Publications by authors named "Joep de Ligt"

48 Publications

Identification of novel human Wnt target genes using adult endodermal tissue-derived organoids.

Dev Biol 2021 Feb 8. Epub 2021 Feb 8.

Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC) Utrecht, Utrecht, the Netherlands; Princess Máxima Centre for Paediatric Oncology, Utrecht, the Netherlands. Electronic address:

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February 2021

An emergent clade of SARS-CoV-2 linked to returned travellers from Iran.

Virus Evol 2020 Jan 10;6(1):veaa027. Epub 2020 Apr 10.

Centre for Infectious Diseases and Microbiology Laboratory Services, NSW Health Pathology - Institute of Clinical Pathology and Medical Research, Westmead, NSW 2145, Australia.

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January 2020

Scalable Workflows and Reproducible Data Analysis for Genomics.

Methods Mol Biol 2019 ;1910:723-745

Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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January 2020

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer.

Genome Res 2019 07 20;29(7):1067-1077. Epub 2019 Jun 20.

Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands.

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July 2019

Natural helix 9 mutants of PPARγ differently affect its transcriptional activity.

Mol Metab 2019 02 16;20:115-127. Epub 2018 Dec 16.

Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Molecular Cancer Research, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address:

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February 2019

A Single Complex Allele in a Patient With Partial Lipodystrophy.

Front Physiol 2018 26;9:1363. Epub 2018 Sep 26.

Center for Molecular Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.

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September 2018

A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells.

Mol Cell Proteomics 2018 10 3;17(10):1892-1908. Epub 2018 Jul 3.

From the ‡Biomolecular Mass Spectrometry and Proteomics Group, Utrecht Institute for Pharmaceutical Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands;

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October 2018

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

Science 2017 10 14;358(6360):234-238. Epub 2017 Sep 14.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, 3584CT Utrecht, Netherlands.

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October 2017

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids.

Proc Natl Acad Sci U S A 2017 03 7;114(12):E2357-E2364. Epub 2017 Mar 7.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center (UMC) Utrecht, 3584 CT Utrecht, The Netherlands;

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March 2017

The Genomic Scrapheap Challenge; Extracting Relevant Data from Unmapped Whole Genome Sequencing Reads, Including Strain Specific Genomic Segments, in Rats.

PLoS One 2016 8;11(8):e0160036. Epub 2016 Aug 8.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Centre Utrecht, Utrecht, The Netherlands.

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August 2017

Allelic Mutations of KITLG, Encoding KIT Ligand, Cause Asymmetric and Unilateral Hearing Loss and Waardenburg Syndrome Type 2.

Am J Hum Genet 2015 Nov 29;97(5):647-60. Epub 2015 Oct 29.

Hearing & Genes Division, Department of Otorhinolaryngology, Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; The Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen 6525GA, the Netherlands. Electronic address:

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November 2015

Novel genetic causes for cerebral visual impairment.

Eur J Hum Genet 2016 May 9;24(5):660-5. Epub 2015 Sep 9.

Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.

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May 2016

Platform comparison of detecting copy number variants with microarrays and whole-exome sequencing.

Genom Data 2014 Dec;2:144-146

Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Institute for Genetic and Metabolic Disease, Radboud University Medical Centre, Nijmegen 6500 HB, The Netherlands.

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December 2014

Toward effective software solutions for big biology.

Nat Biotechnol 2015 Jul;33(7):686-7

Office of the Director, The National Institutes of Health, Bethesda, Maryland, USA.

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July 2015

Cerebral visual impairment and intellectual disability caused by PGAP1 variants.

Eur J Hum Genet 2015 Dec 25;23(12):1689-93. Epub 2015 Mar 25.

Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.

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December 2015