Publications by authors named "Johan Auwerx"

100Publications

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators.

Cell Rep 2020 Sep;32(13):108203

Laboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland. Electronic address:

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September 2020

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury.

Am J Transplant 2020 Sep 28. Epub 2020 Sep 28.

Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Liver Donor Liver Transplantation, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing, China.

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September 2020

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling.

iScience 2020 Sep 2;23(9):101522. Epub 2020 Sep 2.

Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa, Kanagawa 252-0882, Japan; Health Science Laboratory, Keio Research Institute at SFC, Fujisawa, Kanagawa 252-0882, Japan; Department of Environment and Information Studies, Keio University, Fujisawa, Kanagawa 252-0882, Japan; Department of Internal Medicine, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan; Department of Ophthalmology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan. Electronic address:

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September 2020

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice.

J Am Heart Assoc 2020 08 28;9(15):e015862. Epub 2020 Jul 28.

Laboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of Medicine Shanghai China.

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August 2020

NAD homeostasis in health and disease.

Nat Metab 2020 01 20;2(1):9-31. Epub 2020 Jan 20.

Laboratory of Integrative Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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January 2020

A biosensor for measuring NAD levels at the point of care.

Nat Metab 2019 12 13;1(12):1219-1225. Epub 2019 Dec 13.

Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany.

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December 2019

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel.

Nat Metab 2019 12 9;1(12):1226-1242. Epub 2019 Dec 9.

Laboratory of Systems Biology and Genetics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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December 2019

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice.

Aging Cell 2020 08 21;19(8):e13195. Epub 2020 Jul 21.

Research Center for Endocrine and Metabolic Diseases, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Republic of Korea.

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August 2020

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism.

Nat Commun 2020 06 1;11(1):2695. Epub 2020 Jun 1.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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June 2020

Confounding factors from inducible systems for spatiotemporal gene expression regulation.

J Cell Biol 2020 Jul;219(7)

Laboratory for Integrative Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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July 2020

Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome.

Brain 2020 06;143(6):1686-1696

Université Grenoble Alpes, Inserm, U1216, Grenoble Institut des Neurosciences, 38000 Grenoble, France.

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June 2020

NCoR1 Protects Mice From Dextran Sodium Sulfate-Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult.

Cell Mol Gastroenterol Hepatol 2020 7;10(1):133-147. Epub 2020 Feb 7.

Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, California. Electronic address:

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February 2020

Mouse Systems Genetics as a Prelude to Precision Medicine.

Authors:
Hao Li Johan Auwerx

Trends Genet 2020 04 6;36(4):259-272. Epub 2020 Feb 6.

Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland. Electronic address:

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April 2020

Evaluation of the NAD biosynthetic pathway in ALS patients and effect of modulating NAD levels in hSOD1-linked ALS mouse models.

Exp Neurol 2020 05 31;327:113219. Epub 2020 Jan 31.

Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

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May 2020

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.

Neuron 2020 02 16;105(4):630-644.e9. Epub 2019 Dec 16.

Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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February 2020

Identifying gene function and module connections by the integration of multispecies expression compendia.

Genome Res 2019 12 21;29(12):2034-2045. Epub 2019 Nov 21.

Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.

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December 2019

Mitocellular communication: Shaping health and disease.

Science 2019 11 14;366(6467):827-832. Epub 2019 Nov 14.

Laboratory of Integrative Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

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November 2019

Nuclear receptor corepressor 1 represses cardiac hypertrophy.

EMBO Mol Med 2019 11 18;11(11):e9127. Epub 2019 Sep 18.

Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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November 2019

Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity.

Circ Res 2019 09 15;125(7):707-719. Epub 2019 Aug 15.

Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, China (W.S., H.W., B.L., D.D., Z.J.).

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September 2019

Opposing action of NCoR1 and PGC-1α in mitochondrial redox homeostasis.

Free Radic Biol Med 2019 11 10;143:203-208. Epub 2019 Aug 10.

Department of Biochemistry and Immunology, Ribeirão Preto Medical School, USP, Ribeirão Preto, SP, Brazil; Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil; Obesity and Comorbidities Research Center - OCRC - IB - UNICAMP, Campinas, Brazil. Electronic address:

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November 2019

Cross-species functional modules link proteostasis to human normal aging.

PLoS Comput Biol 2019 07 3;15(7):e1007162. Epub 2019 Jul 3.

Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland.

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July 2019

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.

Cell Stem Cell 2019 03;24(3):405-418.e7

Laboratory of Regenerative Hematopoiesis, Swiss Institute for Experimental Cancer Research (ISREC) & Institute of Bioengineering (IBI), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Service and Central Laboratory of Hematology, Departments of Oncology and of Laboratories, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. Electronic address:

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March 2019

The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo.

Blood Adv 2019 02;3(4):644-657

Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

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February 2019

Niacin: an old lipid drug in a new NAD dress.

J Lipid Res 2019 04 19;60(4):741-746. Epub 2019 Feb 19.

Laboratory of Integrative Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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April 2019

Mild inborn errors of metabolism in commonly used inbred mouse strains.

Mol Genet Metab 2019 04 24;126(4):388-396. Epub 2019 Jan 24.

Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY 10029, USA. Electronic address:

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April 2019

The virtuous cycle of human genetics and mouse models in drug discovery.

Nat Rev Drug Discov 2019 04;18(4):255-272

Laboratory of Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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April 2019

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.

Mol Cell 2019 02 11;73(4):775-787.e10. Epub 2019 Jan 11.

Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. Electronic address:

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February 2019

Multimodal imaging and high-throughput image-processing for drug screening on living organisms on-chip.

J Biomed Opt 2018 11;24(2):1-9

Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratory of Microsystems, Lausanne, Switzerland.

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November 2018

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells.

J Cell Physiol 2019 05 11;234(5):6601-6610. Epub 2018 Nov 11.

Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, The Netherlands.

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May 2019

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population.

Mol Cell Proteomics 2018 09 26;17(9):1766-1777. Epub 2018 Jun 26.

From the ‡Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich CH-8093, Switzerland;

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September 2018

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.

Cell Syst 2018 06 13;6(6):722-733.e6. Epub 2018 Jun 13.

Morgridge Institute for Research, Madison, WI 53715, USA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

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June 2018

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.

Cell Syst 2018 06 13;6(6):709-721.e6. Epub 2018 Jun 13.

Laboratory of Integrative and Systems Physiology, École Polytchnique Fédérale de Lausanne, Lausanne 1015, Switzerland. Electronic address:

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June 2018

Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly.

Sci Rep 2018 06 4;8(1):8548. Epub 2018 Jun 4.

Amazentis SA, EPFL Innovation Park, Batiment C, CH-1015, Lausanne, Switzerland.

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June 2018

Reduced oxidative capacity in macrophages results in systemic insulin resistance.

Nat Commun 2018 04 19;9(1):1551. Epub 2018 Apr 19.

Research Center for Endocrine and Metabolic Diseases, Department of Medical Science, School of Medicine, Chungnam National University, Daejeon, 35015, Korea.

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April 2018

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14.

Aging Cell 2018 08 14;17(4):e12751. Epub 2018 Apr 14.

Department of Cell Biology & Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ, USA.

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August 2018

The role of mitochondria in stem cell fate and aging.

Development 2018 04 13;145(8). Epub 2018 Apr 13.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, CH-1015, Switzerland

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April 2018

ERRγ Preserves Brown Fat Innate Thermogenic Activity.

Cell Rep 2018 03;22(11):2849-2859

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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March 2018

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells.

Elife 2018 02 22;7. Epub 2018 Feb 22.

Department of Molecular and Cellular Biology, University of California, Davis, Davis, United States.

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February 2018

Genetic cartography of longevity in humans and mice: Current landscape and horizons.

Biochim Biophys Acta Mol Basis Dis 2018 09 2;1864(9 Pt A):2718-2732. Epub 2018 Feb 2.

Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

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September 2018

α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD) Biosynthesis.

J Med Chem 2018 02 26;61(3):745-759. Epub 2018 Jan 26.

Laboratory of Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne CH-1015 Lausanne, Switzerland.

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February 2018

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.

Nature 2017 12 6;552(7684):187-193. Epub 2017 Dec 6.

Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

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December 2017

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function.

Cell Syst 2018 Jan 30;6(1):90-102.e4. Epub 2017 Nov 30.

Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland. Electronic address:

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January 2018

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress.

Nat Commun 2017 11 28;8(1):1818. Epub 2017 Nov 28.

Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Station 15, 1015, Lausanne, Switzerland.

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November 2017

The corepressor NCOR1 regulates the survival of single-positive thymocytes.

Sci Rep 2017 Nov 21;7(1):15928. Epub 2017 Nov 21.

Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.

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November 2017

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism.

Mol Metab 2017 11 31;6(11):1429-1442. Epub 2017 Aug 31.

Department of Human Biology and Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, 6200MD, The Netherlands. Electronic address:

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November 2017

Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress.

Mol Cell 2017 Nov;68(3):540-551.e5

Laboratory of Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. Electronic address:

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November 2017

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection.

Nat Commun 2017 10 16;8(1):959. Epub 2017 Oct 16.

CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.

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October 2017

Repairing Mitochondrial Dysfunction in Disease.

Annu Rev Pharmacol Toxicol 2018 01 27;58:353-389. Epub 2017 Sep 27.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; email:

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January 2018

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.

Gastroenterology 2017 12 30;153(6):1568-1580.e10. Epub 2017 Aug 30.

Department of Medicine, Columbia University, New York, NY. Electronic address:

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December 2017

A multiscale study of the role of dynamin in the regulation of glucose uptake.

Integr Biol (Camb) 2017 10;9(10):810-819

Laboratory of Microsystems, Ecole Polytechnique Fédérale de Lausanne, EPFL-STI-IMT-LMIS2, Building BM, Station 17, CH-1015 Lausanne, Switzerland.

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October 2017

Modulating NAD metabolism, from bench to bedside.

EMBO J 2017 09 7;36(18):2670-2683. Epub 2017 Aug 7.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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September 2017

Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy.

PLoS One 2017 20;12(7):e0181676. Epub 2017 Jul 20.

Laboratoire d'Optique Biomédicale, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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September 2017

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.

Sci Rep 2017 06 20;7(1):3853. Epub 2017 Jun 20.

Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, CH-1066, Epalinges, Switzerland.

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June 2017

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response.

Trends Biochem Sci 2017 09 1;42(9):712-725. Epub 2017 Jun 1.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Electronic address:

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September 2017

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.

J Cell Biol 2017 07 31;216(7):2027-2045. Epub 2017 May 31.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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July 2017

PPARδ Promotes Running Endurance by Preserving Glucose.

Cell Metab 2017 May;25(5):1186-1193.e4

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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May 2017

Mitochondria and Epigenetics - Crosstalk in Homeostasis and Stress.

Trends Cell Biol 2017 06 6;27(6):453-463. Epub 2017 Mar 6.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

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June 2017

Analysis of mtDNA/nDNA Ratio in Mice.

Curr Protoc Mouse Biol 2017 Mar 2;7(1):47-54. Epub 2017 Mar 2.

Laboratory for Integrative and Systems Physiology, École Polytechnique Federale de Lausanne, Lausanne, Switzerland.

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March 2017

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.

Proc Natl Acad Sci U S A 2017 02 6;114(8):E1432-E1440. Epub 2017 Feb 6.

Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093.

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February 2017

Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.

Cell Metab 2017 02 1;25(2):301-311. Epub 2016 Dec 1.

Aging and Muscle Metabolism Laboratory, Department of Physiology, University of Lausanne, Lausanne 1005, Switzerland; Institute of Sports Sciences, University of Lausanne, Lausanne 1005, Switzerland; Service of Endocrinology, Diabetology, and Metabolism, Department of Medicine, Lausanne University Hospital, Lausanne 1011, Switzerland. Electronic address:

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February 2017

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity.

Nat Commun 2016 10 12;7:13125. Epub 2016 Oct 12.

Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences and School of Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

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October 2016