Dr. Joel M Guthridge, PhD - Oklahoma Medical Research Foundation - Assoc. Res. Member, Dir. of Translational Informatics and Clinical Resources

Dr. Joel M Guthridge

PhD

Oklahoma Medical Research Foundation

Assoc. Res. Member, Dir. of Translational Informatics and Clinical Resources

Oklahoma City, OK | United States

Main Specialties: Biology

Additional Specialties: Immunology, Genetics, Molecular biology, bioinformatics, translational informatics, autoimmune disease, lupus

Dr. Joel M Guthridge, PhD - Oklahoma Medical Research Foundation - Assoc. Res. Member, Dir. of Translational Informatics and Clinical Resources

Dr. Joel M Guthridge

PhD

Introduction

Primary Affiliation: Oklahoma Medical Research Foundation - Oklahoma City, OK , United States

Specialties:

Additional Specialties:

Publications

54Publications

2553Reads

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1984PubMed Central Citations

Vitamin d deficiency in a multiethnic healthy control cohort and altered immune response in vitamin D deficient European-American healthy controls.

PLoS One 2014 11;9(4):e94500. Epub 2014 Apr 11.

Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America; Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094500PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984168PMC
January 2015
16 Reads
11 Citations
3.234 Impact Factor

Evidence of dynamically dysregulated gene expression pathways in hyperresponsive B cells from African American lupus patients.

PLoS One 2013 15;8(8):e71397. Epub 2013 Aug 15.

University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744560PMC
April 2014
30 Reads
2 Citations
3.234 Impact Factor

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

Nat Genet 2013 Nov 6;45(11):1284-92. Epub 2013 Oct 6.

1] Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA. [2] Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

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http://dx.doi.org/10.1038/ng.2792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867192PMC
November 2013
70 Reads
85 Citations
29.352 Impact Factor

Herpes zoster vaccination in SLE: a pilot study of immunogenicity.

J Rheumatol 2013 Nov 15;40(11):1875-80. Epub 2013 Sep 15.

From Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.

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http://dx.doi.org/10.3899/jrheum.130170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867792PMC
November 2013
67 Reads
9 Citations
3.190 Impact Factor

Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse.

J Autoimmun 2013 Mar 18;41:168-74. Epub 2013 Feb 18.

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1016/j.jaut.2012.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622940PMC
March 2013
13 Reads
14 Citations
8.410 Impact Factor

Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functions.

J Biomed Biotechnol 2012 22;2012:594056. Epub 2012 Feb 22.

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1155/2012/594056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304673PMC
September 2012
12 Reads
3 Citations
3.170 Impact Factor

Multiple Autoantibodies Display Association with Lymphopenia, Proteinuria, and Cellular Casts in a Large, Ethnically Diverse SLE Patient Cohort.

Autoimmune Dis 2012 4;2012:819634. Epub 2012 Sep 4.

Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA ; Department of Medicine and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1155/2012/819634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439936PMC
September 2012
50 Reads
7 Citations

Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction.

J Rheumatol 2011 Sep 15;38(9):1866-70. Epub 2011 Jul 15.

Genetic Epidemiology Unit, Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.3899/jrheum.110199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170719PMC
September 2011
12 Reads
10 Citations
3.190 Impact Factor

Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus.

Ann Rheum Dis 2011 Sep 17;70(9):1569-74. Epub 2011 May 17.

Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1136/ard.2010.148494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149865PMC
September 2011
12 Reads
46 Citations
10.380 Impact Factor

Association of a functional IRF7 variant with systemic lupus erythematosus.

Arthritis Rheum 2011 Mar;63(3):749-54

University of California, Los Angeles, and Joint Molecular Rheumatology Laboratory of Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institutes for Biological Sciences, and Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1002/art.30193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063317PMC
March 2011
37 Reads
39 Citations
7.764 Impact Factor

A comprehensive and universal method for assessing the performance of differential gene expression analyses.

PLoS One 2010 Sep 9;5(9). Epub 2010 Sep 9.

Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012657PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936572PMC
September 2010
8 Reads
11 Citations
3.234 Impact Factor

Identification of unique microRNA signature associated with lupus nephritis.

PLoS One 2010 May 11;5(5):e10344. Epub 2010 May 11.

Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010344PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867940PMC
May 2010
10 Reads
59 Citations
3.234 Impact Factor

Early targets of nuclear RNP humoral autoimmunity in human systemic lupus erythematosus.

Arthritis Rheum 2009 Mar;60(3):848-59

Oklahoma Medical Research Foundation, and University of Oklahoma Health Sciences Center, Oklahoma City, and Brigham Young University, Provo, Utah, USA.

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http://dx.doi.org/10.1002/art.24306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653589PMC
March 2009
2 Reads
11 Citations
7.764 Impact Factor

Aberrant Epstein-Barr viral infection in systemic lupus erythematosus.

Autoimmun Rev 2009 Feb 22;8(4):337-42. Epub 2009 Jan 22.

Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.

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http://dx.doi.org/10.1016/j.autrev.2008.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822456PMC
February 2009
27 Reads
33 Citations
7.933 Impact Factor

A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.

Nat Genet 2008 Feb 20;40(2):152-4. Epub 2008 Jan 20.

Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, 825 NE 13th St., Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1038/ng.71DOI Listing
February 2008
37 Reads
104 Citations
29.352 Impact Factor

Fine specificity mapping of autoantigens targeted by anti-centromere autoantibodies.

J Autoimmun 2006 Dec 8;27(4):272-80. Epub 2007 Jan 8.

Arthritis and Immunology Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1016/j.jaut.2006.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906738PMC
December 2006
10 Reads
5 Citations
8.410 Impact Factor

Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.

J Mol Biol 2006 Feb 5;356(2):397-412. Epub 2005 Dec 5.

Department of Biochemistry and Molecular Biology, Darwin Building, University College London, UK.

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http://dx.doi.org/10.1016/j.jmb.2005.11.050DOI Listing
February 2006
4 Reads
3 Citations
4.333 Impact Factor

Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d.

J Mol Biol 2005 Feb 8;346(3):845-58. Epub 2005 Jan 8.

Department of Medicine and Immunology, University of Colorado Health Sciences Center, 4200 East Ninth Ave., Denver, CO 80262, USA.

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http://dx.doi.org/10.1016/j.jmb.2004.12.007DOI Listing
February 2005
6 Reads
15 Citations
4.333 Impact Factor

Interaction of calcium and Ro60: increase of antigenicity.

Mol Immunol 2004 Jul;41(8):809-16

Arthritis and Immunology Program, Oklahoma Medical Research Foundation (OMRF), 825 NE 13th Street, MS# 38, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1016/j.molimm.2004.03.036DOI Listing
July 2004
2 Reads
2 Citations
2.973 Impact Factor

Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation.

J Clin Invest 2003 Jun;111(12):1875-85

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1172/JCI17348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC161422PMC
June 2003
35 Reads
44 Citations
13.215 Impact Factor

The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.

J Mol Biol 2003 Jun;329(3):525-50

Department of Biochemistry and Molecular Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/s0022-2836(03)00492-3DOI Listing
June 2003
3 Reads
11 Citations
4.333 Impact Factor

Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire.

J Immunol 2002 Aug;169(4):2126-33

Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

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http://dx.doi.org/10.4049/jimmunol.169.4.2126DOI Listing
August 2002
1 Read
51 Citations
4.922 Impact Factor

Complement C3 activation is required for antiphospholipid antibody-induced fetal loss.

J Exp Med 2002 Jan;195(2):211-20

Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193604PMC
http://dx.doi.org/10.1084/jem.200116116DOI Listing
January 2002
7 Reads
81 Citations
12.520 Impact Factor

Top co-authors

Judith A James
Judith A James

Arthritis and Clinical Immunology Research Program

41
John B Harley
John B Harley

Cincinnati Children's Hospital Medical Center

34
Joan T Merrill
Joan T Merrill

Oklahoma Medical Research Foundation

25
Kenneth M Kaufman
Kenneth M Kaufman

Cincinnati Children's Hospital Medical Center

25
Jennifer A Kelly
Jennifer A Kelly

Arthritis and Clinical Immunology Research Program

24
Patrick M Gaffney
Patrick M Gaffney

Arthritis and Clinical Immunology Research Program

23
Gary S Gilkeson
Gary S Gilkeson

Medical University of South Carolina

21
Robert P Kimberly
Robert P Kimberly

University of Alabama at Birmingham

19
Chaim O Jacob
Chaim O Jacob

University of Southern California

18
Timothy J Vyse
Timothy J Vyse

King's College London

18