Jochen Kuper

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Jochen Kuper

Publications by authors named "Jochen Kuper"

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39Publications

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Panel Sequencing Shows Recurrent Genetic FAS Alterations in Primary Cutaneous Marginal Zone Lymphoma.

J Invest Dermatol 2018 Feb 23. Epub 2018 Feb 23.

Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany; Department of Dermatology, Venereology and Allergology and Skin Cancer Center, University Hospital Würzburg, Würzburg, Germany.

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February 2018

Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat.

Nat Microbiol 2017 Nov 11;2(11):1523-1532. Epub 2017 Sep 11.

Department of Cell and Developmental Biology, Theodor-Boveri-Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany.

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November 2017

The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.

Nucleic Acids Res 2017 Oct;45(18):10872-10883

Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany.

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October 2017

Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.

ACS Infect Dis 2017 Sep 16;3(9):666-675. Epub 2017 Aug 16.

Department of Chemistry, Stony Brook University , Stony Brook, New York 11794-3400, United States.

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September 2017

Role of XPD in cellular functions: To TFIIH and beyond.

DNA Repair (Amst) 2016 08 16;44:136-142. Epub 2016 May 16.

Rudolf-Virchow-Center for Experimental Biomedicine, University of Wuerzburg, Wuerzburg, Germany. Electronic address:

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August 2016

Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.

Biochemistry 2016 05 17;55(21):2992-3006. Epub 2016 May 17.

Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg , D-97080 Würzburg, Germany.

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May 2016

DNA Helicases in NER, BER, and MMR.

Adv Exp Med Biol 2013 ;767:203-24

Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany,

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April 2016

FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks.

Nucleic Acids Res 2016 Apr 28;44(7):3219-32. Epub 2016 Jan 28.

Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, D-97080 Würzburg, Germany

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April 2016

Crystallizing the 6S and 8S spliceosomal assembly intermediates: a complex project.

Acta Crystallogr D Biol Crystallogr 2015 Oct 26;71(Pt 10):2040-53. Epub 2015 Sep 26.

Department of Biochemistry, Theodor Boveri Institute, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

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October 2015

Impact of age-associated cyclopurine lesions on DNA repair helicases.

PLoS One 2014 19;9(11):e113293. Epub 2014 Nov 19.

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland, United States of America.

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July 2015

Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA).

Proc Natl Acad Sci U S A 2015 Jul 22;112(27):8272-7. Epub 2015 Jun 22.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universität München, 81377 Munich, Germany;

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July 2015

The structure of the TFIIH p34 subunit reveals a von Willebrand factor A like fold.

PLoS One 2014 11;9(7):e102389. Epub 2014 Jul 11.

Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Wuerzburg, Wuerzburg, Germany.

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March 2015

The LisH motif of muskelin is crucial for oligomerization and governs intracellular localization.

Structure 2015 Feb 8;23(2):364-73. Epub 2015 Jan 8.

Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, D-97080 Würzburg, Germany. Electronic address:

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February 2015

In TFIIH, XPD helicase is exclusively devoted to DNA repair.

PLoS Biol 2014 Sep 30;12(9):e1001954. Epub 2014 Sep 30.

Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, Würzburg, Germany; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.

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September 2014

Cryo-electron microscopic structure of SecA protein bound to the 70S ribosome.

J Biol Chem 2014 Mar 17;289(10):7190-9. Epub 2014 Jan 17.

From the Rudolf Virchow Center/DFG Research Center for Experimental Biomedicine, University of Würzburg, Josef Schneider Str. 2, 97078 Würzburg, Germany.

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March 2014

Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.

J Biol Chem 2013 Sep 9;288(39):28217-29. Epub 2013 Aug 9.

From the Laboratory of Molecular Gerontology, NIA, National Institutes of Health, National Institutes of Health Biomedical Research Center, Baltimore, Maryland 21224.

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September 2013

Prokaryotic nucleotide excision repair.

Cold Spring Harb Perspect Biol 2013 Mar 1;5(3):a012591. Epub 2013 Mar 1.

Rudolf-Virchow-Center for Experimental Biomedicine, University of Wuerzburg, 97080 Wuerzburg, Germany.

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March 2013

Structural basis of assembly chaperone- mediated snRNP formation.

Mol Cell 2013 Feb 17;49(4):692-703. Epub 2013 Jan 17.

Department of Biochemistry, Theodor Boveri Institute, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany.

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February 2013

The crystal structure of the protein-disulfide isomerase family member ERp27 provides insights into its substrate binding capabilities.

J Biol Chem 2013 Jan 28;288(3):2029-39. Epub 2012 Nov 28.

Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany.

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January 2013

The role of active-site Phe87 in modulating the organic co-solvent tolerance of cytochrome P450 BM3 monooxygenase.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Sep 29;68(Pt 9):1013-7. Epub 2012 Aug 29.

Rudolf Virchow Centre for Biomedical Research, Josef Schneider Strasse 2, 97070 Würzburg, Germany.

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September 2012

The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.

J Biol Chem 2012 Jun 10;287(26):21699-716. Epub 2012 May 10.

Laboratory of Molecular Gerontology, National Institutes of Health Biomedical Research Center, NIA, Baltimore, Maryland 21224, USA.

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June 2012

Damage recognition in nucleotide excision DNA repair.

Curr Opin Struct Biol 2012 Feb 17;22(1):88-93. Epub 2012 Jan 17.

Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.

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February 2012

Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation.

EMBO J 2012 Jan 11;31(2):494-502. Epub 2011 Nov 11.

Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, Würzburg, Germany.

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January 2012

Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors.

Structure 2012 Jan;20(1):89-100

Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, Josef-Schneider-Strasse 2, University of Würzburg, D-97080 Würzburg, Germany.

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January 2012

Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis.

Proc Natl Acad Sci U S A 2011 Mar 14;108(9):3554-9. Epub 2011 Feb 14.

European Molecular Biology Laboratory, Hamburg Unit, Notkestrasse 85, D-22603 Hamburg, Germany.

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March 2011

Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part.

Biochim Biophys Acta 2011 Feb 24;1810(2):162-9. Epub 2010 Nov 24.

Theodor Boveri Institute, Department of Microbiology, University of Wuerzburg, 97074 Wuerzburg, Germany.

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February 2011

The XPD helicase: XPanDing archaeal XPD structures to get a grip on human DNA repair.

Biol Chem 2010 Jul;391(7):761-5

Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, D-97080 Würzburg, Germany.

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July 2010

Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex.

Sci Signal 2010 Jan 26;3(106):ra6. Epub 2010 Jan 26.

European Molecular Biology Laboratory-Hamburg, Notkestrasse 85, D-22603 Hamburg, Germany.

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January 2010

Crystal structure of YnjE from Escherichia coli, a sulfurtransferase with three rhodanese domains.

Protein Sci 2009 Dec;18(12):2480-91

Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.

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December 2009

Mechanism of Substrate and Inhibitor Binding of Rhodobacter capsulatus Xanthine Dehydrogenase.

J Biol Chem 2009 Mar 24;284(13):8768-76. Epub 2008 Dec 24.

Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany.

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March 2009

Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD.

PLoS Biol 2008 Jun;6(6):e149

Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, Würzburg, Germany.

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June 2008

Understanding a mechanism of organic cosolvent inactivation in heme monooxygenase P450 BM-3.

J Am Chem Soc 2007 May 13;129(18):5786-7. Epub 2007 Apr 13.

EMBL-Hamburg Outstation, DESY, Hamburg, Germany.

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May 2007

Function and structure of the molybdenum cofactor carrier protein from Chlamydomonas reinhardtii.

J Biol Chem 2006 Oct 27;281(40):30186-94. Epub 2006 Jul 27.

Institute of Plant Biology, Technical University Braunschweig, 38106 Braunschweig, Germany.

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October 2006

Two-fold repeated (betaalpha)4 half-barrels may provide a molecular tool for dual substrate specificity.

EMBO Rep 2005 Feb;6(2):134-9

EMBL-Hamburg Outstation, DESY, Notkestrasse 85, 22603 Hamburg, Germany.

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February 2005

Structure of the molybdopterin-bound Cnx1G domain links molybdenum and copper metabolism.

Nature 2004 Aug;430(7001):803-6

Department of Plant Biology, Technical University, Spielmannstrasse 7, D-38106 Braunschweig, Germany.

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August 2004

Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA.

J Biol Chem 2003 Jul 28;278(28):25302-7. Epub 2003 Apr 28.

Departments of Molecular Microbiology and Biological Chemistry, John Innes Centre, Norwich NR4 7UH, United Kingdom.

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July 2003

The active site of the molybdenum cofactor biosynthetic protein domain Cnx1G.

Arch Biochem Biophys 2003 Mar;411(1):36-46

Department of Plant Biology, Technical University of Braunschweig, 38028, Braunschweig, Germany.

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March 2003

In vivo detection of molybdate-binding proteins using a competition assay with ModE in Escherichia coli.

FEMS Microbiol Lett 2003 Jan;218(1):187-93

Department of Plant Biology, Technical University of Braunschweig, 38023, Braunschweig, Germany.

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January 2003