Johan Staaf

Johan Staaf

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Johan Staaf

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Diagnostic Value of Insulinoma-Associated Protein 1 (INSM1) and Comparison With Established Neuroendocrine Markers in Pulmonary Cancers: A Comprehensive Study and Review of the Literature.

Arch Pathol Lab Med 2020 Jan 8. Epub 2020 Jan 8.

From the Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden (Drs Staaf, Nodin, Jirström, Vidarsdottir, Planck, and Brunnström); the Department of Genetics and Pathology, Division of Laboratory Medicine, Region Skåne, Lund, Sweden (Ms Tran, Ms Söderlund, Dr Jirström, and Dr Brunnström); the Department of Surgery, Helsingborg Hospital, Helsingborg, Sweden (Dr Vidarsdottir); the Department of Respiratory Medicine and Allergology, Skåne University Hospital, Lund, Sweden (Dr Planck); and the Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden (Drs Mattsson, Botling, and Micke).

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http://dx.doi.org/10.5858/arpa.2019-0250-OADOI Listing
January 2020

Pre-operative plasma cell-free circulating tumor DNA and serum protein tumor markers as predictors of lung adenocarcinoma recurrence.

Acta Oncol 2019 Aug 24;58(8):1079-1086. Epub 2019 Jun 24.

a Division of Oncology and Pathology, Department of Clinical Sciences Lund , Lund University , Lund , Sweden.

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http://dx.doi.org/10.1080/0284186X.2019.1610573DOI Listing
August 2019

Clinical Application of Fusion Gene Detection Using Next-Generation Sequencing and the NanoString Technology.

Methods Mol Biol 2019 ;1908:139-152

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Medicon Village, Lund, Sweden.

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http://dx.doi.org/10.1007/978-1-4939-9004-7_10DOI Listing
June 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41586-019-0883-2
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http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
February 2019

Performance of gene expression-based single sample predictors for assessment of clinicopathological subgroups and molecular subtypes in cancers: a case comparison study in non-small cell lung cancer.

Brief Bioinform 2019 Feb 4. Epub 2019 Feb 4.

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Medicon Village, Lund, Sweden.

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http://dx.doi.org/10.1093/bib/bbz008DOI Listing
February 2019

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification.

J Thorac Oncol 2017 08 20;12(8):1257-1267. Epub 2017 May 20.

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2017.05.008DOI Listing
August 2017

Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells.

Oncotarget 2017 Jul;8(30):48983-48995

Translational Cancer Research, Department of Laboratory Medicine, Lund University, Medicon Village, Lund, Sweden.

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http://dx.doi.org/10.18632/oncotarget.16904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564742PMC
July 2017

Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity.

Pancreas 2017 03;46(3):358-365

From the Departments of *Medical Cell Biology and †Women's and Children's Health, Uppsala University, Uppsala, Sweden; ‡Department of Paediatrics, Division of Paediatric Gastroenterology, Hepatology and Nutrition and §Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria; ∥Obesity Unit for Children and Adolescents, Uppsala University Children's Hospital, Uppsala, Sweden; ¶Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg; #Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Vienna, Vienna; **Department of Radiology, Paracelsus Medical University, Salzburg; ††Academic Institute for Clinical Nutrition, Vienna, Austria; and Departments of ‡‡Chemistry - BMC, Analytical Chemistry, and SciLifeLab and §§Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1097/MPA.0000000000000771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312728PMC
March 2017

Targeted sequencing may facilitate differential diagnostics of pulmonary tumours: a case series.

Diagn Pathol 2017 Mar 27;12(1):31. Epub 2017 Mar 27.

Department of Pathology, Regional Laboratories Region Skåne, SE-221 85, Lund, Sweden.

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http://dx.doi.org/10.1186/s13000-017-0621-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368924PMC
March 2017

Consensus of Melanoma Gene Expression Subtypes Converges on Biological Entities.

J Invest Dermatol 2016 12 23;136(12):2502-2505. Epub 2016 Jun 23.

Department of Oncology and Pathology, Clinical Sciences, Lund University Hospital, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.05.119DOI Listing
December 2016

Initial hyperinsulinemia and subsequent β-cell dysfunction is associated with elevated palmitate levels.

Pediatr Res 2016 08 11;80(2):267-74. Epub 2016 Apr 11.

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1038/pr.2016.80DOI Listing
August 2016

Consensus of gene expression phenotypes and prognostic risk predictors in primary lung adenocarcinoma.

Oncotarget 2016 Aug;7(33):52957-52973

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Medicon Village, SE 22381, Lund, Sweden.

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http://dx.doi.org/10.18632/oncotarget.10641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288161PMC
August 2016

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature17676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866PMC
June 2016

Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes.

J Clin Endocrinol Metab 2016 Mar 8;101(3):1181-9. Epub 2016 Jan 8.

Department of Medical Cell Biology (H.M., J.S., L.M., H.K., J.C., R.S., P.B.), Uppsala University, 75123 Uppsala, Sweden; Department of Women's and Children's Health (H.M., J.S., J.C., R.S., I.C., A.F.), Uppsala University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1210/jc.2015-3885DOI Listing
March 2016

Prognostic and Chemotherapy Predictive Value of Gene-Expression Phenotypes in Primary Lung Adenocarcinoma.

Clin Cancer Res 2016 Jan 11;22(1):218-29. Epub 2015 Aug 11.

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-0529DOI Listing
January 2016

DNA methylation subgroups in melanoma are associated with proliferative and immunological processes.

BMC Med Genomics 2015 Nov 6;8:73. Epub 2015 Nov 6.

Department of Oncology and Pathology, Clinical Sciences, Lund University Hospital, Lund University, Lund, 221 85, Sweden.

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http://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12920-015-0147-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636848PMC
November 2015

Genome methylation patterns in male breast cancer - Identification of an epitype with hypermethylation of polycomb target genes.

Mol Oncol 2015 Oct 8;9(8):1565-79. Epub 2015 May 8.

Department of Oncology and Pathology, Clinical Sciences, and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528783PMC
October 2015

Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation.

J Invest Dermatol 2015 Jul 23;135(7):1820-1828. Epub 2015 Feb 23.

Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden; CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720161PMC
July 2015

Making breast cancer molecular subtypes robust?

J Natl Cancer Inst 2015 Jan 4;107(1):386. Epub 2014 Dec 4.

Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1093/jnci/dju386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301705PMC
January 2015

Primary melanoma tumors from CDKN2A mutation carriers do not belong to a distinct molecular subclass.

J Invest Dermatol 2014 Dec 7;134(12):3000-3003. Epub 2014 Jul 7.

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.272DOI Listing
December 2014

Genome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome.

Clin Cancer Res 2014 Dec 2;20(23):6127-40. Epub 2014 Oct 2.

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-1087DOI Listing
December 2014

Genomic and transcriptional alterations in lung adenocarcinoma in relation to smoking history.

Clin Cancer Res 2014 Sep 18;20(18):4912-24. Epub 2014 Jul 18.

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0246DOI Listing
September 2014

Genomic and transcriptional alterations in lung adenocarcinoma in relation to EGFR and KRAS mutation status.

PLoS One 2013 24;8(10):e78614. Epub 2013 Oct 24.

Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Medicon Village, Lund, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078614PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812039PMC
August 2014

Molecular and genetic diversity in the metastatic process of melanoma.

J Pathol 2014 May 27;233(1):39-50. Epub 2014 Jan 27.

Department of Oncology, Clinical Sciences, Lund University, Sweden; CREATE Health Strategic Centre for Clinical Cancer Research, Lund University, Sweden.

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http://dx.doi.org/10.1002/path.4318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359751PMC
May 2014

Uppsala Longitudinal Study of Childhood Obesity: protocol description.

Pediatrics 2014 Feb 13;133(2):e386-93. Epub 2014 Jan 13.

Departments of Women's and Children's Health.

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http://dx.doi.org/10.1542/peds.2013-2143DOI Listing
February 2014

Repeatability of the Maximum Standard Uptake Value (SUVmax) in FDG PET.

Mol Imaging Radionucl Ther 2014 Feb 5;23(1):16-20. Epub 2014 Feb 5.

Karolinska University Hospital, Department of Hospital Physics, Stockholm, Sweden.

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http://cms.galenos.com.tr/Uploads/Article_1073/MIRT-23-01-16
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http://dx.doi.org/10.4274/Mirt.76376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957966PMC
February 2014

Detecting EGFR alterations in clinical specimens-pitfalls and necessities.

Virchows Arch 2013 Dec 26;463(6):755-64. Epub 2013 Oct 26.

Department of Clinical Sciences, Division of Oncology, Lund University, Medicon Village, SE-223 81, Lund, Sweden.

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http://dx.doi.org/10.1007/s00428-013-1489-yDOI Listing
December 2013

Histological specificity of alterations and expression of KIT and KITLG in non-small cell lung carcinoma.

Genes Chromosomes Cancer 2013 Nov 10;52(11):1088-96. Epub 2013 Sep 10.

Division of Oncology, Department of Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1002/gcc.22103DOI Listing
November 2013

Identification of transcriptional subgroups in EGFR-mutated and EGFR/KRAS wild-type lung adenocarcinoma reveals gene signatures associated with patient outcome.

Clin Cancer Res 2013 Sep 12;19(18):5116-26. Epub 2013 Aug 12.

Authors' Affiliations: Department of Oncology, Clinical Sciences, Skåne University Hospital; and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0928DOI Listing
September 2013

Nonfamilial breast cancer subtypes.

Methods Mol Biol 2013 ;973:279-95

Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1007/978-1-62703-281-0_18DOI Listing
July 2013

Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma.

Int J Cancer 2013 May 20;132(9):2020-31. Epub 2012 Oct 20.

Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Barngatan 2B, Lund, Sweden.

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http://dx.doi.org/10.1002/ijc.27879DOI Listing
May 2013

Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides.

Anal Bioanal Chem 2013 Feb 11;405(6):1929-35. Epub 2013 Jan 11.

Analytical Chemistry, Department of Chemistry--Biomedical Center and Science for Life Laboratory, Uppsala University, Box 599, 751 24 Uppsala, Sweden.

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http://dx.doi.org/10.1007/s00216-012-6658-3DOI Listing
February 2013

Amplification and overexpression of the ABCC3 (MRP3) gene in primary breast cancer.

Genes Chromosomes Cancer 2012 Sep 14;51(9):832-40. Epub 2012 May 14.

Institute of Biomedical Technology, University of Tampere, and Department of Oncology, Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1002/gcc.21967DOI Listing
September 2012

A revision of the organ radiation doses from 2-fluoro-2-deoxy-D-glucose with reference to tumour presence.

Radiat Prot Dosimetry 2012 Aug 13;151(1):43-50. Epub 2012 Jan 13.

Department of Physics, Stockholm University, Stockholm, Sweden.

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https://academic.oup.com/rpd/article-lookup/doi/10.1093/rpd/
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http://dx.doi.org/10.1093/rpd/ncr471DOI Listing
August 2012

Landscape of somatic allelic imbalances and copy number alterations in HER2-amplified breast cancer.

Breast Cancer Res 2011 14;13(6):R129. Epub 2011 Dec 14.

Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Barngatan 2B, SE 22185 Lund, Sweden.

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http://dx.doi.org/10.1186/bcr3075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326571PMC
June 2012

[Early bridge between preclinical and clinical research].

Lakartidningen 2012 Apr 25-May 8;109(17-18):898

Uppsala universitet.

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June 2012

GOBO: gene expression-based outcome for breast cancer online.

PLoS One 2011 Mar 21;6(3):e17911. Epub 2011 Mar 21.

Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017911PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061871PMC
March 2011

Zoom-in array comparative genomic hybridization (aCGH) to detect germline rearrangements in cancer susceptibility genes.

Methods Mol Biol 2010 ;653:221-35

Department of Oncology, Clinical Sciences, CREATE Health Strategic Centre For Translational Cancer Research, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1007/978-1-60761-759-4_13DOI Listing
December 2010

Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns.

Breast Cancer Res 2010 18;12(3):R36. Epub 2010 Jun 18.

Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, Lund, Sweden.

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http://dx.doi.org/10.1186/bcr2590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917031PMC
November 2010

Genetic profiles distinguish different types of hereditary ovarian cancer.

Oncol Rep 2010 Oct;24(4):885-95

Institute of Clinical Sciences, Department of Oncology, Lund University, 22185 Lund, Sweden.

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http://dx.doi.org/10.3892/or.2010.885DOI Listing
October 2010

Multiple metastases from cutaneous malignant melanoma patients may display heterogeneous genomic and epigenomic patterns.

Melanoma Res 2010 Oct;20(5):381-91

Department of Oncology, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.

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October 2010

Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation.

Cell Biol Int 2008 Dec 22;32(12):1467-77. Epub 2008 Aug 22.

Department of Cell and Organism Biology, Lund University, Helgonavägen 3B, SE-223 62 Lund, Sweden.

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http://dx.doi.org/10.1016/j.cellbi.2008.08.018DOI Listing
December 2008

Heterogeneous genetic profiles in soft tissue myoepitheliomas.

Mod Pathol 2008 Nov 4;21(11):1311-9. Epub 2008 Jul 4.

Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.

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http://dx.doi.org/10.1038/modpathol.2008.124DOI Listing
November 2008

Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line.

Anticancer Drugs 2008 Oct;19(9):871-83

Department of Cell and Organism Biology, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1097/CAD.0b013e32830f902bDOI Listing
October 2008

Array-CGH identifies cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma.

Endocr Relat Cancer 2008 Sep;15(3):801-15

Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, SE-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1677/ERC-08-0018DOI Listing
September 2008