Johan Grooten

Johan Grooten

UNVERIFIED PROFILE

Are you Johan Grooten?   Register this Author

Register author
Johan Grooten

Johan Grooten

Publications by authors named "Johan Grooten"

Are you Johan Grooten?   Register this Author

72Publications

1261Reads

48Profile Views

Post-PEGylated and crosslinked polymeric ssRNA nanocomplexes as adjuvants targeting lymph nodes with increased cytolytic T cell inducing properties.

J Control Release 2018 08 15;284:73-83. Epub 2018 Jun 15.

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2018.06.010DOI Listing
August 2018

Mycolates of modulate the flow of cholesterol for bacillary proliferation in murine macrophages.

J Lipid Res 2017 04 13;58(4):709-718. Epub 2017 Feb 13.

Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, Ghent Zwijnaarde 9052, Belgium

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M073171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392746PMC
April 2017

Type I Interferons Modulate CD8 T Cell Immunity to mRNA Vaccines.

Trends Mol Med 2017 03 7;23(3):216-226. Epub 2017 Feb 7.

Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Cytokine Receptor Laboratory, Department of Biochemistry, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2017.01.006DOI Listing
March 2017

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses.

Mol Ther 2016 Nov 10;24(11):2012-2020. Epub 2016 Aug 10.

Department of Biomedical Molecular Biology, Laboratory Molecular Immunology, Ghent University, Ghent, Belgium; Department of Biochemistry, Cytokine Receptor Lab, Ghent University, Ghent, Belgium; Medical Biotechnology, VIB, Ghent, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2016.161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154477PMC
November 2016

Mycobacterium tuberculosis-associated synthetic mycolates differentially exert immune stimulatory adjuvant activity.

Eur J Immunol 2016 09 29;46(9):2149-54. Epub 2016 Jul 29.

Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201646357DOI Listing
September 2016

Coadministration of a Plasmid Encoding HIV-1 Gag Enhances the Efficacy of Cancer DNA Vaccines.

Mol Ther 2016 09 20;24(9):1686-96. Epub 2016 Jun 20.

Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2016.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113100PMC
September 2016

pH-Degradable Mannosylated Nanogels for Dendritic Cell Targeting.

Biomacromolecules 2016 07 3;17(7):2479-88. Epub 2016 Jun 3.

Department of Chemistry, University of Cincinnati , Cincinnati, Ohio 45221, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biomac.6b00685DOI Listing
July 2016

pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation.

Proc Natl Acad Sci U S A 2016 07 5;113(29):8098-103. Epub 2016 Jul 5.

Department of Pharmaceutics, Ghent University, 9000 Ghent, Belgium; Cancer Research Institute Ghent, 9052 Ghent, Belgium;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1600816113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961133PMC
July 2016

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.

Cell Rep 2016 Apr 31;15(2):274-87. Epub 2016 Mar 31.

Molecular Signaling and Cell Death Unit, Inflammation Research Center, VIB, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Cancer Research Institute Ghent (CRIG), Ghent University, 9052 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.03.037DOI Listing
April 2016

Engineering Polymer Hydrogel Nanoparticles for Lymph Node-Targeted Delivery.

Angew Chem Int Ed Engl 2016 Jan 15;55(4):1334-9. Epub 2015 Dec 15.

Department of Pharmaceutics, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201508626DOI Listing
January 2016

Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages.

J Control Release 2015 Nov 22;217:53-63. Epub 2015 Aug 22.

Laboratory of General Biochemistry and Physical Pharmacy, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2015.08.030DOI Listing
November 2015

E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo.

Sci Rep 2015 Jul 31;5:12599. Epub 2015 Jul 31.

1] Laboratory of Myeloid Cell Immunology, VIB, Brussels, Belgium [2] Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep12599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521155PMC
July 2015

The site of administration influences both the type and the magnitude of the immune response induced by DNA vaccine electroporation.

Vaccine 2015 Jun 14;33(28):3179-85. Epub 2015 May 14.

Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Brussels, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2015.05.005DOI Listing
June 2015

Nanoporous polyelectrolyte vaccine microcarriers. A formulation platform for enhancing humoral and cellular immune responses.

J Control Release 2014 Dec 28;195:99-109. Epub 2014 Jul 28.

Department of Pharmaceutics, Ghent University, Ghent, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2014.07.043DOI Listing
December 2014

Challenges and advances towards the rational design of mRNA vaccines.

Trends Mol Med 2013 Dec 15;19(12):705-13. Epub 2013 Oct 15.

Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, B-2000 Antwerp, Belgium; Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2013.09.002DOI Listing
December 2013

IL-15 augments TCR-induced CD4+ T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4+ T cells.

PLoS One 2012 20;7(9):e45299. Epub 2012 Sep 20.

Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045299PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447928PMC
February 2013

Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members.

BMC Cancer 2012 Nov 13;12:515. Epub 2012 Nov 13.

Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde, 9052, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2407-12-515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534223PMC
November 2012

Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis.

Prog Lipid Res 2012 Oct 30;51(4):325-39. Epub 2012 May 30.

Department Biochemistry, University of Pretoria, Pretoria 0002, South Africa.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01637827120003
Publisher Site
http://dx.doi.org/10.1016/j.plipres.2012.05.002DOI Listing
October 2012

Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function.

Angew Chem Int Ed Engl 2012 Apr 12;51(16):3862-6. Epub 2012 Mar 12.

Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201200048DOI Listing
April 2012

Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen.

J Control Release 2012 Mar 29;158(2):233-9. Epub 2011 Oct 29.

Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2011.10.029DOI Listing
March 2012

Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection.

ACS Nano 2012 Mar 13;6(3):2136-49. Epub 2012 Feb 13.

Laboratory of Pharmaceutical Technology, Department of PharmaceuticsGhent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/nn205099cDOI Listing
March 2012

Single-step formation of degradable intracellular biomolecule microreactors.

ACS Nano 2011 Sep 25;5(9):6886-93. Epub 2011 Aug 25.

Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/nn200901gDOI Listing
September 2011

Polymeric multilayer capsules delivering biotherapeutics.

Adv Drug Deliv Rev 2011 Aug 12;63(9):748-61. Epub 2011 Apr 12.

Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.addr.2011.03.014DOI Listing
August 2011

Lyophilization of protein-loaded polyelectrolyte microcapsules.

Pharm Res 2011 Jul 18;28(7):1765-73. Epub 2011 Mar 18.

Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-011-0411-zDOI Listing
July 2011

Designing polymeric particles for antigen delivery.

Chem Soc Rev 2011 Jan 9;40(1):320-39. Epub 2010 Nov 9.

Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b914943kDOI Listing
January 2011

Facile two-step synthesis of porous antigen-loaded degradable polyelectrolyte microspheres.

Angew Chem Int Ed Engl 2010 Nov;49(46):8620-4

Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201001046DOI Listing
November 2010

PH1-derived bivalent bibodies and trivalent tribodies bind differentially to shed and tumour cell-associated MUC1.

Protein Eng Des Sel 2010 Sep 8;23(9):721-8. Epub 2010 Jul 8.

Molecular Immunology Laboratory, Department of Molecular Biology, Ghent University, Technologiepark 927, B-9052 Zwijnaarde, Belgium.

View Article

Download full-text PDF

Source
https://academic.oup.com/peds/article-lookup/doi/10.1093/pro
Publisher Site
http://dx.doi.org/10.1093/protein/gzq044DOI Listing
September 2010

Polymeric multilayer capsules in drug delivery.

Angew Chem Int Ed Engl 2010 Sep;49(39):6954-73

Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.200906266DOI Listing
September 2010

Biodegradable polyelectrolyte microcapsules: antigen delivery tools with Th17 skewing activity after pulmonary delivery.

J Immunol 2010 Jan 30;184(1):203-11. Epub 2009 Nov 30.

Department of Biomedical Molecular Biology, Ghent University, Zwijnaarde, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0803591DOI Listing
January 2010

Efficient production of human bivalent and trivalent anti-MUC1 Fab-scFv antibodies in Pichia pastoris.

BMC Biotechnol 2009 Aug 11;9:70. Epub 2009 Aug 11.

Department for Molecular Biomedical Research, VIB, Technologie Park 927, B-9052 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1472-6750-9-70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736937PMC
August 2009

Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice.

J Clin Invest 2009 Jun 11;119(6):1626-37. Epub 2009 May 11.

Laboratory of Mycobacterial Immunology, Scientific Institute of Public Health, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI35288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689129PMC
June 2009

New asthma biomarkers: lessons from murine models of acute and chronic asthma.

Am J Physiol Lung Cell Mol Physiol 2009 Feb 21;296(2):L185-97. Epub 2008 Nov 21.

GIGA-Research Laboratory of Fundamental Virology and Immunology, Univ. of Liège, B-4000 Liège, Belgium.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajplung.90367.2008
Publisher Site
http://dx.doi.org/10.1152/ajplung.90367.2008DOI Listing
February 2009

Where asthma and hypersensitivity pneumonitis meet and differ: noneosinophilic severe asthma.

Am J Pathol 2009 Jan 12;174(1):3-13. Epub 2008 Dec 12.

Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2353/ajpath.2009.071151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631313PMC
January 2009

Macrophage reprogramming by mycolic acid promotes a tolerogenic response in experimental asthma.

Am J Respir Crit Care Med 2006 Jul 4;174(2):152-60. Epub 2006 May 4.

Department for Molecular Biomedical Research (DMBR), VIB-Ghent University, "Fiers-Schell-Van Montagu" Building, Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.200507-1175OCDOI Listing
July 2006

Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy.

Free Radic Biol Med 2006 Jan 17;40(2):285-94. Epub 2005 Oct 17.

Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and Ghent University, Molecular Immunology Unit, Technologiepark 927, B-9052 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2005.08.033DOI Listing
January 2006

CD3 x CD28 cross-interacting bispecific antibodies improve tumor cell dependent T-cell activation.

Cancer Immunol Immunother 2005 Nov 13;54(11):1059-71. Epub 2005 May 13.

Flanders Interuniversity Institute for Biotechnology (VIB), Department for Molecular Biomedical Research, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00262-005-0671-8DOI Listing
November 2005

Lysophosphatidic acid affinity chromatography reveals pyruvate kinase as a specific LPA-binding protein.

Biol Chem 2005 Nov;386(11):1137-47

Department of Medical Protein Research, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Faculty of Medicine and Health Sciences, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/BC.2005.130DOI Listing
November 2005

IL-15 and IL-15Ralpha in CD4+T cell immunity.

Arch Immunol Ther Exp (Warsz) 2005 Mar-Apr;53(2):115-26

Molecular Immunology Unit, Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB) and Laboratory for Molecular Biology, University of Ghent, Gent-Zwijnaarde, Belgium.

View Article

Download full-text PDF

Source
August 2005

Enhancement of polymethacrylate-mediated gene delivery by Penetratin.

Eur J Pharm Sci 2005 Apr;24(5):525-37

Department of Biochemistry, Ghent University, 9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejps.2005.01.004DOI Listing
April 2005

The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen-associated host innate immune responses.

Eur J Immunol 2005 Mar;35(3):890-900

Department of Molecular Biomedical Research, Molecular Immunology Unit, VIB, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200425332DOI Listing
March 2005

Lipoprotein I, a TLR2/4 ligand modulates Th2-driven allergic immune responses.

J Immunol 2005 Jan;174(2):1097-103

Department for Molecular and Cellular Interactions, Flanders Interuniversity Institute for Biotechnology and Vrije Universiteit Brussel, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.174.2.1097DOI Listing
January 2005

Buffering properties of cationic polymethacrylates are not the only key to successful gene delivery.

Biomacromolecules 2004 Mar-Apr;5(2):379-88

Polymer Materials Research Group, Department of Organic Chemistry, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bm034438dDOI Listing
November 2004

Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter.

J Biol Chem 2004 Sep 24;279(36):37779-88. Epub 2004 Jun 24.

Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M401821200DOI Listing
September 2004

Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders.

Mamm Genome 2004 Jul;15(7):537-43

Unit for Molecular Genetics in the Mouse, Department of Molecular Biomedical Research, Ghent University-Flanders Interuniversity Institute for Biotechnology, Zwijnaarde, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00335-004-3002-zDOI Listing
July 2004

New strategies in polypeptide and antibody synthesis: an overview.

Cancer Biother Radiopharm 2004 Feb;19(1):99-109

Department of Molecular Biomedical Research, Flanders Interuniversity Institute of Biotechnology (VIB), Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/108497804773391748
Publisher Site
http://dx.doi.org/10.1089/108497804773391748DOI Listing
February 2004

Antigen presentation by local macrophages promotes nonallergic airway responses in sensitized mice.

Am J Respir Cell Mol Biol 2003 Nov 30;29(5):634-41. Epub 2003 May 30.

Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and Ghent University, Technologiepark 927, 9052 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2003-0014OCDOI Listing
November 2003

Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on Fc gamma R and IFN-gamma.

J Immunol 2003 Aug;171(4):2080-9

Department for Molecular Biomedical Research, Unit of Molecular Immunology, Flanders Interuniversity Institute for Biotechnology and Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.171.4.2080DOI Listing
August 2003

Optimizing expression and purification from cell culture medium of trispecific recombinant antibody derivatives.

J Chromatogr B Analyt Technol Biomed Life Sci 2003 Mar;786(1-2):161-76

Department of Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology (VIB), University of Ghent, K.L. Ledeganckstraat 35, 9000, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1570-0232(02)00813-9DOI Listing
March 2003

Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE.

Proc Natl Acad Sci U S A 2002 Jan 15;99(2):949-54. Epub 2002 Jan 15.

Department of Medical Protein Research, Ghent University and Flanders Interuniversity Institute for Biotechnology, K. L. Ledeganckstraat 35, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.012432399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117411PMC
January 2002