Joel Gelernter

Joel Gelernter

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Joel Gelernter

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Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study.

Depress Anxiety 2019 Aug 6. Epub 2019 Aug 6.

U.S. Department of Veterans Affairs National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, Connecticut.

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http://dx.doi.org/10.1002/da.22912DOI Listing
August 2019

Genome-wide scan identifies opioid overdose risk locus close to MCOLN1.

Addict Biol 2019 Jul 30:e12811. Epub 2019 Jul 30.

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, New Haven, CT, USA.

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http://dx.doi.org/10.1111/adb.12811DOI Listing
July 2019

Inviting in the Exome for Alcohol and Smoking Traits.

Authors:
Joel Gelernter

Biol Psychiatry 2019 Jun;85(11):889-890

Yale University School of Medicine and the Veterans Affairs Connecticut Healthcare Center, West Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.04.005DOI Listing
June 2019

Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.

J Clin Psychiatry 2017 Sep/Oct;78(8):e1058-e1059

US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, Connecticut, USA.

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http://www.psychiatrist.com/JCP/article/Pages/2017/v78n08/17
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http://dx.doi.org/10.4088/JCP.17l11646DOI Listing
April 2019

Genetics of Alcoholism.

Curr Psychiatry Rep 2019 Mar 9;21(4):26. Epub 2019 Mar 9.

Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, CB 8134, Saint Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11920-019-1008-1DOI Listing
March 2019

Alcohol-responsive genes identified in human iPSC-derived neural cultures.

Transl Psychiatry 2019 03 12;9(1):96. Epub 2019 Mar 12.

Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, 06030-1410, USA.

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http://dx.doi.org/10.1038/s41398-019-0426-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414668PMC
March 2019

Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women.

Sci Rep 2019 Mar 15;9(1):4660. Epub 2019 Mar 15.

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://www.nature.com/articles/s41598-019-41110-7
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http://dx.doi.org/10.1038/s41598-019-41110-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420601PMC
March 2019

Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of Val122Ile Mutation Is Modulated by Non-Coding Variants.

J Clin Med 2019 Feb 22;8(2). Epub 2019 Feb 22.

Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.

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http://dx.doi.org/10.3390/jcm8020269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406512PMC
February 2019

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.

Nat Genet 2019 01 26;51(1):63-75. Epub 2018 Nov 26.

Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41588-018-0269-7
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http://dx.doi.org/10.1038/s41588-018-0269-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481311PMC
January 2019

GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.

Am J Med Genet B Neuropsychiatr Genet 2019 Jan 28;180(1):3-11. Epub 2018 Nov 28.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/ajmg.b.32692DOI Listing
January 2019

Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.

Alcohol Clin Exp Res 2018 12 25;42(12):2337-2348. Epub 2018 Oct 25.

Department of Psychiatry , Division of Human Genetics, VA CT Healthcare Center, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1111/acer.13890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317871PMC
December 2018

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Authors:
Raymond K Walters Renato Polimanti Emma C Johnson Jeanette N McClintick Mark J Adams Amy E Adkins Fazil Aliev Silviu-Alin Bacanu Anthony Batzler Sarah Bertelsen Joanna M Biernacka Tim B Bigdeli Li-Shiun Chen Toni-Kim Clarke Yi-Ling Chou Franziska Degenhardt Anna R Docherty Alexis C Edwards Pierre Fontanillas Jerome C Foo Louis Fox Josef Frank Ina Giegling Scott Gordon Laura M Hack Annette M Hartmann Sarah M Hartz Stefanie Heilmann-Heimbach Stefan Herms Colin Hodgkinson Per Hoffmann Jouke Jan Hottenga Martin A Kennedy Mervi Alanne-Kinnunen Bettina Konte Jari Lahti Marius Lahti-Pulkkinen Dongbing Lai Lannie Ligthart Anu Loukola Brion S Maher Hamdi Mbarek Andrew M McIntosh Matthew B McQueen Jacquelyn L Meyers Yuri Milaneschi Teemu Palviainen John F Pearson Roseann E Peterson Samuli Ripatti Euijung Ryu Nancy L Saccone Jessica E Salvatore Sandra Sanchez-Roige Melanie Schwandt Richard Sherva Fabian Streit Jana Strohmaier Nathaniel Thomas Jen-Chyong Wang Bradley T Webb Robbee Wedow Leah Wetherill Amanda G Wills Jason D Boardman Danfeng Chen Doo-Sup Choi William E Copeland Robert C Culverhouse Norbert Dahmen Louisa Degenhardt Benjamin W Domingue Sarah L Elson Mark A Frye Wolfgang Gäbel Caroline Hayward Marcus Ising Margaret Keyes Falk Kiefer John Kramer Samuel Kuperman Susanne Lucae Michael T Lynskey Wolfgang Maier Karl Mann Satu Männistö Bertram Müller-Myhsok Alison D Murray John I Nurnberger Aarno Palotie Ulrich Preuss Katri Räikkönen Maureen D Reynolds Monika Ridinger Norbert Scherbaum Marc A Schuckit Michael Soyka Jens Treutlein Stephanie Witt Norbert Wodarz Peter Zill Daniel E Adkins Joseph M Boden Dorret I Boomsma Laura J Bierut Sandra A Brown Kathleen K Bucholz Sven Cichon E Jane Costello Harriet de Wit Nancy Diazgranados Danielle M Dick Johan G Eriksson Lindsay A Farrer Tatiana M Foroud Nathan A Gillespie Alison M Goate David Goldman Richard A Grucza Dana B Hancock Kathleen Mullan Harris Andrew C Heath Victor Hesselbrock John K Hewitt Christian J Hopfer John Horwood William Iacono Eric O Johnson Jaakko A Kaprio Victor M Karpyak Kenneth S Kendler Henry R Kranzler Kenneth Krauter Paul Lichtenstein Penelope A Lind Matt McGue James MacKillop Pamela A F Madden Hermine H Maes Patrik Magnusson Nicholas G Martin Sarah E Medland Grant W Montgomery Elliot C Nelson Markus M Nöthen Abraham A Palmer Nancy L Pedersen Brenda W J H Penninx Bernice Porjesz John P Rice Marcella Rietschel Brien P Riley Richard Rose Dan Rujescu Pei-Hong Shen Judy Silberg Michael C Stallings Ralph E Tarter Michael M Vanyukov Scott Vrieze Tamara L Wall John B Whitfield Hongyu Zhao Benjamin M Neale Joel Gelernter Howard J Edenberg Arpana Agrawal

Nat Neurosci 2018 12 26;21(12):1656-1669. Epub 2018 Nov 26.

Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41593-018-0275-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430207PMC
December 2018

Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.

Biol Psychiatry 2018 11 11;84(10):762-770. Epub 2018 Jan 11.

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Massachusetts; Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, Massachusetts; VA Connecticut Healthcare Center, West Haven, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041180PMC
November 2018

Genome-wide analysis of insomnia disorder.

Mol Psychiatry 2018 11 8;23(11):2238-2250. Epub 2018 Mar 8.

Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41380-018-0033-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129221PMC
November 2018

Inferring phenotypes from substance use via collaborative matrix completion.

BMC Syst Biol 2018 11 22;12(Suppl 6):104. Epub 2018 Nov 22.

Department of Computer Science and Engineering, University of Connecticut, 371 Fairfield Way, Unit 4155, Storrs, CT, USA.

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http://dx.doi.org/10.1186/s12918-018-0623-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249733PMC
November 2018

Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers.

Pharmacol Biochem Behav 2018 10 11;173:36-43. Epub 2018 Aug 11.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States of America; VA Connecticut Healthcare System, West Haven, CT, United States of America.

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http://dx.doi.org/10.1016/j.pbb.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125200PMC
October 2018

Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid Disorders.

J Clin Med 2018 Sep 21;7(10). Epub 2018 Sep 21.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.

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http://dx.doi.org/10.3390/jcm7100296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210201PMC
September 2018

Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test.

Am J Med Genet B Neuropsychiatr Genet 2018 07;177(5):511-519

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/ajmg.b.32642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110090PMC
July 2018

Genetically determined schizophrenia is not associated with impaired glucose homeostasis.

Schizophr Res 2018 05 29;195:286-289. Epub 2017 Oct 29.

Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1016/j.schres.2017.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924728PMC
May 2018

Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.

Alcohol Clin Exp Res 2018 05 13;42(5):861-868. Epub 2018 Mar 13.

Department of Psychiatry , King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

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http://dx.doi.org/10.1111/acer.13614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916336PMC
May 2018

ADH1B: From alcoholism, natural selection, and cancer to the human phenome.

Am J Med Genet B Neuropsychiatr Genet 2018 03 27;177(2):113-125. Epub 2017 Mar 27.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, Connecticut.

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http://dx.doi.org/10.1002/ajmg.b.32523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617762PMC
March 2018

Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits.

Genome Med 2018 03 26;10(1):24. Epub 2018 Mar 26.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, 950 Campbell Avenue, West Haven, CT, 06516, USA.

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http://dx.doi.org/10.1186/s13073-018-0532-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870256PMC
March 2018

Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.

Depress Anxiety 2018 02 24;35(2):168-177. Epub 2017 Nov 24.

Clinical Neurosciences Division, U.S. Department of Veterans Affairs National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA.

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http://dx.doi.org/10.1002/da.22698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794529PMC
February 2018

Psychiatric Genomics: An Update and an Agenda.

Am J Psychiatry 2018 Jan 3;175(1):15-27. Epub 2017 Oct 3.

From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm; the Departments of Genetics, Psychiatry, and Nutrition, University of North Carolina, Chapel Hill, N.C.; the Department of Psychiatry, Washington University School of Medicine, St Louis; the Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Oslo and Oslo University Hospital, Oslo; the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark; the Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark; the Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark; the Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London; the National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, London; the Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland; the Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, Bonn, Germany; the Institute of Neuroscience and Medicine, Juelich, Germany; the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis; the Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, N.Y.; the Department of Psychiatry, Yale University, New Haven, Conn.; the Department of Psychiatry and the Genetics Institute, University of Florida, Gainesville; the Department of Psychiatry, University of California-San Diego, La Jolla, Calif., the Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, and the Department of Psychiatry, Massachusetts General Hospital, Boston; the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Mass.; and the MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, U.K.

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http://dx.doi.org/10.1176/appi.ajp.2017.17030283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756100PMC
January 2018

Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease.

Neurobiol Aging 2018 01 6;61:207-214. Epub 2017 Oct 6.

Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722236PMC
January 2018

Psychiatric Genomics: An Update and an Agenda.

Am J Psychiatry 2018 Jan 3;175(1):15-27. Epub 2017 Oct 3.

From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm; the Departments of Genetics, Psychiatry, and Nutrition, University of North Carolina, Chapel Hill, N.C.; the Department of Psychiatry, Washington University School of Medicine, St Louis; the Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Oslo and Oslo University Hospital, Oslo; the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark; the Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark; the Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark; the Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London; the National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, London; the Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland; the Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, Bonn, Germany; the Institute of Neuroscience and Medicine, Juelich, Germany; the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis; the Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, N.Y.; the Department of Psychiatry, Yale University, New Haven, Conn.; the Department of Psychiatry and the Genetics Institute, University of Florida, Gainesville; the Department of Psychiatry, University of California-San Diego, La Jolla, Calif., the Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, and the Department of Psychiatry, Massachusetts General Hospital, Boston; the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Mass.; and the MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, U.K.

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http://dx.doi.org/10.1176/appi.ajp.2017.17030283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756100PMC
January 2018

Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.

Am J Med Genet B Neuropsychiatr Genet 2017 Dec 9;174(8):846-853. Epub 2017 Oct 9.

Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut.

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http://dx.doi.org/10.1002/ajmg.b.32604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861711PMC
December 2017

Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.

JAMA Psychiatry 2017 12;74(12):1234-1241

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.3275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331050PMC
December 2017

GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers.

Alcohol Clin Exp Res 2017 Dec 13;41(12):2025-2032. Epub 2017 Nov 13.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1111/acer.13516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764175PMC
December 2017

Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.

J Psychiatr Res 2017 11 8;94:139-147. Epub 2017 Jul 8.

U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605420PMC
November 2017

Collaborative Phenotype Inference from Comorbid Substance Use Disorders and Genotypes.

Proceedings (IEEE Int Conf Bioinformatics Biomed) 2017 Nov 18;2017:392-397. Epub 2017 Dec 18.

Department of Computer Science and Engineering, University of Connecticut, Storrs, Connecticut.

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http://dx.doi.org/10.1109/BIBM.2017.8217681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947969PMC
November 2017

Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center.

J Addict Med 2017 Jan/Feb;11(1):19-27

Department of Psychiatry (TR, RK), King Chulalongkorn Memorial Hospital; Department of Psychiatry (TR, RK), Faculty of Medicine, Chulalongkorn University, Bangkok; Princess Mother National Institute on Drug Abuse and Treatment (Thanyarak Institute) (VV), Thailand Ministry of Public Health, Pathumthani, Thailand; and Department of Psychiatry (JG, RTM), Yale School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1097/ADM.0000000000000262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291761PMC
October 2017

Genetic and psychosocial predictors of alcohol use trajectories among disaster-exposed adolescents.

Am J Addict 2017 Sep 8;26(6):623-631. Epub 2017 Jun 8.

Virginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University, Charleston, South Carolina.

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http://dx.doi.org/10.1111/ajad.12575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627968PMC
September 2017

Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits.

PLoS One 2016 18;11(8):e0160654. Epub 2016 Aug 18.

Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160654PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990182PMC
August 2017

Review: DNA methylation and alcohol use disorders: Progress and challenges.

Am J Addict 2017 Aug 19;26(5):502-515. Epub 2016 Oct 19.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1111/ajad.12465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003819PMC
August 2017

identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours.

J Psychiatry Neurosci 2017 06;42(4):252-261

From the Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, Conn., USA (Polimanti, Pearlson, Gelernter); Olin Research Center, Institute of Living/Hartford Hospital, Hartford, Conn., USA (Meda, Pearlson); the Department of Neuroscience, Yale University School of Medicine, New Haven, Conn., USA (Pearlson, Gelernter); the Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Mass., USA (Sherva, Farrer); the Department of Biostatistics, Yale University School of Public Health, New Haven, Conn., USA (Zhao); the Department of Genetics, Yale University School of Medicine, New Haven, Conn., USA (Zhao, Gelernter); the Departments of Neurology, Ophthalmology, Biostatistics, and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Mass., USA (Farrer); and the Department of Psychiatry, University of Pennsylvania School of Medicine and VISN 4 MIRECC, Crescenz VAMC, Philadelphia, Pa., USA (Kranzler).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487272PMC
June 2017

Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era.

Genome Biol 2017 06 19;18(1):120. Epub 2017 Jun 19.

Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Taub Institute for Research on Alzheimer's disease and the Aging Brain, New York, NY, 10032, USA.

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http://dx.doi.org/10.1186/s13059-017-1250-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477265PMC
June 2017

Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B.

Alcohol Clin Exp Res 2017 May 10;41(5):998-1003. Epub 2017 Apr 10.

Department of Psychiatry, University of Pennsylvania Perelman School of Medicine and VISN 4 MIRECC, Crescenz VAMC, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/acer.13373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501250PMC
May 2017

Sex-specific linkage scans in opioid dependence.

Am J Med Genet B Neuropsychiatr Genet 2017 Apr 20;174(3):261-268. Epub 2016 Oct 20.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/ajmg.b.32507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695218PMC
April 2017

Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.

Sci Rep 2017 04 21;7(1):1034. Epub 2017 Apr 21.

Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, CT, United States.

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http://dx.doi.org/10.1038/s41598-017-01098-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430682PMC
April 2017

Genome-wide association study of body mass index in subjects with alcohol dependence.

Addict Biol 2017 Mar 12;22(2):535-549. Epub 2015 Oct 12.

Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, CT, USA.

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http://dx.doi.org/10.1111/adb.12317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102811PMC
March 2017

Schizophrenia and substance use comorbidity: a genome-wide perspective.

Genome Med 2017 03 21;9(1):25. Epub 2017 Mar 21.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT, USA.

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http://dx.doi.org/10.1186/s13073-017-0423-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359801PMC
March 2017

Multivariate Imaging Genetics Study of MRI Gray Matter Volume and SNPs Reveals Biological Pathways Correlated with Brain Structural Differences in Attention Deficit Hyperactivity Disorder.

Front Psychiatry 2016 25;7:128. Epub 2016 Jul 25.

Olin Neuropsychiatry Research Center, Institute of Living, Hartford HealthCare, Hartford, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.3389/fpsyt.2016.00128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959119PMC
August 2016

The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.

Neuropsychopharmacology 2017 02 17;42(3):598-605. Epub 2016 Aug 17.

Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, CT, USA.

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http://dx.doi.org/10.1038/npp.2016.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240175PMC
February 2017

Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes.

Sci Rep 2017 02 6;7:41816. Epub 2017 Feb 6.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/srep41816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292964PMC
February 2017

Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder.

PLoS Genet 2017 02 10;13(2):e1006618. Epub 2017 Feb 10.

Department of Psychiatry, Yale School of Medicine, West Haven, Connecticut, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1006618
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http://dx.doi.org/10.1371/journal.pgen.1006618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328401PMC
February 2017

The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect.

Behav Brain Res 2016 12 6;315:71-4. Epub 2016 Aug 6.

Center for Child and Family Traumatic Stress, Kennedy Krieger Institute, United States; Department of Psychiatry, Johns Hopkins School of Medicine, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2016.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396458PMC
December 2016

Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women.

Neuropsychopharmacology 2016 10 17;41(11):2688-96. Epub 2016 May 17.

Department of Psychiatry, Yale School of Medicine, West Haven, CT, USA.

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http://dx.doi.org/10.1038/npp.2016.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026736PMC
October 2016

Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics.

J Stud Alcohol Drugs 2016 09;77(5):676-80

Department of Psychiatry, Genetics, and Neuroscience, Yale University School of Medicine, New Haven, Connecticut.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015465PMC
http://dx.doi.org/10.15288/jsad.2016.77.676DOI Listing
September 2016

CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation.

Nicotine Tob Res 2016 09 31;18(9):1845-52. Epub 2016 Mar 31.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT; Department of Radiology, Yale University School of Medicine, New Haven, CT;

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http://dx.doi.org/10.1093/ntr/ntw081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978979PMC
September 2016

Multivariate Imaging Genetics Study of MRI Gray Matter Volume and SNPs Reveals Biological Pathways Correlated with Brain Structural Differences in Attention Deficit Hyperactivity Disorder.

Front Psychiatry 2016 25;7:128. Epub 2016 Jul 25.

Olin Neuropsychiatry Research Center, Institute of Living, Hartford HealthCare, Hartford, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.3389/fpsyt.2016.00128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959119PMC
August 2016

FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study.

Psychoneuroendocrinology 2016 07 5;69:98-105. Epub 2016 Apr 5.

U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.psyneuen.2016.04.001DOI Listing
July 2016

Dissecting ancestry genomic background in substance dependence genome-wide association studies.

Pharmacogenomics 2015 12;16(13):1487-98. Epub 2015 Aug 12.

Department of Psychiatry, Yale University School of Medicine, VA CT 116A2, 950 Campbell Avenue, West Haven, CT 06516, USA.

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http://dx.doi.org/10.2217/pgs.15.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632979PMC
June 2016

Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons.

PLoS One 2015 12;10(8):e0134907. Epub 2015 Aug 12.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States of America; VA Medical Center, VA Connecticut Healthcare System, West Haven, CT, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534442PMC
May 2016

Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.

JAMA Psychiatry 2016 May;73(5):472-80

VA Cooperative Studies Program Coordinating Center, West Haven, Connecticut8Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut13Department of Psychiatry, VA Connecticut Healthcare Center, Yale University School of Medicine, West Hav.

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http://dx.doi.org/10.1001/jamapsychiatry.2016.0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974817PMC
May 2016

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.

Authors:
Tae-Hwi Schwantes-An Juan Zhang Li-Shiun Chen Sarah M Hartz Robert C Culverhouse Xiangning Chen Hilary Coon Josef Frank Helen M Kamens Bettina Konte Leena Kovanen Antti Latvala Lisa N Legrand Brion S Maher Whitney E Melroy Elliot C Nelson Mark W Reid Jason D Robinson Pei-Hong Shen Bao-Zhu Yang Judy A Andrews Paul Aveyard Olga Beltcheva Sandra A Brown Dale S Cannon Sven Cichon Robin P Corley Norbert Dahmen Louisa Degenhardt Tatiana Foroud Wolfgang Gaebel Ina Giegling Stephen J Glatt Richard A Grucza Jill Hardin Annette M Hartmann Andrew C Heath Stefan Herms Colin A Hodgkinson Per Hoffmann Hyman Hops David Huizinga Marcus Ising Eric O Johnson Elaine Johnstone Radka P Kaneva Kenneth S Kendler Falk Kiefer Henry R Kranzler Ken S Krauter Orna Levran Susanne Lucae Michael T Lynskey Wolfgang Maier Karl Mann Nicholas G Martin Manuel Mattheisen Grant W Montgomery Bertram Müller-Myhsok Michael F Murphy Michael C Neale Momchil A Nikolov Denise Nishita Markus M Nöthen John Nurnberger Timo Partonen Michele L Pergadia Maureen Reynolds Monika Ridinger Richard J Rose Noora Rouvinen-Lagerström Norbert Scherbaum Christine Schmäl Michael Soyka Michael C Stallings Michael Steffens Jens Treutlein Ming Tsuang Tamara L Wall Norbert Wodarz Vadim Yuferov Peter Zill Andrew W Bergen Jingchun Chen Paul M Cinciripini Howard J Edenberg Marissa A Ehringer Robert E Ferrell Joel Gelernter David Goldman John K Hewitt Christian J Hopfer William G Iacono Jaakko Kaprio Mary Jeanne Kreek Ivo M Kremensky Pamela A F Madden Matt McGue Marcus R Munafò Robert A Philibert Marcella Rietschel Alec Roy Dan Rujescu Sirkku T Saarikoski Gary E Swan Alexandre A Todorov Michael M Vanyukov Robert B Weiss Laura J Bierut Nancy L Saccone

Behav Genet 2016 Mar 21;46(2):151-69. Epub 2015 Sep 21.

Department of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St. Louis, MO, 63110, USA.

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http://link.springer.com/10.1007/s10519-015-9737-3
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http://dx.doi.org/10.1007/s10519-015-9737-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752855PMC
March 2016

RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders.

Am J Med Genet B Neuropsychiatr Genet 2016 Jan 22;171B(1):81-91. Epub 2015 Nov 22.

Center for Child and Family Traumatic Stress, Kennedy Krieger Institute, Baltimore, Maryland.

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http://dx.doi.org/10.1002/ajmg.b.32395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754782PMC
January 2016

DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders.

Sci Rep 2016 Jan 14;6:19430. Epub 2016 Jan 14.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/srep19430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725922PMC
January 2016

Further analyses support the association between light eye color and alcohol dependence.

Am J Med Genet B Neuropsychiatr Genet 2015 Dec 20;168(8):757-60. Epub 2015 Aug 20.

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont.

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http://dx.doi.org/10.1002/ajmg.b.32357DOI Listing
December 2015

The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores.

Am J Med Genet B Neuropsychiatr Genet 2015 Dec 14;168(8):739-48. Epub 2015 Sep 14.

Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.b.32379DOI Listing
December 2015

Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS.

Hum Genet 2015 Nov 4;134(11-12):1195-209. Epub 2015 Sep 4.

Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.

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http://link.springer.com/10.1007/s00439-015-1596-8
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http://dx.doi.org/10.1007/s00439-015-1596-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630076PMC
November 2015

The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children.

J Am Acad Child Adolesc Psychiatry 2015 Aug 10;54(8):617-25. Epub 2015 Jun 10.

State University of New York Downstate Medical Center, New York City.

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http://dx.doi.org/10.1016/j.jaac.2015.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515569PMC
August 2015