Dr. Joe Yeong Poh Sheng, MBBS PhD Mmed (Pathology) - Singapore General Hospital

Introduction

Dr. Joe Yeong poh sheng is a MBBS, PhD holder and currently is a Group Leader in Institute of Molecular Cell Biology (IMCB, A*STAR), having a joint appointment in Singapore General Hospital Anatomical Pathology Department. He has gone through multidisciplinary training which includes clinical (MBBS), Immunology (PhD) and histopathology (British Royal College of Pathologist, Associateship; Mmed (Pathology) from Australia) with more than 10 years of translational research experience.
He is the pioneer and KOL in automation of quantitative multiplex immunohistochemistry (m-IHC) with clinical autostainer to study and quantitate the tumor immune microenvironment on clinical samples. The integrative m-IHC pathology platform that he established in Singapore General Hospital Anatomical Pathology Department provided is the first of its kind in the Asia-Pacific (APAC) region to provide a one-stop solution for scientists, clinicians, immunologists and pathologists to work together, not only to discover biomarker, but also to translate the biomarkers to clinical practice. In the era of cancer immunotherapy, such platform perfectly showcases the importance of the emerging new branch of specialty – immunopathology.
His work on breast cancer, liver cancer and colorectal cancer are included in multiple NMRC funded studies as well as pharma sponsored projects. He is associate member of British Royal College of Pathologist (RCPATH), United States and Canadian Academy of Pathology (USCAP) and Society for Immunotherapy of Cancer (SITC). His key vision is to bridge between immunologists and pathologists to better harness the advances of immunotherapy and further beyond. He is one of the winners of the Best Mentor award of NUS Wong Hock Boon Research Society in 2017, for his dedication to mentor medical student on translational research.
He also served as a committee in the World Immunotherapy Council (WIC), and he is one of the organizers for 2019 WIC Young Investigator Symposium in National Harbor, USA.

Starting from 2018, he set up the automated quantitative m-IHC Immuno-Mapping service platform in IMCB, A*STAR as an official service portal providing solution for academic collaborators, industry partners who keen to understand immunology profile and landscape of cancers and other diseases. Powered by the state-of-the-art autostainer, 9-colored Imaging system and analytic packages, this platform is envisioned and well-prepared to become the APAC hub on Immuno-Mapping domain. The experience, track records, know-how as well as proprietary protocols and solution that the group have built in the past few years safeguard the standard, quality and the robustness of the platform. Other immuno-profiling, such as multi-colored flow cytometry (up-to 24 markers), Mass Cytometry, Multi-analyte profiling and multi-photon imaging that offered in the ecosystem complement the Immuno-Mapping platform and offer multi-modal integration and interpretation of the data which would be essential in the era of immunotherapy.

Primary Affiliation: Singapore General Hospital - Singapore

Specialties:

Cytopathology
Gastroenterology
Hematology & Oncology
Hepatology
Medical Genetics
Oncology
Pathology-Anatomic & Clinical
Thoracic Surgery-Integrated
Urology

Additional Specialties:

Oncoimmunology
Immunpathology
Tissue Imaging
Cancer prognostic and diagnostic

Research Interests:

immunopathology
immunotherapy

View Dr. Joe Yeong Poh Sheng’s Resume / CV

Education

Dec 2019

University of Western Sydney

Mmed (Pathology)

Nov 2016

Royal College of Pathologist

Associateship

Oct 2014

NUS

PhD

Aug 2009

Fudan Univerisity

MBBS

Experience

Oct 2018

Group Leader

Apr 2015

Visiting Scientist

Apr 2014

Senior Research Fellow

Aug 2010

A*STAR Scholar

Aug 2009

Medical Officer

Publications

22Publications

1149Reads

61Profile Views

80PubMed Central Citations

The role of Ki-67 in Asian triple negative breast cancers: a novel combinatory panel approach.

Authors:

An Sen Tan Joe Poe Sheng Yeong Chi Peng Timothy Lai Chong Hui Clara Ong Bernett Lee Jeffrey Chun Tatt Lim Aye Aye Thike Jabed Iqbal Rebecca Alexandra Dent Elaine Hsuen Lim Puay Hoon Tan

Virchows Arch 2019 Dec 12;475(6):709-725. Epub 2019 Aug 12.

Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, Diagnostics Tower, Singapore, 169856, Singapore.

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http://dx.doi.org/10.3389/fimmu.2019.02093	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738266	PMC

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http://dx.doi.org/10.3389/fimmu.2018.01209	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988856	PMC

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http://dx.doi.org/10.1038/s41698-019-0087-0	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531473	PMC

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https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0	Publisher Site
http://dx.doi.org/10.1186/s40425-019-0499-y	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366051	PMC

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http://www.nature.com/articles/s41586-018-0130-2	Publisher Site
http://dx.doi.org/10.1038/s41586-018-0130-2	DOI Listing

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http://dx.doi.org/10.18632/oncotarget.24398	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837769	PMC

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http://dx.doi.org/10.1186/s13073-017-0404-6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319034	PMC

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http://dx.doi.org/10.1136/gutjnl-2015-310814	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5284473	PMC

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http://dx.doi.org/10.1080/2162402X.2015.1085146	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839350	PMC

Dr. Joe Yeong Poh Sheng