Joe V Chakkalakal

Joe V Chakkalakal

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Joe V Chakkalakal

Joe V Chakkalakal

Publications by authors named "Joe V Chakkalakal"

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The Composition, Development, and Regeneration of Neuromuscular Junctions.

Curr Top Dev Biol 2018 10;126:99-124. Epub 2017 Nov 10.

Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States; Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Rochester, NY, United States; The Rochester Aging Research Center, University of Rochester Medical Center, Rochester, NY, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.ctdb.2017.08.005DOI Listing
February 2019

Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution.

Development 2018 10 25;145(20). Epub 2018 Oct 25.

Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Ave Box 711, Rochester, NY 14642, USA.

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http://dev.biologists.org/lookup/doi/10.1242/dev.167197
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http://dx.doi.org/10.1242/dev.167197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215399PMC
October 2018

Castration induces satellite cell activation that contributes to skeletal muscle maintenance.

JCSM Rapid Commun 2018 ;1(1)

Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959044PMC
January 2018

Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia.

Curr Opin Support Palliat Care 2017 Dec;11(4):278-286

aWilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York bDepartment of Medicine, University of Washington School of Medicine, Seattle, Washington cDepartment of Supportive Care Medicine, City of Hope, Duarte dSchool of Sport and Exercise Science, University of Northern Colorado, Greeley, Colorado eDepartment of Medicine, Brown University, Providence, Rhode Island fDepartment of Medicine, The University of Chicago, Chicago, Ilinois gKaiser Permanente Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.

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http://Insights.ovid.com/crossref?an=01263393-201712000-0000
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http://dx.doi.org/10.1097/SPC.0000000000000301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658778PMC
December 2017

Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration.

Elife 2017 06 6;6. Epub 2017 Jun 6.

Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, United States.

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http://dx.doi.org/10.7554/eLife.26464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462534PMC
June 2017

TGFβ Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice.

Endocrinology 2016 Nov 9;157(11):4461-4472. Epub 2016 Sep 9.

Department of Cancer Genetics (C.P., S.S., J.J.K., K.L.N.) and Center for Personalized Medicine (J.J.K.), Roswell Park Cancer Institute; Buffalo, New York 14263; and James P. Wilmot Cancer Center and Department of Medicine (D.M.S.), Department of Orthopedics and Center for Musculoskeletal Research (J.V.C.), and Department of Pathology and Laboratory Medicine (K.L.N.), University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642.

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http://dx.doi.org/10.1210/en.2016-1580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414572PMC
November 2016

Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration.

Elife 2016 11 18;5. Epub 2016 Nov 18.

Center for Musculoskeletal Research, Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, United States.

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http://dx.doi.org/10.7554/eLife.19484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138033PMC
November 2016

Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury.

Radiat Res 2016 07 22;186(1):1-16. Epub 2016 Jun 22.

c   Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York.

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http://dx.doi.org/10.1667/RR14473.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991354PMC
July 2016

Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions.

Elife 2015 Aug 27;4. Epub 2015 Aug 27.

Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, United States.

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http://dx.doi.org/10.7554/eLife.09221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579298PMC
August 2015

The aged niche disrupts muscle stem cell quiescence.

Nature 2012 Oct 26;490(7420):355-60. Epub 2012 Sep 26.

Center of Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature11438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605795PMC
October 2012

Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons.

Development 2010 Oct 15;137(20):3489-99. Epub 2010 Sep 15.

Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1242/dev.053348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947760PMC
October 2010

Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice.

Hum Mol Genet 2009 Dec 10;18(23):4640-9. Epub 2009 Sep 10.

Department of Cellular & Molecular Medicine and Center for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5.

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http://dx.doi.org/10.1093/hmg/ddp431DOI Listing
December 2009

Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling.

Nucleic Acids Res 2008 Feb 15;36(3):826-38. Epub 2007 Dec 15.

Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkm1107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241908PMC
February 2008

Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression.

Appl Physiol Nutr Metab 2007 Oct;32(5):921-9

Department of Chemistry and Biochemistry,Concordia University, The Richard J. Renaud Science Complex, Montreal, QC H4B 1R6, Canada.

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http://www.nrcresearchpress.com/doi/10.1139/H07-093
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http://dx.doi.org/10.1139/H07-093DOI Listing
October 2007

Targeted inhibition of Ca2+ /calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle.

Hum Mol Genet 2006 May 21;15(9):1423-35. Epub 2006 Mar 21.

Department of Cellular and Molecular Medicine, Centre for Neuromuscular Diseases, Faculty of Medicine, University of Ottawa, Ottawa, Ont., Canada K1H 8M5.

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http://dx.doi.org/10.1093/hmg/ddl065DOI Listing
May 2006

Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction.

Am J Physiol Cell Physiol 2005 Oct 1;289(4):C908-17. Epub 2005 Jun 1.

Department of Cellular and Molecular Medicine, and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5.

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http://dx.doi.org/10.1152/ajpcell.00196.2005DOI Listing
October 2005

The utrophin A 5'-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers.

J Biol Chem 2005 Sep 1;280(38):32997-3005. Epub 2005 Aug 1.

Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

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http://dx.doi.org/10.1074/jbc.M503994200DOI Listing
September 2005

A 1.3 kb promoter fragment confers spatial and temporal expression of utrophin A mRNA in mouse skeletal muscle fibers.

Neuromuscul Disord 2005 Jun;15(6):437-49

Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ont., Canada K1H 8M5.

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http://linkinghub.elsevier.com/retrieve/pii/S096089660500091
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http://dx.doi.org/10.1016/j.nmd.2005.03.008DOI Listing
June 2005

Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies.

FASEB J 2005 Jun;19(8):880-91

Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1096/fj.04-1956revDOI Listing
June 2005

Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway.

FASEB J 2004 Dec 29;18(15):1937-9. Epub 2004 Sep 29.

Ottawa Health Research Institute, Molecular Medicine Program, Ottawa Hospital, General Campus, Ottawa, Canada.

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http://dx.doi.org/10.1096/fj.04-1859fjeDOI Listing
December 2004

Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice.

Hum Mol Genet 2004 Feb 17;13(4):379-88. Epub 2003 Dec 17.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1093/hmg/ddh037DOI Listing
February 2004

Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling.

Proc Natl Acad Sci U S A 2003 Jun 13;100(13):7791-6. Epub 2003 Jun 13.

Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5.

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http://dx.doi.org/10.1073/pnas.0932671100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164666PMC
June 2003

Localizing synaptic mRNAs at the neuromuscular junction: it takes more than transcription.

Bioessays 2003 Jan;25(1):25-31

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1002/bies.10205DOI Listing
January 2003

Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy.

J Physiol Paris 2002 Jan-Mar;96(1-2):31-42

Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, and Ottawa Health Research Institute, Ottawa, Ontario, Canada K1H 8M5.

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April 2002