Johan Auwerx

Johan Auwerx

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Johan Auwerx

Publications by authors named "Johan Auwerx"

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Opposing action of NCoR1 and PGC-1α in mitochondrial redox homeostasis.

Free Radic Biol Med 2019 Nov 10;143:203-208. Epub 2019 Aug 10.

Department of Biochemistry and Immunology, Ribeirão Preto Medical School, USP, Ribeirão Preto, SP, Brazil; Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil; Obesity and Comorbidities Research Center - OCRC - IB - UNICAMP, Campinas, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.08.006DOI Listing
November 2019

Nuclear receptor corepressor 1 represses cardiac hypertrophy.

EMBO Mol Med 2019 Nov 18;11(11):e9127. Epub 2019 Sep 18.

Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.15252/emmm.201809127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835202PMC
November 2019

Mitocellular communication: Shaping health and disease.

Science 2019 11 14;366(6467):827-832. Epub 2019 Nov 14.

Laboratory of Integrative Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1126/science.aax3768DOI Listing
November 2019

Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity.

Circ Res 2019 Sep 15;125(7):707-719. Epub 2019 Aug 15.

Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, China (W.S., H.W., B.L., D.D., Z.J.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742548PMC
September 2019

Cross-species functional modules link proteostasis to human normal aging.

PLoS Comput Biol 2019 Jul 3;15(7):e1007162. Epub 2019 Jul 3.

Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1371/journal.pcbi.1007162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634426PMC
July 2019

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells.

J Cell Physiol 2019 May 11;234(5):6601-6610. Epub 2018 Nov 11.

Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, The Netherlands.

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http://dx.doi.org/10.1002/jcp.27401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344277PMC
May 2019

The virtuous cycle of human genetics and mouse models in drug discovery.

Nat Rev Drug Discov 2019 04;18(4):255-272

Laboratory of Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://www.nature.com/articles/s41573-018-0009-9
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http://dx.doi.org/10.1038/s41573-018-0009-9DOI Listing
April 2019

Mild inborn errors of metabolism in commonly used inbred mouse strains.

Mol Genet Metab 2019 04 24;126(4):388-396. Epub 2019 Jan 24.

Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY 10029, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967192183071
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http://dx.doi.org/10.1016/j.ymgme.2019.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535113PMC
April 2019

Niacin: an old lipid drug in a new NAD dress.

J Lipid Res 2019 Apr 19;60(4):741-746. Epub 2019 Feb 19.

Laboratory of Integrative Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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http://dx.doi.org/10.1194/jlr.S092007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446705PMC
April 2019

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.

Cell Stem Cell 2019 Mar;24(3):405-418.e7

Laboratory of Regenerative Hematopoiesis, Swiss Institute for Experimental Cancer Research (ISREC) & Institute of Bioengineering (IBI), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Service and Central Laboratory of Hematology, Departments of Oncology and of Laboratories, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193006
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http://dx.doi.org/10.1016/j.stem.2019.02.012DOI Listing
March 2019

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.

Mol Cell 2019 02 11;73(4):775-787.e10. Epub 2019 Jan 11.

Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183100
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http://dx.doi.org/10.1016/j.molcel.2018.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396316PMC
February 2019

The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo.

Blood Adv 2019 02;3(4):644-657

Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1182/bloodadvances.2018022756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391666PMC
February 2019

Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans.

Lab Chip 2018 12;19(1):120-135

Laboratory of Microsystems, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1039/c8lc00863aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309680PMC
December 2018

Multimodal imaging and high-throughput image-processing for drug screening on living organisms on-chip.

J Biomed Opt 2018 11;24(2):1-9

Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratory of Microsystems, Lausanne, Switzerland.

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http://dx.doi.org/10.1117/1.JBO.24.2.021205DOI Listing
November 2018

Genetic cartography of longevity in humans and mice: Current landscape and horizons.

Biochim Biophys Acta Mol Basis Dis 2018 09 2;1864(9 Pt A):2718-2732. Epub 2018 Feb 2.

Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066442PMC
September 2018

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population.

Mol Cell Proteomics 2018 09 26;17(9):1766-1777. Epub 2018 Jun 26.

From the ‡Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich CH-8093, Switzerland;

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http://dx.doi.org/10.1074/mcp.RA118.000554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126393PMC
September 2018

Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.

Cardiovasc Res 2018 08;114(10):1324-1334

Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY, USA.

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http://dx.doi.org/10.1093/cvr/cvy089DOI Listing
August 2018

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14.

Aging Cell 2018 08 14;17(4):e12751. Epub 2018 Apr 14.

Department of Cell Biology & Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ, USA.

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http://dx.doi.org/10.1111/acel.12751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052469PMC
August 2018

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.

Cell Syst 2018 06 13;6(6):709-721.e6. Epub 2018 Jun 13.

Laboratory of Integrative and Systems Physiology, École Polytchnique Fédérale de Lausanne, Lausanne 1015, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397773PMC
June 2018

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.

Cell Syst 2018 06 13;6(6):722-733.e6. Epub 2018 Jun 13.

Morgridge Institute for Research, Madison, WI 53715, USA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054463PMC
June 2018

The role of mitochondria in stem cell fate and aging.

Development 2018 04 13;145(8). Epub 2018 Apr 13.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, CH-1015, Switzerland

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http://dev.biologists.org/lookup/doi/10.1242/dev.143420
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http://dx.doi.org/10.1242/dev.143420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964648PMC
April 2018

Reduced oxidative capacity in macrophages results in systemic insulin resistance.

Nat Commun 2018 04 19;9(1):1551. Epub 2018 Apr 19.

Research Center for Endocrine and Metabolic Diseases, Department of Medical Science, School of Medicine, Chungnam National University, Daejeon, 35015, Korea.

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http://dx.doi.org/10.1038/s41467-018-03998-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908799PMC
April 2018

ERRγ Preserves Brown Fat Innate Thermogenic Activity.

Cell Rep 2018 03;22(11):2849-2859

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884669PMC
March 2018

α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD) Biosynthesis.

J Med Chem 2018 02 26;61(3):745-759. Epub 2018 Jan 26.

Laboratory of Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne CH-1015 Lausanne, Switzerland.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01254
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http://dx.doi.org/10.1021/acs.jmedchem.7b01254DOI Listing
February 2018

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells.

Elife 2018 02 22;7. Epub 2018 Feb 22.

Department of Molecular and Cellular Biology, University of California, Davis, Davis, United States.

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http://dx.doi.org/10.7554/eLife.31019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823543PMC
February 2018

Repairing Mitochondrial Dysfunction in Disease.

Annu Rev Pharmacol Toxicol 2018 01 27;58:353-389. Epub 2017 Sep 27.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010716-104908DOI Listing
January 2018

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function.

Cell Syst 2018 Jan 30;6(1):90-102.e4. Epub 2017 Nov 30.

Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.10.016DOI Listing
January 2018

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.

Gastroenterology 2017 12 30;153(6):1568-1580.e10. Epub 2017 Aug 30.

Department of Medicine, Columbia University, New York, NY. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.08.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705280PMC
December 2017

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.

Nature 2017 12 6;552(7684):187-193. Epub 2017 Dec 6.

Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1038/nature25143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730497PMC
December 2017

Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress.

Mol Cell 2017 Nov;68(3):540-551.e5

Laboratory of Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.10.006DOI Listing
November 2017

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism.

Mol Metab 2017 11 31;6(11):1429-1442. Epub 2017 Aug 31.

Department of Human Biology and Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, 6200MD, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681243PMC
November 2017

The corepressor NCOR1 regulates the survival of single-positive thymocytes.

Sci Rep 2017 Nov 21;7(1):15928. Epub 2017 Nov 21.

Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.

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http://dx.doi.org/10.1038/s41598-017-15918-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698297PMC
November 2017

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress.

Nat Commun 2017 11 28;8(1):1818. Epub 2017 Nov 28.

Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Station 15, 1015, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/s41467-017-01903-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703887PMC
November 2017

A multiscale study of the role of dynamin in the regulation of glucose uptake.

Integr Biol (Camb) 2017 10;9(10):810-819

Laboratory of Microsystems, Ecole Polytechnique Fédérale de Lausanne, EPFL-STI-IMT-LMIS2, Building BM, Station 17, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1039/c7ib00015dDOI Listing
October 2017

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection.

Nat Commun 2017 10 16;8(1):959. Epub 2017 Oct 16.

CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.

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http://dx.doi.org/10.1038/s41467-017-00931-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643384PMC
October 2017

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response.

Trends Biochem Sci 2017 09 1;42(9):712-725. Epub 2017 Jun 1.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2017.05.002DOI Listing
September 2017

Modulating NAD metabolism, from bench to bedside.

EMBO J 2017 09 7;36(18):2670-2683. Epub 2017 Aug 7.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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http://dx.doi.org/10.15252/embj.201797135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599801PMC
September 2017

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.

J Cell Biol 2017 07 31;216(7):2027-2045. Epub 2017 May 31.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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http://dx.doi.org/10.1083/jcb.201702058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496626PMC
July 2017

Mitochondria and Epigenetics - Crosstalk in Homeostasis and Stress.

Trends Cell Biol 2017 06 6;27(6):453-463. Epub 2017 Mar 6.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2017.02.004DOI Listing
June 2017

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.

Sci Rep 2017 06 20;7(1):3853. Epub 2017 Jun 20.

Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, CH-1066, Epalinges, Switzerland.

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http://dx.doi.org/10.1038/s41598-017-04263-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478639PMC
June 2017

PPARδ Promotes Running Endurance by Preserving Glucose.

Cell Metab 2017 May;25(5):1186-1193.e4

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492977PMC
May 2017

Analysis of mtDNA/nDNA Ratio in Mice.

Curr Protoc Mouse Biol 2017 Mar 2;7(1):47-54. Epub 2017 Mar 2.

Laboratory for Integrative and Systems Physiology, École Polytechnique Federale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/cpmo.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335900PMC
March 2017

Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.

Cell Metab 2017 02 1;25(2):301-311. Epub 2016 Dec 1.

Aging and Muscle Metabolism Laboratory, Department of Physiology, University of Lausanne, Lausanne 1005, Switzerland; Institute of Sports Sciences, University of Lausanne, Lausanne 1005, Switzerland; Service of Endocrinology, Diabetology, and Metabolism, Department of Medicine, Lausanne University Hospital, Lausanne 1011, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.11.004DOI Listing
February 2017

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons.

Hum Mol Genet 2017 02;26(3):582-598

Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1093/hmg/ddw418DOI Listing
February 2017

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.

Proc Natl Acad Sci U S A 2017 02 6;114(8):E1432-E1440. Epub 2017 Feb 6.

Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093.

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http://dx.doi.org/10.1073/pnas.1700232114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338369PMC
February 2017

Plasma membrane-bound G protein-coupled bile acid receptor attenuates liver ischemia/reperfusion injury via the inhibition of toll-like receptor 4 signaling in mice.

Liver Transpl 2017 01;23(1):63-74

Translational Medicine Research Center, Affiliated Jiangning Hospital and Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

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http://dx.doi.org/10.1002/lt.24628DOI Listing
January 2017

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease.

J Hepatol 2017 01 20;66(1):132-141. Epub 2016 Sep 20.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.08.024DOI Listing
January 2017

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.

Nat Protoc 2016 10 1;11(10):1798-816. Epub 2016 Sep 1.

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1038/nprot.2016.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040492PMC
October 2016

The Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms.

Curr Protoc Neurosci 2016 10 3;77:8.37.1-8.37.21. Epub 2016 Oct 3.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/cpns.17DOI Listing
October 2016

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity.

Nat Commun 2016 10 12;7:13125. Epub 2016 Oct 12.

Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences and School of Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1038/ncomms13125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064016PMC
October 2016

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.

Nat Med 2016 08 11;22(8):879-88. Epub 2016 Jul 11.

Laboratory for Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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https://documents.epfl.ch/groups/e/ep/epflmedia/www/20160711
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http://dx.doi.org/10.1038/nm.4132DOI Listing
August 2016

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice.

Science 2016 Jun 28;352(6292):1436-43. Epub 2016 Apr 28.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1126/science.aaf2693DOI Listing
June 2016

Systems proteomics of liver mitochondria function.

Science 2016 Jun;352(6291):aad0189

Laboratory of Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, CH-1015, Switzerland.

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http://dx.doi.org/10.1126/science.aad0189DOI Listing
June 2016

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.

Genes Dev 2016 06;30(11):1255-60

Metabolic Signaling, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland;

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http://dx.doi.org/10.1101/gad.277483.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911925PMC
June 2016

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.

Cell 2016 May 28;165(5):1209-1223. Epub 2016 Apr 28.

Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; The Paul F. Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889222PMC
May 2016

Mitonuclear communication in homeostasis and stress.

Nat Rev Mol Cell Biol 2016 Apr 9;17(4):213-26. Epub 2016 Mar 9.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.

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http://www.nature.com/articles/nrm.2016.23
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http://dx.doi.org/10.1038/nrm.2016.23DOI Listing
April 2016

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.

Proc Natl Acad Sci U S A 2016 Apr 5;113(16):4320-5. Epub 2016 Apr 5.

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853; Howard Hughes Medical Institute, Cornell University, Ithaca, NY 14853

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http://dx.doi.org/10.1073/pnas.1519858113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843474PMC
April 2016

Analysis of Mitochondrial Respiratory Chain Supercomplexes Using Blue Native Polyacrylamide Gel Electrophoresis (BN-PAGE).

Curr Protoc Mouse Biol 2016 Mar 1;6(1):1-14. Epub 2016 Mar 1.

Laboratory for Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/9780470942390.mo150182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823378PMC
March 2016

Protein acetylation in metabolism - metabolites and cofactors.

Nat Rev Endocrinol 2016 Jan 27;12(1):43-60. Epub 2015 Oct 27.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Station 15, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1038/nrendo.2015.181DOI Listing
January 2016

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.

Eur Heart J 2015 Dec 25;36(48):3404-12. Epub 2015 Jun 25.

Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland Zurich Center of Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland

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http://dx.doi.org/10.1093/eurheartj/ehv290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685177PMC
December 2015

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance.

Aging Cell 2015 Dec 1;14(6):1075-84. Epub 2015 Oct 1.

Department of Cell Biology & Molecular Medicine, New Jersey Medical School, Rutgers University, Newark, NJ, USA.

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http://dx.doi.org/10.1111/acel.12401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693460PMC
December 2015

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice.

Hepatology 2015 Nov 22;62(5):1606-18. Epub 2015 Jul 22.

Laboratory of Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/hep.27907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618256PMC
November 2015

Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research.

Cancer Res 2015 Nov 16;75(21):4446-9. Epub 2015 Oct 16.

Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631686PMC
November 2015

Antibiotic use and abuse: a threat to mitochondria and chloroplasts with impact on research, health, and environment.

Bioessays 2015 Oct 8;37(10):1045-53. Epub 2015 Sep 8.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/bies.201500071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698130PMC
October 2015

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.

Cell Metab 2015 Jul 25;22(1):31-53. Epub 2015 Jun 25.

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487780PMC
July 2015

The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis.

Cell 2015 Jul;162(1):23-32

Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493761PMC
July 2015

The mitochondrial unfolded protein response—synchronizing genomes.

Curr Opin Cell Biol 2015 Apr 23;33:74-81. Epub 2014 Dec 23.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2014.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380587PMC
April 2015

Editorial overview: Cell regulation: cell biology, fueling a renaissance in metabolism.

Curr Opin Cell Biol 2015 Apr 17;33:vi-vii. Epub 2015 Mar 17.

Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2015.02.005DOI Listing
April 2015

Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism.

Cell Metab 2015 Apr;21(4):628-36

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393848PMC
April 2015

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.

Cell Rep 2015 Mar 12;10(10):1681-1691. Epub 2015 Mar 12.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565776PMC
March 2015

Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas.

Sci Rep 2015 Mar 20;5:9087. Epub 2015 Mar 20.

1] Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/CNRS UMR 7104/INSERM U 964/Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France [2] Institut Clinique de la Souris, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1038/srep09087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367156PMC
March 2015