 25.

The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.25692DOI Listing
December 2015

Treatment of young children with CNS-positive acute lymphoblastic leukemia without cranial radiotherapy.

Pediatr Blood Cancer 2015 Nov 7;62(11):1881-5. Epub 2015 Jul 7.

Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada.

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http://doi.wiley.com/10.1002/pbc.25620
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http://dx.doi.org/10.1002/pbc.25620DOI Listing
November 2015

Neuropsychological late effects of treatment for acute leukemia in children with Down syndrome.

Pediatr Blood Cancer 2015 May 24;62(5):854-8. Epub 2014 Dec 24.

The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.25362DOI Listing
May 2015

The outcome of allogeneic hematopoietic cell transplantation for children with FMS-like tyrosine kinase 3 internal tandem duplication-positive acute myelogenous leukemia.

Biol Blood Marrow Transplant 2015 Jan 16;21(1):172-5. Epub 2014 Aug 16.

Division of Pediatric Hematology/Oncology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennesee. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.08.008DOI Listing
January 2015

Transient myeloproliferative disorder in neonates without Down syndrome: case report and review.

Eur J Haematol 2015 May 14;94(5):456-62. Epub 2014 Jun 14.

Department of haematology/oncology, University Children's Hospital Basel, Basel, Switzerland.

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http://www.springerlink.com/index/54540310824G38P2.pdf
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http://doi.wiley.com/10.1111/ejh.12382
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http://dx.doi.org/10.1111/ejh.12382DOI Listing
May 2015

Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia.

Sci Transl Med 2014 May;6(236):236ra62

Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1126/scitranslmed.3008661DOI Listing
May 2014

Assessment of the outcomes associated with periprocedural anticoagulation management in children with acute lymphoblastic leukemia.

J Pediatr 2014 May 25;164(5):1201-7. Epub 2014 Feb 25.

Division of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00223476140005
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http://dx.doi.org/10.1016/j.jpeds.2014.01.031DOI Listing
May 2014

Leukapheresis and low-dose chemotherapy do not reduce early mortality in acute myeloid leukemia hyperleukocytosis: a systematic review and meta-analysis.

Leuk Res 2014 Apr 10;38(4):460-8. Epub 2014 Jan 10.

Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada; Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2014.01.004DOI Listing
April 2014

Outcomes of treatment for relapsed acute lymphoblastic leukaemia in children with Down syndrome.

Br J Haematol 2013 Jul 18;162(1):98-106. Epub 2013 Apr 18.

Paediatric Haematology/Oncology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany.

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http://dx.doi.org/10.1111/bjh.12348DOI Listing
July 2013

Transient leukemia in newborns without down syndrome: diagnostic and management challenges.

J Pediatr Hematol Oncol 2011 Aug;33(6):e261-3

Division of Hematology/Oncology, Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MPH.0b013e3182159f4eDOI Listing
August 2011

Acute leukemias in children with Down syndrome.

Hematol Oncol Clin North Am 2010 Feb;24(1):19-34

Department of Pediatric Oncology/Hematology, Erasmus MC/Sophia Children's Hospital, Dr Molewaterplein 60, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.hoc.2009.11.009DOI Listing
February 2010

Outcome and toxicity of chemotherapy for acute lymphoblastic leukemia in children with Down syndrome.

Pediatr Blood Cancer 2009 Jan;52(1):14-9

Division of Hematology/Oncology, University of Toronto, Toronto, Ontario, Canada.

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https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.21737
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http://doi.wiley.com/10.1002/pbc.21737
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http://dx.doi.org/10.1002/pbc.21737DOI Listing
January 2009

Lumbar spinal fluid collections in children treated with intrathecal chemotherapy: elevated CSF protein as a diagnostic clue.

Pediatr Blood Cancer 2008 Aug;51(2):295-8

Division of Haematology/Oncology, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.21592DOI Listing
August 2008

Isolated central nervous system relapse in childhood acute promyelocytic leukemia.

J Pediatr Hematol Oncol 2008 Feb;30(2):160-2

Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/MPH.0b013e318159a582DOI Listing
February 2008

Acute leukemias in children with Down syndrome.

Pediatr Clin North Am 2008 Feb;55(1):53-70, x

Department of Pediatric Oncology/Hematology, Erasmus MC/Sophia Children's Hospital, Dr Molewaterplein 60, Rotterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S003139550700160
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http://dx.doi.org/10.1016/j.pcl.2007.11.001DOI Listing
February 2008

Acute megakaryoblastic leukemia in Down syndrome.

Authors:
Johann K Hitzler

Pediatr Blood Cancer 2007 Dec;49(7 Suppl):1066-9

Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ont., Canada M5G 1X8.

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http://dx.doi.org/10.1002/pbc.21353DOI Listing
December 2007

Features at presentation predict children with acute lymphoblastic leukemia at low risk for tumor lysis syndrome.

Cancer 2007 Oct;110(8):1832-9

Division of Hematology/Oncology, the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/cncr.22990
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http://dx.doi.org/10.1002/cncr.22990DOI Listing
October 2007

Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate.

J Clin Oncol 2006 Aug;24(24):3858-64

Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2006.05.9055DOI Listing
August 2006

Long-term results of an ultra low-dose cytarabine-based regimen for the treatment of acute megakaryoblastic leukaemia in children with Down syndrome.

Br J Haematol 2006 Jun;133(6):646-8

Division of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ont., Canada.

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http://doi.wiley.com/10.1111/j.1365-2141.2006.06097.x
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http://dx.doi.org/10.1111/j.1365-2141.2006.06097.xDOI Listing
June 2006

Use of recombinant factor VIIa prior to lumbar puncture in pediatric patients with acute leukemia.

Pediatr Blood Cancer 2006 Aug;47(2):206-9

The Hospital for Sick Children, Division of Hematology/Oncology, Department of Pediatrics, University of Toronto, Toronto, Ontario M5G1X8, Canada.

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http://dx.doi.org/10.1002/pbc.20467DOI Listing
August 2006

DDAVP-induced hyponatremia in young children.

J Pediatr Hematol Oncol 2005 Jun;27(6):330-2

Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1097/01.mph.0000168728.49519.4aDOI Listing
June 2005

A basic classification and a comprehensive examination of pediatric myeloproliferative syndromes.

J Pediatr Hematol Oncol 2005 Apr;27(4):192-6

Divisions of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1097/01.mph.0000159934.35079.b5DOI Listing
April 2005

Reduced intensity hematopoietic stem-cell transplantation across human leukocyte antigen barriers in a patient with congenital amegakaryocytic thrombocytopenia and monosomy 7.

Pediatr Blood Cancer 2005 Aug;45(2):212-6

Marrow Failure and Myelodysplasia Programme, and Blood and Marrow Transplantation Section, Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.20332DOI Listing
August 2005

Origins of leukaemia in children with Down syndrome.

Nat Rev Cancer 2005 Jan;5(1):11-20

Department of Pediatrics, Division of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nrc1525DOI Listing
January 2005

cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.

Oncogene 2004 Apr;23(20):3700-7

Department of Neurosurgery, The University of Tennessee Health Science Center, 847 Monroe, Room 427, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1038/sj.onc.1207448DOI Listing
April 2004

CNS-directed therapy in young children with T-lineage acute lymphoblastic leukemia: High-dose methotrexate versus cranial irradiation.

Pediatr Blood Cancer 2004 Jan;42(1):24-9

Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children Research Institute, The University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.10392DOI Listing
January 2004

Purine nucleoside phosphorylase deficiency associated with a dysplastic marrow morphology.

Pediatr Res 2004 Mar 7;55(3):472-7. Epub 2004 Jan 7.

Division of Immunology and Allergy, The Hospital for Sick Children, 555 University Ave., Rm. 7279 Elm Wing, Toronto, Ontario, M5G 1X8, Canada.

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http://dx.doi.org/10.1203/01.PDR.0000111286.23110.F8DOI Listing
March 2004

GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome.

Blood 2003 Jun 13;101(11):4301-4. Epub 2003 Feb 13.

Department of Pediatrics, The Hospital for Sick Children, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2003-01-0013DOI Listing
June 2003

GATA1--a player in normal and leukemic megakaryopoiesis.

Authors:
Johann K Hitzler

Pediatr Res 2002 Dec;52(6):831

Division of Hematology/Oncology and Program for Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8 Canada.

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http://dx.doi.org/10.1203/00006450-200212000-00003DOI Listing
December 2002

Treatment of life-threatening post-haemorrhagic anaemia with cell-free haemoglobin solution in an adolescent Jehovah's Witness.

Br J Haematol 2002 Sep;118(4):1183-6

Department of Critical Care Medicine, The Hospital for Sick Children, and the Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03694.xDOI Listing
September 2002