Publications by authors named "Johann De Bono"

100Publications

Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer.

N Engl J Med 2020 12 20;383(24):2345-2357. Epub 2020 Sep 20.

From the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.); Vall d'Hebron Institute of Oncology and Vall d'Hebron University Hospital, Barcelona (J.M.), the Spanish National Cancer Research Center, Madrid (D.O.), and Instituto de Investigación Biomédica de Málaga, Málaga (D.O.) - all in Spain; Institut Gustave Roussy, University of Paris Saclay, Villejuif (K.F.), the Department of Medical Oncology, Centre Hospitalier Universitaire Besançon, Besançon (A.T.-V.), and the Department of Medical Oncology, Institut Bergonié, Bordeaux (G.R.) - all in France; Centre Hospitalier de l'Université de Montréal-Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal (F.S.), and BC Cancer Agency, Vancouver (K.N.C.) - both in Canada; Carolina Urologic Research Center, Myrtle Beach, SC (N.S.); Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (S.S.); Tulane University School of Medicine, New Orleans (O.S.); Huntsman Cancer Institute, University of Utah, Salt Lake City (N.A.); John Wayne Cancer Institute, Santa Monica, CA (P.T.); Istanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, Istanbul, Turkey (M.O.); AstraZeneca, Global Medicines Development, Oncology, Gaithersburg, MD (J.K.); Merck, Kenilworth, NJ (J.B.); and Global Medicines Development, Oncology (C.G.), Precision Medicine and Biosamples, R&D Oncology (C.C.), and Translational Medicine (C.A.A.), AstraZeneca, Cambridge, and the Institute of Cancer Research and Royal Marsden, London (J.B.) - both in the United Kingdom.

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December 2020

Olaparib for Metastatic Castration-Resistant Prostate Cancer. Reply.

N Engl J Med 2020 08;383(9):891

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL.

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August 2020

Prostate Cancer 2020: "The Times They Are a'Changing".

Cancer Cell 2020 Jul;38(1):25-27

The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, London, UK. Electronic address:

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July 2020

DNA Repair and Prostate Cancer: A Field Ripe for Harvest.

Eur Urol 2020 Oct 5;78(4):486-488. Epub 2020 Jul 5.

Experimental Cancer Medicine, Institute for Cancer Research, London, UK; Royal Marsden Hospital, London, UK.

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October 2020

A risk-based approach to experimental early phase clinical trials during the COVID-19 pandemic.

Lancet Oncol 2020 07;21(7):889-891

Phase I Drug Development Unit, The Royal Marsden Hospital and The Institute of Cancer Research, Sutton, UK. Electronic address:

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July 2020

Prostate carcinogenesis: inflammatory storms.

Nat Rev Cancer 2020 08 16;20(8):455-469. Epub 2020 Jun 16.

Institute of Oncology Research, Bellinzona, Switzerland.

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August 2020

Olaparib for Metastatic Castration-Resistant Prostate Cancer.

N Engl J Med 2020 05 28;382(22):2091-2102. Epub 2020 Apr 28.

From the Institute of Cancer Research and Royal Marsden Hospital, London (J. de Bono), and AstraZeneca, Translational Medicine, Cambridge (C.A.A.) - all in the United Kingdom; Vall d'Hebron Institute of Oncology and Vall d'Hebron University Hospital, Barcelona (J.M.), the Spanish National Cancer Research Center, Madrid (D.O.), and Hospitales Universitarios Virgen de la Victoria y Regional de Málaga, Malaga (D.O.) - all in Spain; Institut Gustave Roussy, University of Paris Sud, Villejuif (K.F.), and the Department of Medical Oncology, Centre Hospitalier Universitaire Besançon, Besançon (A.T.-V.) - all in France; Centre Hospitalier de l'Université de Montréal-Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal (F.S.), and BC Cancer Agency, Vancouver (K.N.C.) - all in Canada; Carolina Urologic Research Center, Myrtle Beach, SC (N.S.); Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (S.S.); Tulane University School of Medicine, New Orleans (O.S.); Huntsman Cancer Institute, University of Utah Comprehensive Cancer Center, Salt Lake City (N.A.); John Wayne Cancer Institute, Santa Monica, CA (P.T.); Radboud University Medical Center, Nijmegen, the Netherlands (N.M.); AstraZeneca, Global Medicines Development, Oncology, Gaithersburg, MD (C.G., J.K., W.W.); Merck, Kenilworth, NJ (J. Burgents); AstraZeneca, Precision Medicine, Oncology Research and Development, Gaithersburg, MD (A.K.); and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.).

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May 2020

Systematic Review of Efficacy and Health Economic Implications of Real-world Treatment Sequencing in Prostate Cancer: Where Do the Newer Agents Enzalutamide and Abiraterone Fit in?

Eur Urol Focus 2020 Apr 6. Epub 2020 Apr 6.

Cancer Health Services Research, Centre for Health Policy, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne Centre for Cancer Research, Melbourne, VIC, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Victorian Comprehensive Cancer Centre, VIC, Australia.

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April 2020

Cabazitaxel in Metastatic Prostate Cancer. Reply.

N Engl J Med 2020 03;382(13):1286

12 de Octubre University Hospital, Madrid, Spain.

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March 2020

Circulating cell-free DNA: Translating prostate cancer genomics into clinical care.

Mol Aspects Med 2020 04 16;72:100837. Epub 2020 Jan 16.

Institute of Cancer Research, Sutton, UK; Royal Marsden National Hospital Trust, Sutton, UK.

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April 2020

Tumour-derived extracellular vesicles in blood of metastatic cancer patients associate with overall survival.

Br J Cancer 2020 03 15;122(6):801-811. Epub 2020 Jan 15.

Department of Medical Cell BioPhysics, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands.

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March 2020

Genetic Analysis of Circulating Tumour Cells.

Recent Results Cancer Res 2020 ;215:57-76

The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK.

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October 2019

Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer.

N Engl J Med 2019 12 30;381(26):2506-2518. Epub 2019 Sep 30.

From the Erasmus Medical Center, Rotterdam, the Netherlands (R.W.); the Institute of Cancer Research and the Royal Marsden Hospital, London (J.B.); Englander Institute for Precision Medicine, Weill Cornell Medicine, New York (C.N.S.); Institut Gustave Roussy and University of Paris Sud, Villejuif (K.F.), Jean Godinot Institute and Reims Champagne-Ardenne University, Reims (J.-C.E.), Foch Hospital, Suresnes (C.T.), Hôpital d'Instruction des Armées Bégin, Saint Mandé (C.H.), and Sanofi, Europe Medical Oncology, Paris (C.G.-R.) - all in France; Institut de Recherche Clinique, Université Catholique de Louvain, Louvain, Belgium (B.T.); the Department of Urology, Asklepios Tumorzentrum Hamburg, Asklepios Klinik Altona, Hamburg (C.W.), and Studienpraxis Urologie, Nürtingen (S.F.) - both in Germany; the Medical University of Vienna, Vienna (G.K.); Alexandra Hospital, National and Kapodistrian University of Athens, Athens (A.B.); Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital, Barcelona (J.C.); Azienda Ospedaliera Universitaria Integrata, Verona, and Fondazione Policlinico Agostino Gemelli IRCCS, Rome - both in Italy (R.I.); Palacky University Medical School and Teaching Hospital, Olomouc, Czech Republic (B.M.); Landspitali University Hospital, Reykjavik, Iceland (Á.S.); Sanofi, Global Medical Oncology, Cambridge, MA (A.O.); and 12 de Octubre University Hospital, Madrid (D.C.).

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December 2019

Abiraterone in "High-" and "Low-risk" Metastatic Hormone-sensitive Prostate Cancer.

Eur Urol 2019 12 23;76(6):719-728. Epub 2019 Aug 23.

The Christie and Royal Salford Hospitals, Manchester, UK; Genito Urinary Cancer Research Group and the FASTMAN Centre of Excellence, Division of Cancer Sciences, The University of Manchester, Manchester, UK. Electronic address:

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December 2019

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.

Cell Rep 2019 08;28(8):2156-2168.e5

Institute of Oncology Research (IOR), 6500 Bellinzona, Switzerland; Faculty of Medicine, Università della Svizzera Italiana, 1011 Lugano, Switzerland; Department of Medicine, University of Padua, 35131 Padua, Italy; Medical Oncology, Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland. Electronic address:

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August 2019

Dissecting Prognostic From Predictive Utility: Circulating AR-V7 Biomarker Testing for Advanced Prostate Cancer.

J Clin Oncol 2019 08 2;37(24):2182-2184. Epub 2019 Jul 2.

Adam Sharp, MD, PhD, The Institute of Cancer Research; The Royal Marsden, London, United Kingdom; Nuria Porta, PhD; Maryou B.K. Lambros, MPhil; and Jonathan C. Welti, PhD, The Institute of Cancer Research, London, United Kingdom; Alec Paschalis, MD, The Institute of Cancer Research; The Royal Marsden, London, United Kingdom; Ganesh V. Raj, MD, PhD, The University of Texas Southwestern Medical Center, Dallas, TX; Stephen P. Plymate, MD, University of Washington; VA Puget Sound Health Care System Geriatric Research Education and Clinical Center, Seattle, WA; and Johann S. de Bono, MD, PhD, The Institute of Cancer Research; The Royal Marsden, London, United Kingdom.

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August 2019

Imaging Diagnosis and Follow-up of Advanced Prostate Cancer: Clinical Perspectives and State of the Art.

Radiology 2019 08 25;292(2):273-286. Epub 2019 Jun 25.

From the Radiomics Group, Vall D'Hebron Institute of Oncology, Barcelona, Spain (R.P.L.); Departments of Radiology (N.T., D.M.K.) and Nuclear Medicine (W.J.G.O.), Royal Marsden NHS Foundation Trust, Downs Road, Sutton SM2 5PT, England; Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, England (A.R.P.); Divisions of Radiotherapy and Imaging (W.J.G.O., D.M.K.) and Clinical Studies & Prostate Cancer Targeted Therapy Group (J.d.B.), Institute of Cancer Research, Sutton, England; Departments of Radiology (S.F.) and Genitourinary Oncology Service and Medicine (M.J.M.), Memorial Sloan-Kettering Cancer Center, New York, NY; Department of Oncology and Haematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland (H.A.V., A.O.); Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Switzerland (H.A.V., A.O.); and Department of Medicine, Weill Cornell Medicine, New York, NY (M.J.M.).

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August 2019

PARP Inhibitors for Advanced Prostate Cancer: Validating Predictive Biomarkers.

Eur Urol 2019 10 4;76(4):459-460. Epub 2019 Apr 4.

The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.

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October 2019

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression.

Mol Cell 2019 01 6;73(1):22-35.e6. Epub 2018 Dec 6.

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Urology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. Electronic address:

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January 2019

Immunotherapy for lethal prostate cancer.

Nat Rev Urol 2019 02;16(2):69-70

Division of Clinical Studies, The Institute of Cancer Research, London, UK.

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February 2019

Serum Free Methylated Glutathione S-transferase 1 DNA Levels, Survival, and Response to Docetaxel in Metastatic, Castration-resistant Prostate Cancer: Post Hoc Analyses of Data from a Phase 3 Trial.

Eur Urol 2019 09 19;76(3):306-312. Epub 2018 Nov 19.

Chris O'Brien Lifehouse, Sydney, Australia; Garvan Institute of Medical Research, Sydney, Australia; University of NSW, Sydney, Australia; University of Sydney, Sydney, Australia. Electronic address:

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September 2019

Scanning Electron Microscopy of Circulating Tumor Cells and Tumor-Derived Extracellular Vesicles.

Cancers (Basel) 2018 Oct 31;10(11). Epub 2018 Oct 31.

Department of Medical Cell BioPhysics, University of Twente, 7522 NH Enschede, The Netherlands.

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October 2018

A study of 1088 consecutive cases of electrolyte abnormalities in oncology phase I trials.

Eur J Cancer 2018 11 10;104:32-38. Epub 2018 Oct 10.

The Royal Marsden NHS Foundation Trust, Downs Rd, Sutton, SM2 5PT, London, UK; The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, London, UK. Electronic address:

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November 2018

Alternative splicing in prostate cancer.

Nat Rev Clin Oncol 2018 11;15(11):663-675

The Institute for Cancer Research, London, UK.

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November 2018

Managing Nonmetastatic Castration-resistant Prostate Cancer.

Eur Urol 2019 02 14;75(2):285-293. Epub 2018 Aug 14.

The Royal Marsden Hospital and The Institute of Cancer Research, London, UK. Electronic address:

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February 2019

Health economic impact of liquid biopsies in cancer management.

Expert Rev Pharmacoecon Outcomes Res 2018 Dec 7;18(6):593-599. Epub 2018 Aug 7.

e Department of Medical Cell Biophysics , University of Twente , Enschede , the Netherlands.

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December 2018

Relevance of poly (ADP-ribose) polymerase inhibitors in prostate cancer.

Curr Opin Support Palliat Care 2018 09;12(3):339-343

The Institute of Cancer Research, London, UK.

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September 2018

Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer.

Cell 2018 06;173(7):1770-1782.e14

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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June 2018

Reply to C. Ren et al.

J Clin Oncol 2018 08 12;36(22):2354-2356. Epub 2018 Jun 12.

Glenn Heller, Memorial Sloan Kettering Cancer Center, New York, NY; Robert McCormack and Thian Kheoh, Janssen Research & Development, Raritan, NJ; Arturo Molina, Janssen Research & Development, Los Angeles, CA; Matthew R. Smith, Massachusetts General Hospital, Boston, MA; Robert Dreicer, University of Virginia Medical School, Charlottesville, VA; Fred Saad, University of Montreal, Montreal, Quebec, Canada; Ronald de Wit, Erasmus Medical Center, Rotterdam, Netherlands; Dana T. Aftab, Exelixis, South San Francisco, CA; Mohammed Hirmand, Medivation, San Francisco, CA; Ana Limon-Carrera, Takeda Oncology, Cambridge, MA; Karim Fizazi, Institut Gustave Roussy, Villejuif, and University of Paris Sud, Orsay, France; Martin Fleisher, Memorial Sloan Kettering Cancer Center, New York, NY; Johann S. de Bono, The Institute of Cancer Research, and The Royal Marsden Hospital, Sutton, Surrey, United Kingdom; and Howard I. Scher, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, New York, NY.

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August 2018

Hypoxia and Noncoding RNAs in Taxane Resistance.

Trends Pharmacol Sci 2018 08 8;39(8):695-709. Epub 2018 Jun 8.

School of Life Health and Chemical Sciences, The Open University, Milton Keynes, UK. Electronic address:

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August 2018