Dr. Joe Yeong Poh Sheng, MBBS PhD Mmed (Pathology) - Singapore General Hospital

Dr. Joe Yeong Poh Sheng

MBBS PhD Mmed (Pathology)

Singapore General Hospital

Singapore

Main Specialties: Cytopathology, Gastroenterology, Hematology & Oncology, Hepatology, Medical Genetics, Oncology, Pathology-Anatomic & Clinical, Thoracic Surgery-Integrated, Urology

Additional Specialties: Oncoimmunology, Immunpathology, Tissue Imaging, Cancer prognostic and diagnostic

ORCID logohttps://orcid.org/0000-0002-6674-7153


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Dr. Joe Yeong Poh Sheng, MBBS PhD Mmed (Pathology) - Singapore General Hospital

Dr. Joe Yeong Poh Sheng

MBBS PhD Mmed (Pathology)

Introduction

Dr. Joe Yeong poh sheng is a MBBS, PhD holder and currently is a Group Leader in Institute of Molecular Cell Biology (IMCB, A*STAR), having a joint appointment in Singapore General Hospital Anatomical Pathology Department. He has gone through multidisciplinary training which includes clinical (MBBS), Immunology (PhD) and histopathology (British Royal College of Pathologist, Associateship; Mmed (Pathology) from Australia) with more than 10 years of translational research experience.
He is the pioneer and KOL in automation of quantitative multiplex immunohistochemistry (m-IHC) with clinical autostainer to study and quantitate the tumor immune microenvironment on clinical samples. The integrative m-IHC pathology platform that he established in Singapore General Hospital Anatomical Pathology Department provided is the first of its kind in the Asia-Pacific (APAC) region to provide a one-stop solution for scientists, clinicians, immunologists and pathologists to work together, not only to discover biomarker, but also to translate the biomarkers to clinical practice. In the era of cancer immunotherapy, such platform perfectly showcases the importance of the emerging new branch of specialty – immunopathology.
His work on breast cancer, liver cancer and colorectal cancer are included in multiple NMRC funded studies as well as pharma sponsored projects. He is associate member of British Royal College of Pathologist (RCPATH), United States and Canadian Academy of Pathology (USCAP) and Society for Immunotherapy of Cancer (SITC). His key vision is to bridge between immunologists and pathologists to better harness the advances of immunotherapy and further beyond. He is one of the winners of the Best Mentor award of NUS Wong Hock Boon Research Society in 2017, for his dedication to mentor medical student on translational research.
He also served as a committee in the World Immunotherapy Council (WIC), and he is one of the organizers for 2019 WIC Young Investigator Symposium in National Harbor, USA.

Starting from 2018, he set up the automated quantitative m-IHC Immuno-Mapping service platform in IMCB, A*STAR as an official service portal providing solution for academic collaborators, industry partners who keen to understand immunology profile and landscape of cancers and other diseases. Powered by the state-of-the-art autostainer, 9-colored Imaging system and analytic packages, this platform is envisioned and well-prepared to become the APAC hub on Immuno-Mapping domain. The experience, track records, know-how as well as proprietary protocols and solution that the group have built in the past few years safeguard the standard, quality and the robustness of the platform. Other immuno-profiling, such as multi-colored flow cytometry (up-to 24 markers), Mass Cytometry, Multi-analyte profiling and multi-photon imaging that offered in the ecosystem complement the Immuno-Mapping platform and offer multi-modal integration and interpretation of the data which would be essential in the era of immunotherapy.


Primary Affiliation: Singapore General Hospital - Singapore

Specialties:

Additional Specialties:

Research Interests:


View Dr. Joe Yeong Poh Sheng’s Resume / CV

Education

Dec 2019
University of Western Sydney
Mmed (Pathology)
Nov 2016
Royal College of Pathologist
Associateship
Oct 2014
NUS
PhD
Aug 2009
Fudan Univerisity
MBBS

Experience

Oct 2018
Group Leader
Apr 2015
Visiting Scientist
Apr 2014
Senior Research Fellow
Aug 2010
A*STAR Scholar
Aug 2009
Medical Officer

Publications

22Publications

1149Reads

61Profile Views

80PubMed Central Citations

The role of Ki-67 in Asian triple negative breast cancers: a novel combinatory panel approach.

Virchows Arch 2019 Dec 12;475(6):709-725. Epub 2019 Aug 12.

Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, Diagnostics Tower, Singapore, 169856, Singapore.

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http://dx.doi.org/10.1007/s00428-019-02635-4DOI Listing
December 2019
7 Reads
2.651 Impact Factor

Evaluation of phospho-histone H3 in Asian triple-negative breast cancer using multiplex immunofluorescence.

Breast Cancer Res Treat 2019 Nov 13;178(2):295-305. Epub 2019 Aug 13.

Division of Pathology, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.

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http://dx.doi.org/10.1007/s10549-019-05396-5DOI Listing
November 2019
4 Reads
3.940 Impact Factor

Prognostic role of immune infiltrates in breast ductal carcinoma in situ.

Breast Cancer Res Treat 2019 Aug 27;177(1):17-27. Epub 2019 May 27.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1007/s10549-019-05272-2DOI Listing
August 2019
7 Reads
3.940 Impact Factor

Pan-cancer analysis connects tumor matrisome to immune response.

NPJ Precis Oncol 2019 22;3:15. Epub 2019 May 22.

1NUS Graduate School for Integrative Sciences & Engineering, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41698-019-0087-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531473PMC
May 2019
2 Reads

An integrated automated multispectral imaging technique that simultaneously detects and quantitates viral RNA and immune cell protein markers in fixed sections from Epstein-Barr virus-related tumours.

Ann Diagn Pathol 2018 Dec 11;37:12-19. Epub 2018 Sep 11.

Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Diagnostics Tower, 169856, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.002DOI Listing
December 2018
22 Reads
1.112 Impact Factor

An automated staining protocol for seven-colour immunofluorescence of human tissue sections for diagnostic and prognostic use.

Pathology 2018 Apr 9;50(3):333-341. Epub 2018 Feb 9.

Department of Anatomical Pathology, Singapore General Hospital, Singapore; Duke-NUS Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2017.11.087DOI Listing
April 2018
245 Reads
1 Citation
2.190 Impact Factor

Gleason grade grouping of prostate cancer is of prognostic value in Asian men.

J Clin Pathol 2017 Sep 13;70(9):745-753. Epub 2017 Mar 13.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1136/jclinpath-2016-204276DOI Listing
September 2017
43 Reads
1 Citation
2.920 Impact Factor

Higher densities of Foxp3 regulatory T cells are associated with better prognosis in triple-negative breast cancer.

Breast Cancer Res Treat 2017 May 23;163(1):21-35. Epub 2017 Feb 23.

Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 10, Diagnostics Tower, Singapore, 169856, Singapore.

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http://dx.doi.org/10.1007/s10549-017-4161-4DOI Listing
May 2017
55 Reads
5 Citations
3.940 Impact Factor

Identifying progression predictors of breast ductal carcinoma in situ.

J Clin Pathol 2017 Feb 18;70(2):102-108. Epub 2016 Nov 18.

Division of Pathology, Singapore General Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1136/jclinpath-2016-204154DOI Listing
February 2017
45 Reads
2 Citations
2.920 Impact Factor

Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury.

Arch Toxicol 2017 Jan 6;91(1):271-287. Epub 2016 Apr 6.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.

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http://dx.doi.org/10.1007/s00204-016-1693-zDOI Listing
January 2017
30 Reads
1 Citation
5.980 Impact Factor

Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer.

Breast Cancer Res Treat 2016 Apr 9;156(2):237-47. Epub 2016 Mar 9.

Department of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 10, Singapore, 169856, Singapore.

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http://dx.doi.org/10.1007/s10549-016-3743-xDOI Listing
April 2016
37 Reads
6 Citations
3.940 Impact Factor

PD-1 expression on dendritic cells suppresses CD8 T cell function and antitumor immunity.

Oncoimmunology 2016 Mar 31;5(3):e1085146. Epub 2015 Aug 31.

Genomics, Genetics and Biology Innovation Pole (PoloGGB), Piazza Gambuli, Edificio D, 3° Piano, Perugia, Italy; A. Menarini Biomarkers Singapore Pte Ltd, 30 Pasir Panjang Road, #08-32, Mapletree Business City, Singapore.

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http://dx.doi.org/10.1080/2162402X.2015.1085146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839350PMC
March 2016
61 Reads
18 Citations
6.283 Impact Factor

Activation and regulation of interferon-β in immune responses.

Immunol Res 2012 Sep;53(1-3):25-40

Laboratory of Gene Regulation and Inflammation, Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #04 Immunos, Biopolis, Singapore.

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http://dx.doi.org/10.1007/s12026-012-8293-7DOI Listing
September 2012
18 Reads
17 Citations
3.100 Impact Factor

Top co-authors

Puay Hoon Tan
Puay Hoon Tan

Singapore General Hospital

12
Aye Aye Thike
Aye Aye Thike

Singapore General Hospital

10
Jabed Iqbal
Jabed Iqbal

Singapore General Hospital

9
Huihua Li
Huihua Li

Institute of Basic Medical Sciences

6
Bernett Lee
Bernett Lee

Singapore Immunology Network

6
Chun Jye Lim
Chun Jye Lim

STIIC/Singhealth

4
Valerie Chew
Valerie Chew

Biomedical Sciences Institutes

4
Han Chong Toh
Han Chong Toh

11 Hospital Drive

3