Jochen H Weishaupt

Jochen H Weishaupt

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Jochen H Weishaupt

Publications by authors named "Jochen H Weishaupt"

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Update on amyotrophic lateral sclerosis genetics.

Curr Opin Neurol 2019 Oct;32(5):735-739

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1097/WCO.0000000000000737DOI Listing
October 2019

Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis.

Acta Neuropathol Commun 2019 Jul 12;7(1):114. Epub 2019 Jul 12.

Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/s40478-019-0759-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626434PMC
July 2019

Story of the ALS-FTD continuum retold: rather two distinct entities.

J Neurol Neurosurg Psychiatry 2019 May 26;90(5):586-589. Epub 2018 Sep 26.

Department of Neurology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1136/jnnp-2018-318800DOI Listing
May 2019

Analysis of CACNA1A CAG repeat lengths in patients with familial ALS.

Neurobiol Aging 2019 02 22;74:235.e5-235.e8. Epub 2018 Sep 22.

Department of Neurology, University of Ulm, Ulm, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183034
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.09.019DOI Listing
February 2019

Chromogranin A levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis.

Neurobiol Aging 2018 07 27;67:21-22. Epub 2018 Feb 27.

Department of Neurology, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.02.017DOI Listing
July 2018

Current knowledge and recent insights into the genetic basis of amyotrophic lateral sclerosis.

Med Genet 2018 13;30(2):252-258. Epub 2018 Jul 13.

1Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1007/s11825-018-0185-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132774PMC
July 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

The fecal microbiome of ALS patients.

Neurobiol Aging 2018 01 3;61:132-137. Epub 2017 Oct 3.

Department of Neurology, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.09.023DOI Listing
January 2018

Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis.

Neurology 2018 01 6;90(1):e22-e30. Epub 2017 Dec 6.

From the Nuffield Department of Clinical Neurosciences (E.F., E.G., M.R.T.), University of Oxford, UK; Department of Neurology (P.O., P.S., F.V., J.H.W., P.W., A.C.L., M.O.), Ulm University Hospital, Germany; Department of Pathophysiology and Transplantation (F.V., V.S.), Università degli Studi di Milano; Department of Neurology-Stroke Unit and Laboratory of Neuroscience (F.V., C.M., V.S.), IRCCS Istituto Auxologico Italiano, Milan, Italy; Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine (C.B., J.K.), University Hospital and University of Basel, Switzerland; Department of Neurology (P.V.D.) and Laboratory of Molecular Neurobiomarker Research and Laboratory Medicine (K.P.), University Hospitals Leuven; KU Leuven-University of Leuven (P.V.D.); Department of Neurosciences (P.V.D.), VIB-Center for Brain & Disease Research, Leuven, Belgium; Department of Neurology (J.G., P.M., B.S.), Jena University Hospital, Germany; Department of Metabolic Biochemistry (C.J., F.L.) and Neurological Diseases Department (M.d.M.A., F.S.), Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France; Department of Neurology (S.K., S.P.), Hannover Medical School; Institute for Epidemiology and Medical Biometry (B.M.) Ulm University, Germany; Donders Institute for Brain, Cognition and Behaviour, Department of Neurology (J.R., M.M.V.), and Radboud Alzheimer Center, Department of Laboratory Medicine (M.M.V.), Radboud University Medical Center, Nijmegen, the Netherlands; and Department of Neurodegenerative Disease and Gerontopsychiatry/Neurology (P.W.), Bonn University Hospital, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000004761DOI Listing
January 2018

Instability of C154Y variant of aldo-keto reductase 1C3.

Chem Biol Interact 2017 Oct 23;276:194-202. Epub 2016 Dec 23.

Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00092797163075
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http://dx.doi.org/10.1016/j.cbi.2016.12.018DOI Listing
October 2017

Genetic analysis of VCP and WASH complex genes in a German cohort of sporadic ALS-FTD patients.

Neurobiol Aging 2017 08 3;56:213.e1-213.e5. Epub 2017 May 3.

Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Cologne, Germany; Department of Neurology, Heimer Institute for Muscle Research, University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.04.023DOI Listing
August 2017

Age Increases Monocyte Adhesion on Collagen.

Sci Rep 2017 05 17;7:46532. Epub 2017 May 17.

Institute for Experimental Physics, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1038/srep46532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434452PMC
May 2017

Impaired activation of ALS monocytes by exosomes.

Immunol Cell Biol 2017 02 12;95(2):207-214. Epub 2016 Sep 12.

Department of Neurology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1038/icb.2016.89DOI Listing
February 2017

Association of Mutations in TBK1 With Sporadic and Familial Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

JAMA Neurol 2017 Jan;74(1):110-113

Department of Neurology, Ulm University, Ulm, Germany2Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1001/jamaneurol.2016.3712DOI Listing
January 2017

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Nat Genet 2016 09 25;48(9):1037-42. Epub 2016 Jul 25.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560030PMC
September 2016

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016

Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Trends Mol Med 2016 09 4;22(9):769-783. Epub 2016 Aug 4.

Institute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences, Goethe University, Max-von-Laue-Strasse 15, 60438 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.07.005DOI Listing
September 2016

Aggregated α-Synuclein Increases SOD1 Oligomerization in a Mouse Model of Amyotrophic Lateral Sclerosis.

Am J Pathol 2016 08 18;186(8):2152-2161. Epub 2016 Jun 18.

Department of Neurology, University of Ulm, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.04.008DOI Listing
August 2016

Comment on "Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice".

J Immunol 2016 Jan;196(2):530-1

Department of Neurology, Ulm University, 89081 Ulm, Germany; and

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http://dx.doi.org/10.4049/jimmunol.1502255DOI Listing
January 2016

Commentary: alpha-synuclein interacts with SOD1 and promotes its oligomerization.

J Neurol Neuromedicine 2016 ;1(7):28-30

Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108581PMC
January 2016

α-synuclein interacts with SOD1 and promotes its oligomerization.

Mol Neurodegener 2015 Dec 8;10:66. Epub 2015 Dec 8.

Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.

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http://dx.doi.org/10.1186/s13024-015-0062-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672499PMC
December 2015

De novo FUS mutations are the most frequent genetic cause in early-onset German ALS patients.

Neurobiol Aging 2015 Nov 15;36(11):3117.e1-3117.e6. Epub 2015 Aug 15.

Institute of Human Genetics, University of Ulm, Ulm, Germany; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.08.005DOI Listing
November 2015

Sumoylation of p35 modulates p35/cyclin-dependent kinase (Cdk) 5 complex activity.

Neuromolecular Med 2015 Mar 13;17(1):12-23. Epub 2014 Nov 13.

Department of Neurology, University Medical Center Göttingen, Waldweg 33, 37073, Göttingen, Germany.

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http://dx.doi.org/10.1007/s12017-014-8336-4DOI Listing
March 2015

[Amyotrophic lateral sclerosis].

Med Monatsschr Pharm 2014 Oct;37(10):356-64; quiz 365-6

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October 2014

FXN GAA repeat expansions in amyotrophic lateral sclerosis.

J Clin Neurosci 2014 Aug 27;21(8):1319-22. Epub 2014 Jan 27.

Department of Neurology, Ulm University, Albert-Einstein-Allee 11, Ulm 89081, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2013.10.029DOI Listing
August 2014

Can lesions to the motor cortex induce amyotrophic lateral sclerosis?

J Neurol 2014 Feb 20;261(2):283-90. Epub 2013 Nov 20.

Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00415-013-7185-7DOI Listing
February 2014

Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis.

Acta Neuropathol Commun 2013 Jul 30;1:42. Epub 2013 Jul 30.

Department of Neurology, Ulm University, Albert-Einstein-Allee 11, Ulm 89081, Germany.

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http://dx.doi.org/10.1186/2051-5960-1-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893596PMC
July 2013

Sumoylation in neurodegenerative diseases.

Cell Mol Life Sci 2013 Jun 25;70(12):2123-38. Epub 2012 Sep 25.

Neuroscience, Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4002, Basel, Switzerland.

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http://dx.doi.org/10.1007/s00018-012-1158-3DOI Listing
June 2013

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease.

Brain 2012 Nov 19;135(Pt 11):3355-70. Epub 2012 Oct 19.

Department of Neurology, University Medicine Göttingen, Robert-Koch-Str 40, 37075 Göttingen, Germany.

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http://dx.doi.org/10.1093/brain/aws254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501973PMC
November 2012

Amyotrophic lateral sclerosis.

Curr Opin Neurol 2012 Oct;25(5):530-5

Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany.

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http://dx.doi.org/10.1097/WCO.0b013e328356d328DOI Listing
October 2012

Sumoylation fights "aggregopathies".

Cell Cycle 2012 Feb;11(4):641-2

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http://dx.doi.org/10.4161/cc.11.4.19356DOI Listing
February 2012

Cell-Penetrating Fragments of the Cdk5 Regulatory Subunit Are Protective in Models of Neurodegeneration.

Pharmaceuticals (Basel) 2010 Apr 23;3(4):1232-1240. Epub 2010 Apr 23.

Department 828, Molecular Neurobiology, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark.

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http://dx.doi.org/10.3390/ph3041232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034031PMC
April 2010

Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells.

Mol Cell Neurosci 2009 Dec 25;42(4):427-37. Epub 2009 Sep 25.

Department of Neurology, University Medicine Göttingen, Georg-August-University Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.mcn.2009.09.005DOI Listing
December 2009

Stimulation of Toll-like receptor 9 by chronic intraventricular unmethylated cytosine-guanine DNA infusion causes neuroinflammation and impaired spatial memory.

J Neuropathol Exp Neurol 2009 Oct;68(10):1116-24

Department of Neurology, RWTH University, Pauwelsstrasse 30, Aachen, Germany.

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http://dx.doi.org/10.1097/NEN.0b013e3181b7fde5DOI Listing
October 2009

A highly sensitive automated complex running wheel test to detect latent motor deficits in the mouse MPTP model of Parkinson's disease.

Exp Neurol 2007 May 7;205(1):207-13. Epub 2007 Feb 7.

Department of Clinical Neurophysiology, Georg-August-University, Robert-Koch Strasse 40, 37099 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.expneurol.2007.01.030DOI Listing
May 2007

Hematopoietic cytokines--on the verge of conquering neurology.

Curr Mol Med 2007 Mar;7(2):157-70

Deptartment of Neurology, Georg-August-University Göttingen, Faculty of Medicine, S1-Laboratory, Waldweg 33, 37073 Göttingen, Germany.

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March 2007

Neuronal apoptosis in neurodegenerative diseases: from basic research to clinical application.

Neurodegener Dis 2004 ;1(1):9-19

Department of Neurology, University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1159/000076665DOI Listing
September 2006