Publications by authors named "Johan Botling"

86Publications

Programmed Cell Death Ligand 1 Expression in Resected Non-Small Cell Lung Cancer.

Clin Lung Cancer 2020 Oct 15. Epub 2020 Oct 15.

Mount Sinai Cancer, Mount Sinai Health System, Icahn School of Medicine, New York, NY.

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http://dx.doi.org/10.1016/j.cllc.2020.09.018DOI Listing
October 2020

An immune gene expression signature distinguishes central nervous system metastases from primary tumours in non-small-cell lung cancer.

Eur J Cancer 2020 06 20;132:24-34. Epub 2020 Apr 20.

Thoracic Oncology Center, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology and Pathology, Karolinska Institutet, Visionsgatan 4, 17164 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2020.03.014DOI Listing
June 2020

Evaluation of a Hybrid Capture-Based Pan-Cancer Panel for Analysis of Treatment Stratifying Oncogenic Aberrations and Processes.

J Mol Diagn 2020 06 20;22(6):757-769. Epub 2020 Mar 20.

Department of Pathology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands; Department of Human Genetics, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2020.02.009DOI Listing
June 2020

Diagnostic Value of Insulinoma-Associated Protein 1 (INSM1) and Comparison With Established Neuroendocrine Markers in Pulmonary Cancers.

Arch Pathol Lab Med 2020 09;144(9):1075-1085

Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden (Staaf, Nodin, Jirström, Vidarsdottir, Planck, Brunnström).

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http://dx.doi.org/10.5858/arpa.2019-0250-OADOI Listing
September 2020

High-Grade Progression Confers Poor Survival in Pancreatic Neuroendocrine Tumors.

Neuroendocrinology 2020 29;110(11-12):891-898. Epub 2019 Oct 29.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden,

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http://dx.doi.org/10.1159/000504392DOI Listing
October 2019

Prognostic Impact of BRAF and KRAS Mutation in Patients with Colorectal and Appendiceal Peritoneal Metastases Scheduled for CRS and HIPEC.

Ann Surg Oncol 2020 Jan 30;27(1):293-300. Epub 2019 Sep 30.

Department of Surgical Sciences, Akademiska sjukhuset, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1245/s10434-019-07452-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925063PMC
January 2020

c-MET as a biomarker in patients with surgically resected non-small cell lung cancer.

Lung Cancer 2019 07 1;133:69-74. Epub 2019 May 1.

Thoracic Oncology Center, Theme Cancer, Karolinska University Hospital/Department of Oncology- Pathology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.lungcan.2019.04.028DOI Listing
July 2019

Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases.

Hum Pathol 2019 02 31;84:221-230. Epub 2018 Oct 31.

Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, SE-221 00 Lund, Sweden; Department of Genetics and Pathology, Division of Laboratory Medicine, Region Skåne, SE-221 85 Lund, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183039
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http://dx.doi.org/10.1016/j.humpath.2018.10.009DOI Listing
February 2019

Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer.

Int J Cancer 2018 10 13;143(7):1741-1752. Epub 2018 May 13.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Department of Pathology, Uppsala University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1002/ijc.31545DOI Listing
October 2018

Serotonin, ATRX, and DAXX Expression in Pituitary Adenomas: Markers in the Differential Diagnosis of Neuroendocrine Tumors of the Sellar Region.

Am J Surg Pathol 2017 Sep;41(9):1238-1246

Departments of *Immunology, Genetics and Pathology §Medical Sciences ∥Surgical Sciences, Uppsala University †Department of Clinical Pathology, Uppsala University Hospital, Uppsala, Sweden ‡Department of Pathology, Oslo University Hospital, Oslo, Norway ¶Department of Pathology, Odense University Hospital #Department of Clinical Research, University of Southern Denmark, Odense, Denmark **Faculty of Medicine Lyon-Est ††Centre de Pathologie et de Biologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, University of Lyon, Lyon, France.

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http://dx.doi.org/10.1097/PAS.0000000000000908DOI Listing
September 2017

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification.

J Thorac Oncol 2017 08 20;12(8):1257-1267. Epub 2017 May 20.

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2017.05.008DOI Listing
August 2017

Immune Biomarkers on the Radar-Comprehensive "Immunograms" for Multimodal Treatment Prediction.

J Thorac Oncol 2017 05;12(5):770-772

Clinical and Experimental Oncology Unit, Department of Immunology Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.

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http://dx.doi.org/10.1016/j.jtho.2017.03.009DOI Listing
May 2017

The Human Adrenal Gland Proteome Defined by Transcriptomics and Antibody-Based Profiling.

Endocrinology 2017 02;158(2):239-251

Department of Immunology Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1210/en.2016-1758DOI Listing
February 2017

Various Antibody Clones of Napsin A, Thyroid Transcription Factor 1, and p40 and Comparisons With Cytokeratin 5 and p63 in Histopathologic Diagnostics of Non-Small Cell Lung Carcinoma.

Appl Immunohistochem Mol Morphol 2016 10;24(9):648-659

*Department of Pathology, Regional Laboratories Region Skåne ‡Department of Clinical Sciences, Division of Oncology and Pathology, Lund University §Department of Thoracic Surgery, Lund University and Skåne University Hospital ∥Department of Oncology, Skåne University Hospital, Lund †Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1097/PAI.0000000000000235DOI Listing
October 2016

The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs.

J Thorac Oncol 2016 06 9;11(6):862-72. Epub 2016 Feb 9.

Department of Clinical Sciences in Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden; Department of Pathology, Regional Laboratories, Region Skåne, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.01.020DOI Listing
June 2016

Identification of sample annotation errors in gene expression datasets.

Arch Toxicol 2015 Dec 25;89(12):2265-72. Epub 2015 Nov 25.

Department of Statistics, TU Dortmund University, Vogelpothsweg 87, 44227, Dortmund, Germany.

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http://dx.doi.org/10.1007/s00204-015-1632-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673097PMC
December 2015

HaloPlex Targeted Resequencing for Mutation Detection in Clinical Formalin-Fixed, Paraffin-Embedded Tumor Samples.

J Mol Diagn 2015 Nov 3;17(6):729-39. Epub 2015 Sep 3.

Department of Immunology Genetics and Pathology, Uppsala University, Science for Life Laboratory, Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2015.06.009DOI Listing
November 2015

Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas.

Endocr Relat Cancer 2015 Oct;22(5):735-44

Department of Surgical SciencesUppsala University, Uppsala, SwedenDepartment of Endocrinology and MetabolismRostock University Medical Center, GermanyGeneralVisceral and Pediatric Surgery University Hospital Düsseldorf, Düsseldorf, GermanyUniversity of SydneyEndocrine Surgical Unit and Cancer Genetics, Hormones and Cancer Group, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, AustraliaDepartment of Medicine IUniversity of Lübeck, University Hospital, Lübeck, GermanyDepartment of GeneralVisceral and Vascular Surgery, University Hospital, University of Halle-Wittenberg, Halle/Saale, GermanyDepartment of Molecular Medicine and SurgeryEndocrine Surgery Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, SwedenDepartment of ImmunologyGenetics and Pathology, Uppsala University, Uppsala, SwedenKlinik für Chirurgie und Zentrum für Minimal Invasive ChirurgieKliniken Essen-Mitte, Essen, Germany.

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http://dx.doi.org/10.1530/ERC-15-0321DOI Listing
October 2015

Oligonucleotide gap-fill ligation for mutation detection and sequencing in situ.

Nucleic Acids Res 2015 Dec 3;43(22):e151. Epub 2015 Aug 3.

Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-17121 Sweden

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http://dx.doi.org/10.1093/nar/gkv772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678841PMC
December 2015

Comprehensive genomic profiles of small cell lung cancer.

Nature 2015 Aug 13;524(7563):47-53. Epub 2015 Jul 13.

1] Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany. [2] Department of Pathology, University Hospital Cologne, 50937 Cologne, Germany.

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http://dx.doi.org/10.1038/nature14664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861069PMC
August 2015

Patients with Non-small Cell Lung Cancer Analyzed for EGFR: Adherence to Guidelines, Prevalence and Outcome.

Anticancer Res 2015 Jul;35(7):3979-85

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Unit of Molecular Pathology, Uppsala University Hospital, Uppsala, Sweden.

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July 2015

LRIG1 is a prognostic biomarker in non-small cell lung cancer.

Acta Oncol 2015 27;54(8):1113-9. Epub 2015 Mar 27.

a Department of Radiation Sciences , Oncology, Umeå University , Umeå , Sweden.

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http://dx.doi.org/10.3109/0284186X.2015.1021427DOI Listing
June 2016

Genomic and transcriptional alterations in lung adenocarcinoma in relation to smoking history.

Clin Cancer Res 2014 Sep 18;20(18):4912-24. Epub 2014 Jul 18.

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0246DOI Listing
September 2014

An integrative analysis of the tumorigenic role of TAZ in human non-small cell lung cancer.

Clin Cancer Res 2014 Sep 20;20(17):4660-72. Epub 2014 Jun 20.

Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3328DOI Listing
September 2014

Genomic and transcriptional alterations in lung adenocarcinoma in relation to EGFR and KRAS mutation status.

PLoS One 2013 24;8(10):e78614. Epub 2013 Oct 24.

Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Medicon Village, Lund, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078614PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812039PMC
August 2014

In situ sequencing for RNA analysis in preserved tissue and cells.

Nat Methods 2013 Sep 14;10(9):857-60. Epub 2013 Jul 14.

Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nmeth.2563DOI Listing
September 2013

Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing.

BMC Genomics 2013 Mar 12;14:165. Epub 2013 Mar 12.

Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, SE 751 85, Sweden.

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http://dx.doi.org/10.1186/1471-2164-14-165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600027PMC
March 2013

Parallel visualization of multiple protein complexes in individual cells in tumor tissue.

Mol Cell Proteomics 2013 Jun 22;12(6):1563-71. Epub 2013 Feb 22.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden.

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http://dx.doi.org/10.1074/mcp.O112.023374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675814PMC
June 2013

Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma.

Int J Cancer 2013 May 20;132(9):2020-31. Epub 2012 Oct 20.

Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Barngatan 2B, Lund, Sweden.

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http://dx.doi.org/10.1002/ijc.27879DOI Listing
May 2013

Consistent mutation status within histologically heterogeneous lung cancer lesions.

Histopathology 2012 Oct;61(4):744-8

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1111/j.1365-2559.2012.04245.xDOI Listing
October 2012

Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity.

Genome Biol 2011 Oct 24;12(10):R108. Epub 2011 Oct 24.

Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, SE-751 85 Uppsala, Sweden.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2011-12-10-r108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333778PMC
October 2011

KRAS analysis in colorectal carcinoma: analytical aspects of Pyrosequencing and allele-specific PCR in clinical practice.

BMC Cancer 2010 Dec 1;10:660. Epub 2010 Dec 1.

Molecular Pathology Unit, Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.

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http://dx.doi.org/10.1186/1471-2407-10-660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002357PMC
December 2010

Fresh frozen tissue: RNA extraction and quality control.

Methods Mol Biol 2011 ;675:405-13

Rudbeck Laboratory, Department of Genetics and Pathology, University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1007/978-1-59745-423-0_25DOI Listing
January 2011

Biobanking of fresh frozen tissue from clinical surgical specimens: transport logistics, sample selection, and histologic characterization.

Methods Mol Biol 2011 ;675:299-306

Department of Genetics and Pathology, University Hospital, Uppsala, Sweden.

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http://link.springer.com/10.1007/978-1-59745-423-0_16
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http://dx.doi.org/10.1007/978-1-59745-423-0_16DOI Listing
January 2011

Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer.

Mol Oncol 2010 Aug 26;4(4):357-68. Epub 2010 Jun 26.

Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway.

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http://dx.doi.org/10.1016/j.molonc.2010.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527914PMC
August 2010

Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer.

Cancer Res 2010 Apr 16;70(7):2644-54. Epub 2010 Mar 16.

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3644DOI Listing
April 2010

The glucocorticoid receptor is overexpressed in malignant adrenocortical tumors.

J Clin Endocrinol Metab 2009 Nov 9;94(11):4591-9. Epub 2009 Oct 9.

Cancer Genetics Unit, Hormones and Cancer Group, Kolling Institute of Medical Research, University of Sydney, Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.1210/jc.2009-0546DOI Listing
November 2009

Impact of thawing on RNA integrity and gene expression analysis in fresh frozen tissue.

Diagn Mol Pathol 2009 Mar;18(1):44-52

Department of Genetics and Pathology, University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1097/PDM.0b013e3181857e92DOI Listing
March 2009

Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer.

Exp Cell Res 2007 Apr 6;313(7):1285-94. Epub 2007 Feb 6.

Department of Genetics and Pathology, the Rudbeck Laboratory, Uppsala University, S-751 85 Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.yexcr.2007.01.021DOI Listing
April 2007

In situ identification of genes regulated specifically in fibroblasts of human basal cell carcinoma.

J Invest Dermatol 2007 Jun 1;127(6):1516-23. Epub 2007 Feb 1.

Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/sj.jid.5700714DOI Listing
June 2007

Malignant insulinoma in ectopic pancreatic tissue.

Dig Surg 2005 28;22(5):377-9. Epub 2004 May 28.

Department of Surgery, Uppsala University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1159/000090998DOI Listing
June 2006

Biobanking of fresh frozen tissue: RNA is stable in nonfixed surgical specimens.

Lab Invest 2006 Feb;86(2):202-11

Cancer Center Karolinska, Department of Pathology-Oncology, Karolinska Institute, Stockholm, Sweden.

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http://www.nature.com/articles/3700372
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http://dx.doi.org/10.1038/labinvest.3700372DOI Listing
February 2006