Jochen Hecht

Jochen Hecht

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Jochen Hecht

Publications by authors named "Jochen Hecht"

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Computational Processing and Quality Control of Hi-C, Capture Hi-C and Capture-C Data.

Genes (Basel) 2019 07 18;10(7). Epub 2019 Jul 18.

The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06032, USA.

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http://dx.doi.org/10.3390/genes10070548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678864PMC
July 2019

BKV Clearance Time Correlates With Exhaustion State and T-Cell Receptor Repertoire Shape of BKV-Specific T-Cells in Renal Transplant Patients.

Front Immunol 2019 10;10:767. Epub 2019 Apr 10.

Center for Translational Medicine, Medical Clinic I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468491PMC
April 2019

Diagnostic strategies and genotype-phenotype correlation in a large Indian cohort of osteogenesis imperfecta.

Bone 2018 05 27;110:368-377. Epub 2018 Feb 27.

Department of Medical Genetics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2018.02.029DOI Listing
May 2018

Genome-wide strategies identify downstream target genes of chick connective tissue-associated transcription factors.

Development 2018 03 29;145(7). Epub 2018 Mar 29.

Freie Universität Berlin, Institute of Chemistry and Biochemistry, Thielallee 63, 14195 Berlin, Germany

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http://dx.doi.org/10.1242/dev.161208DOI Listing
March 2018

De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction.

Am J Hum Genet 2017 Nov;101(5):833-843

Institute of Medical and Human Genetics, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany; Max Planck Institute for Molecular Genetics, Development and Disease Group, 14195 Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673623PMC
November 2017

Generating Aptamers Interacting with Polymeric Surfaces for Biofunctionalization.

Macromol Biosci 2016 12 30;16(12):1776-1791. Epub 2016 Sep 30.

Institute of Biomaterial Science and Berlin-Brandenburger Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstraße 55, 14513, Teltow, Germany.

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http://dx.doi.org/10.1002/mabi.201600319DOI Listing
December 2016

Q-nexus: a comprehensive and efficient analysis pipeline designed for ChIP-nexus.

BMC Genomics 2016 11 4;17(1):873. Epub 2016 Nov 4.

Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany.

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http://dx.doi.org/10.1186/s12864-016-3164-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097360PMC
November 2016

A homozygous HOXD13 missense mutation causes a severe form of synpolydactyly with metacarpal to carpal transformation.

Am J Med Genet A 2016 Mar 18;170(3):615-21. Epub 2015 Nov 18.

Institute for Medical Genetics and Human Genetics, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1002/ajmg.a.37464DOI Listing
March 2016

Strategies to improve the performance of rare variant association studies by optimizing the selection of controls.

Bioinformatics 2015 Nov 6;31(22):3577-83. Epub 2015 Aug 6.

Institute of Medical Genetics and Human Genetics, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany and.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btv457DOI Listing
November 2015

Key features and clinical variability of COG6-CDG.

Mol Genet Metab 2015 Nov 29;116(3):163-70. Epub 2015 Jul 29.

Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitaetsmedizin Berlin, Berlin, Germany; Institute of Medical Genetics and Human Genetics, Charité-Universitaetsmedizin Berlin, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967192153003
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http://dx.doi.org/10.1016/j.ymgme.2015.07.003DOI Listing
November 2015

IMSEQ--a fast and error aware approach to immunogenetic sequence analysis.

Bioinformatics 2015 Sep 18;31(18):2963-71. Epub 2015 May 18.

Berlin-Brandenburg Center for Regenerative Therapies, Charité Universitätsmedizin, Berlin, Department of Computer Science, Freie Universität, Berlin, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany, Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel, Marien Hospital Herne, Ruhr University Bochum, Bochum and Institute of Medical Genetics and Human Genetics, Charité Universitätsmedizin Berlin, Berlin, Germany Berlin-Brandenburg Center for Regenerative Therapies, Charité Universitätsmedizin, Berlin, Department of Computer Science, Freie Universität, Berlin, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany, Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel, Marien Hospital Herne, Ruhr University Bochum, Bochum and Institute of Medical Genetics and Human Genetics, Charité Universitätsmedizin Berlin, Berlin, Germany Berlin-Brandenburg Center for Regenerative Therapies, Charité Universitätsmedizin, Berlin, Department of Computer Science, Freie Universität, Berlin, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany, Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel, Marien Hospital Herne, Ruhr University Bochum, Bochum and Institute of Medical Genetics and Human Genetics, Charité Universitätsmedizin Berlin, Berlin, Germany Berlin-Brandenburg Center for Regenerative Therapies, Charité Universitätsmedizin, Berlin, Department of Computer Science, Freie Universität, Berlin, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany, Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel, Marien Hospital Herne, Ruhr University Bochum, Bochum and Institute of Medical Genetics and Human Genetics, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btv309DOI Listing
September 2015

Saturation analysis of ChIP-seq data for reproducible identification of binding peaks.

Genome Res 2015 Sep 10;25(9):1391-400. Epub 2015 Jul 10.

Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany; Berlin Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany; Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany; Institute for Bioinformatics, Department of Mathematics and Computer Science, Freie Universität Berlin, 14195 Berlin, Germany.

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http://genome.cshlp.org/content/suppl/2015/07/14/gr.189894.1
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http://genome.cshlp.org/lookup/doi/10.1101/gr.189894.115
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http://dx.doi.org/10.1101/gr.189894.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561497PMC
September 2015

Somatic neurofibromatosis type 1 (NF1) inactivation events in cutaneous neurofibromas of a single NF1 patient.

Eur J Hum Genet 2015 Jun 8;23(6):870-3. Epub 2014 Oct 8.

1] FG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany [2] Institute for Medical Genetics and Human Genetics, Universitätsmedizin Berlin, Charité Berlin - Campus Virchow, Berlin, Germany.

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http://dx.doi.org/10.1038/ejhg.2014.210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795057PMC
June 2015

Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.

Cell 2015 May 7;161(5):1012-1025. Epub 2015 May 7.

Max Planck Institute for Molecular Genetics, RG Development & Disease, 14195 Berlin, Germany; Institute for Medical and Human Genetics, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin, 13353 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791538PMC
May 2015

First description of a patient with Vici syndrome due to a mutation affecting the penultimate exon of EPG5 and review of the literature.

Am J Med Genet A 2014 Dec 20;164A(12):3170-5. Epub 2014 Oct 20.

Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1002/ajmg.a.36772DOI Listing
December 2014

Homozygous and compound-heterozygous mutations in TGDS cause Catel-Manzke syndrome.

Am J Hum Genet 2014 Dec;95(6):763-70

Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany; Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259972PMC
December 2014

Generation and analysis of draft sequences of 'stolbur' phytoplasma from multiple displacement amplification templates.

J Mol Microbiol Biotechnol 2014 18;24(1):1-11. Epub 2013 Oct 18.

Laboratory of Applied Phytopathology, Institute of Pesticides and Environmental Protection, Belgrade, Serbia.

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http://dx.doi.org/10.1159/000353904DOI Listing
September 2014

Analysis of the intestinal microbiome of a recovered Clostridium difficile patient after fecal transplantation.

Digestion 2013 5;88(4):243-51. Epub 2013 Dec 5.

Institute of Medical Microbiology, University of Zurich, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1159/000355955DOI Listing
September 2014

Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome.

Sci Transl Med 2014 Sep;6(252):252ra123

Institute for Medical Genetics and Human Genetics, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. Max Planck Institute for Molecular Genetics, Ihnestr. 63-73, 14195 Berlin, Germany. Berlin-Brandenburg Center for Regenerative Therapies, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany. Institute for Bioinformatics, Department of Mathematics and Computer Science, Freie Universität Berlin, Takustr. 9, 14195 Berlin, Germany.

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http://dx.doi.org/10.1126/scitranslmed.3009262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512639PMC
September 2014

Estimating exome genotyping accuracy by comparing to data from large scale sequencing projects.

Genome Med 2013 31;5(7):69. Epub 2013 Jul 31.

Institute for Medical Genetics and Human Genetics, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany ; Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195 Berlin, Germany.

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http://dx.doi.org/10.1186/gm473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978951PMC
May 2014

Mutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation.

Am J Hum Genet 2014 Feb 16;94(2):278-87. Epub 2014 Jan 16.

Institute for Medical Genetics and Human Genetics, Charité Universitätsmedizin, 13353 Berlin, Germany; Berlin Brandenburg Center for Regenerative Therapies, Charité Universitätsmedizin, 13353 Berlin, Germany; Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(13)00582-X.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971300582
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http://dx.doi.org/10.1016/j.ajhg.2013.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928656PMC
February 2014

Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish.

Development 2013 Dec 20;140(24):4982-7. Epub 2013 Nov 20.

German Center for Neurodegenerative Diseases (DZNE), Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1242/dev.099085DOI Listing
December 2013

Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion.

J Med Genet 2013 Sep 24;50(9):579-84. Epub 2013 May 24.

Department of Medical Genetics, Poznan University of Medical Sciences, Poznan, Poland.

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http://dx.doi.org/10.1136/jmedgenet-2013-101659DOI Listing
September 2013

The allele distribution in next-generation sequencing data sets is accurately described as the result of a stochastic branching process.

Nucleic Acids Res 2012 Mar 29;40(6):2426-31. Epub 2011 Nov 29.

Institute for Medical and Human Genetics, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1093/nar/gkr1073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315291PMC
March 2012

FGFR3 is a target of the homeobox transcription factor SHOX in limb development.

Hum Mol Genet 2011 Apr 27;20(8):1524-35. Epub 2011 Jan 27.

Department of Human Molecular Genetics, University of Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/hmg/ddr030DOI Listing
April 2011

Analysis of single nucleotide polymorphisms in three chromosomes of European sea bass Dicentrarchus labrax.

Comp Biochem Physiol Part D Genomics Proteomics 2011 Mar 18;6(1):70-5. Epub 2010 Apr 18.

Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1016/j.cbd.2010.04.003DOI Listing
March 2011

Composite transcriptome assembly of RNA-seq data in a sheep model for delayed bone healing.

BMC Genomics 2011 Mar 24;12:158. Epub 2011 Mar 24.

Institute for Medical Genetics, Charité-Universitätsmedizin Berlin, Augustenburgerplatz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1186/1471-2164-12-158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074554PMC
March 2011

A short ultraconserved sequence drives transcription from an alternate FBN1 promoter.

Int J Biochem Cell Biol 2008 2;40(4):638-50. Epub 2007 Oct 2.

Institute for Medical Genetics, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1016/j.biocel.2007.09.004DOI Listing
July 2008

Induction of macrophage chemotaxis by aortic extracts of the mgR Marfan mouse model and a GxxPG-containing fibrillin-1 fragment.

Circulation 2006 Oct 9;114(17):1855-62. Epub 2006 Oct 9.

Institute of Medical Genetics, Charité Universitätsmedizin, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.601674DOI Listing
October 2006