Publications by authors named "Joel Gelernter"

98Publications

Polygenic risk for autism spectrum disorder associates with anger recognition in a neurodevelopment-focused phenome-wide scan of unaffected youths from a population-based cohort.

PLoS Genet 2020 Sep 17;16(9):e1009036. Epub 2020 Sep 17.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1009036DOI Listing
September 2020

Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children.

Psychiatry Res Neuroimaging 2020 04 22;298:111058. Epub 2020 Feb 22.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States; Center for Child and Family Traumatic Stress, Kennedy Krieger Institute, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pscychresns.2020.111058DOI Listing
April 2020

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.

Authors:
Melissa A Munn-Chernoff Emma C Johnson Yi-Ling Chou Jonathan R I Coleman Laura M Thornton Raymond K Walters Zeynep Yilmaz Jessica H Baker Christopher Hübel Scott Gordon Sarah E Medland Hunna J Watson Héléna A Gaspar Julien Bryois Anke Hinney Virpi M Leppä Manuel Mattheisen Stephan Ripke Shuyang Yao Paola Giusti-Rodríguez Ken B Hanscombe Roger A H Adan Lars Alfredsson Tetsuya Ando Ole A Andreassen Wade H Berrettini Ilka Boehm Claudette Boni Vesna Boraska Perica Katharina Buehren Roland Burghardt Matteo Cassina Sven Cichon Maurizio Clementi Roger D Cone Philippe Courtet Scott Crow James J Crowley Unna N Danner Oliver S P Davis Martina de Zwaan George Dedoussis Daniela Degortes Janiece E DeSocio Danielle M Dick Dimitris Dikeos Christian Dina Monika Dmitrzak-Weglarz Elisa Docampo Laramie E Duncan Karin Egberts Stefan Ehrlich Geòrgia Escaramís Tõnu Esko Xavier Estivill Anne Farmer Angela Favaro Fernando Fernández-Aranda Manfred M Fichter Krista Fischer Manuel Föcker Lenka Foretova Andreas J Forstner Monica Forzan Christopher S Franklin Steven Gallinger Ina Giegling Johanna Giuranna Fragiskos Gonidakis Philip Gorwood Monica Gratacos Mayora Sébastien Guillaume Yiran Guo Hakon Hakonarson Konstantinos Hatzikotoulas Joanna Hauser Johannes Hebebrand Sietske G Helder Stefan Herms Beate Herpertz-Dahlmann Wolfgang Herzog Laura M Huckins James I Hudson Hartmut Imgart Hidetoshi Inoko Vladimir Janout Susana Jiménez-Murcia Antonio Julià Gursharan Kalsi Deborah Kaminská Leila Karhunen Andreas Karwautz Martien J H Kas James L Kennedy Anna Keski-Rahkonen Kirsty Kiezebrink Youl-Ri Kim Kelly L Klump Gun Peggy S Knudsen Maria C La Via Stephanie Le Hellard Robert D Levitan Dong Li Lisa Lilenfeld Bochao Danae Lin Jolanta Lissowska Jurjen Luykx Pierre J Magistretti Mario Maj Katrin Mannik Sara Marsal Christian R Marshall Morten Mattingsdal Sara McDevitt Peter McGuffin Andres Metspalu Ingrid Meulenbelt Nadia Micali Karen Mitchell Alessio Maria Monteleone Palmiero Monteleone Benedetta Nacmias Marie Navratilova Ioanna Ntalla Julie K O'Toole Roel A Ophoff Leonid Padyukov Aarno Palotie Jacques Pantel Hana Papezova Dalila Pinto Raquel Rabionet Anu Raevuori Nicolas Ramoz Ted Reichborn-Kjennerud Valdo Ricca Samuli Ripatti Franziska Ritschel Marion Roberts Alessandro Rotondo Dan Rujescu Filip Rybakowski Paolo Santonastaso André Scherag Stephen W Scherer Ulrike Schmidt Nicholas J Schork Alexandra Schosser Jochen Seitz Lenka Slachtova P Eline Slagboom Margarita C T Slof-Op't Landt Agnieszka Slopien Sandro Sorbi Beata Świątkowska Jin P Szatkiewicz Ioanna Tachmazidou Elena Tenconi Alfonso Tortorella Federica Tozzi Janet Treasure Artemis Tsitsika Marta Tyszkiewicz-Nwafor Konstantinos Tziouvas Annemarie A van Elburg Eric F van Furth Gudrun Wagner Esther Walton Elisabeth Widen Eleftheria Zeggini Stephanie Zerwas Stephan Zipfel Andrew W Bergen Joseph M Boden Harry Brandt Steven Crawford Katherine A Halmi L John Horwood Craig Johnson Allan S Kaplan Walter H Kaye James Mitchell Catherine M Olsen John F Pearson Nancy L Pedersen Michael Strober Thomas Werge David C Whiteman D Blake Woodside Jakob Grove Anjali K Henders Janne T Larsen Richard Parker Liselotte V Petersen Jennifer Jordan Martin A Kennedy Andreas Birgegård Paul Lichtenstein Claes Norring Mikael Landén Preben Bo Mortensen Renato Polimanti Jeanette N McClintick Amy E Adkins Fazil Aliev Silviu-Alin Bacanu Anthony Batzler Sarah Bertelsen Joanna M Biernacka Tim B Bigdeli Li-Shiun Chen Toni-Kim Clarke Franziska Degenhardt Anna R Docherty Alexis C Edwards Jerome C Foo Louis Fox Josef Frank Laura M Hack Annette M Hartmann Sarah M Hartz Stefanie Heilmann-Heimbach Colin Hodgkinson Per Hoffmann Jouke-Jan Hottenga Bettina Konte Jari Lahti Marius Lahti-Pulkkinen Dongbing Lai Lannie Ligthart Anu Loukola Brion S Maher Hamdi Mbarek Andrew M McIntosh Matthew B McQueen Jacquelyn L Meyers Yuri Milaneschi Teemu Palviainen Roseann E Peterson Euijung Ryu Nancy L Saccone Jessica E Salvatore Sandra Sanchez-Roige Melanie Schwandt Richard Sherva Fabian Streit Jana Strohmaier Nathaniel Thomas Jen-Chyong Wang Bradley T Webb Robbee Wedow Leah Wetherill Amanda G Wills Hang Zhou Jason D Boardman Danfeng Chen Doo-Sup Choi William E Copeland Robert C Culverhouse Norbert Dahmen Louisa Degenhardt Benjamin W Domingue Mark A Frye Wolfgang Gäebel Caroline Hayward Marcus Ising Margaret Keyes Falk Kiefer Gabriele Koller John Kramer Samuel Kuperman Susanne Lucae Michael T Lynskey Wolfgang Maier Karl Mann Satu Männistö Bertram Müller-Myhsok Alison D Murray John I Nurnberger Ulrich Preuss Katri Räikkönen Maureen D Reynolds Monika Ridinger Norbert Scherbaum Marc A Schuckit Michael Soyka Jens Treutlein Stephanie H Witt Norbert Wodarz Peter Zill Daniel E Adkins Dorret I Boomsma Laura J Bierut Sandra A Brown Kathleen K Bucholz E Jane Costello Harriet de Wit Nancy Diazgranados Johan G Eriksson Lindsay A Farrer Tatiana M Foroud Nathan A Gillespie Alison M Goate David Goldman Richard A Grucza Dana B Hancock Kathleen Mullan Harris Victor Hesselbrock John K Hewitt Christian J Hopfer William G Iacono Eric O Johnson Victor M Karpyak Kenneth S Kendler Henry R Kranzler Kenneth Krauter Penelope A Lind Matt McGue James MacKillop Pamela A F Madden Hermine H Maes Patrik K E Magnusson Elliot C Nelson Markus M Nöthen Abraham A Palmer Brenda W J H Penninx Bernice Porjesz John P Rice Marcella Rietschel Brien P Riley Richard J Rose Pei-Hong Shen Judy Silberg Michael C Stallings Ralph E Tarter Michael M Vanyukov Scott Vrieze Tamara L Wall John B Whitfield Hongyu Zhao Benjamin M Neale Tracey D Wade Andrew C Heath Grant W Montgomery Nicholas G Martin Patrick F Sullivan Jaakko Kaprio Gerome Breen Joel Gelernter Howard J Edenberg Cynthia M Bulik Arpana Agrawal

Addict Biol 2020 Feb 16:e12880. Epub 2020 Feb 16.

Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA.

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http://dx.doi.org/10.1111/adb.12880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429266PMC
February 2020

Genome-Wide Association Study of Opioid Cessation.

J Clin Med 2020 Jan 9;9(1). Epub 2020 Jan 9.

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.3390/jcm9010180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019731PMC
January 2020

Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program.

Am J Psychiatry 2020 03 7;177(3):223-232. Epub 2020 Jan 7.

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., and Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, Conn. (Levey, Gelernter, Polimanti, Zhou, Cheng); VA Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, Conn. (Aslan, Concato, Radhakrishnan); Department of Medicine, Yale University School of Medicine, New Haven, Conn. (Aslan, Concato); Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston (Quaden); College of Medicine, University of Kentucky, Lexington (Radhakrishnan); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Bryois, Sullivan); Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill (Sullivan); Psychiatry Service, VA San Diego Healthcare System, San Diego, and Departments of Psychiatry and of Family Medicine and Public Health, University of California San Diego, La Jolla (Stein).

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http://dx.doi.org/10.1176/appi.ajp.2019.19030256DOI Listing
March 2020

Genome-wide association study of shared liability to anxiety disorders in Army STARRS.

Am J Med Genet B Neuropsychiatr Genet 2020 06 30;183(4):197-207. Epub 2019 Dec 30.

Department of Family Medicine & Public Health, University of California San Diego, La Jolla, California.

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http://dx.doi.org/10.1002/ajmg.b.32776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210051PMC
June 2020

Author Correction: Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women.

Sci Rep 2019 Dec 5;9(1):18774. Epub 2019 Dec 5.

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41598-019-55022-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892860PMC
December 2019

Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans.

Sci Rep 2019 12 2;9(1):18070. Epub 2019 Dec 2.

Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41598-019-53560-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889277PMC
December 2019

Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study.

Mol Neurobiol 2020 Mar 30;57(3):1542-1552. Epub 2019 Nov 30.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, VA CT 116A2, 950 Campbell Avenue, West Haven, CT, 06516, USA.

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http://dx.doi.org/10.1007/s12035-019-01823-2DOI Listing
March 2020

Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci.

Drug Alcohol Depend 2020 01 4;206:107703. Epub 2019 Nov 4.

Department of Psychiatry, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands; QIMR Berghofer, Translational Neurogenomics group, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.drugalcdep.2019.107703DOI Listing
January 2020

Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders.

J Clin Med 2019 Nov 21;8(12). Epub 2019 Nov 21.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.

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http://dx.doi.org/10.3390/jcm8122040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947231PMC
November 2019

A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans.

Transl Psychiatry 2019 11 18;9(1):309. Epub 2019 Nov 18.

Division of Human Genetics, Department of Psychiatry, VA CT Healthcare Center, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41398-019-0639-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861240PMC
November 2019

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.

Authors:
Caroline M Nievergelt Adam X Maihofer Torsten Klengel Elizabeth G Atkinson Chia-Yen Chen Karmel W Choi Jonathan R I Coleman Shareefa Dalvie Laramie E Duncan Joel Gelernter Daniel F Levey Mark W Logue Renato Polimanti Allison C Provost Andrew Ratanatharathorn Murray B Stein Katy Torres Allison E Aiello Lynn M Almli Ananda B Amstadter Søren B Andersen Ole A Andreassen Paul A Arbisi Allison E Ashley-Koch S Bryn Austin Esmina Avdibegovic Dragan Babić Marie Bækvad-Hansen Dewleen G Baker Jean C Beckham Laura J Bierut Jonathan I Bisson Marco P Boks Elizabeth A Bolger Anders D Børglum Bekh Bradley Megan Brashear Gerome Breen Richard A Bryant Angela C Bustamante Jonas Bybjerg-Grauholm Joseph R Calabrese José M Caldas-de-Almeida Anders M Dale Mark J Daly Nikolaos P Daskalakis Jürgen Deckert Douglas L Delahanty Michelle F Dennis Seth G Disner Katharina Domschke Alma Dzubur-Kulenovic Christopher R Erbes Alexandra Evans Lindsay A Farrer Norah C Feeny Janine D Flory David Forbes Carol E Franz Sandro Galea Melanie E Garrett Bizu Gelaye Elbert Geuze Charles Gillespie Aferdita Goci Uka Scott D Gordon Guia Guffanti Rasha Hammamieh Supriya Harnal Michael A Hauser Andrew C Heath Sian M J Hemmings David Michael Hougaard Miro Jakovljevic Marti Jett Eric Otto Johnson Ian Jones Tanja Jovanovic Xue-Jun Qin Angela G Junglen Karen-Inge Karstoft Milissa L Kaufman Ronald C Kessler Alaptagin Khan Nathan A Kimbrel Anthony P King Nastassja Koen Henry R Kranzler William S Kremen Bruce R Lawford Lauren A M Lebois Catrin E Lewis Sarah D Linnstaedt Adriana Lori Bozo Lugonja Jurjen J Luykx Michael J Lyons Jessica Maples-Keller Charles Marmar Alicia R Martin Nicholas G Martin Douglas Maurer Matig R Mavissakalian Alexander McFarlane Regina E McGlinchey Katie A McLaughlin Samuel A McLean Sarah McLeay Divya Mehta William P Milberg Mark W Miller Rajendra A Morey Charles Phillip Morris Ole Mors Preben B Mortensen Benjamin M Neale Elliot C Nelson Merete Nordentoft Sonya B Norman Meaghan O'Donnell Holly K Orcutt Matthew S Panizzon Edward S Peters Alan L Peterson Matthew Peverill Robert H Pietrzak Melissa A Polusny John P Rice Stephan Ripke Victoria B Risbrough Andrea L Roberts Alex O Rothbaum Barbara O Rothbaum Peter Roy-Byrne Ken Ruggiero Ariane Rung Bart P F Rutten Nancy L Saccone Sixto E Sanchez Dick Schijven Soraya Seedat Antonia V Seligowski Julia S Seng Christina M Sheerin Derrick Silove Alicia K Smith Jordan W Smoller Scott R Sponheim Dan J Stein Jennifer S Stevens Jennifer A Sumner Martin H Teicher Wesley K Thompson Edward Trapido Monica Uddin Robert J Ursano Leigh Luella van den Heuvel Miranda Van Hooff Eric Vermetten Christiaan H Vinkers Joanne Voisey Yunpeng Wang Zhewu Wang Thomas Werge Michelle A Williams Douglas E Williamson Sherry Winternitz Christiane Wolf Erika J Wolf Jonathan D Wolff Rachel Yehuda Ross McD Young Keith A Young Hongyu Zhao Lori A Zoellner Israel Liberzon Kerry J Ressler Magali Haas Karestan C Koenen

Nat Commun 2019 10 8;10(1):4558. Epub 2019 Oct 8.

Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41467-019-12576-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783435PMC
October 2019

Retrospective Association Analysis of Longitudinal Binary Traits Identifies Important Loci and Pathways in Cocaine Use.

Genetics 2019 12 7;213(4):1225-1236. Epub 2019 Oct 7.

Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut 06520

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http://dx.doi.org/10.1534/genetics.119.302598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893384PMC
December 2019

A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction

J Psychiatry Neurosci 2020 01;45(1):34-44

From the Department of Computer Science and Engineering, University of Connecticut, School of Engineering, Storrs, CT (Sun, Bi); the University of Pennsylvania Perelman School of Medicine, Department of Psychiatry, Center for Studies of Addiction and Corporal Michael Crescenz VAMC, Philadelphia, PA (Kranzler); and the Yale University School of Medicine, Department of Psychiatry, Division of Human Genetics and Departments of Genetics and Neurobiology; and VA CT Healthcare Center, New Haven, CT (Gelernter).

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http://dx.doi.org/10.1503/jpn.180098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919916PMC
January 2020

Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study.

Depress Anxiety 2019 09 6;36(9):834-845. Epub 2019 Aug 6.

U.S. Department of Veterans Affairs National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, Connecticut.

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http://dx.doi.org/10.1002/da.22912DOI Listing
September 2019

Genome-wide scan identifies opioid overdose risk locus close to MCOLN1.

Addict Biol 2020 03 30;25(2):e12811. Epub 2019 Jul 30.

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, New Haven, CT, USA.

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http://dx.doi.org/10.1111/adb.12811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485539PMC
March 2020

Inviting in the Exome for Alcohol and Smoking Traits.

Authors:
Joel Gelernter

Biol Psychiatry 2019 06;85(11):889-890

Yale University School of Medicine and the Veterans Affairs Connecticut Healthcare Center, West Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401834PMC
June 2019

Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women.

Sci Rep 2019 03 15;9(1):4660. Epub 2019 Mar 15.

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://www.nature.com/articles/s41598-019-41110-7
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http://dx.doi.org/10.1038/s41598-019-41110-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420601PMC
March 2019

Alcohol-responsive genes identified in human iPSC-derived neural cultures.

Transl Psychiatry 2019 03 12;9(1):96. Epub 2019 Mar 12.

Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, 06030-1410, USA.

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http://dx.doi.org/10.1038/s41398-019-0426-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414668PMC
March 2019

Genetics of Alcoholism.

Curr Psychiatry Rep 2019 03 9;21(4):26. Epub 2019 Mar 9.

Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, CB 8134, Saint Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11920-019-1008-1DOI Listing
March 2019

Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of Val122Ile Mutation Is Modulated by Non-Coding Variants.

J Clin Med 2019 Feb 22;8(2). Epub 2019 Feb 22.

Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.

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http://dx.doi.org/10.3390/jcm8020269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406512PMC
February 2019

GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.

Am J Med Genet B Neuropsychiatr Genet 2019 01 28;180(1):3-11. Epub 2018 Nov 28.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/ajmg.b.32692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918694PMC
January 2019

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Authors:
Raymond K Walters Renato Polimanti Emma C Johnson Jeanette N McClintick Mark J Adams Amy E Adkins Fazil Aliev Silviu-Alin Bacanu Anthony Batzler Sarah Bertelsen Joanna M Biernacka Tim B Bigdeli Li-Shiun Chen Toni-Kim Clarke Yi-Ling Chou Franziska Degenhardt Anna R Docherty Alexis C Edwards Pierre Fontanillas Jerome C Foo Louis Fox Josef Frank Ina Giegling Scott Gordon Laura M Hack Annette M Hartmann Sarah M Hartz Stefanie Heilmann-Heimbach Stefan Herms Colin Hodgkinson Per Hoffmann Jouke Jan Hottenga Martin A Kennedy Mervi Alanne-Kinnunen Bettina Konte Jari Lahti Marius Lahti-Pulkkinen Dongbing Lai Lannie Ligthart Anu Loukola Brion S Maher Hamdi Mbarek Andrew M McIntosh Matthew B McQueen Jacquelyn L Meyers Yuri Milaneschi Teemu Palviainen John F Pearson Roseann E Peterson Samuli Ripatti Euijung Ryu Nancy L Saccone Jessica E Salvatore Sandra Sanchez-Roige Melanie Schwandt Richard Sherva Fabian Streit Jana Strohmaier Nathaniel Thomas Jen-Chyong Wang Bradley T Webb Robbee Wedow Leah Wetherill Amanda G Wills Jason D Boardman Danfeng Chen Doo-Sup Choi William E Copeland Robert C Culverhouse Norbert Dahmen Louisa Degenhardt Benjamin W Domingue Sarah L Elson Mark A Frye Wolfgang Gäbel Caroline Hayward Marcus Ising Margaret Keyes Falk Kiefer John Kramer Samuel Kuperman Susanne Lucae Michael T Lynskey Wolfgang Maier Karl Mann Satu Männistö Bertram Müller-Myhsok Alison D Murray John I Nurnberger Aarno Palotie Ulrich Preuss Katri Räikkönen Maureen D Reynolds Monika Ridinger Norbert Scherbaum Marc A Schuckit Michael Soyka Jens Treutlein Stephanie Witt Norbert Wodarz Peter Zill Daniel E Adkins Joseph M Boden Dorret I Boomsma Laura J Bierut Sandra A Brown Kathleen K Bucholz Sven Cichon E Jane Costello Harriet de Wit Nancy Diazgranados Danielle M Dick Johan G Eriksson Lindsay A Farrer Tatiana M Foroud Nathan A Gillespie Alison M Goate David Goldman Richard A Grucza Dana B Hancock Kathleen Mullan Harris Andrew C Heath Victor Hesselbrock John K Hewitt Christian J Hopfer John Horwood William Iacono Eric O Johnson Jaakko A Kaprio Victor M Karpyak Kenneth S Kendler Henry R Kranzler Kenneth Krauter Paul Lichtenstein Penelope A Lind Matt McGue James MacKillop Pamela A F Madden Hermine H Maes Patrik Magnusson Nicholas G Martin Sarah E Medland Grant W Montgomery Elliot C Nelson Markus M Nöthen Abraham A Palmer Nancy L Pedersen Brenda W J H Penninx Bernice Porjesz John P Rice Marcella Rietschel Brien P Riley Richard Rose Dan Rujescu Pei-Hong Shen Judy Silberg Michael C Stallings Ralph E Tarter Michael M Vanyukov Scott Vrieze Tamara L Wall John B Whitfield Hongyu Zhao Benjamin M Neale Joel Gelernter Howard J Edenberg Arpana Agrawal

Nat Neurosci 2018 12 26;21(12):1656-1669. Epub 2018 Nov 26.

Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41593-018-0275-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430207PMC
December 2018

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.

Nat Genet 2019 01 26;51(1):63-75. Epub 2018 Nov 26.

Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41588-018-0269-7
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http://dx.doi.org/10.1038/s41588-018-0269-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481311PMC
January 2019

Inferring phenotypes from substance use via collaborative matrix completion.

BMC Syst Biol 2018 11 22;12(Suppl 6):104. Epub 2018 Nov 22.

Department of Computer Science and Engineering, University of Connecticut, 371 Fairfield Way, Unit 4155, Storrs, CT, USA.

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http://dx.doi.org/10.1186/s12918-018-0623-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249733PMC
November 2018

Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.

Alcohol Clin Exp Res 2018 12 25;42(12):2337-2348. Epub 2018 Oct 25.

Department of Psychiatry , Division of Human Genetics, VA CT Healthcare Center, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1111/acer.13890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317871PMC
December 2018

Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid Disorders.

J Clin Med 2018 Sep 21;7(10). Epub 2018 Sep 21.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.

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http://dx.doi.org/10.3390/jcm7100296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210201PMC
September 2018

Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test.

Am J Med Genet B Neuropsychiatr Genet 2018 07;177(5):511-519

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/ajmg.b.32642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110090PMC
July 2018

Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers.

Pharmacol Biochem Behav 2018 10 11;173:36-43. Epub 2018 Aug 11.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States of America; VA Connecticut Healthcare System, West Haven, CT, United States of America.

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http://dx.doi.org/10.1016/j.pbb.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125200PMC
October 2018

Genome-wide association meta-analysis of age at first cannabis use.

Addiction 2018 11 19;113(11):2073-2086. Epub 2018 Aug 19.

Department of Psychiatry, Academic Medical Centre, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1111/add.14368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087375PMC
November 2018

Collaborative Phenotype Inference from Comorbid Substance Use Disorders and Genotypes.

Proceedings (IEEE Int Conf Bioinformatics Biomed) 2017 Nov 18;2017:392-397. Epub 2017 Dec 18.

Department of Computer Science and Engineering, University of Connecticut, Storrs, Connecticut.

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http://dx.doi.org/10.1109/BIBM.2017.8217681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947969PMC
November 2017

Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits.

Genome Med 2018 03 26;10(1):24. Epub 2018 Mar 26.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, 950 Campbell Avenue, West Haven, CT, 06516, USA.

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http://dx.doi.org/10.1186/s13073-018-0532-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870256PMC
March 2018

Genome-wide analysis of insomnia disorder.

Mol Psychiatry 2018 11 8;23(11):2238-2250. Epub 2018 Mar 8.

Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41380-018-0033-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129221PMC
November 2018

Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.

Biol Psychiatry 2018 11 11;84(10):762-770. Epub 2018 Jan 11.

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Massachusetts; Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, Massachusetts; VA Connecticut Healthcare Center, West Haven, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041180PMC
November 2018

Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.

Alcohol Clin Exp Res 2018 05 13;42(5):861-868. Epub 2018 Mar 13.

Department of Psychiatry , King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

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http://dx.doi.org/10.1111/acer.13614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916336PMC
May 2018

Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.

Depress Anxiety 2018 02 24;35(2):168-177. Epub 2017 Nov 24.

Clinical Neurosciences Division, U.S. Department of Veterans Affairs National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA.

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http://dx.doi.org/10.1002/da.22698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794529PMC
February 2018

GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers.

Alcohol Clin Exp Res 2017 Dec 13;41(12):2025-2032. Epub 2017 Nov 13.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1111/acer.13516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764175PMC
December 2017

Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease.

Neurobiol Aging 2018 01 6;61:207-214. Epub 2017 Oct 6.

Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722236PMC
January 2018

Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.

J Clin Psychiatry 2017 Sep/Oct;78(8):e1058-e1059

US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, Connecticut, USA.

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http://www.psychiatrist.com/JCP/article/Pages/2017/v78n08/17
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http://dx.doi.org/10.4088/JCP.17l11646DOI Listing
April 2019

Genetically determined schizophrenia is not associated with impaired glucose homeostasis.

Schizophr Res 2018 05 29;195:286-289. Epub 2017 Oct 29.

Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1016/j.schres.2017.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924728PMC
May 2018

Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.

JAMA Psychiatry 2017 12;74(12):1234-1241

Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.3275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331050PMC
December 2017

Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.

Am J Med Genet B Neuropsychiatr Genet 2017 Dec 9;174(8):846-853. Epub 2017 Oct 9.

Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut.

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http://dx.doi.org/10.1002/ajmg.b.32604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861711PMC
December 2017

Psychiatric Genomics: An Update and an Agenda.

Am J Psychiatry 2018 Jan 3;175(1):15-27. Epub 2017 Oct 3.

From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm; the Departments of Genetics, Psychiatry, and Nutrition, University of North Carolina, Chapel Hill, N.C.; the Department of Psychiatry, Washington University School of Medicine, St Louis; the Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Oslo and Oslo University Hospital, Oslo; the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark; the Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark; the Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark; the Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London; the National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, London; the Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland; the Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, Bonn, Germany; the Institute of Neuroscience and Medicine, Juelich, Germany; the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis; the Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, N.Y.; the Department of Psychiatry, Yale University, New Haven, Conn.; the Department of Psychiatry and the Genetics Institute, University of Florida, Gainesville; the Department of Psychiatry, University of California-San Diego, La Jolla, Calif., the Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, and the Department of Psychiatry, Massachusetts General Hospital, Boston; the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Mass.; and the MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, U.K.

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http://dx.doi.org/10.1176/appi.ajp.2017.17030283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756100PMC
January 2018

Psychiatric Genomics: An Update and an Agenda.

Am J Psychiatry 2018 Jan 3;175(1):15-27. Epub 2017 Oct 3.

From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm; the Departments of Genetics, Psychiatry, and Nutrition, University of North Carolina, Chapel Hill, N.C.; the Department of Psychiatry, Washington University School of Medicine, St Louis; the Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Oslo and Oslo University Hospital, Oslo; the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark; the Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark; the Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark; the Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London; the National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, London; the Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland; the Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, Bonn, Germany; the Institute of Neuroscience and Medicine, Juelich, Germany; the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis; the Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, N.Y.; the Department of Psychiatry, Yale University, New Haven, Conn.; the Department of Psychiatry and the Genetics Institute, University of Florida, Gainesville; the Department of Psychiatry, University of California-San Diego, La Jolla, Calif., the Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, and the Department of Psychiatry, Massachusetts General Hospital, Boston; the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Mass.; and the MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, U.K.

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http://dx.doi.org/10.1176/appi.ajp.2017.17030283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756100PMC
January 2018

Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.

J Psychiatr Res 2017 11 8;94:139-147. Epub 2017 Jul 8.

U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605420PMC
November 2017

Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era.

Genome Biol 2017 06 19;18(1):120. Epub 2017 Jun 19.

Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Taub Institute for Research on Alzheimer's disease and the Aging Brain, New York, NY, 10032, USA.

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http://dx.doi.org/10.1186/s13059-017-1250-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477265PMC
June 2017

Genetic and psychosocial predictors of alcohol use trajectories among disaster-exposed adolescents.

Am J Addict 2017 Sep 8;26(6):623-631. Epub 2017 Jun 8.

Virginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University, Charleston, South Carolina.

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http://dx.doi.org/10.1111/ajad.12575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627968PMC
September 2017

Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.

Sci Rep 2017 04 21;7(1):1034. Epub 2017 Apr 21.

Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, CT, United States.

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http://dx.doi.org/10.1038/s41598-017-01098-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430682PMC
April 2017

identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours.

J Psychiatry Neurosci 2017 06;42(4):252-261

From the Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, Conn., USA (Polimanti, Pearlson, Gelernter); Olin Research Center, Institute of Living/Hartford Hospital, Hartford, Conn., USA (Meda, Pearlson); the Department of Neuroscience, Yale University School of Medicine, New Haven, Conn., USA (Pearlson, Gelernter); the Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Mass., USA (Sherva, Farrer); the Department of Biostatistics, Yale University School of Public Health, New Haven, Conn., USA (Zhao); the Department of Genetics, Yale University School of Medicine, New Haven, Conn., USA (Zhao, Gelernter); the Departments of Neurology, Ophthalmology, Biostatistics, and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Mass., USA (Farrer); and the Department of Psychiatry, University of Pennsylvania School of Medicine and VISN 4 MIRECC, Crescenz VAMC, Philadelphia, Pa., USA (Kranzler).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487272PMC
http://dx.doi.org/10.1503/jpn.160189DOI Listing
June 2017

ADH1B: From alcoholism, natural selection, and cancer to the human phenome.

Am J Med Genet B Neuropsychiatr Genet 2018 03 27;177(2):113-125. Epub 2017 Mar 27.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, Connecticut.

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http://dx.doi.org/10.1002/ajmg.b.32523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617762PMC
March 2018

Schizophrenia and substance use comorbidity: a genome-wide perspective.

Genome Med 2017 03 21;9(1):25. Epub 2017 Mar 21.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT, USA.

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http://dx.doi.org/10.1186/s13073-017-0423-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359801PMC
March 2017

Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B.

Alcohol Clin Exp Res 2017 May 10;41(5):998-1003. Epub 2017 Apr 10.

Department of Psychiatry, University of Pennsylvania Perelman School of Medicine and VISN 4 MIRECC, Crescenz VAMC, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/acer.13373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501250PMC
May 2017

Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder.

PLoS Genet 2017 02 10;13(2):e1006618. Epub 2017 Feb 10.

Department of Psychiatry, Yale School of Medicine, West Haven, Connecticut, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1006618
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http://dx.doi.org/10.1371/journal.pgen.1006618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328401PMC
February 2017

Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes.

Sci Rep 2017 02 6;7:41816. Epub 2017 Feb 6.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/srep41816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292964PMC
February 2017

Sex-specific linkage scans in opioid dependence.

Am J Med Genet B Neuropsychiatr Genet 2017 Apr 20;174(3):261-268. Epub 2016 Oct 20.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/ajmg.b.32507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695218PMC
April 2017

Review: DNA methylation and alcohol use disorders: Progress and challenges.

Am J Addict 2017 Aug 19;26(5):502-515. Epub 2016 Oct 19.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1111/ajad.12465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003819PMC
August 2017