Johan Bussink

Johan Bussink

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Johan Bussink

Publications by authors named "Johan Bussink"

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Learning from scanners: Bias reduction and feature correction in radiomics.

Clin Transl Radiat Oncol 2019 Nov 16;19:33-38. Epub 2019 Jul 16.

Department of Radiation Oncology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1016/j.ctro.2019.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690665PMC
November 2019

Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer.

Acta Oncol 2019 Jul 4:1-8. Epub 2019 Jul 4.

a OncoRay - National Center for Radiation Research in Oncology , Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf , Dresden , Germany.

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http://dx.doi.org/10.1080/0284186X.2019.1629017DOI Listing
July 2019

Inhibition of CDK4/CDK6 Enhances Radiosensitivity of HPV Negative Head and Neck Squamous Cell Carcinomas.

Int J Radiat Oncol Biol Phys 2019 Jul 2. Epub 2019 Jul 2.

CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2019.06.2531DOI Listing
July 2019

Downregulation of matrix Gla protein is a biomarker for tamoxifen-resistant and radioresistant breast cancer.

Biomark Med 2019 Jul 18;13(10):841-850. Epub 2019 Jul 18.

Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.2217/bmm-2019-0050DOI Listing
July 2019

Changes in DNA damage repair gene expression and cell cycle gene expression do not explain radioresistance in tamoxifen-resistant breast cancer.

Oncol Res 2019 Apr 18. Epub 2019 Apr 18.

Radboud University Medical Center, Department of Radiation Oncology, Radiotherapy and OncoImmunology Laboratory, Nijmegen, The Netherlands.

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http://dx.doi.org/10.3727/096504019X15555794826018DOI Listing
April 2019

Image-guided adaptive radiotherapy in patients with locally advanced non-small cell lung cancer: the art of PET.

Q J Nucl Med Mol Imaging 2018 Dec 4;62(4):369-384. Epub 2018 Jun 4.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.23736/S1824-4785.18.03084-4DOI Listing
December 2018

Targeting glucose and glutamine metabolism combined with radiation therapy in non-small cell lung cancer.

Lung Cancer 2018 12 15;126:32-40. Epub 2018 Oct 15.

Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud university medical center, Nijmegen, the Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183060
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http://dx.doi.org/10.1016/j.lungcan.2018.10.016DOI Listing
December 2018

Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study.

PLoS Med 2018 11 30;15(11):e1002711. Epub 2018 Nov 30.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.plos.org/10.1371/journal.pmed.1002711
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http://dx.doi.org/10.1371/journal.pmed.1002711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269088PMC
November 2018

Interferon-Stimulated Genes Are Involved in Cross-resistance to Radiotherapy in Tamoxifen-Resistant Breast Cancer.

Clin Cancer Res 2018 07 16;24(14):3397-3408. Epub 2018 Apr 16.

Department of Radiation Oncology, Radiotherapy and OncoImmunology Laboratory, Radboud university medical center, Nijmegen, the Netherlands.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-2551DOI Listing
July 2018

Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers.

Med Phys 2018 Jul 13;45(7):3449-3459. Epub 2018 Jun 13.

The D-lab: Decision Support for Precision Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/mp.12967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095141PMC
July 2018

Preclinical validation of In-girentuximab-F(ab') as a tracer to image hypoxia related marker CAIX expression in head and neck cancer xenografts.

Radiother Oncol 2017 09 5;124(3):521-525. Epub 2017 Aug 5.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2017.07.025DOI Listing
September 2017

The Predictive Value of Early In-Treatment F-FDG PET/CT Response to Chemotherapy in Combination with Bevacizumab in Advanced Nonsquamous Non-Small Cell Lung Cancer.

J Nucl Med 2017 08 23;58(8):1243-1248. Epub 2017 Mar 23.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2967/jnumed.116.185314DOI Listing
August 2017

Survival prediction of non-small cell lung cancer patients using radiomics analyses of cone-beam CT images.

Radiother Oncol 2017 06 12;123(3):363-369. Epub 2017 May 12.

Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC), The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2017.04.016DOI Listing
June 2017

Tumor Delineation and Quantitative Assessment of Glucose Metabolic Rate within Histologic Subtypes of Non-Small Cell Lung Cancer by Using Dynamic F Fluorodeoxyglucose PET.

Radiology 2017 05 15;283(2):547-559. Epub 2016 Nov 15.

From the Departments of Radiation Oncology (T.W.H.M., J.B.), Radiology and Nuclear Medicine (L.F.d.G.O., E.P.V., W.J.G.O.), Pathology (M.G.L.S.), and Cardiothoracic Surgery (A.F.T.M.V.), Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands (L.F.d.G.O., D. Vriens); Biomedical Photonic Imaging Group, MIRA Institute, University of Twente, Enschede, the Netherlands (L.F.d.G.O.); Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, England (W.J.G.O.); and INSERM, UMR 1101, LaTIM, Université de Bretagne Occidentale, Brest, France (D. Visvikis).

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http://dx.doi.org/10.1148/radiol.2016160329DOI Listing
May 2017

Radiation-induced rib fractures after stereotactic body radiation therapy: Predict to prevent?

Radiother Oncol 2017 05 27;123(2):173-175. Epub 2017 Mar 27.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01678140173010
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http://dx.doi.org/10.1016/j.radonc.2017.03.010DOI Listing
May 2017

Esophageal wall dose-surface maps do not improve the predictive performance of a multivariable NTCP model for acute esophageal toxicity in advanced stage NSCLC patients treated with intensity-modulated (chemo-)radiotherapy.

Phys Med Biol 2017 05 5;62(9):3668-3681. Epub 2017 Apr 5.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Radiation Oncology (MAASTRO clinic), GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1088/1361-6560/aa5e9eDOI Listing
May 2017

Comparison of toxicity and outcome in advanced stage non-small cell lung cancer patients treated with intensity-modulated (chemo-)radiotherapy using IMRT or VMAT.

Radiother Oncol 2017 02 30;122(2):295-299. Epub 2016 Nov 30.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2016.11.015DOI Listing
February 2017

Adverse effect of smoking on prognosis in human papillomavirus-associated oropharyngeal carcinoma.

Head Neck 2016 12 1;38(12):1780-1787. Epub 2016 Jun 1.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/hed.24516DOI Listing
December 2016

Engineered microparticles delivering oxygen to enhance radiotherapy efficacy.

Proc Natl Acad Sci U S A 2016 12 7;113(50):E8009. Epub 2016 Dec 7.

Department of Radiation Oncology, Radboud University Medical Centre Nijmegen, Nijmegen 6500HB, The Netherlands.

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http://dx.doi.org/10.1073/pnas.1617279114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167185PMC
December 2016

The Impact of Optimal Respiratory Gating and Image Noise on Evaluation of Intratumor Heterogeneity on 18F-FDG PET Imaging of Lung Cancer.

J Nucl Med 2016 Nov 9;57(11):1692-1698. Epub 2016 Jun 9.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2967/jnumed.116.173112DOI Listing
November 2016

PET of EGFR with (64) Cu-cetuximab-F(ab')2 in mice with head and neck squamous cell carcinoma xenografts.

Contrast Media Mol Imaging 2016 Jan-Feb;11(1):65-70. Epub 2015 Aug 4.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/cmmi.1659DOI Listing
October 2016

Epidermal growth factor receptor imaging in human head and neck cancer xenografts.

Acta Oncol 2015 6;54(9):1263-7. Epub 2015 Aug 6.

a Department of Radiation Oncology , Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.3109/0284186X.2015.1063778DOI Listing
August 2016

Performance of automatic image segmentation algorithms for calculating total lesion glycolysis for early response monitoring in non-small cell lung cancer patients during concomitant chemoradiotherapy.

Radiother Oncol 2016 06 10;119(3):473-9. Epub 2016 May 10.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; Biomedical Photonic Imaging Group, MIRA Institute, University of Twente, Enschede, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S01678140163108
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http://dx.doi.org/10.1016/j.radonc.2016.04.039DOI Listing
June 2016

Radiation Promptly Alters Cancer Live Cell Metabolic Fluxes: An In Vitro Demonstration.

Radiat Res 2016 05 29;185(5):496-504. Epub 2016 Apr 29.

a   Laboratory for Optical and Computational Instrumentation, Vice Chancellor Office for Graduate Research and Education and Departments of.

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http://dx.doi.org/10.1667/RR14093.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882764PMC
May 2016

Exploratory Study to Identify Radiomics Classifiers for Lung Cancer Histology.

Front Oncol 2016 30;6:71. Epub 2016 Mar 30.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.3389/fonc.2016.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811956PMC
April 2016

Interaction between hypoxia, AKT and HIF-1 signaling in HNSCC and NSCLC: implications for future treatment strategies.

Future Sci OA 2016 Mar 29;2(1):FSO84. Epub 2016 Jan 29.

Department of Radiation Oncology, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands; Department of Radiation Oncology, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.4155/fso.15.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137923PMC
March 2016

Stereotactic versus conventional radiotherapy for pain reduction and quality of life in spinal metastases: study protocol for a randomized controlled trial.

Trials 2016 Feb 2;17:61. Epub 2016 Feb 2.

Department of Radiation Oncology, Radboud University Medical Center Nijmegen, Geert Grooteplein-Zuid 32, route 874, PB 9101, Nijmegen, GA, 6525, The Netherlands.

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http://link.springer.com/content/pdf/10.1186%2Fs13063-016-11
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http://www.trialsjournal.com/content/17/1/61
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http://dx.doi.org/10.1186/s13063-016-1178-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735957PMC
February 2016

Poor prognosis of constitutive γ-H2AX expressing triple-negative breast cancers is associated with telomere length.

Biomark Med 2015 ;9(4):383-90

Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2217/bmm.15.2DOI Listing
January 2016

Evaluating the use of optimally respiratory gated 18F-FDG-PET in target volume delineation and its influence on radiation doses to the organs at risk in non-small-cell lung cancer patients.

Nucl Med Commun 2016 Jan;37(1):66-73

Departments of aRadiation Oncology bRadiology and Nuclear Medicine cPulmonary Diseases, Radboud University Medical Center, Nijmegen dDepartment of Radiology, Leiden University Medical Center, Leiden eBiomedical Photonic Imaging Group, MIRA Institute, University of Twente, Enschede, The Netherlands fInstitute of Radiooncology, Helmholtz-Zentrum Dresden-Rossendorf gDepartment of Radiotherapy and Radiooncology, University Hospital Carl Gustav Carus at the Technische Universität Dresden hOncoRay, National Center for Radiation Research in Oncology, Dresden, Germany.

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http://dx.doi.org/10.1097/MNM.0000000000000409DOI Listing
January 2016

The mechanical microenvironment in cancer: How physics affects tumours.

Semin Cancer Biol 2015 Dec 5;35:62-70. Epub 2015 Sep 5.

Department of Radiation Oncology, Radboud University Medical Center, Geert grooteplein-zuid 32, 6525 GA Nijmegen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1044579X150007
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http://dx.doi.org/10.1016/j.semcancer.2015.09.001DOI Listing
December 2015

GABARAPL1 is required for increased EGFR membrane expression during hypoxia.

Radiother Oncol 2015 Sep 8;116(3):417-22. Epub 2015 Jul 8.

Maastricht Radiation Oncology (MaastRO) lab, GROW - School for Oncology and Developmental Biology, Maastricht University, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2015.06.023DOI Listing
September 2015

PET Imaging in Head and Neck Cancer Patients to Monitor Treatment Response: A Future Role for EGFR-Targeted Imaging.

Clin Cancer Res 2015 Aug 30;21(16):3602-9. Epub 2015 Apr 30.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0348DOI Listing
August 2015

PET in the management of locally advanced and metastatic NSCLC.

Nat Rev Clin Oncol 2015 Jul 28;12(7):395-407. Epub 2015 Apr 28.

Department of Radiation Oncology, Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, Netherlands.

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http://www.nature.com/articles/nrclinonc.2015.75
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http://dx.doi.org/10.1038/nrclinonc.2015.75DOI Listing
July 2015

Hypoxic regulation of the PERK/ATF4/LAMP3-arm of the unfolded protein response in head and neck squamous cell carcinoma.

Head Neck 2015 Jun 27;37(6):896-905. Epub 2014 Jun 27.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/hed.23693DOI Listing
June 2015

Radiomic feature clusters and prognostic signatures specific for Lung and Head & Neck cancer.

Sci Rep 2015 Jun 5;5:11044. Epub 2015 Jun 5.

1] Departments of Radiation Oncology [2] Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [3] Department of Biostatistics &Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/srep11044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937496PMC
June 2015

Therapeutic targeting of autophagy in cancer. Part I: molecular pathways controlling autophagy.

Semin Cancer Biol 2015 Apr 29;31:89-98. Epub 2014 May 29.

Department of Radiation Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2014.05.004DOI Listing
April 2015

Therapeutic targeting of autophagy in cancer. Part II: pharmacological modulation of treatment-induced autophagy.

Semin Cancer Biol 2015 Apr 14;31:99-105. Epub 2014 Jun 14.

Department of Radiation Oncology, Radboud university medical center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1044579X140007
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http://dx.doi.org/10.1016/j.semcancer.2014.06.001DOI Listing
April 2015

γ-H2AX foci in peripheral blood lymphocytes to quantify radiation-induced DNA damage after 177Lu-DOTA-octreotate peptide receptor radionuclide therapy.

J Nucl Med 2015 Apr 26;56(4):501-2. Epub 2015 Feb 26.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2967/jnumed.115.153841DOI Listing
April 2015

Biology of hypoxia.

Semin Nucl Med 2015 Mar;45(2):101-9

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.semnuclmed.2014.10.002DOI Listing
March 2015

111In-cetuximab-F(ab')2 SPECT and 18F-FDG PET for prediction and response monitoring of combined-modality treatment of human head and neck carcinomas in a mouse model.

J Nucl Med 2015 Feb 31;56(2):287-92. Epub 2014 Dec 31.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands; and.

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http://dx.doi.org/10.2967/jnumed.114.148296DOI Listing
February 2015

The unfolded protein response as a target for cancer therapy.

Biochim Biophys Acta 2014 Dec 25;1846(2):277-84. Epub 2014 Jul 25.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.07.006DOI Listing
December 2014

Improving chemoradiation efficacy by PI3-K/AKT inhibition.

Cancer Treat Rev 2014 Dec 5;40(10):1182-91. Epub 2014 Oct 5.

Dept. of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ctrv.2014.09.005DOI Listing
December 2014

Glucose metabolism in NSCLC is histology-specific and diverges the prognostic potential of 18FDG-PET for adenocarcinoma and squamous cell carcinoma.

J Thorac Oncol 2014 Oct;9(10):1485-93

Departments of *Pulmonary Diseases, †Radiation Oncology, ‡Pathology, and §Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/JTO.0000000000000286DOI Listing
October 2014

Early response monitoring with 18F-FDG PET and cetuximab-F(ab')2-SPECT after radiotherapy of human head and neck squamous cell carcinomas in a mouse model.

J Nucl Med 2014 Oct 18;55(10):1665-70. Epub 2014 Sep 18.

Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands; and.

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http://dx.doi.org/10.2967/jnumed.114.141762DOI Listing
October 2014

Hypoxia, metabolism, and growth factor signaling in head and neck squamous cell carcinoma: correlation between primary and xenograft tumors.

Head Neck 2014 Sep 6;36(9):1288-95. Epub 2013 Nov 6.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/hed.23446DOI Listing
September 2014

Effect of hypoxia on the expression of αB-crystallin in head and neck squamous cell carcinoma.

BMC Cancer 2014 Apr 11;14:252. Epub 2014 Apr 11.

Department of Biomolecular Chemistry, Institute for Molecules and Materials and Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, 271, RIMLS, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/1471-2407-14-252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990244PMC
April 2014

Improved recurrence-free survival with ARCON for anemic patients with laryngeal cancer.

Clin Cancer Res 2014 Mar 22;20(5):1345-54. Epub 2014 Jan 22.

Authors' Affiliations: Department of Radiation Oncology; Department of Oto-Rhino-Laryngology and Head & Neck Surgery, Radboud University Nijmegen Medical Centre, Nijmegen; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht; Departments of Radiation Oncology and Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam; Department of Radiation Oncology, University Medical Center Groningen, Groningen; Department of Radiation Oncology (MAASTRO), Maastricht University Medical Centre, Maastricht; and Department of Clinical Oncology, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1730DOI Listing
March 2014

Imaging integrin αvβ3 on blood vessels with 111In-RGD2 in head and neck tumor xenografts.

J Nucl Med 2014 Feb 9;55(2):281-6. Epub 2014 Jan 9.

Department of Nuclear Medicine, Radboud UMC, Nijmegen, The Netherlands.

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http://jnm.snmjournals.org/cgi/doi/10.2967/jnumed.113.129668
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http://dx.doi.org/10.2967/jnumed.113.129668DOI Listing
February 2014

LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy.

Endocr Relat Cancer 2014 Feb 16;21(1):101-12. Epub 2014 Jan 16.

Departments of Radiation Oncology, Laboratory Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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https://erc.bioscientifica.com/downloadpdf/journals/erc/21/1
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http://www.jbc.org/content/274/18/12692
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https://erc.bioscientifica.com/view/journals/erc/21/1/101.xm
Publisher Site
http://dx.doi.org/10.1530/ERC-13-0183DOI Listing
February 2014

αB-crystallin expression is correlated with phospho-ERK1/2 expression in human breast cancer.

Int J Biol Markers 2013 Dec 17;28(4):e365-70. Epub 2013 Dec 17.

Department of Biomolecular Chemistry, Institute for Molecules and Materials and Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen - The Netherlands.

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http://dx.doi.org/10.5301/jbm.5000032DOI Listing
December 2013

Imaging of epidermal growth factor receptor expression in head and neck cancer with SPECT/CT and 111In-labeled cetuximab-F(ab')2.

J Nucl Med 2013 Dec 17;54(12):2118-24. Epub 2013 Oct 17.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; and.

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http://dx.doi.org/10.2967/jnumed.113.123612DOI Listing
December 2013

Low phosphorylated AKT expression in laryngeal cancer: indications for a higher metastatic risk.

Int J Radiat Oncol Biol Phys 2013 Oct 23;87(2):349-55. Epub 2013 Jul 23.

Department of Radiation Oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ijrobp.2013.05.046DOI Listing
October 2013

Molecular PET imaging for biology-guided adaptive radiotherapy of head and neck cancer.

Acta Oncol 2013 Oct 5;52(7):1257-71. Epub 2013 Sep 5.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre , Nijmegen , The Netherlands.

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http://dx.doi.org/10.3109/0284186X.2013.812799DOI Listing
October 2013

Cardiac comorbidity is an independent risk factor for radiation-induced lung toxicity in lung cancer patients.

Radiother Oncol 2013 Oct 14;109(1):100-6. Epub 2013 Sep 14.

Department of Radiation Oncology (Maastro Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2013.08.035DOI Listing
October 2013

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia.

Radiother Oncol 2013 Sep 9;108(3):529-34. Epub 2013 Jul 9.

Department of Radiation Oncology (Maastro Lab), GROW School for Oncology & Developmental Biology, Maastricht University Medical Center+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2013.06.015DOI Listing
September 2013

18F-FDG PET early response evaluation of locally advanced non-small cell lung cancer treated with concomitant chemoradiotherapy.

J Nucl Med 2013 Sep 17;54(9):1528-34. Epub 2013 Jul 17.

Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2967/jnumed.112.116921DOI Listing
September 2013

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival.

Radiother Oncol 2013 Sep 25;108(3):479-83. Epub 2013 Jul 25.

Maastricht Radiation Oncology (MaastRO) Lab, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2013.06.033DOI Listing
September 2013

The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response.

Radiother Oncol 2013 Sep 25;108(3):415-21. Epub 2013 Jul 25.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, The Netherlands; Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2013.06.037DOI Listing
September 2013

111In-cetuximab-F(ab')2 SPECT imaging for quantification of accessible epidermal growth factor receptors (EGFR) in HNSCC xenografts.

Radiother Oncol 2013 Sep 7;108(3):484-8. Epub 2013 Aug 7.

Department of Radiation Oncology, Radboud University Nijmegen Medical Center, The Netherlands; Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2013.06.034DOI Listing
September 2013

Toll-like receptor 4 in bone marrow-derived cells as well as tissue-resident cells participate in aggravating autoimmune destructive arthritis.

Ann Rheum Dis 2013 Aug 3;72(8):1407-15. Epub 2013 Jan 3.

Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2012-202467DOI Listing
August 2013

Interaction of EGFR with the tumour microenvironment: implications for radiation treatment.

Radiother Oncol 2013 Jul 5;108(1):17-23. Epub 2013 Jun 5.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2013.05.006DOI Listing
July 2013

Generation of multicellular tumor spheroids of breast cancer cells: how to go three-dimensional.

Anal Biochem 2013 Jun 19;437(1):17-9. Epub 2013 Feb 19.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ab.2013.02.004DOI Listing
June 2013

Hypoxia regulation of phosphokinases and the prognostic value of pAKT in breast cancer.

Int J Biol Markers 2013 Jun 28;28(2):151-60. Epub 2013 Jun 28.

Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.5301/jbm.5000008DOI Listing
June 2013

Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers.

Radiother Oncol 2013 Jun 14;107(3):434-41. Epub 2013 May 14.

University of Groningen, University Medical Center Groningen, Department of Surgery, Section of Surgical Oncology, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2013.03.027DOI Listing
June 2013

Regulation of TRIB3 mRNA and protein in breast cancer.

PLoS One 2012 20;7(11):e49439. Epub 2012 Nov 20.

Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049439PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502484PMC
May 2013

18F-FLT PET during radiotherapy or chemoradiotherapy in head and neck squamous cell carcinoma is an early predictor of outcome.

J Nucl Med 2013 Apr 23;54(4):532-40. Epub 2013 Jan 23.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2967/jnumed.112.105999DOI Listing
April 2013

Diffusion-weighted MR imaging in liver metastases of colorectal cancer: reproducibility and biological validation.

Eur Radiol 2013 Mar 23;23(3):748-56. Epub 2012 Sep 23.

Department of Medical Oncology 452, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00330-012-2654-4DOI Listing
March 2013

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

Proc Natl Acad Sci U S A 2013 Mar 7;110(12):4622-7. Epub 2013 Mar 7.

Department of Radiation Oncology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1210633110
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http://dx.doi.org/10.1073/pnas.1210633110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607059PMC
March 2013

αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma.

BMC Cancer 2013 Mar 18;13:128. Epub 2013 Mar 18.

Department of Biomolecular Chemistry, Institute for Molecules and Materials and Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/1471-2407-13-128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606599PMC
March 2013

Combretastatin A-4 phosphate affects tumor vessel volume and size distribution as assessed using MRI-based vessel size imaging.

Clin Cancer Res 2012 Dec 15;18(23):6469-77. Epub 2012 Oct 15.

Department of Experimental Clinical Oncology, Danish National Research Foundations Center of Functionally Integrative Neuroscience, Aarhus University Hospital, Aarhus, Denmark.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-2014DOI Listing
December 2012

Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck.

BMC Cancer 2012 Oct 10;12:463. Epub 2012 Oct 10.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/1471-2407-12-463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517352PMC
October 2012

Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy.

Clin Cancer Res 2012 Oct;18(20):5585-94

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0858DOI Listing
October 2012

Treatment outcome and toxicity of intensity-modulated (chemo) radiotherapy in stage III non-small cell lung cancer patients.

Radiat Oncol 2012 Sep 7;7:150. Epub 2012 Sep 7.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands.

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http://dx.doi.org/10.1186/1748-717X-7-150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493323PMC
September 2012