Publications by authors named "Joelle Dubois"

90Publications

Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity.

Bioorg Chem 2020 Oct 26;103:104184. Epub 2020 Aug 26.

'Alexandru Ioan Cuza' University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, France; Yncréa Hauts-de-France, Hautes Etudes d'Ingénieur (HEI), UCLille, Health & Environment Department, Sustainable Chemistry Team, Laboratoire de Chimie Durable et Santé, 13 rue de Toul, F-59046 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2020.104184DOI Listing
October 2020

Synthesis and Anticancer Properties of Oxazepines Related to Azaisoerianin and IsoCoQuines.

ChemMedChem 2020 Jun 2. Epub 2020 Jun 2.

Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France.

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http://dx.doi.org/10.1002/cmdc.202000197DOI Listing
June 2020

Ultrasounds-mediated 10-seconds synthesis of chalcones as potential farnesyltransferase inhibitors.

Bioorg Med Chem Lett 2020 06 29;30(11):127149. Epub 2020 Mar 29.

Yncréa Hauts-de-France, Laboratory of Sustainable Chemistry and Health, Health & Environment Department, Team Sustainable Chemistry, Ecole des Hautes Etudes d'Ingénieur (HEI), UCLille, 13 rue de Toul, F-59046 Lille, France; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, France; 'Al. I. Cuza' University of Iasi, Faculty of Chemistry, Bd. Carol I, nr. 11, 700506 Iasi, Romania. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2020.127149DOI Listing
June 2020

Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands.

Bioorg Chem 2020 03 30;96:103643. Epub 2020 Jan 30.

Yncréa Hauts-de-France, Hautes Etudes d'Ingénieur (HEI), UCLille, Health & Environment Department, Team Sustainable Chemistry, Laboratoire de Chimie Durable et Santé, 13 rue de Toul, F-59046 Lille, France; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, France.

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http://dx.doi.org/10.1016/j.bioorg.2020.103643DOI Listing
March 2020

Dibenzocyclooctynes: Effect of Aryl Substitution on Their Reactivity toward Strain-Promoted Alkyne-Azide Cycloaddition.

J Org Chem 2019 07 14;84(13):8542-8551. Epub 2019 Jun 14.

Institut de Chimie des Substances Naturelles, CNRS UPR 2301 , Univ. Paris-Sud, Univ. Paris-Saclay , 1, av. de la Terrasse , Gif-sur-Yvette 91198 , France.

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http://dx.doi.org/10.1021/acs.joc.9b00895DOI Listing
July 2019

Exploring isoxazoles and pyrrolidinones decorated with the 4,6-dimethoxy-1,3,5-triazine unit as human farnesyltransferase inhibitors.

Arch Pharm (Weinheim) 2019 May 4;352(5):e1800227. Epub 2019 Apr 4.

Faculty of Chemistry, Al. I. Cuza' University of Iasi, Iasi, Romania.

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http://dx.doi.org/10.1002/ardp.201800227DOI Listing
May 2019

N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents.

Eur J Med Chem 2019 Apr 16;168:176-188. Epub 2019 Feb 16.

BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 92290, Châtenay-Malabry, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.02.038DOI Listing
April 2019

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.

J Med Chem 2019 02 21;62(4):1902-1916. Epub 2018 Dec 21.

BioCIS, Université Paris-Sud, CNRS, Équipe Labellisée Ligue Contre le Cancer , Université Paris-Saclay , F-92290 Châtenay-Malabry , France.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01386DOI Listing
February 2019

One-Pot Synthesis of 2-Styrylindoles from Ortho-Substituted Chloroenynes.

J Org Chem 2018 12 11;83(24):15323-15332. Epub 2018 Dec 11.

Univ. Paris-Sud, BioCIS, CNRS, University Paris-Saclay, Equipe Labellisée Ligue Contre Le Cancer, F-92296 Châtenay-Malabry , France.

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http://dx.doi.org/10.1021/acs.joc.8b02563DOI Listing
December 2018

Iodine(III)-mediated halogenations of acyclic monoterpenoids.

Beilstein J Org Chem 2018 18;14:1103-1111. Epub 2018 May 18.

Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.

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http://dx.doi.org/10.3762/bjoc.14.96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009204PMC
May 2018

On the discovery of new potent human farnesyltransferase inhibitors: emerging pyroglutamic derivatives.

Org Biomol Chem 2017 Oct;15(38):8110-8118

Inserm U995, LIRIC, Université de Lille, CHRU de Lille, Faculté de médecine - Pôle recherche, Place Verdun, F-59045 Lille Cedex, France.

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http://dx.doi.org/10.1039/c7ob01489aDOI Listing
October 2017

Chemodivergent, Tunable, and Selective Iodine(III)-Mediated Bromo-Functionalizations of Polyprenoids.

Org Lett 2017 09 30;19(18):4766-4769. Epub 2017 Aug 30.

Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay , Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.

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http://dx.doi.org/10.1021/acs.orglett.7b02125DOI Listing
September 2017

Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.

Bioorg Med Chem 2017 08 19;25(16):4433-4443. Epub 2017 Jun 19.

School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

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http://dx.doi.org/10.1016/j.bmc.2017.06.029DOI Listing
August 2017

Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors.

Eur J Med Chem 2017 Feb 9;127:1025-1034. Epub 2016 Nov 9.

BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 92290, Châtenay-Malabry, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.11.012DOI Listing
February 2017

Methylene versus carbonyl bridge in the structure of new tubulin polymerization inhibitors with tricyclic A-rings.

Bioorg Med Chem 2016 11 26;24(22):6021-6030. Epub 2016 Sep 26.

"Alexandru Ioan Cuza" University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania; Inserm U995, LIRIC, Université de Lille, CHRU de Lille, Faculté de médecine-Pôle recherche, Place Verdun, F-59045 Lille Cedex, France; Hautes Etudes d'Ingénieur (HEI), Groupe HEI-ISA-ISEN, UCLille, Laboratoire de Pharmacochimie, 13 rue de Toul, F-59046 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.09.063DOI Listing
November 2016

New indolizine-chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation.

Bioorg Med Chem Lett 2016 08 26;26(15):3730-4. Epub 2016 May 26.

'Alexandru Ioan Cuza' University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.05.074DOI Listing
August 2016

Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors.

Bioorg Med Chem 2016 07 18;24(14):3102-7. Epub 2016 May 18.

School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.05.024DOI Listing
July 2016

Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents.

Bioorg Med Chem 2016 05 1;24(10):2307-17. Epub 2016 Apr 1.

Department of Organic Chemistry, 'Al. I. Cuza' University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.04.001DOI Listing
May 2016

Mallotojaponins B and C: Total Synthesis, Antiparasitic Evaluation, and Preliminary SAR Studies.

Org Lett 2016 Feb 1;18(4):708-11. Epub 2016 Feb 1.

Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud , Univ. Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.

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http://dx.doi.org/10.1021/acs.orglett.5b03676DOI Listing
February 2016

Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors.

Eur J Med Chem 2016 Feb 29;109:173-86. Epub 2015 Dec 29.

CNRS UPR2301, Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.12.045DOI Listing
February 2016

Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds.

Bioorg Med Chem Lett 2015 Oct 7;25(20):4447-52. Epub 2015 Sep 7.

Department of Organic Chemistry, Faculty of Chemistry, 'Al. I. Cuza' University of Iasi, B-dul Carol I, Nr. 11, Corp A, 700506 Iasi, Romania; Inserm, LIRIC-U995, Université de Lille 2, CHRU de Lille, Faculté de Médecine-Pôle Recherche, Place Verdun, F-59045 Lille Cedex, France; Hautes Etudes d'Ingénieur (HEI), UCLille, Laboratoire de pharmacochimie, 13 rue de Toul, BP 41290, F-59014 Lille Cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.09.008DOI Listing
October 2015

Discovery of indolizines containing triazine moiety as new leads for the development of antitumoral agents targeting mitotic events.

Bioorg Med Chem Lett 2015 Sep 17;25(18):3975-9. Epub 2015 Jul 17.

Department of Organic Chemistry, Faculty of Chemistry, 'Al. I. Cuza' University of Iasi, B-dul Carol I, Nr. 11, Corp A, 700506 Iasi, Romania. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.07.025DOI Listing
September 2015

IsoCombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity.

ChemMedChem 2015 Aug 15;10(8):1392-402. Epub 2015 Jun 15.

Univ. Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Equipe Labellisée Ligue Contre le Cancer, LabEx LERMIT, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, 92296 (France).

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http://dx.doi.org/10.1002/cmdc.201500069DOI Listing
August 2015

Intussusception of the Meckel's diverticulum within its own lumen: Unknown complication.

Int J Surg Case Rep 2015 25;10:111-4. Epub 2015 Mar 25.

Department of General Surgery, CHU Hospital, Jean Monnet University, Saint Étienne, France.

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http://dx.doi.org/10.1016/j.ijscr.2015.03.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430118PMC
May 2015

The proper reload selection during laparoscopic sleeve gastrectomy.

Int J Surg 2015 Apr 5;16(Pt A):42-43. Epub 2015 Mar 5.

Department of General Surgery, CHU Hospital, Jean Monnet University, Saint Etienne, France.

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http://dx.doi.org/10.1016/j.ijsu.2015.02.018DOI Listing
April 2015

First enantioselective total synthesis and configurational assignments of suberosenone and suberosanone as potential antitumor agents.

Chem Commun (Camb) 2015 Feb;51(16):3458-61

CNRS-BioCIS UMR 8076, Chimie des Substances Naturelles, IPSIT and LabEx LERMIT, Faculté de Pharmacie, Université de Paris Sud, 5, rue J.-B. Clément, 92296 Châtenay-Malabry, France.

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http://dx.doi.org/10.1039/c4cc10041gDOI Listing
February 2015

Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.

Eur J Med Chem 2015 Jan 15;90:834-44. Epub 2014 Dec 15.

University Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Equipe Labellisée Ligue Contre Le Cancer, LabEx LERMIT, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.12.024DOI Listing
January 2015

Studies on indolizines. Evaluation of their biological properties as microtubule-interacting agents and as melanoma targeting compounds.

Eur J Med Chem 2015 Jan 16;89:115-27. Epub 2014 Oct 16.

Department of Organic Chemistry, Faculty of Chemistry, 'Al. I. Cuza' University of Iasi, B-dul Carol I, Nr. 11, Corp A, 700506 Iasi, Romania. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.10.041DOI Listing
January 2015

Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase.

Bioorg Med Chem Lett 2014 Dec 22;24(24):5777-5781. Epub 2014 Oct 22.

Department of Organic Chemistry, Faculty of Chemistry, 'Al. I. Cuza' University of Iasi, B-dul Carol I, Nr. 11, Corp A, 700506 Iasi, Romania. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.10.044DOI Listing
December 2014

Perforated diverticulitis of the sigmoid colon causing a subcutaneous emphysema.

Int J Surg Case Rep 2014 11;5(12):1190-2. Epub 2014 Nov 11.

Department of General Surgery, CHU Hospital, Jean Monnet University, Saint Étienne, France.

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http://dx.doi.org/10.1016/j.ijscr.2014.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275823PMC
December 2014

Synthesis of a 3-(α-styryl)benzo[b]-thiophene library via bromocyclization of alkynes and palladium-catalyzed to sylhydrazones cross-couplings: evaluation as antitubulin agents.

ACS Comb Sci 2014 Dec 25;16(12):702-10. Epub 2014 Sep 25.

Univ Paris Sud, CNRS, BioCIS-UMR 8076 , Laboratoire de Chimie Thérapeutique, Equipe Labellisée Ligue Contre le Cancer, LabEx LERMIT, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1021/co500115bDOI Listing
December 2014

Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase.

Bioorg Med Chem Lett 2014 Jul 12;24(14):3180-5. Epub 2014 May 12.

Department of Organic Chemistry, Faculty of Chemistry, 'Al. I. Cuza' University of Iasi, B-dul Carol I, Nr. 11, Corp A, 700506 Iasi, Romania. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.04.102DOI Listing
July 2014

Discovery of azaisoerianin derivatives as potential antitumors agents.

Eur J Med Chem 2014 May 13;78:178-89. Epub 2014 Mar 13.

Univ Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, LabEx LERMIT, Equipe Labellisée Ligue Contre le Cancer, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.03.032DOI Listing
May 2014

Imidazopyridine-fused [1,3]-diazepinones: synthesis and antiproliferative activity.

Eur J Med Chem 2014 Mar 30;75:382-90. Epub 2014 Jan 30.

Institut des Biomolécules Max Mousseron, UMR 5247, CNRS, Universités Montpellier I et II, UFR des Sciences Pharmaceutiques et Biologiques, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.01.044DOI Listing
March 2014

Squamous cell carcinoma of middle rectum: Literature review.

Int J Surg Case Rep 2014 21;5(2):86-90. Epub 2013 Dec 21.

Department of General Surgery, CHU Hospital, Jean Monnet University, Saint Étienne, France.

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http://dx.doi.org/10.1016/j.ijscr.2013.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921652PMC
February 2014

Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors.

Bioorg Med Chem Lett 2013 Nov 3;23(21):5887-92. Epub 2013 Sep 3.

Department of Organic Chemistry, 'Al. I. Cuza' University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania.

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http://dx.doi.org/10.1016/j.bmcl.2013.08.088DOI Listing
November 2013

Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.

Bioorg Med Chem 2013 Sep 12;21(17):4885-92. Epub 2013 Jul 12.

CNRS, Institut de Chimie des Substances Naturelles, UPR2301, Centre de Recherche de Gif, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1016/j.bmc.2013.07.002DOI Listing
September 2013

Discovery of two new inhibitors of Botrytis cinerea chitin synthase by a chemical library screening.

Bioorg Med Chem 2013 Sep 2;21(17):4997-5003. Epub 2013 Jul 2.

UPMC Univ Paris 06, CNRS UMR 7203, Laboratoire des Biomolécules, 75005 Paris, France.

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http://dx.doi.org/10.1016/j.bmc.2013.06.058DOI Listing
September 2013

Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatin.

Bioorg Med Chem 2013 Jun 4;21(11):2932-40. Epub 2013 Apr 4.

Department of Organic Chemistry, Al. I. Cuza University of Iasi, Faculty of Chemistry, Bd., Carol I, nr. 11, 700506 Iasi, Romania.

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http://dx.doi.org/10.1016/j.bmc.2013.03.064DOI Listing
June 2013

An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity.

Org Biomol Chem 2013 Jun;11(22):3664-73

Université Paris-Sud, CNRS, BioCIS UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J-B Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1039/c3ob40263kDOI Listing
June 2013

Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs.

Eur J Med Chem 2013 Apr 4;62:28-39. Epub 2013 Jan 4.

Univ. Paris-Sud, CNRS, BioCIS-UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France.

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http://dx.doi.org/10.1016/j.ejmech.2012.12.042DOI Listing
April 2013

3-tert-Butyl 5-methyl (2R,4S,5R)-2-(4-methoxyphenyl)-4-(3-nitrophenyl)-1,3-oxazolidine-3,5-dicarboxylate.

Acta Crystallogr Sect E Struct Rep Online 2012 Nov 20;68(Pt 11):o3146-7. Epub 2012 Oct 20.

Benemérita Universidad Autónoma de Puebla, Facultad de Ciencias Químicas, Ciudad Universitaria, Puebla, Pue. 72570, Mexico.

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http://dx.doi.org/10.1107/S160053681204192XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515246PMC
November 2012

Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors.

Eur J Med Chem 2013 Jan 14;59:101-10. Epub 2012 Nov 14.

Department of Organic Chemistry, Al. I. Cuza University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania.

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http://dx.doi.org/10.1016/j.ejmech.2012.11.008DOI Listing
January 2013

Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents.

Bioorg Med Chem Lett 2013 Jan 8;23(1):147-52. Epub 2012 Nov 8.

Department of Organic Chemistry, Al. I. Cuza University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania.

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http://dx.doi.org/10.1016/j.bmcl.2012.10.135DOI Listing
January 2013

Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4.

Bioorg Med Chem Lett 2012 Dec 24;22(23):7227-31. Epub 2012 Sep 24.

Université de Lyon, Université Lyon 1, Faculté de Pharmacie, ISPB, EA 4446 Biomolécules, Cancer et Chimiorésistances, SFR Santé Lyon-Est CNRS UMS3453-INSERM US7, 8 avenue Rockefeller, F-69373 Lyon cedex 08, France.

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http://dx.doi.org/10.1016/j.bmcl.2012.09.047DOI Listing
December 2012

Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors.

Org Biomol Chem 2013 Jan 9;11(3):430-42. Epub 2012 Oct 9.

Université Paris-Sud, CNRS, BioCIS UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J-B Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1039/c2ob26253cDOI Listing
January 2013

Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors.

Bioorg Med Chem Lett 2012 Nov 17;22(22):6896-902. Epub 2012 Sep 17.

Department of Organic Chemistry, 'Al. I. Cuza' University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania.

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http://dx.doi.org/10.1016/j.bmcl.2012.09.030DOI Listing
November 2012

New farnesyltransferase inhibitors in the phenothiazine series.

Bioorg Med Chem Lett 2012 Jul 9;22(14):4517-22. Epub 2012 Jun 9.

Department of Organic Chemistry, Al. I. Cuza University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania.

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http://dx.doi.org/10.1016/j.bmcl.2012.06.007DOI Listing
July 2012

Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.

Eur J Med Chem 2012 Jun 9;52:22-32. Epub 2012 Mar 9.

Univ. Paris-Sud, CNRS, BioCIS-UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France.

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http://dx.doi.org/10.1016/j.ejmech.2012.03.001DOI Listing
June 2012

Influence of the skeleton on the cytotoxicity of flavonoids.

Bioorg Med Chem 2012 Feb 30;20(3):1231-9. Epub 2011 Dec 30.

Laboratoire de Pharmacognosie, (Univ. Paris-Sud 11, BIOCIS, UMR-8076 CNRS), Faculté de Pharmacie, av. J.B. Clément, 92296 Châtenay-Malabry Cedex, France.

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http://dx.doi.org/10.1016/j.bmc.2011.12.038DOI Listing
February 2012

New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis.

J Enzyme Inhib Med Chem 2013 Feb 11;28(1):163-71. Epub 2012 Jan 11.

Institut de Chimie des Substances Naturelles, CNRS, Centre de Recherche de Gif, Gif sur Yvette, France.

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http://dx.doi.org/10.3109/14756366.2011.643302DOI Listing
February 2013

B-ring-modified isocombretastatin A-4 analogues endowed with interesting anticancer activities.

ChemMedChem 2011 Dec 11;6(12):2179-91. Epub 2011 Oct 11.

Université Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, 92296, France.

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http://dx.doi.org/10.1002/cmdc.201100325DOI Listing
December 2011

The metabolic fate of isocombretastatin A-4 in human liver microsomes: identification, synthesis and biological evaluation of metabolites.

ChemMedChem 2011 Oct 11;6(10):1781-8. Epub 2011 Jul 11.

Univ Paris-Sud, Faculté de Pharmacie, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, 5 Rue J.-B. Clément, Châtenay-Malabry 92296, France.

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http://dx.doi.org/10.1002/cmdc.201100193DOI Listing
October 2011

Design, synthesis and antiproliferative activities of biarylolefins based on polyhydroxylated and carbohydrate scaffolds.

Eur J Med Chem 2011 Sep 13;46(9):3570-80. Epub 2011 May 13.

UMR 7565 SRSMC, Nancy Université-CNRS, Groupe SUCRES, BP 239, F-54506 Nancy Vandœuvre, France.

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http://dx.doi.org/10.1016/j.ejmech.2011.05.021DOI Listing
September 2011

Discovery of isoerianin analogues as promising anticancer agents.

ChemMedChem 2011 Mar 14;6(3):488-97. Epub 2011 Jan 14.

Université Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 Rue J.-B. Clément, Châtenay-Malabry, 92296, France.

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http://dx.doi.org/10.1002/cmdc.201000456DOI Listing
March 2011

Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer.

J Med Chem 2011 Mar 7;54(5):1178-90. Epub 2011 Feb 7.

Institut de Chimie Pharmaceutique Albert Lespagnol, Université Lille-Nord de France, EA4481, IFR114, 3 Rue du Pr Laguesse, BP 83, F-59006 Lille, France.

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http://dx.doi.org/10.1021/jm101067yDOI Listing
March 2011

Chemical and biological explorations of the electrophilic reactivity of the bioactive marine natural product halenaquinone with biomimetic nucleophiles.

Bioorg Med Chem Lett 2011 Feb 16;21(4):1261-4. Epub 2010 Dec 16.

Department of Chemistry, University of Auckland, Private Bag 92019, Auckland, New Zealand.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X100182
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http://dx.doi.org/10.1016/j.bmcl.2010.12.056DOI Listing
February 2011

Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.

Bioorg Med Chem 2011 Jan 20;19(1):186-96. Epub 2010 Nov 20.

Laboratoire de Pharmacognosie, (Univ. Paris-Sud 11, BIOCIS, UMR-8076 CNRS), Faculté de Pharmacie, Av. J.B. Clément, 92296 Châtenay-Malabry Cedex, France.

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http://dx.doi.org/10.1016/j.bmc.2010.11.035DOI Listing
January 2011

Glycopeptide dendrimer colchicine conjugates targeting cancer cells.

Bioorg Med Chem 2010 Sep 11;18(17):6589-97. Epub 2010 Apr 11.

Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH-3012 Berne, Switzerland.

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http://dx.doi.org/10.1016/j.bmc.2010.04.026DOI Listing
September 2010

New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.

Bioorg Med Chem 2010 Aug 25;18(16):6006-11. Epub 2010 Jun 25.

Laboratoire des Molécules de Communication et Adaptation des Micro-organismes, FRE 3206 CNRS, Muséum National d'Histoire Naturelle, Paris, France.

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http://dx.doi.org/10.1016/j.bmc.2010.06.066DOI Listing
August 2010

Synthesis and tubulin-binding properties of new allocolchicinoids.

Bioorg Chem 2010 Aug 15;38(4):149-58. Epub 2010 Mar 15.

Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1 avenue de la Terrasse, F-91198 Gif-sur-Yvette Cedex, France.

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http://linkinghub.elsevier.com/retrieve/pii/S004520681000015
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http://dx.doi.org/10.1016/j.bioorg.2010.03.003DOI Listing
August 2010

Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin.

J Nat Prod 2010 Apr;73(4):702-6

Laboratoire de Pharmacognosie, Faculte de Pharmacie, Universite Paris-Sud 11 BIOCIS UMR-8076 CNRS, Avenue J.B. Clement, 92296 Chatenay-Malabry Cedex, France.

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http://dx.doi.org/10.1021/np100065vDOI Listing
April 2010

Semisynthesis of alpha-methyl-gamma-lactones and in vitro evaluation of their activity on protein farnesyltransferase.

J Enzyme Inhib Med Chem 2010 Apr;25(2):172-9

IFR 149 QUASAV, Laboratoire SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, Angers, France.

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http://www.tandfonline.com/doi/full/10.3109/1475636090316959
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http://dx.doi.org/10.3109/14756360903169592DOI Listing
April 2010

Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues.

Bioorg Med Chem 2010 Jan 11;18(2):543-56. Epub 2009 Dec 11.

Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Centre de Recherche de Gif-sur-Yvette, Avenue de la Terrasse 91198 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1016/j.bmc.2009.12.017DOI Listing
January 2010

Discovery of a new class of protein farnesyltransferase inhibitors in the arylthiophene series.

J Med Chem 2009 Oct;52(20):6205-8

Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Centre de Recherche de Gif-sur-Yvette, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1021/jm901280qDOI Listing
October 2009

New asymmetric synthesis of protein farnesyltransferase inhibitors via palladium-catalyzed cross-coupling reactions of 2-iodo-imidazoles.

Org Biomol Chem 2009 May 6;7(10):2214-22. Epub 2009 Apr 6.

Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Centre de Recherche de Gif-sur-Yvette, Avenue de la Terrasse, 91198 Gif-sur-Yvette cedex, France.

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http://dx.doi.org/10.1039/b902601kDOI Listing
May 2009

Synthesis and biological evaluation of cis-locked vinylogous combretastatin-A4 analogues: derivatives with a cyclopropyl-vinyl or a cyclopropyl-amide bridge.

Bioorg Med Chem Lett 2009 Mar 27;19(5):1318-22. Epub 2009 Jan 27.

Institut Curie, Centre de Recherche, 26 rue d'Ulm, 75248 Paris, France; CNRS, UMR 176, 26 rue d'Ulm, 75248 Paris, France.

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http://dx.doi.org/10.1016/j.bmcl.2009.01.062DOI Listing
March 2009

Synthesis and antitumor activity of benzils related to combretastatin A-4.

Bioorg Med Chem Lett 2008 Jun 25;18(11):3266-71. Epub 2008 Apr 25.

Univ Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, rue J.B. Clément, F-92296 Châtenay-Malabry, France.

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http://dx.doi.org/10.1016/j.bmcl.2008.04.053DOI Listing
June 2008

Synthesis and biological evaluation of potential bisubstrate inhibitors of protein farnesyltransferase. Design and synthesis of functionalized imidazoles.

Org Biomol Chem 2007 Oct 28;5(20):3299-309. Epub 2007 Aug 28.

Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198, Gif-sur-Yvette cedex, France.

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http://dx.doi.org/10.1039/b709854eDOI Listing
October 2007

Novel C2-C3' N-peptide linked macrocyclic taxoids. Part 2: synthesis and biological activities of docetaxel analogues with a peptide side chain at C2 and their macrocyclic derivatives.

Bioorg Med Chem 2007 Jan 24;15(1):563-74. Epub 2006 Oct 24.

Institut de Chimie des Substances Naturelles, CNRS, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1016/j.bmc.2006.09.030DOI Listing
January 2007

Semisynthesis and biological evaluation of a novel D-seco docetaxel analogue.

Org Lett 2006 May;8(11):2301-4

Institut de Chimie des Substances Naturelles-CNRS, Gif sur Yvette, France.

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http://dx.doi.org/10.1021/ol060531dDOI Listing
May 2006

Novel C2-C3' N-peptide linked macrocyclic taxoids. Part 1: Synthesis and biological activities of docetaxel analogues with a peptide side chain at C3'.

Bioorg Med Chem Lett 2005 Nov;15(21):4722-6

Institut de Chimie des Substanes Naturelles, CNRS, 1 avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France.

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http://dx.doi.org/10.1016/j.bmcl.2005.07.069DOI Listing
November 2005

Synthesis of C2-C3'N-linked macrocyclic taxoids. Novel docetaxel analogues with high tubulin activity.

J Med Chem 2004 Nov;47(24):5937-44

Institut de Chimie des Substances Naturelles, CNRS, 91190 Gif sur Yvette, France.

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http://dx.doi.org/10.1021/jm0497996DOI Listing
November 2004

Deletion of the oxetane ring in docetaxel analogues: synthesis and biological evaluation.

Org Lett 2003 Dec;5(26):5031-4

Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1021/ol036043cDOI Listing
December 2003

Synthesis of novel macrocyclic docetaxel analogues. Influence of their macrocyclic ring size on tubulin activity.

J Med Chem 2003 Aug;46(17):3623-30

Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France.

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http://dx.doi.org/10.1021/jm030770wDOI Listing
August 2003

Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship.

Drug Metab Dispos 2002 Apr;30(4):438-45

Centre National de la Recherche Scientifique Unité Mixte Recherche 8532, Villejuif, France.

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http://dx.doi.org/10.1124/dmd.30.4.438DOI Listing
April 2002

Synthesis of Biphenyls Mimicking the Structure of the Antimitotic Rhazinilam.

J Org Chem 1998 Sep;63(18):6414-6420

Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1021/jo980697vDOI Listing
September 1998