Jochen Schacht

Jochen Schacht

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Jochen Schacht

Publications by authors named "Jochen Schacht"

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Assessing ototoxicity due to chronic lead and cadmium intake with and without noise exposure in the mature mouse.

J Toxicol Environ Health A 2018 21;81(20):1041-1057. Epub 2018 Sep 21.

a Department of Environmental Health Sciences Department , University of Michigan , Ann Arbor , USA.

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http://dx.doi.org/10.1080/15287394.2018.1521320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349363PMC
August 2019

Auditory metabolomics, an approach to identify acute molecular effects of noise trauma.

Sci Rep 2019 Jun 25;9(1):9273. Epub 2019 Jun 25.

Kresge Hearing Research Institute and Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, 48109, Ann Arbor, USA.

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http://dx.doi.org/10.1038/s41598-019-45385-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592947PMC
June 2019

Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity.

Front Cell Neurosci 2017 24;11:315. Epub 2017 Oct 24.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States.

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http://dx.doi.org/10.3389/fncel.2017.00315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660723PMC
October 2017

Vestibular dysfunction in the adult CBA/CaJ mouse after lead and cadmium treatment.

Environ Toxicol 2017 03 3;32(3):869-876. Epub 2016 Jun 3.

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1002/tox.22286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235991PMC
March 2017

Emerging therapeutic interventions against noise-induced hearing loss.

Expert Opin Investig Drugs 2017 Jan 14;26(1):85-96. Epub 2016 Dec 14.

b Kresge Hearing Research Institute , University of Michigan , Ann Arbor , MI , USA.

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http://dx.doi.org/10.1080/13543784.2017.1269171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527323PMC
January 2017

Age-related hearing impairment and the triad of acquired hearing loss.

Front Cell Neurosci 2015 27;9:276. Epub 2015 Jul 27.

Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan Ann Arbor, MI, USA.

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http://dx.doi.org/10.3389/fncel.2015.00276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515558PMC
August 2015

Disparities in auditory physiology and pathology between C57BL/6J and C57BL/6N substrains.

Hear Res 2014 Dec 22;318:18-22. Epub 2014 Oct 22.

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109-5616, USA. Electronic address:

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http://dx.doi.org/10.1016/j.heares.2014.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258454PMC
December 2014

Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo.

Neurosci Lett 2014 Nov 18;583:65-9. Epub 2014 Sep 18.

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109-5616, USA.

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http://dx.doi.org/10.1016/j.neulet.2014.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253637PMC
November 2014

Tumor necrosis factor-alpha-mutant mice exhibit high frequency hearing loss.

J Assoc Res Otolaryngol 2013 Dec 31;14(6):801-11. Epub 2013 Aug 31.

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI, 48109-5616, USA.

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http://dx.doi.org/10.1007/s10162-013-0410-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825018PMC
December 2013

Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea.

PLoS One 2013 23;8(4):e61999. Epub 2013 Apr 23.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061999PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633911PMC
November 2013

The mitochondrion: a perpetrator of acquired hearing loss.

Hear Res 2013 Sep 27;303:12-9. Epub 2013 Jan 27.

Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.heares.2013.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681877PMC
September 2013

Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.

Anat Rec (Hoboken) 2012 Nov 8;295(11):1837-50. Epub 2012 Oct 8.

Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109-5616, USA.

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http://dx.doi.org/10.1002/ar.22578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596108PMC
November 2012

Ototoxicity in dogs and cats.

Vet Clin North Am Small Anim Pract 2012 Nov 10;42(6):1259-71. Epub 2012 Oct 10.

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, MI 48109-5616, USA.

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http://dx.doi.org/10.1016/j.cvsm.2012.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490132PMC
November 2012

Alleles that modulate late life hearing in genetically heterogeneous mice.

Neurobiol Aging 2012 Aug 2;33(8):1842.e15-29. Epub 2012 Feb 2.

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346888PMC
August 2012

Antioxidant-enriched diet does not delay the progression of age-related hearing loss.

Neurobiol Aging 2012 May 7;33(5):1010.e15-6. Epub 2011 Dec 7.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306450PMC
May 2012

Activation of apoptotic pathways in the absence of cell death in an inner-ear immortomouse cell line.

Hear Res 2012 Feb 31;284(1-2):33-41. Epub 2011 Dec 31.

Department of Pathology and Laboratory Medicine, College of Medicine, Medical University of South Carolina, 39 Sabin Street, Charleston, SC 29425, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03785955110030
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http://dx.doi.org/10.1016/j.heares.2011.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289757PMC
February 2012

New developments in aminoglycoside therapy and ototoxicity.

Hear Res 2011 Nov 27;281(1-2):28-37. Epub 2011 May 27.

Kresge Hearing Research Institute, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5616, USA.

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http://dx.doi.org/10.1016/j.heares.2011.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169717PMC
November 2011

Apoptosis in acquired and genetic hearing impairment: the programmed death of the hair cell.

Hear Res 2011 Nov 18;281(1-2):18-27. Epub 2011 Jul 18.

Center of Medical Genetics, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.heares.2011.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341727PMC
November 2011

Introduction: Pathology of the inner ear.

Hear Res 2011 Nov;281(1-2):1-2

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http://dx.doi.org/10.1016/j.heares.2011.10.005DOI Listing
November 2011

Emerging treatments for noise-induced hearing loss.

Expert Opin Emerg Drugs 2011 Jun 20;16(2):235-45. Epub 2011 Jan 20.

Kresge Hearing Research Institute, Medical Sciences Bldg I, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5616, USA.

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http://dx.doi.org/10.1517/14728214.2011.552427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102156PMC
June 2011

Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice.

Aging Cell 2011 Apr 1;10(2):362-3. Epub 2011 Feb 1.

Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2010.00668.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079202PMC
April 2011

PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse.

Hear Res 2010 Jun 15;264(1-2):86-92. Epub 2009 Sep 15.

Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S037859550900217
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http://dx.doi.org/10.1016/j.heares.2009.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868099PMC
June 2010

Activation of cell death pathways in the inner ear of the aging CBA/J mouse.

Hear Res 2009 Aug 5;254(1-2):92-9. Epub 2009 May 5.

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S037859550900102
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http://dx.doi.org/10.1016/j.heares.2009.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749985PMC
August 2009

Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.

J Med Chem 2009 May;52(9):2836-45

The Edith and Joseph Fischer Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 32000, Israel.

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http://dx.doi.org/10.1021/jm801640kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832307PMC
May 2009

Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea.

J Neurochem 2009 Mar 29;108(5):1226-36. Epub 2009 Jan 29.

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.05871.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341988PMC
March 2009

Age-related auditory pathology in the CBA/J mouse.

Hear Res 2008 Sep 7;243(1-2):87-94. Epub 2008 Jun 7.

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109-5616, USA.

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http://dx.doi.org/10.1016/j.heares.2008.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577824PMC
September 2008

Oxidative imbalance in the aging inner ear.

Neurobiol Aging 2007 Oct 22;28(10):1605-12. Epub 2006 Aug 22.

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109-0506, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2006.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453750PMC
October 2007

Creatine and tempol attenuate noise-induced hearing loss.

Brain Res 2007 May 21;1148:83-9. Epub 2007 Feb 21.

Kresge Hearing Research Institute, University of Michigan, 1301 E. Ann Street, Ann Arbor, MI 48109-0506, USA.

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http://dx.doi.org/10.1016/j.brainres.2007.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680083PMC
May 2007

Aspirin attenuates gentamicin ototoxicity: from the laboratory to the clinic.

Hear Res 2007 Apr 17;226(1-2):178-82. Epub 2006 Jul 17.

Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi'an, PR China.

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http://dx.doi.org/10.1016/j.heares.2006.05.008DOI Listing
April 2007

Kanamycin alters cytoplasmic and nuclear phosphoinositide signaling in the organ of Corti in vivo.

J Neurochem 2006 Oct 11;99(1):269-76. Epub 2006 Aug 11.

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04117.xDOI Listing
October 2006

A BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss.

J Neurosci Res 2006 Jun;83(8):1564-72

Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1002/jnr.20832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1525045PMC
June 2006

Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics.

J Neurosci Res 2006 Jun;83(8):1544-51

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1002/jnr.20833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1525046PMC
June 2006

Sketches of otohistory Part 12: The history of otology in traditional Chinese medicine.

Audiol Neurootol 2006 2;11(3):145-50. Epub 2006 Mar 2.

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.

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http://dx.doi.org/10.1159/000091411DOI Listing
May 2006

Aspirin to prevent gentamicin-induced hearing loss.

N Engl J Med 2006 Apr;354(17):1856-7

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http://dx.doi.org/10.1056/NEJMc053428DOI Listing
April 2006

Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss.

Audiol Neurootol 2006 10;11(1):1-6. Epub 2005 Oct 10.

Kresge Hearing Research Institute, University of Michigan, Ann Arbor, 48109, USA.

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https://www.karger.com/Article/FullText/88850
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http://dx.doi.org/10.1159/000088850DOI Listing
March 2006

Sketches of otohistory. Part 10: noise-induced hearing loss.

Audiol Neurootol 2005 Nov-Dec;10(6):305-9. Epub 2005 Aug 11.

Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109-0506, USA.

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http://dx.doi.org/10.1159/000087347DOI Listing
December 2005

Sketches of otohistory. Part 9: presby[a]cusis.

Audiol Neurootol 2005 Sep-Oct;10(5):243-7. Epub 2005 Jun 21.

Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Mich. 48109-0506, USA.

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http://dx.doi.org/10.1159/000086524DOI Listing
September 2005

Sketches of otohistory. Part 7: The nineteenth-century rise of laryngology.

Audiol Neurootol 2005 May-Jun;10(3):130-3. Epub 2005 Feb 17.

Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109-0506, USA.

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http://dx.doi.org/10.1159/000084022DOI Listing
July 2005

Sketches of otohistory. Part 8: The emergence of vestibular science.

Audiol Neurootol 2005 Jul-Aug;10(4):185-90. Epub 2005 Apr 12.

Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109-0506, USA.

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http://dx.doi.org/10.1159/000085076DOI Listing
July 2005

NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity.

J Neurosci Res 2005 Mar;79(5):644-51

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan 48109-0506, USA.

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http://dx.doi.org/10.1002/jnr.20392DOI Listing
March 2005

Elevation of superoxide dismutase increases acoustic trauma from noise exposure.

Free Radic Biol Med 2005 Feb;38(4):492-8

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo-ku, 606-8507 Kyoto, Japan.

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http://dx.doi.org/10.1016/j.freeradbiomed.2004.11.008DOI Listing
February 2005

Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species.

Chem Res Toxicol 2005 Feb;18(2):357-64

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/tx0496946DOI Listing
February 2005

Sketches of otohistory part 4: a cell by any other name: cochlear eponyms.

Audiol Neurootol 2004 Nov-Dec;9(6):317-27. Epub 2004 Oct 1.

Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1159/000081311DOI Listing
January 2005

Antioxidant protection in a new animal model of cisplatin-induced ototoxicity.

Hear Res 2004 Dec;198(1-2):137-43

Kresge Hearing Research Institute, University of Michigan, 1301 E. Ann Street, Ann Arbor, MI 48109-0506, USA.

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http://dx.doi.org/10.1016/j.heares.2004.07.016DOI Listing
December 2004

AIF and EndoG in noise-induced hearing loss.

Neuroreport 2004 Dec;15(18):2719-22

Kresge Hearing Research Institute, University of Michigan, 1301 E. Ann Street, Ann Arbor, MI 48109 0506, USA.

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December 2004

Calcineurin activation contributes to noise-induced hearing loss.

J Neurosci Res 2004 Nov;78(3):383-92

Kresge Hearing Research Institute, University of Michigan, 1301 E. Ann Street, Ann Arbor, MI 48109-0506, USA.

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http://dx.doi.org/10.1002/jnr.20267DOI Listing
November 2004

Delayed production of free radicals following noise exposure.

Brain Res 2004 Sep;1019(1-2):201-9

Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/j.brainres.2004.05.104DOI Listing
September 2004

Antioxidant gene therapy can protect hearing and hair cells from ototoxicity.

Mol Ther 2004 Feb;9(2):173-81

Department of Otolaryngology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8506, Japan.

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http://dx.doi.org/10.1016/j.ymthe.2003.11.020DOI Listing
February 2004

An isocratic separation of underivatized gentamicin components, 1H NMR assignment and protonation pattern.

Carbohydr Res 2003 Nov;338(24):2853-62

Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, 1331 E Ann, Ann Arbor, MI 48109-0506, USA.

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http://dx.doi.org/10.1016/j.carres.2003.08.005DOI Listing
November 2003

8-iso-prostaglandin F(2alpha), a product of noise exposure, reduces inner ear blood flow.

Audiol Neurootol 2003 Jul-Aug;8(4):207-21

Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0506, USA.

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http://dx.doi.org/10.1159/000071061DOI Listing
August 2003

Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo.

Antimicrob Agents Chemother 2003 Jun;47(6):1836-41

Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0506, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155857PMC
http://dx.doi.org/10.1128/aac.47.6.1836-1841.2003DOI Listing
June 2003

Solution chemistry of copper(II)-gentamicin complexes: relevance to metal-related aminoglycoside toxicity.

Inorg Chem 2003 Mar;42(5):1420-9

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor 48109, USA.

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http://dx.doi.org/10.1021/ic025965tDOI Listing
March 2003

Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea.

Brain Res 2003 Mar;966(2):265-73

Kresge Hearing Research Institute, The University of Michigan, 1301 East Ann Street, Ann Arbor, Michigan, MI 48109-0506, USA.

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http://dx.doi.org/10.1016/s0006-8993(02)04205-1DOI Listing
March 2003

Recent advances in understanding aminoglycoside ototoxicity and its prevention.

Audiol Neurootol 2002 May-Jun;7(3):171-4

Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Mich., USA.

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http://dx.doi.org/10.1159/000058305DOI Listing
August 2002

Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action.

Lab Invest 2002 May;82(5):585-96

Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.1038/labinvest.3780453DOI Listing
May 2002