Joel S Bedford

Joel S Bedford

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Joel S Bedford

Joel S Bedford

Publications by authors named "Joel S Bedford"

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Directional Genomic Hybridization (dGH) for Detection of Intrachromosomal Rearrangements.

Methods Mol Biol 2019 ;1984:107-116

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.

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http://dx.doi.org/10.1007/978-1-4939-9432-8_13DOI Listing
January 2020

Persistence of Gamma-H2AX Foci in Bronchial Cells Correlates with Susceptibility to Radiation Associated Lung Cancer in Mice.

Radiat Res 2019 01 6;191(1):67-75. Epub 2018 Nov 6.

a   Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado.

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http://www.rrjournal.org/doi/10.1667/RR14979.1
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http://dx.doi.org/10.1667/RR14979.1DOI Listing
January 2019

Directional genomic hybridization: inversions as a potential biodosimeter for retrospective radiation exposure.

Radiat Environ Biophys 2014 May 30;53(2):255-63. Epub 2014 Jan 30.

Department of Environmental & Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA,

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http://link.springer.com/10.1007/s00411-014-0513-1
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http://dx.doi.org/10.1007/s00411-014-0513-1DOI Listing
May 2014

Genetic susceptibility: radiation effects relevant to space travel.

Health Phys 2012 Nov;103(5):607-20

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.

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http://dx.doi.org/10.1097/HP.0b013e31826945b9DOI Listing
November 2012

Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo.

Cancer Res 2011 Jun 28;71(12):4130-7. Epub 2011 Apr 28.

Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117017PMC
June 2011

Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability.

Radiat Res 2011 Jan 17;175(1):83-9. Epub 2010 Nov 17.

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.

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http://dx.doi.org/10.1667/RR2092.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073160PMC
January 2011

Some unsolved problems and unresolved issues in radiation cytogenetics: a review and new data on roles of homologous recombination and non-homologous end joining.

Mutat Res 2010 Aug 16;701(1):12-22. Epub 2010 Mar 16.

Department of Environmental and Radiological Health Sciences, 1618 Campus Delivery, Colorado State University, Fort Collins, CO 80523, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S138357181000107
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http://dx.doi.org/10.1016/j.mrgentox.2010.03.003DOI Listing
August 2010

Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.

Sci Signal 2010 Feb 23;3(110):ra13. Epub 2010 Feb 23.

Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1126/scisignal.2000634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905599PMC
February 2010

G2-phase chromosomal radiosensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls.

Radiat Res 2010 Jan;173(1):62-70

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.

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http://dx.doi.org/10.1667/RR1943.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819004PMC
January 2010

Variations in radiosensitivity among individuals: a potential impact on risk assessment?

Health Phys 2009 Nov;97(5):470-80

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.

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http://dx.doi.org/10.1097/HP.0b013e3181b08eeeDOI Listing
November 2009

Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis.

J Cell Physiol 2009 Jun;219(3):760-5

Department of Environmental & Radiological Sciences, Colorado State University, Ft. Collins, Colorado.

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http://dx.doi.org/10.1002/jcp.21726DOI Listing
June 2009

Comparison of several radiation effects in human MCF10A mammary epithelial cells cultured as 2D monolayers or 3D acinar stuctures in matrigel.

Radiat Res 2009 Jun;171(6):708-15

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.

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http://dx.doi.org/10.1667/RR1554.1DOI Listing
June 2009

Radiation sensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls: colony formation ability during continuous low-dose-rate gamma irradiation.

Radiat Res 2008 May;169(5):483-94

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.

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http://dx.doi.org/10.1667/RR1333.1DOI Listing
May 2008

Comparison of the induction and disappearance of DNA double strand breaks and gamma-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells.

Mutat Res 2008 Mar 29;639(1-2):108-12. Epub 2007 Nov 29.

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States.

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http://dx.doi.org/10.1016/j.mrfmmm.2007.11.006DOI Listing
March 2008

Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination.

DNA Repair (Amst) 2008 Mar 7;7(3):515-22. Epub 2008 Jan 7.

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.

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http://dx.doi.org/10.1016/j.dnarep.2007.11.014DOI Listing
March 2008

Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks: Comparative studies using radiosensitive mutant and wild-type CHO cells.

Int J Radiat Biol 2007 Sep;83(9):583-91

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, USA.

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http://dx.doi.org/10.1080/09553000701481790DOI Listing
September 2007

A defect in DNA double strand break processing in cells from unaffected parents of retinoblastoma patients and other apparently normal humans.

DNA Repair (Amst) 2007 Jun 6;6(6):818-29. Epub 2007 Mar 6.

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States.

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http://dx.doi.org/10.1016/j.dnarep.2007.01.008DOI Listing
June 2007

Studies on chromosome aberration induction: what can they tell us about DNA repair?

DNA Repair (Amst) 2006 Sep 30;5(9-10):1171-81. Epub 2006 Jun 30.

Colorado State University, Fort Collins, CO 80523, USA.

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http://dx.doi.org/10.1016/j.dnarep.2006.05.033DOI Listing
September 2006

Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma.

Cancer Res 2006 Apr;66(7):3428-33

Radiation Biology and Oncology Branches, Center for Cancer Research, National Cancer Institute/NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2847DOI Listing
April 2006

Repression of mutagenesis by Rad51D-mediated homologous recombination.

Nucleic Acids Res 2006 6;34(5):1358-68. Epub 2006 Mar 6.

Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA.

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http://dx.doi.org/10.1093/nar/gkl020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1390685PMC
March 2006

A unique role of the DNA fragmentation factor in maintaining genomic stability.

Proc Natl Acad Sci U S A 2006 Jan 23;103(5):1504-9. Epub 2006 Jan 23.

Departments of Radiation Oncology and Pathology, Duke University Medical Center, Durham, NC 27710, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0507779103
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http://dx.doi.org/10.1073/pnas.0507779103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360538PMC
January 2006

Suppression of DNA-PK by RNAi has different quantitative effects on telomere dysfunction and mutagenesis in human lymphoblasts treated with gamma rays or HZE particles.

Radiat Res 2005 Oct;164(4 Pt 2):497-504

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.

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http://dx.doi.org/10.1667/rr3366.1DOI Listing
October 2005

Polymerase chain reaction-based suppression of repetitive sequences in whole chromosome painting probes for FISH.

Chromosome Res 2005 ;13(1):27-32

Biology and Biotechnology Research Program, L-448 Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.

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http://dx.doi.org/10.1007/s10577-005-2349-7DOI Listing
August 2005

Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.

Cancer Res 2005 Mar;65(5):1670-7

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3451DOI Listing
March 2005

Radiosensitization of normal human cells by LY294002: cell killing and the rejoining of DNA and interphase chromosome breaks.

J Radiat Res 2003 Dec;44(4):329-33

International Space Radiation Laboratory, National Institute of Radiological Sciences, Inage-ku, Chiba, Japan.

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http://dx.doi.org/10.1269/jrr.44.329DOI Listing
December 2003

Applications of RNA interference for studies in DNA damage processing, genome stability, mutagenesis, and cancer.

Semin Cancer Biol 2003 Aug;13(4):301-8

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.

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http://dx.doi.org/10.1016/s1044-579x(03)00044-0DOI Listing
August 2003

Induction of DNA double strand breaks by arsenite: comparative studies with DNA breaks induced by X-rays.

DNA Repair (Amst) 2003 Mar;2(3):309-14

International Space Radiation Laboratory and Environmental Toxicological Research Group, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

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http://dx.doi.org/10.1016/s1568-7864(02)00220-3DOI Listing
March 2003

Are chromosomal instabilities induced by exposure of cultured normal human cells to low- or high-LET radiation?

Radiat Res 2003 Mar;159(3):301-11

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.

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http://dx.doi.org/10.1667/0033-7587(2003)159[0301:aciibe]2.0.co;2DOI Listing
March 2003

Inhibition of DNA-double strand break repair by antimony compounds.

Toxicology 2002 Dec;180(3):249-56

Environmental and Toxicological Research Group, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, 263-8555, Chiba, Japan.

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http://dx.doi.org/10.1016/s0300-483x(02)00401-8DOI Listing
December 2002

Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation.

Cancer Res 2002 Nov;62(22):6400-4

Department of Environmental and Radiological Health Sciences, Colorado State University Fort Collins, Colorado 80523-1681, USA.

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November 2002

Radiation Research Society. 1952-2002. Historical and current highlights in radiation biology: has anything important been learned by irradiating cells?

Radiat Res 2002 Sep;158(3):251-91

Department of Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523-1673, USA.

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http://dx.doi.org/10.1667/0033-7587(2002)158[0251:hachir]2.0.co;2DOI Listing
September 2002

Physical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays.

Genome Biol 2002 14;3(6):RESEARCH0026. Epub 2002 May 14.

Department of Vascular Biology, The Scripps Research Institute, 10550 N, Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC116723PMC
http://dx.doi.org/10.1186/gb-2002-3-6-research0026DOI Listing
August 2002

D-alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells.

J Am Coll Nutr 2002 Aug;21(4):339-43

Center for Vitamins and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver 80262-0278, USA.

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http://dx.doi.org/10.1080/07315724.2002.10719232DOI Listing
August 2002

Caffeine eliminates gamma-ray-induced G2-phase delay in human tumor cells but not in normal cells.

Radiat Res 2002 Jan;157(1):26-31

Department of Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523-1673, USA.

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http://dx.doi.org/10.1667/0033-7587(2002)157[0026:cegrig]2.0.co;2DOI Listing
January 2002