Joel D Leverson

Joel D Leverson

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Joel D Leverson

Joel D Leverson

Publications by authors named "Joel D Leverson"

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47Publications

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Neutralization of BCL-2/X Enhances the Cytotoxicity of T-DM1 .

Mol Cancer Ther 2019 06 8;18(6):1115-1126. Epub 2019 Apr 8.

Department of Cell Biology and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758547PMC
June 2019

Functional profiling of venetoclax sensitivity can predict clinical response in multiple myeloma.

Leukemia 2019 05 24;33(5):1291-1296. Epub 2019 Jan 24.

Department of Hematology and Medical Oncology, Emory University School of Medicine and the Winship Cancer Institute of Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1038/s41375-018-0374-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891824PMC
May 2019

Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment?

Front Oncol 2018 22;8:458. Epub 2018 Oct 22.

Oncology Discovery, AbbVie, Inc., North Chicago, IL, United States.

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https://www.frontiersin.org/article/10.3389/fonc.2018.00458/
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http://dx.doi.org/10.3389/fonc.2018.00458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204401PMC
October 2018

Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells.

Cancer Res 2018 06 20;78(11):3075-3086. Epub 2018 Mar 20.

Department of Internal Medicine, Virginia Commonwealth University and the Massey Cancer Center, Virginia.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984704PMC
June 2018

Coamplification of protects -amplified breast cancers from targeted therapy.

Proc Natl Acad Sci U S A 2018 03 23;115(11):E2594-E2603. Epub 2018 Feb 23.

Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298;

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http://dx.doi.org/10.1073/pnas.1717820115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856537PMC
March 2018

Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy.

Cancer Cell 2017 Dec;32(6):748-760.e6

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730338PMC
December 2017

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.

Nat Rev Drug Discov 2017 Apr 17;16(4):273-284. Epub 2017 Feb 17.

AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, USA.

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http://www.nature.com/articles/nrd.2016.253
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http://dx.doi.org/10.1038/nrd.2016.253DOI Listing
April 2017

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells.

Sci Transl Med 2016 09;8(355):355ra117

Section of Molecular Hematology and Therapy, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/scitranslmed.aag1180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111086PMC
September 2016

A New Staple: Peptide-Targeted Covalent Inhibitors.

Authors:
Joel D Leverson

Cell Chem Biol 2016 09;23(9):1043-1044

Oncology Development, AbbVie, Inc., 1 Waukegan Road, North Chicago, IL 60064, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.09.004DOI Listing
September 2016

Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors.

Authors:
Joel D Leverson

Mol Cell Oncol 2016 Jan 26;3(1):e1050155. Epub 2015 May 26.

Oncology Development , AbbVie, Chicago, IL, USA.

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https://www.tandfonline.com/doi/full/10.1080/23723556.2015.1
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http://dx.doi.org/10.1080/23723556.2015.1050155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845185PMC
January 2016

Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia.

Cancer Discov 2014 Mar 17;4(3):362-75. Epub 2013 Dec 17.

Departments of 1Leukemia, 2Pediatrics, and 3Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas; 4Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; 5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 6The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio; 7AbbVie Inc., North Chicago, Illinois; and 8Department of Laboratory Medicine, University of California San Francisco, San Francisco, California; 9Department of Internal Medicine III, University Hospital of Ulm, Ulm; 10MLL Munich Leukemia Laboratory, Munich, Germany.

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http://research4.dfci.harvard.edu/letai/Publications/2013-12
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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-13-0609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975047PMC
March 2014

Aminopyrimidinone cdc7 kinase inhibitors.

Bioorg Med Chem Lett 2012 Mar 25;22(5):1940-3. Epub 2012 Jan 25.

Abbott Laboratories, 100 Abbott Park Rd., R47S AP10/307, Abbott Park, IL 60064-6101, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.01.041DOI Listing
March 2012

Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins.

EMBO J 2007 Sep 30;26(18):4102-12. Epub 2007 Aug 30.

Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7601839
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http://dx.doi.org/10.1038/sj.emboj.7601839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230674PMC
September 2007

New opportunities in chemosensitization and radiosensitization: modulating the DNA-damage response.

Expert Rev Anticancer Ther 2005 Apr;5(2):333-42

Department R47S, Cancer Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.

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http://dx.doi.org/10.1586/14737140.5.2.333DOI Listing
April 2005