Joel E Kleinman

Joel E Kleinman

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Joel E Kleinman

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NURR1 and ERR1 modulate the expression of genes of a co-expression network enriched for schizophrenia risk.

J Neurosci 2019 Dec 6. Epub 2019 Dec 6.

Group of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, 70124, Italy

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http://dx.doi.org/10.1523/JNEUROSCI.0786-19.2019DOI Listing
December 2019

Correction: Temporal dynamics of miRNAs in human DLPFC and its association with miRNA dysregulation in schizophrenia.

Transl Psychiatry 2019 Sep 23;9(1):237. Epub 2019 Sep 23.

Section on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41398-019-0572-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757035PMC
September 2019

Temporal dynamics of miRNAs in human DLPFC and its association with miRNA dysregulation in schizophrenia.

Transl Psychiatry 2019 08 20;9(1):196. Epub 2019 Aug 20.

Section on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41398-019-0538-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702224PMC
August 2019

Prefrontal Coexpression of Schizophrenia Risk Genes Is Associated With Treatment Response in Patients.

Biol Psychiatry 2019 Jul 3;86(1):45-55. Epub 2019 Apr 3.

Group of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy; Azienda Ospedaliero-Universitaria Consorziale Policlinico, Bari, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.03.981DOI Listing
July 2019

Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia.

Neuron 2019 07 4;103(2):203-216.e8. Epub 2019 Jun 4.

Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA; Center for Computational Biology, Johns Hopkins University, Baltimore, MD 21205, USA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.05.013DOI Listing
July 2019

DLPFC transcriptome defines two molecular subtypes of schizophrenia.

Transl Psychiatry 2019 05 9;9(1):147. Epub 2019 May 9.

Dartmouth College, Hanover, NH, 03755, USA.

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http://dx.doi.org/10.1038/s41398-019-0472-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509343PMC
May 2019

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease.

Acta Neuropathol 2019 04 2;137(4):557-569. Epub 2019 Feb 2.

Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1007/s00401-019-01966-5DOI Listing
April 2019

Neurons with Complex Karyotypes Are Rare in Aged Human Neocortex.

Cell Rep 2019 01;26(4):825-835.e7

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Center for Brain Immunology and Glia, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Child Health Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.107DOI Listing
January 2019

Implementation and clinical characteristics of a posttraumatic stress disorder brain collection.

J Neurosci Res 2018 01 13;96(1):16-20. Epub 2017 Jun 13.

Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/jnr.24093DOI Listing
January 2018

Early-life decline in neurogenesis markers and age-related changes of TrkB splice variant expression in the human subependymal zone.

Eur J Neurosci 2017 Jul 7;46(2):1768-1778. Epub 2017 Jul 7.

Schizophrenia Research Laboratory, Neuroscience Research Australia, Margarete Ainsworth Building, 139 Barker Street, Randwick, NSW, 2031, Australia.

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http://dx.doi.org/10.1111/ejn.13623DOI Listing
July 2017

qSVA framework for RNA quality correction in differential expression analysis.

Proc Natl Acad Sci U S A 2017 07 20;114(27):7130-7135. Epub 2017 Jun 20.

Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205.

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http://dx.doi.org/10.1073/pnas.1617384114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502589PMC
July 2017

Temporal, Diagnostic, and Tissue-Specific Regulation of NRG3 Isoform Expression in Human Brain Development and Affective Disorders.

Am J Psychiatry 2017 03 24;174(3):256-265. Epub 2016 Oct 24.

From the Department of Psychiatry and the Department of Cell and Developmental Biology, School of Medicine, University of Colorado, Aurora; the Lieber Institute for Brain Development, Johns Hopkins University, Baltimore; and the Department of Psychiatry and Behavioral Sciences, the Department of Neurology, the Department of Neuroscience, and the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore.

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http://dx.doi.org/10.1176/appi.ajp.2016.16060721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892449PMC
March 2017

Assessment of genetic risk for distribution of total interstitial white matter neurons in dorsolateral prefrontal cortex: role in schizophrenia.

Schizophr Res 2016 10 27;176(2-3):141-143. Epub 2016 May 27.

Clinical Brain Disorders Branch, Genes Cognition and Psychosis, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, United States; Lieber Institute for Brain Development, Rangos Building, Johns Hopkins Medical Campus, Baltimore, MD 21205, United States.

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http://dx.doi.org/10.1016/j.schres.2016.04.007DOI Listing
October 2016

Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals.

J Psychiatry Neurosci 2016 10;41(6):386-394

From the Laboratory of Behavioral Neuroimmunology, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Clark, Nicholson, Tonelli); the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Pocivavsek, Notarangelo, McMahon, Schwarcz); the Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD (Langenberg); the Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Kleinman, Hyde); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Kleinman, Hyde); and the Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD (Stiller, Postolache).

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http://jpn.ca/wp-content/uploads/2016/04/reduce-tonelli-at-1
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http://jpn.ca/wp-content/uploads/2016/04/41-3-150226.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082509PMC
http://dx.doi.org/10.1503/jpn.150226DOI Listing
October 2016

Genetic and epigenetic analysis of schizophrenia in blood-a no-brainer?

Genome Med 2016 Sep 21;8(1):96. Epub 2016 Sep 21.

Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1186/s13073-016-0354-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031351PMC
September 2016

Cortical Transcriptional Profiles in APOE4 Carriers with Alzheimer's Disease: Patterns of Protection and Degeneration.

J Alzheimers Dis 2015 ;48(4):969-78

The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institute for Medical Research, Manhasset, NY, USA.

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http://dx.doi.org/10.3233/JAD-150345DOI Listing
August 2016

GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders.

PLoS One 2016 5;11(2):e0148558. Epub 2016 Feb 5.

The Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148558PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744057PMC
August 2016

Dynamic regulation of RNA editing in human brain development and disease.

Nat Neurosci 2016 08 27;19(8):1093-9. Epub 2016 Jun 27.

Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nn.4337DOI Listing
August 2016

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons.

Cell Stem Cell 2016 08 28;19(2):248-257. Epub 2016 Jul 28.

Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore; Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 639798, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510242PMC
August 2016

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Biol Psychiatry 2016 07;80(2):84-86

Department of Psychiatry, University Neuropsychiatric Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.biopsych.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150945PMC
July 2016

Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1.

Neuron 2016 Apr 10;90(1):43-55. Epub 2016 Mar 10.

Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824652PMC
April 2016

Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance.

Br J Psychiatry 2016 Feb 3;208(2):128-37. Epub 2015 Sep 3.

Ming Li, PhD, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China, and Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland, USA; Xiong-jian Luo, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Mikael Landén, MD, PhD, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, and Section of Psychiatry and Neurochemistry, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden; Sarah E. Bergen, PhD, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden, and Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA; Christina M. Hultman, PhD, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Xiao Li, MSc, Wen Zhang, PhD, Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Chen Zhang, PhD, Schizophrenia Program, Shanghai Mental Health Center, and Shanghai Jiao Tong University School of Medicine, Shanghai, China; Jiewei Liu, MSc, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, and Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China; Manuel Mattheisen, MD, Department of Biomedicine, Aarhus University, Aarhus C, Denmark; Sven Cichon, PhD, Division of Medical Genetics, University of Basel, Basel, Switzerland, Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn, and Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organi

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https://genepi.qimr.edu.au/contents/p/staff/Li_BrJnlPsychiat
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http://bjp.rcpsych.org/cgi/doi/10.1192/bjp.bp.114.156976
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http://dx.doi.org/10.1192/bjp.bp.114.156976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829352PMC
February 2016

CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders.

Am J Psychiatry 2015 Nov 24;172(11):1122-30. Epub 2015 Jul 24.

From the Human Brain Collection Core, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Md.; the Department of Neuropsychiatry, Fukushima Medical University School of Medicine, Hikarigaoka, Fukushima City, Fukushima, Japan; the Unit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health, National Institutes of Health, Bethesda, Md.; the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore; the Department of Psychiatry and Behavioral Sciences, John Hopkins University School of Medicine, Baltimore; and the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore.

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http://dx.doi.org/10.1176/appi.ajp.2015.14080978DOI Listing
November 2015

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus.

Cell Rep 2015 Nov 29;13(6):1073-1080. Epub 2015 Oct 29.

Unit on Metabolism and Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD 20892, USA; Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD 20892, USA; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)01107-9.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471501107
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http://dx.doi.org/10.1016/j.celrep.2015.09.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644471PMC
November 2015

Pathologic Implications for Microtubule-Associated Protein 2 in Schizophrenia Primary Auditory Cortex.

Biol Psychiatry 2015 Sep;78(6):359-60

Lieber Institute for Brain Development Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Psychiatry & Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063223150060
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http://dx.doi.org/10.1016/j.biopsych.2015.07.011DOI Listing
September 2015

Alzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of Age.

Cogn Behav Neurol 2015 Sep;28(3):144-52

*Department of Pathology, Division of Neuropathology §Department of Neurology, Johns Hopkins University School of Medicine †Lieber Institute for Brain Development, Baltimore, Maryland ‡Office of the Chief Medical Examiner, Baltimore, Maryland.

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http://dx.doi.org/10.1097/WNN.0000000000000071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588069PMC
September 2015

Investigation of the prenatal expression patterns of 108 schizophrenia-associated genetic loci.

Biol Psychiatry 2015 Jun 22;77(11):e43-51. Epub 2014 Oct 22.

Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland; Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2014.10.008DOI Listing
June 2015

Myelin, myelin-related disorders, and psychosis.

Schizophr Res 2015 Jan 23;161(1):85-93. Epub 2014 Oct 23.

Lieber Institute for Brain Development, Johns Hopkins Medical Institutions, 855 N. Wolfe Street, Suite 300, Baltimore, MD 21205, USA; Department of Psychiatry & Behavioral Sciences, Johns Hopkins Medical School, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins Medical School, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2014.09.040DOI Listing
January 2015

Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.

Cell Stem Cell 2014 Jul;15(1):79-91

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237009PMC
July 2014

Differential effects of common variants in SCN2A on general cognitive ability, brain physiology, and messenger RNA expression in schizophrenia cases and control individuals.

JAMA Psychiatry 2014 Jun;71(6):647-56

Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland2Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, Maryland8Depar.

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http://dx.doi.org/10.1001/jamapsychiatry.2014.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160812PMC
June 2014

Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia.

J Neurosci 2014 Apr;34(14):4929-40

Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, Department of Psychiatry, Hiroshima City Hospital, Hiroshima City, Hiroshima Prefecture, 730-8518, Japan, Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland 21205, Neurodevelopmental and Neuropsychiatric Genetics Laboratory, Departments of Psychiatry and Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, and Departments of Psychiatry, Neurology, Neuroscience and the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.1423-13.2
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http://dx.doi.org/10.1523/JNEUROSCI.1423-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972720PMC
April 2014

Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex.

Biol Psychiatry 2013 Mar 13;73(6):546-54. Epub 2012 Nov 13.

Department of Pharmacology, Program in Pharmacogenomics, College of Medicine, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1016/j.biopsych.2012.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582836PMC
March 2013

Use of postmortem human dura mater and scalp for deriving human fibroblast cultures.

PLoS One 2012 27;7(9):e45282. Epub 2012 Sep 27.

Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045282PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459947PMC
February 2013

Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophrenia.

Schizophr Res 2012 Nov 19;141(2-3):185-8. Epub 2012 Aug 19.

Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1003, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S092099641200415
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http://dx.doi.org/10.1016/j.schres.2012.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463751PMC
November 2012

Analysis of copy number variations in brain DNA from patients with schizophrenia and other psychiatric disorders.

Biol Psychiatry 2012 Oct 15;72(8):651-4. Epub 2012 Jul 15.

Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.biopsych.2012.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3456994PMC
October 2012

Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders.

J Neurosci 2012 Apr;32(15):5216-22

Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1385, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.4626-11.2
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http://dx.doi.org/10.1523/JNEUROSCI.4626-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752043PMC
April 2012

DNA methylation signatures in development and aging of the human prefrontal cortex.

Am J Hum Genet 2012 Feb 2;90(2):260-72. Epub 2012 Feb 2.

Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00029297110055
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http://dx.doi.org/10.1016/j.ajhg.2011.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276664PMC
February 2012

Temporal dynamics and genetic control of transcription in the human prefrontal cortex.

Nature 2011 Oct 26;478(7370):519-23. Epub 2011 Oct 26.

Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature10524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510670PMC
October 2011

Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia.

J Neurosci 2011 Jul;31(30):11088-95

Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1234-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758549PMC
July 2011

Evidence of sex-modulated association of ZNF804A with schizophrenia.

Biol Psychiatry 2011 May 24;69(10):914-7. Epub 2011 Feb 24.

Genes, Cognition and Psychosis Program and Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1016/j.biopsych.2011.01.003DOI Listing
May 2011

Genetic variation in PCLO is associated with prefrontal cortex expression and bipolar disorder.

Authors:
Joel E Kleinman

Biol Psychiatry 2011 Feb;69(4):298

Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1016/j.biopsych.2010.12.008DOI Listing
February 2011

Psychiatric brain banking: three perspectives on current trends and future directions.

Biol Psychiatry 2011 Jan 31;69(2):104-12. Epub 2010 Jul 31.

Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1016/j.biopsych.2010.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105380PMC
January 2011

Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains.

Biol Psychiatry 2011 Jan;69(2):140-5

Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.biopsych.2010.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351748PMC
January 2011

Genetic variation in CACNA1C affects brain circuitries related to mental illness.

Arch Gen Psychiatry 2010 Sep;67(9):939-45

Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1001/archgenpsychiatry.2010.96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282053PMC
September 2010

Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain.

Proc Natl Acad Sci U S A 2010 Aug 16;107(35):15619-24. Epub 2010 Aug 16.

Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1385, USA.

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http://dx.doi.org/10.1073/pnas.1005410107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932571PMC
August 2010

No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression.

Biol Psychiatry 2010 Jul;68(1):105-7

Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1379, USA.

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http://dx.doi.org/10.1016/j.biopsych.2010.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900542PMC
July 2010

The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain.

Hum Mol Genet 2010 Jun 1;19(12):2487-96. Epub 2010 Apr 1.

Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK.

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http://dx.doi.org/10.1093/hmg/ddq130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876891PMC
June 2010

Human locus coeruleus neurons express the GABA(A) receptor gamma2 subunit gene and produce benzodiazepine binding.

Neurosci Lett 2010 Jun 22;477(2):77-81. Epub 2010 Apr 22.

Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, POB 63 (Haartmaninkatu 8), FI-00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.neulet.2010.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282555PMC
June 2010

Genetic variation in FGF20 modulates hippocampal biology.

J Neurosci 2010 Apr;30(17):5992-7

Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institutes of Health-National Institute of Mental Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5773-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909689PMC
April 2010

Epigenetic mechanisms in schizophrenia.

Biochim Biophys Acta 2009 Sep 25;1790(9):869-77. Epub 2009 Jun 25.

Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, 35294, USA.

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http://dx.doi.org/10.1016/j.bbagen.2009.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779706PMC
September 2009

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms.

Proc Natl Acad Sci U S A 2009 Sep 2;106(37):15873-8. Epub 2009 Sep 2.

Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1385, USA.

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http://dx.doi.org/10.1073/pnas.0903413106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736903PMC
September 2009

A comparison of human brain dissection by drill versus saw on nucleic acid quality.

J Neurosci Methods 2009 Apr 9;179(1):68-70. Epub 2009 Jan 9.

National Institutes of Mental Health, Clinical Brain Disorders Branch, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2008.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775563PMC
April 2009

Evaluation of tissue collection for postmortem studies of bipolar disorder.

Bipolar Disord 2008 Nov;10(7):822-8

Division of Intramural Research Programs, Section on Neuropathology, Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA.

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http://doi.wiley.com/10.1111/j.1399-5618.2008.00607.x
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http://dx.doi.org/10.1111/j.1399-5618.2008.00607.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847801PMC
November 2008

Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP.

Neuropsychopharmacology 2008 Oct 6;33(11):2626-34. Epub 2008 Feb 6.

Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/sj.npp.1301669DOI Listing
October 2008

Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex.

Brain Struct Funct 2008 Sep 10;213(1-2):255-71. Epub 2008 May 10.

Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00429-008-0181-5DOI Listing
September 2008

It is time to take a stand for medical research and against terrorism targeting medical scientists.

Biol Psychiatry 2008 Apr;63(8):725-7

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1016/j.biopsych.2008.03.005DOI Listing
April 2008

Postmortem diagnosis and toxicological validation of illicit substance use.

Addict Biol 2008 Mar 14;13(1):105-17. Epub 2008 Jan 14.

Cellular Neurobiology Research Branch, National Institute on Drug Abuse (NIDA IRP), National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1111/j.1369-1600.2007.00085.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639787PMC
March 2008

Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients.

Schizophr Res 2008 Jan 24;98(1-3):105-10. Epub 2007 Oct 24.

MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.schres.2007.05.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246024PMC
January 2008

Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia.

Schizophr Res 2008 Jan 26;98(1-3):129-38. Epub 2007 Oct 26.

Clinical Brain Disorders Branch, Section on Neuropathology, DIRP/NIMH/NIH, Bethesda, MD, 20892-1385, USA.

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http://dx.doi.org/10.1016/j.schres.2007.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259271PMC
January 2008

Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition.

J Clin Invest 2007 Mar 8;117(3):672-82. Epub 2007 Feb 8.

Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health (NIMH), NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1172/JCI30413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784004PMC
March 2007

Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia.

Hum Mol Genet 2007 Jan 12;16(2):129-41. Epub 2006 Dec 12.

Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK.

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http://dx.doi.org/10.1093/hmg/ddl449DOI Listing
January 2007

Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse.

PLoS One 2006 Dec 27;1:e114. Epub 2006 Dec 27.

Cellular Neurobiology Research Branch and Chemistry and Drug Metabolism Section, National Institute on Drug Abuse (NIDA) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000114PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762434PMC
December 2006