Joel Perlmutter

Joel Perlmutter

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Joel Perlmutter

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Exploration of Sulfur-Containing Analogues for Imaging Vesicular Acetylcholine Transporter in the Brain.

ChemMedChem 2018 09 19;13(18):1978-1987. Epub 2018 Aug 19.

Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://doi.wiley.com/10.1002/cmdc.201800411
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http://dx.doi.org/10.1002/cmdc.201800411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422167PMC
September 2018

Automated production of a sphingosine-1 phosphate receptor 1 (S1P1) PET radiopharmaceutical [C]CS1P1 for human use.

Appl Radiat Isot 2019 Oct 20;152:30-36. Epub 2019 Jun 20.

Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.apradiso.2019.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708718PMC
October 2019

Low Back Pain--Related Disability in Parkinson Disease: Impact on Functional Mobility, Physical Activity, and Quality of Life.

Phys Ther 2019 Oct;99(10):1346-1353

Department of Neurology, Program in Physical Therapy, Department of Neuroscience, Department of Radiology, and Program in Occupational Therapy, Washington University School of Medicine in Saint Louis.

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http://dx.doi.org/10.1093/ptj/pzz094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821152PMC
October 2019

The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases.

J Neurochem 2019 Oct 15. Epub 2019 Oct 15.

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1111/jnc.14898DOI Listing
October 2019

Head tremor at disease onset: an ataxic phenotype of cervical dystonia.

J Neurol 2019 Aug 26;266(8):1844-1851. Epub 2019 Apr 26.

Department of Neurology, Gardner Family Center for Parkinson's Disease and Movement Disorders, University of Cincinnati, Cincinnati, OH, USA.

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http://dx.doi.org/10.1007/s00415-019-09341-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642013PMC
August 2019

Neuroinflammation and Myelin Status in Alzheimer's Disease, Parkinson's Disease, and Normal Aging Brains: A Small Sample Study.

Parkinsons Dis 2019 4;2019:7975407. Epub 2019 Jul 4.

Department of Radiology, Washington University School of Medicine, 510 S, Kingshighway Blvd, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1155/2019/7975407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637678PMC
July 2019

Development of a carbon-11 PET radiotracer for imaging TRPC5 in the brain.

Org Biomol Chem 2019 Jun;17(22):5586-5594

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1039/c9ob00893dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582641PMC
June 2019

Emergent Functional Network Effects in Parkinson Disease.

Cereb Cortex 2019 Apr;29(4):1701

Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.

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http://dx.doi.org/10.1093/cercor/bhy229DOI Listing
April 2019

Thalamic and ventricular volumes predict motor response to deep brain stimulation for Parkinson's disease.

Parkinsonism Relat Disord 2019 04 28;61:64-69. Epub 2018 Nov 28.

Department of Neurology, Washington University in St Louis, 660 S Euclid Ave, Campus Box 8111, St Louis, MO, 63110, USA; Department of Radiology, Washington University in St. Louis, 660 S. Euclid Ave, Campus Box 8225, St. Louis, MO, 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.11.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488428PMC
April 2019

Validation of diffusion tensor imaging measures of nigrostriatal neurons in macaques.

PLoS One 2018 5;13(9):e0202201. Epub 2018 Sep 5.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202201PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124722PMC
February 2019

Exercise and Parkinson Disease: Comparing Tango, Treadmill, and Stretching.

J Neurol Phys Ther 2019 Jan;43(1):26-32

Program in Physical Therapy (K.S.R., M.E.M., R.P.D., J.S.P., G.M.E.), Department of Neurology (M.E.M., R.P.D., J.S.P., G.M.E.), Department of Neuroscience (J.S.P., G.M.E.), Department of Radiology (J.S.P.), and Program in Occupational Therapy (J.S.P.), Washington University School of Medicine in Saint Louis, Missouri; and Department of Kinesiology and Occupational Therapy Program, University of Wisconsin-Madison (K.A.P.).

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http://Insights.ovid.com/crossref?an=01253086-201901000-0000
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http://dx.doi.org/10.1097/NPT.0000000000000245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294320PMC
January 2019

Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates.

Org Biomol Chem 2018 12;16(47):9171-9184

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1039/c8ob02609bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561338PMC
December 2018

Relationships Among Apathy, Health-Related Quality of Life, and Function in Huntington's Disease.

J Neuropsychiatry Clin Neurosci 2018 21;30(3):194-201. Epub 2018 Mar 21.

From the Departments of Health Care Sciences and Neurology, Wayne State University, Detroit (NEF); the Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor (NRB, NEC); the Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia (JCS); the Department of Psychological and Brain Sciences, University of Massachusetts Amherst, Amherst (RR); the Departments of Neurology, Radiology, Neuroscience, Physical Therapy, and Occupational Therapy, Washington University, St. Louis (JSP, SB); the Department of Neurology, Department of Psychiatry, and Department of Psychological and Brain Sciences, University of Iowa, Iowa City (JSP); the Department of Medical and Molecular Genetics, Indiana University, Indianapolis (KQ); the Department of Psychiatry, Rutgers University Robert Wood Johnson Medical School, Piscataway, NJ (MKM); Department of Pathology, Rowan University, School of Medicine, Stratford, NJ (MKM); and the Department of Neurology, University of California Los Angeles, Los Angeles (SLP).

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http://dx.doi.org/10.1176/appi.neuropsych.17080173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081241PMC
November 2018

Radiosynthesis and evaluation of a fluorine-18 labeled radioligand targeting vesicular acetylcholine transporter.

Bioorg Med Chem Lett 2018 11 24;28(21):3425-3430. Epub 2018 Sep 24.

Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183077
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http://dx.doi.org/10.1016/j.bmcl.2018.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221475PMC
November 2018

PET Imaging in Movement Disorders.

Semin Nucl Med 2018 11 16;48(6):513-524. Epub 2018 Aug 16.

Department of Neurology, Washington University in St. Louis, St Louis, MO; Department of Radiology, Washington University in St. Louis, St Louis, MO; Department of Neuroscience, Washington University in St. Louis, St Louis, MO; Department of Physical Therapy, Washington University in St. Louis, St Louis, MO; Department of Occupational Therapy, Washington University in St. Louis, St Louis, MO.

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https://linkinghub.elsevier.com/retrieve/pii/S00012998183005
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http://dx.doi.org/10.1053/j.semnuclmed.2018.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195228PMC
November 2018

Predictors of alcohol responsiveness in dystonia.

Neurology 2018 11 19;91(21):e2020-e2026. Epub 2018 Oct 19.

From the Institute of Neurogenetics (J. Junker, V.B., A.W., N.B.) and Department of Neurology (J. Junker, N.B.), University of Luebeck, Germany; Department of Psychology (V.B.), Centre for Innovation in Mental Health, University of Southampton, UK; Department of Neurology (B.D.B.), University of Colorado Anschutz Medical Campus, Aurora; Neurology Section (B.D.B.), Denver VA Medical Center, CO; Département de Neurologie (M.V., E.R.), Hôpital Pitié-Salpêtrière, Assistance Publique-Hopitaux de Paris; Sorbonne Universités (M.V.), Pierre Marie Curie Paris-6, Institute of Brain and Spine (ICM), Inserm U 1127, Paris, France; Department of Neurology (C.C.), Rush University Medical Center, Chicago, IL; Department of Neurology (I.A.M.), Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville; Department of Neurology (J. Jankovic), Baylor College of Medicine, Houston, TX; Department of Neurology (M.S.L.), University of Tennessee Health Science Center, Memphis; Neuromed Institute (IRCCS) (A.B.), Pozzilli (IS), and Department of Neurology and Psychiatry, Sapienza University di Roma, Italy; Department of Neurology (R.B.), University of Rochester Medical Center, NY; Department of Neurology (S.G.R.), University of Maryland Medical Center, Baltimore; Department of Neurology (J.S.P.), Washington University in St. Louis, MO; and Department of Neurology and Human Genetics (H.A.J.), Emory University, Atlanta, GA.

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http://dx.doi.org/10.1212/WNL.0000000000006551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260199PMC
November 2018

Pharmacokinetics and Toxicology of the Neuroprotective e,e,e-Methanofullerene(60)-63-tris Malonic Acid [C] in Mice and Primates.

Eur J Drug Metab Pharmacokinet 2018 Oct;43(5):543-554

Department of Medicine, Division of Geriatric Medicine, Vanderbilt University, 2215 Garland Av., 529 LH, Nashville, TN, 37232, USA.

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http://link.springer.com/10.1007/s13318-018-0464-z
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http://dx.doi.org/10.1007/s13318-018-0464-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128740PMC
October 2018

ESM-CT: a precise method for localization of DBS electrodes in CT images.

J Neurosci Methods 2018 10 7;308:366-376. Epub 2018 Sep 7.

Department of Neurology, Washington University School of Medicine, (CB 8111), 660 S. Euclid Avenue, St. Louis, MO, 63110, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01650270183027
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http://dx.doi.org/10.1016/j.jneumeth.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205293PMC
October 2018

Exploration of Sulfur-Containing Analogues for Imaging Vesicular Acetylcholine Transporter in the Brain.

ChemMedChem 2018 09 19;13(18):1978-1987. Epub 2018 Aug 19.

Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://doi.wiley.com/10.1002/cmdc.201800411
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http://dx.doi.org/10.1002/cmdc.201800411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422167PMC
September 2018

Selective D2 receptor PET in manganese-exposed workers.

Neurology 2018 09 10;91(11):e1022-e1030. Epub 2018 Aug 10.

From the Department of Neurology (S.R.C., M.N.W., S.S.N., J.S.P., J.L.-K., B.A.R.), Department of Radiology (J.S.P., S.M.M.), Department of Neuroscience (J.S.P.), Program in Physical Therapy (J.S.P.), Program in Occupational Therapy (J.S.P.), and Department of Biochemistry and Molecular Biophysics (S.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Environmental and Occupational Health Sciences (L.S.) and Department of Biostatistics (L.S.), University of Washington, School of Public Health, Seattle; Department of Family Medicine and Public Health (H.C.) and Department of Neurosciences (H.C.), University of California, San Diego, School of Medicine, La Jolla; and School of Public Health (B.A.R.), Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.

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http://dx.doi.org/10.1212/WNL.0000000000006163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140373PMC
September 2018

Mapping movement, mood, motivation and mentation in the subthalamic nucleus.

R Soc Open Sci 2018 Jul 18;5(7):171177. Epub 2018 Jul 18.

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1098/rsos.171177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083651PMC
July 2018

Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?

Toxicon 2018 Jun 6;147:89-95. Epub 2017 Sep 6.

Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.1016/j.toxicon.2017.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839920PMC
June 2018

Cervical dystonia and substance abuse.

J Neurol 2018 Apr 22;265(4):970-975. Epub 2018 Mar 22.

Department of Neurology, Henry Ford Health System, Henry Ford Hospital, 2799 W Grand Blvd., K-11, Detroit, MI, 48202, USA.

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http://dx.doi.org/10.1007/s00415-018-8840-9DOI Listing
April 2018

Factors Associated With End-of-Life Planning in Huntington Disease.

Am J Hosp Palliat Care 2018 Mar 28;35(3):440-447. Epub 2017 Jun 28.

2 University of Michigan, Department of Physical Medicine & Rehabilitation, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1177/1049909117708195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074046PMC
March 2018

Quantitative, clinically relevant acoustic measurements of focal embouchure dystonia.

Mov Disord 2018 03 20;33(3):449-458. Epub 2018 Feb 20.

Departments of Neurology, Neuroscience, and Pediatrics, University of Rochester, Rochester, New York, USA.

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http://dx.doi.org/10.1002/mds.27298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839997PMC
March 2018

Physical therapy and deep brain stimulation in Parkinson's Disease: protocol for a pilot randomized controlled trial.

Pilot Feasibility Stud 2018 21;4:54. Epub 2018 Feb 21.

1Program in Physical Therapy, Washington University School of Medicine in Saint Louis, Campus Box 8502, 4444 Forest Park Blvd, St. Louis, MO 63108 USA.

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http://dx.doi.org/10.1186/s40814-018-0243-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822622PMC
February 2018

[F]FDOPA positron emission tomography in manganese-exposed workers.

Neurotoxicology 2018 01 8;64:43-49. Epub 2017 Jul 8.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X173011
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http://dx.doi.org/10.1016/j.neuro.2017.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758438PMC
January 2018

7T MRI subthalamic nucleus atlas for use with 3T MRI.

J Med Imaging (Bellingham) 2018 Jan 8;5(1):015002. Epub 2018 Jan 8.

Washington University in St. Louis School of Medicine, Mallinckgrodt Institute of Radiology, St. Louis, Missouri, United States.

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http://dx.doi.org/10.1117/1.JMI.5.1.015002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757662PMC
January 2018

TMEM230 in Parkinson's disease.

Neurobiol Aging 2017 08 16;56:212.e1-212.e3. Epub 2017 Mar 16.

Department of Psychiatry, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University in Saint Louis, Saint Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526081PMC
August 2017

Adult-onset dystonia with marfanoid features.

Neurol Clin Pract 2017 Aug;7(4):e31-e34

Departments of Neurology (SAN, AP, JSP), Radiology (MH, JSP), Neuroscience (JSP), Occupational Therapy (JSP), Physical Therapy (JSP), and Pediatrics (MS), and Division of Genetics and Genomic Medicine (MS), Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1212/CPJ.0000000000000297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566795PMC
August 2017

Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response.

Nucl Med Commun 2017 May;38(5):372-382

Departments of aRadiology bNeurology, Neuroscience, Physical Therapy and Occupational Therapy, Washington University School of Medicine cDepartment of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1097/MNM.0000000000000660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401628PMC
May 2017

Research Priorities in Limb and Task-Specific Dystonias.

Front Neurol 2017 3;8:170. Epub 2017 May 3.

Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.3389/fneur.2017.00170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413505PMC
May 2017

Striatal molecular imaging of presynaptic markers: Ready, fire, aim.

Neurology 2017 04 10;88(15):1388-1389. Epub 2017 Mar 10.

From the Department of Neurology (A.T.), National Hospital Organization, Sendai-Nishitaga Hospital, Sendai, Miyagi, Japan; and Departments of Neurology, Radiology, and Neuroscience and Programs in Physical Therapy and Occupational Therapy (J.S.P.), Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1212/WNL.0000000000003827DOI Listing
April 2017

Preliminary evidence that negative symptom severity relates to multilocus genetic profile for dopamine signaling capacity and D2 receptor binding in healthy controls and in schizophrenia.

J Psychiatr Res 2017 03 17;86:9-17. Epub 2016 Nov 17.

Psychiatry Department, Washington University School of Medicine, St. Louis, MO, USA; Radiology Department, Washington University School of Medicine, St. Louis, MO, USA; Psychological & Brain Sciences Department, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2016.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272837PMC
March 2017

Molecular imaging to track Parkinson's disease and atypical parkinsonisms: New imaging frontiers.

Mov Disord 2017 02 2;32(2):181-192. Epub 2017 Feb 2.

Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Neurology Div/Dept. Medicine, Toronto Western Hospital, UHN; Krembil Research Institute, UHN; Research Imaging Centre, Campbell Family Mental Health Research Institute, CAMH, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/mds.26907DOI Listing
February 2017

A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.

Neurology 2017 Jan 2;88(2):152-159. Epub 2016 Dec 2.

From Cooper University Healthcare at Rowan University (A.M.), Camden, NJ; University of Rochester (M.M., K.K., E.A.d.B., K.B., P.C.); Weill Cornell Medical Center (F.B.); Columbia Presbyterian Medical Center (K.M.), New York, NY; Johns Hopkins Medical Center (C.R.), Baltimore, MD; Georgetown University (I.S.), Washington, DC; NINDS (P.G.), Bethesda, MD; Hereditary Neurological Disease Center (W.M.M.), Wichita, KS; The Centre for Movement Disorders (M.G.), Toronto, Canada; Indiana University School of Medicine (J.W.), Indianapolis; Colorado Neurological Institute (R.K.), Englewood; University of Tennessee Health Science Center (M.S.L.), Memphis; London Health Sciences Centre (M.J.), Canada; Massachusetts General Hospital (H.D.R.), Boston; Struthers Parkinson's Center (M.N.), Minneapolis, MN; University of Kansas Medical Center (R.M.D.), Kansas City; Rush University Medical Center (K.M.S.), Chicago, IL; University of Texas Southwestern Medical Center (P.O.), Dallas; University of Michigan (K.C.), Ann Arbor; Wake Forest University (F.W.), Winston-Salem, NC; University of Alberta (W.M.), Edmonton, Canada; University of California Davis (V.L.W.), Sacramento; Westmead Hospital (E. McCusker), Westmead, Australia; Baylor College of Medicine (J.J.), Houston, TX; University of Miami Miller School of Medicine (C.S.), FL; University of South Florida (J.S.-R.), Tampa; Duke University (B.S.), Durham, NC; University of Calgary (O.S.), Canada; Emory University School of Medicine (S.A.F.), Atlanta, GA; Albany Medical College (D.S.H., Eric Molho), NY; University of Cincinnati (F.R.), OH; Mayo Clinic Arizona (J.N.C.), Scottsdale; Butler Hospital (J.H.F.), Providence, RI; Washington University (J.S.P.), St. Louis, MO; Feinstein Institute for Medical Research (A.F.), Manhasset, NY; Georgetown University (K.A.), Washington, DC; University of Florida (R.R., N.R.M.), Gainesville; Johns Hopkins University (R.L.M.), Baltimore, MD; University of Nevada School of Medicine (E.S.F.), Reno; University of British Columbia (L.A.R.), Vancouver, Canada; University of Pittsburgh (V.S.), PA; Ohio State University (S.K.), Columbus; The Cooper University Health System (A.C.), Camden, NJ; Idaho Elks Rehabilitation Hospital (L.S.), Boise, ID; University of Iowa (E.E.), Iowa City; North York General Hospital 1 (S.E.), Toronto, Canada; St. Luke's Hospital (N.D.), Allentown, PA; North York General Hospital 2 (W.L.A.F.), University of Toronto, Canada; Washington Regional Medical Center (A.D.), Fayetteville, AR; Beth-Israel Deaconess Medical Center (S.F.), Boston, MA; NJ Neuroscience Institute (P.H.), Edison; University of California Irvine (N.H.); The University of Alabama at Birmingham (L.S.D.); and Massachusetts General Hospital (M.C.), Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000003478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224719PMC
January 2017

Objective, computerized video-based rating of blepharospasm severity.

Neurology 2016 Nov 21;87(20):2146-2153. Epub 2016 Oct 21.

From the Computational Neurobiology Laboratory (D.A.P., T.J.S.) and Howard Hughes Medical Institute (T.J.S.), Salk Institute for Biological Studies; Institute for Neural Computation (D.A.P., G.C.L., M.S.B., T.J.S.), Kavli Institute for Brain and Mind (D.A.P., T.J.S.), Machine Perception Laboratory (G.C.L., M.S.B.), and Division of Biological Sciences (T.J.S.), University of California, San Diego, La Jolla; Sobell Department of Motor Neuroscience and Movement Disorders (A.M.), National Hospital of Neurology and Neurosurgery, Institute of Neurology, University College London, UK; Departments of Neurology, Radiology, and Anatomy and Neurobiology, and Programs in Physical Therapy and Occupational Therapy (J.S.P.), Washington University School of Medicine, St. Louis, MO; Departments of Neurology, Human Genetics, and Pediatrics (H.A.J.), Emory University, Atlanta, GA; and Human Motor Control Section (M.H.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD.

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http://dx.doi.org/10.1212/WNL.0000000000003336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109937PMC
November 2016

Absorbed radiation dosimetry of the D-specific PET radioligand [F]FluorTriopride estimated using rodent and nonhuman primate.

Am J Nucl Med Mol Imaging 2016 30;6(6):301-309. Epub 2016 Nov 30.

Mallinckrodt Institute of Radiology, School of Medicine, Washington University St. Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218859PMC
November 2016

Comparison of [C]TZ1964B and [F]MNI659 for PET imaging brain PDE10A in nonhuman primates.

Pharmacol Res Perspect 2016 10 26;4(5):e00253. Epub 2016 Aug 26.

Department of Radiology Washington University School of Medicine St. Louis Missouri.

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http://dx.doi.org/10.1002/prp2.253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045939PMC
October 2016

Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D2 Receptor Binding and Age in Obesity.

Diabetes 2016 09 15;65(9):2618-23. Epub 2016 Jun 15.

Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO Department of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO.

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http://dx.doi.org/10.2337/db16-0407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001180PMC
September 2016

Clinical and genetic features of cervical dystonia in a large multicenter cohort.

Neurol Genet 2016 Jun 11;2(3):e69. Epub 2016 Apr 11.

Departments of Neurology and Anatomy & Neurobiology (M.S.L., S.R.V., J.X., M.M.T.), University of Tennessee Health Science Center, Memphis, TN; Department of Neurology (J.S.P., L.J.W.), Washington University School of Medicine, St. Louis, MO; Departments of Neurology (A.R.R.), Human Genetics, and Pediatrics (H.A.J.), School of Medicine, Emory University, Atlanta, GA; Department of Neurology (P.H.), Vanderbilt University, Nashville, TN; Department of Neurological Sciences (C.L.C.), Rush University, Chicago, IL; Institute of Neurogenetics (A.W., J. Junker), University of Lübeck, Germany; Department of Neurology (J. Jankovic), Baylor College of Medicine, Houston, TX; Department of Neurology (R.L.B.), University of Rochester, NY; Department of Neurology (S.G.R.), University of Maryland, Baltimore, MD; Department of Neurology (R.L.R.), University of Florida, Gainesville, FL; Department of Neurology (B.D.B.), University of Colorado Denver School of Medicine, Aurora, CO; Center of Excellence in Neuroscience (S.C.), University of Montreal, QC, Canada; Mirken Department of Neurology (L.S.), Mt. Sinai Beth Israel Medical Center, New York, NY; Booth Gardner Parkinson's Care Center (P.A.), Kirkland, WA; and Department of Neurology (N.P.S.), University of Alabama at Birmingham, AL.

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http://dx.doi.org/10.1212/NXG.0000000000000069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830199PMC
June 2016

Neuroimaging Analysis of the Dopamine Basis for Apathetic Behaviors in an MPTP-Lesioned Primate Model.

PLoS One 2015 2;10(7):e0132064. Epub 2015 Jul 2.

Department of Neurology, Washington University, St. Louis, Missouri, United States of America; Department of Radiology, Washington University, St. Louis, Missouri, United States of America; Department of Neurobiology, Washington University, St. Louis, Missouri, United States of America; Program of Occupational Therapy, Washington University, St. Louis, Missouri, United States of America; Program of Physical Therapy, Washington University, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132064PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489892PMC
May 2016

Insulin, Central Dopamine D2 Receptors, and Monetary Reward Discounting in Obesity.

PLoS One 2015 20;10(7):e0133621. Epub 2015 Jul 20.

Psychiatry Department, Washington University in St. Louis, St. Louis, MO, United States of America; Radiology Department, Washington University in St. Louis, St. Louis, MO, United States of America; Neurology Department, Washington University in St. Louis, St. Louis, MO, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133621PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507849PMC
April 2016

Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates.

Nucl Med Biol 2016 Feb 7;43(2):131-9. Epub 2015 Nov 7.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nucmedbio.2015.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753027PMC
February 2016

Automated production of [¹⁸F]VAT suitable for clinical PET study of vesicular acetylcholine transporter.

Appl Radiat Isot 2016 Jan 10;107:40-46. Epub 2015 Sep 10.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.apradiso.2015.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681605PMC
January 2016

Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.

Authors:
Kevin Michael Biglan Ira Shoulson Karl Kieburtz David Oakes Elise Kayson M Aileen Shinaman Hongwei Zhao Megan Romer Anne Young Steven Hersch Jack Penney Karen Marder Jane Paulsen Kimberly Quaid Eric Siemers Caroline Tanner William Mallonee Greg Suter Richard Dubinsky Carolyn Gray Martha Nance Scott Bundlie Dawn Radtke Sandra Kostyk Corrine Baic James Caress Francis Walker Victoria Hunt Christine O'Neill Sylvain Chouinard Stewart Factor Timothy Greenamyre Cathy Wood-Siverio Jody Corey-Bloom David Song Guerry Peavy Carol Moskowitz Melissa Wesson Ali Samii Thomas Bird Hillary Lipe Karen Blindauer Frederick Marshall Carol Zimmerman Jody Goldstein Diana Rosas Peter Novak John Caviness Charles Adler Amy Duffy Vicki Wheelock Teresa Tempkin David Richman Lauren Seeberger Roger Albin Kelvin L Chou Brad Racette Joel S Perlmutter Susan Perlman Yvette Bordelon Wayne Martin Marguerite Wieler Blair Leavitt Lynn Raymond Joji Decolongon Lorne Clarke Joseph Jankovic Christine Hunter Robert A Hauser Juan Sanchez-Ramos Sarah Furtado Oksana Suchowersky Mary Lou Klimek Mark Guttman Rustom Sethna Andrew Feigin Marie Cox Barbara Shannon Alan Percy Leon Dure Madaline Harrison William Johnson Donald Higgins Eric Molho Constance Nickerson Sharon Evans Douglas Hobson Carlos Singer Nestor Galvez-Jimenez Kathleen Shannon Cynthia Comella Christopher Ross Marie H Saint-Hilaire Claudia Testa Adam Rosenblatt Penelope Hogarth William Weiner Peter Como Rajeev Kumar Candace Cotto Julie Stout Alicia Brocht Arthur Watts Shirley Eberly Christine Weaver Tatiana Foroud James Gusella Marcy MacDonald Richard Myers Stanley Fahn Clifford Shults

JAMA Neurol 2016 Jan;73(1):102-10

Department of Neuroscience, University of California, San Diego, La Jolla.

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http://dx.doi.org/10.1001/jamaneurol.2015.2736DOI Listing
January 2016

Variants in GBA, SNCA, and MAPT influence Parkinson disease risk, age at onset, and progression.

Neurobiol Aging 2016 Jan 30;37:209.e1-209.e7. Epub 2015 Sep 30.

Department of Psychiatry, Washington University, School of Medicine, St. Louis, MO, USA; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688052PMC
January 2016

The Human Experience with Intravenous Levodopa.

Front Pharmacol 2015 6;6:307. Epub 2016 Jan 6.

Division of Biology and Biomedical Sciences, Departments of Psychiatry, Neurology, Radiology, and Anatomy and Neurobiology, Washington University School of Medicine St. Louis, MO, USA.

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http://dx.doi.org/10.3389/fphar.2015.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701937PMC
January 2016

Radiation dosimetry of [(18)F]VAT in nonhuman primates.

EJNMMI Res 2015 Dec 10;5(1):73. Epub 2015 Dec 10.

Mallinckrodt Institute of Radiology, Washington University Medical School, St. Louis, MO, USA.

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http://dx.doi.org/10.1186/s13550-015-0149-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675760PMC
December 2015

Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate.

J Med Chem 2015 Nov 15;58(21):8584-600. Epub 2015 Oct 15.

Department of Radiology and ‡Department of Neurology, Washington University School of Medicine , St. Louis, Missouri 63110, United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b01205
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http://dx.doi.org/10.1021/acs.jmedchem.5b01205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697445PMC
November 2015

Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease.

Ann Clin Transl Neurol 2015 Oct 12;2(10):949-59. Epub 2015 Sep 12.

Department of Neurology, Washington University School of Medicine St. Louis, Missouri ; Department of Developmental Biology, Washington University School of Medicine St. Louis, Missouri ; Hope Center for Neurological Disorders, Washington University School of Medicine St. Louis, Missouri.

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http://dx.doi.org/10.1002/acn3.246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603378PMC
October 2015

Cognitive reserve and β-amyloid pathology in Parkinson disease.

Parkinsonism Relat Disord 2015 Aug 27;21(8):899-904. Epub 2015 May 27.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13538020150023
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http://dx.doi.org/10.1016/j.parkreldis.2015.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509801PMC
August 2015

Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter.

Bioorg Med Chem 2015 Aug 5;23(15):4699-709. Epub 2015 Jun 5.

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd., St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, 510 South Kingshighway Blvd., St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.bmc.2015.05.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524497PMC
August 2015

Acute changes in mood induced by subthalamic deep brain stimulation in Parkinson disease are modulated by psychiatric diagnosis.

Brain Stimul 2014 Sep-Oct;7(5):701-8. Epub 2014 Jun 12.

Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2014.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167923PMC
June 2015

CSF proteins and resting-state functional connectivity in Parkinson disease.

Neurology 2015 Jun 15;84(24):2413-21. Epub 2015 May 15.

From the Departments of Neurology (M.C.C., C.B., P.T.K., J.S.P.), Radiology (M.C.C., A.Z.S., J.S.P.), Psychiatry (J.M.K.), and Anatomy & Neurobiology (J.S.P.), and Programs in Occupational Therapy (J.S.P.) and Physical Therapy (J.S.P.), Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1212/WNL.0000000000001681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478033PMC
June 2015

Emotional Eating Phenotype is Associated with Central Dopamine D2 Receptor Binding Independent of Body Mass Index.

Sci Rep 2015 Jun 12;5:11283. Epub 2015 Jun 12.

1] Departments of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA [2] Departments of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA [3] Departments of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1038/srep11283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464302PMC
June 2015

Secured web-based video repository for multicenter studies.

Parkinsonism Relat Disord 2015 Apr 20;21(4):366-71. Epub 2015 Jan 20.

Neurology, Washington University School of Medicine, St. Louis, MO, USA; Radiology, Washington University School of Medicine, St. Louis, MO, USA; Anatomy and Neurobiology, Physical Therapy, Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2015.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372455PMC
April 2015

In vitro and ex vivo characterization of (-)-TZ659 as a ligand for imaging the vesicular acetylcholine transporter.

Eur J Pharmacol 2015 Apr 9;752:18-25. Epub 2015 Feb 9.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369186PMC
April 2015

Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging.

PeerJ 2015 17;3:e834. Epub 2015 Mar 17.

Department of Neurology, Washington University School of Medicine , St Louis, MO , USA ; Department of Psychiatry, Washington University School of Medicine , St Louis, MO , USA ; Department of Radiology, Washington University School of Medicine , St Louis, MO , USA ; Departments of Anatomy and Neurobiology, Washington University School of Medicine , St Louis, MO , USA ; Division of Biology and Biomedical Sciences, Washington University School of Medicine , St Louis, MO , USA.

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http://dx.doi.org/10.7717/peerj.834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369335PMC
March 2015

The role of dopamine and dopaminergic pathways in dystonia: insights from neuroimaging.

Tremor Other Hyperkinet Mov (N Y) 2015 29;5:280. Epub 2015 Jan 29.

Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA ; Department of Radiology, Neurobiology, Physical Therapy and Occupational Therapy, Washington University in St. Louis, St. Louis, MO, USA.

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http://dx.doi.org/10.7916/D8J101XVDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314610PMC
February 2015

Correlation between decreased CSF α-synuclein and Aβ₁₋₄₂ in Parkinson disease.

Neurobiol Aging 2015 Jan 4;36(1):476-84. Epub 2014 Aug 4.

Department of Neurology, Washington University School of Medicine, St Louis, MO, USA; Department of Developmental Biology, Washington University School of Medicine, St Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.07.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268043PMC
January 2015

In vitro and in vivo characterization of two C-11-labeled pet tracers for vesicular acetylcholine transporter.

Mol Imaging Biol 2014 Dec;16(6):773-80

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd., St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11307-014-0749-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404702PMC
December 2014

Syntheses and radiosyntheses of two carbon-11 labeled potent and selective radioligands for imaging vesicular acetylcholine transporter.

Mol Imaging Biol 2014 Dec;16(6):765-72

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11307-014-0748-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414325PMC
December 2014

Neuroimaging biomarkers for Parkinson disease: facts and fantasy.

Ann Neurol 2014 Dec 7;76(6):769-83. Epub 2014 Nov 7.

Departments of Neurology, Radiology, Anatomy & Neurobiology, Occupational Therapy, and Physical Therapy, Washington University, St Louis, MO.

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http://dx.doi.org/10.1002/ana.24291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245400PMC
December 2014

Radiosynthesis and evaluation of a novel σ selective PET ligand.

Medchemcomm 2014 Nov;5(11):1669-1677

Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://xlink.rsc.org/?DOI=C4MD00240G
Publisher Site
http://dx.doi.org/10.1039/C4MD00240GDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288033PMC
November 2014

Smoking and Parkinson disease: where there is smoke there may not be fire.

Neurology 2014 Oct 12;83(16):1392-3. Epub 2014 Sep 12.

From the Department of Neurology (L.A.H.), University of Oklahoma Health Sciences Center, Oklahoma City; and Departments of Neurology, Radiology, and Neurobiology, and Programs of Physical Therapy and Occupational Therapy (J.S.P.), Washington University, St. Louis, MO.

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http://dx.doi.org/10.1212/WNL.0000000000000896DOI Listing
October 2014

Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates.

Ann Neurol 2014 Sep 22;76(3):393-402. Epub 2014 Jul 22.

Departments of Medicine, University of California, San Diego, San Diego, CA; Departments of Neurosciences, University of California, San Diego, San Diego, CA; Departments of Neurology, Washington University, St Louis, MO.

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http://dx.doi.org/10.1002/ana.24220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165715PMC
September 2014

In vivo measures of nigrostriatal neuronal response to unilateral MPTP treatment.

Brain Res 2014 Jul 15;1571:49-60. Epub 2014 May 15.

Neurology, Washington University, St. Louis, MO 63110, USA; Radiology, Washington University, St. Louis, MO 63110, USA; Neurobiology, Washington University, St. Louis, MO 63110, USA; Occupational Therapy, Washington University, St. Louis, MO 63110, USA; Physical Therapy, Washington University, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2014.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104119PMC
July 2014

Comment: fMRI biomarker for premanifest HD?

Neurology 2014 Jul 4;83(1):71. Epub 2014 Jun 4.

From the Departments of Neurology, Radiology, and Neurobiology and Programs in Physical Therapy and Occupational Therapy, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1212/WNL.0000000000000553DOI Listing
July 2014