Jochen H M Prehn

Jochen H M Prehn

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Jochen H M Prehn

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System-based approaches as prognostic tools for glioblastoma.

BMC Cancer 2019 Nov 12;19(1):1092. Epub 2019 Nov 12.

Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1186/s12885-019-6280-2DOI Listing
November 2019

Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer's disease.

Sci Rep 2019 Oct 28;9(1):15437. Epub 2019 Oct 28.

Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), c/Nicolás Cabrera 1, Universidad Autónoma de Madrid, Cantoblanco, 28049, Madrid, Spain.

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http://dx.doi.org/10.1038/s41598-019-51837-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817868PMC
October 2019

Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model.

Dis Model Mech 2019 08 13;12(8). Epub 2019 Aug 13.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1242/dmm.040238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737946PMC
August 2019

Implementing Reverse Phase Protein Array Profiling as a Sensitive Method for the Early Pre-Clinical Detection of Off-Target Toxicities Associated with Sunitinib Malate.

Proteomics Clin Appl 2019 07 19;13(4):e1800159. Epub 2019 Mar 19.

RCSI Centre for Systems Medicine, Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, D02 HX03, Ireland.

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http://dx.doi.org/10.1002/prca.201800159DOI Listing
July 2019

Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression.

Brain Stimul 2019 Nov - Dec;12(6):1390-1401. Epub 2019 Jun 7.

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt and Center for Personalized Translational Epilepsy Research (CePTER), Goethe University, Frankfurt, Germany; Department of Neurology, Philipps University, Marburg, Germany.

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http://dx.doi.org/10.1016/j.brs.2019.06.009DOI Listing
June 2019

ER stress signaling has an activating transcription factor 6α (ATF6)-dependent "off-switch".

J Biol Chem 2018 11 4;293(47):18270-18284. Epub 2018 Oct 4.

From the Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 6, Ireland

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http://dx.doi.org/10.1074/jbc.RA118.002121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254332PMC
November 2018

Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers.

J Mol Med (Berl) 2018 10 1;96(10):1025-1037. Epub 2018 Aug 1.

RCSI Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1007/s00109-018-1675-0DOI Listing
October 2018

Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1.

Front Cell Dev Biol 2018 11;6:113. Epub 2018 Sep 11.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.3389/fcell.2018.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141706PMC
September 2018

Riluzole does not improve lifespan or motor function in three ALS mouse models.

Amyotroph Lateral Scler Frontotemporal Degener 2018 08 8;19(5-6):438-445. Epub 2017 Dec 8.

a Centre for the Study of Neurological Disorders, Department of Physiology and Medical Physics , Royal College of Surgeons In Ireland, St. Stephen's Green , Dublin , Ireland.

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http://dx.doi.org/10.1080/21678421.2017.1407796DOI Listing
August 2018

Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab.

J Clin Oncol 2018 07 24;36(20):2052-2060. Epub 2018 May 24.

Erik van Dijk, Hedde D. Biesma, Martijn Cordes, Maarten Neerincx, Paul P. Eijk, Henk M.W. Verheul, Nicole C.T. van Grieken, and Bauke Ylstra, Vrije Universiteit Medical Center; Gerrit A. Meijer, Netherlands Cancer Institute; Cornelis J.A. Punt, Academic Medical Center, Amsterdam; Miriam Koopman, University Medical Center Utrecht, Utrecht, the Netherlands; Dominiek Smeets and Diether Lambrechts, KU Leuven, Leuven, Belgium; Sudipto Das, Orna Bacon, Jochen H.M. Prehn, Bryan T. Hennessey, Darran P. O'Connor, and Annette T. Byrne, Royal College of Surgeons in Ireland; Verena Murphy, Cancer Trials Ireland; Anna Barat, Deborah A. McNamara, and Elaine W. Kay, Beaumont Hospital; Bozena Fender and William M. Gallagher, OncoMark Ltd; Rut Klinger and William M. Gallagher, University College Dublin, Dublin, United Kingdom; Johannes Betge, Timo Gaiser, and Matthias P.A. Ebert, University Hospital Mannheim, Mannheim, Germany; and Fotios Loupakis, Veneto Institute of Oncology IOV-IRCCS Padua, Italy.

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http://dx.doi.org/10.1200/JCO.2017.77.1782DOI Listing
July 2018

Pleiotropic activity of systemically delivered angiogenin in the SOD1 mouse model.

Neuropharmacology 2018 05 25;133:503-511. Epub 2018 Feb 25.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.02.022DOI Listing
May 2018

Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation.

J Neuroinflammation 2018 May 2;15(1):130. Epub 2018 May 2.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1186/s12974-018-1143-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930864PMC
May 2018

BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose.

Oncotarget 2018 May 25;9(40):26046-26063. Epub 2018 May 25.

Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://dx.doi.org/10.18632/oncotarget.25433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995245PMC
May 2018

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer.

EBioMedicine 2018 Apr 23;30:29-37. Epub 2018 Mar 23.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://dx.doi.org/10.1016/j.ebiom.2018.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952348PMC
April 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

A constitutively-active IKK-complex at the axon initial segment.

Brain Res 2018 Jan 24;1678:356-366. Epub 2017 Oct 24.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 Saint Stephen's Green, Dublin 2, Ireland; Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 Saint Stephen's Green, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2017.10.020DOI Listing
January 2018

Orexin-A/hypocretin-1 Immunoreactivity in the Lateral Hypothalamus is Reduced in Genetically Obese but not in Diet-induced Obese Mice.

Neuroscience 2018 01 10;369:183-191. Epub 2017 Nov 10.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1016/j.neuroscience.2017.11.009DOI Listing
January 2018

Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells.

Cell Death Dis 2018 01 19;9(2):42. Epub 2018 Jan 19.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, 2, Ireland.

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http://dx.doi.org/10.1038/s41419-017-0039-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833806PMC
January 2018

The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer.

Cell Death Dis 2018 01 26;9(2):125. Epub 2018 Jan 26.

Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://dx.doi.org/10.1038/s41419-017-0140-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833733PMC
January 2018

Control of mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok.

Neurochem Int 2017 Oct 15;109:162-170. Epub 2017 Mar 15.

Department of Physiology & Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2017.03.010DOI Listing
October 2017

Time-lapse imaging of p65 and IκBα translocation kinetics following Ca-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons.

Mol Cell Neurosci 2017 04 24;80:148-158. Epub 2017 Feb 24.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 Saint Stephen's Green, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2017.02.007DOI Listing
April 2017

miRNAmeConverter: an R/bioconductor package for translating mature miRNA names to different miRBase versions.

Bioinformatics 2017 02;33(4):592-593

Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Centre for Systems Medicine, Dublin 2, Ireland.

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http://dx.doi.org/10.1093/bioinformatics/btw660DOI Listing
February 2017

NF-κB regulates neuronal ankyrin-G via a negative feedback loop.

Sci Rep 2017 02 9;7:42006. Epub 2017 Feb 9.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 Saint Stephen's Green, Dublin 2, Ireland.

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http://www.nature.com/articles/srep42006
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http://dx.doi.org/10.1038/srep42006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299403PMC
February 2017

Advances in immunotherapy for the treatment of glioblastoma.

J Neurooncol 2017 01 14;131(1):1-9. Epub 2016 Oct 14.

Department of Physiology and Medical Physics and RCSI Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1007/s11060-016-2299-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258809PMC
January 2017

Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia.

eNeuro 2016 Mar-Apr;3(2). Epub 2016 May 12.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland , 123 St. Stephen's Green , Dublin 2, Ireland.

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http://dx.doi.org/10.1523/ENEURO.0099-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870272PMC
December 2016

MicroRNAs in epilepsy: pathophysiology and clinical utility.

Lancet Neurol 2016 Dec;15(13):1368-1376

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Goethe-University Frankfurt, Frankfurt, Germany; Epilepsy Center Marburg, Department of Neurology, Philipps University Marburg, Marburg, Germany.

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http://dx.doi.org/10.1016/S1474-4422(16)30246-0DOI Listing
December 2016

In the Middle of a Chain Interaction.

Mol Cell 2016 10;64(2):217-218

Department of Physiology and Medical Physics and Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.09.036DOI Listing
October 2016

A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43A315T mutant C57BL6/J mice.

Dis Model Mech 2016 09 4;9(9):1029-37. Epub 2016 Aug 4.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047697PMC
http://dx.doi.org/10.1242/dmm.024786DOI Listing
September 2016

Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer.

J Transl Med 2016 07 1;14(1):196. Epub 2016 Jul 1.

Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1186/s12967-016-0948-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930591PMC
July 2016

Erratum to: Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer.

J Transl Med 2016 07 26;14(1):222. Epub 2016 Jul 26.

Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1186/s12967-016-0984-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962400PMC
July 2016

Caspase 6 has a protective role in SOD1(G93A) transgenic mice.

Biochim Biophys Acta 2016 06 11;1862(6):1063-73. Epub 2016 Mar 11.

Centre for the Study of Neurological Disorders, Royal College of Surgeons In Ireland, St. Stephen's Green, Dublin 2, Ireland; Department of Physiology and Medical Physics, Royal College of Surgeons In Ireland, St. Stephen's Green, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.03.006DOI Listing
June 2016

Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.

Eur J Pharmacol 2016 Jun 17;780:53-64. Epub 2016 Mar 17.

Centre for Systems Medicine and Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2016.03.031DOI Listing
June 2016

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury.

J Neurosci 2016 Apr;36(16):4564-78

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin 2, Ireland, and

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http://dx.doi.org/10.1523/JNEUROSCI.3780-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601822PMC
April 2016

Endoplasmic reticulum stress-mediated upregulation of miR-29a enhances sensitivity to neuronal apoptosis.

Eur J Neurosci 2016 Mar 9;43(5):640-52. Epub 2016 Feb 9.

Centre for the Study of Neurological Disorders and Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin, 2, Ireland.

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http://dx.doi.org/10.1111/ejn.13160DOI Listing
March 2016

Integrating Colon Cancer Microarray Data: Associating Locus-Specific Methylation Groups to Gene Expression-Based Classifications.

Microarrays (Basel) 2015 Nov 23;4(4):630-46. Epub 2015 Nov 23.

Centre for Systems Medicine and Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 123 Saint Stephen's Green, Dublin 2, D02 YN77 Ireland.

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http://dx.doi.org/10.3390/microarrays4040630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996409PMC
November 2015

Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme.

Front Neurosci 2015 16;9:218. Epub 2015 Jun 16.

Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland Dublin, Ireland.

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http://dx.doi.org/10.3389/fnins.2015.00218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468867PMC
July 2015

The metabolic response to excitotoxicity - lessons from single-cell imaging.

J Bioenerg Biomembr 2015 Apr 28;47(1-2):75-88. Epub 2014 Sep 28.

Department of Physiology and Medical Physics, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1007/s10863-014-9578-4DOI Listing
April 2015

"Preconditioning" with latrepirdine, an adenosine 5'-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1(G93A) mice.

Neurobiol Aging 2015 Feb 26;36(2):1140-50. Epub 2014 Sep 26.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.09.022DOI Listing
February 2015

Bax regulates neuronal Ca2+ homeostasis.

J Neurosci 2015 Jan;35(4):1706-22

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders and 3U-COEN, Royal College of Surgeons in Ireland, Dublin 2, Ireland; and

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http://dx.doi.org/10.1523/JNEUROSCI.2453-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795257PMC
January 2015

Hsp27 binding to the 3'UTR of bim mRNA prevents neuronal death during oxidative stress-induced injury: a novel cytoprotective mechanism.

Mol Biol Cell 2014 Nov 3;25(21):3413-23. Epub 2014 Sep 3.

Department of Physiology and Medical Physics and RCSI Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin 2, Ireland

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http://dx.doi.org/10.1091/mbc.E13-08-0495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214787PMC
November 2014

The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes.

Neurobiol Dis 2014 Oct 21;70:99-107. Epub 2014 Jun 21.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.06.008DOI Listing
October 2014

Anti-apoptotic BCL-2 family proteins in acute neural injury.

Front Cell Neurosci 2014 30;8:281. Epub 2014 Sep 30.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland Dublin, Ireland.

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http://dx.doi.org/10.3389/fncel.2014.00281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179715PMC
October 2014

Validation of an imageable surgical resection animal model of Glioblastoma (GBM).

J Neurosci Methods 2014 Aug 18;233:99-104. Epub 2014 Jun 18.

Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.jneumeth.2014.05.006DOI Listing
August 2014

Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation.

J Neurosci 2014 Jul;34(31):10192-205

Department of Physiology and Medical Physics, Centre of Systems Medicine, and Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin 2, Ireland, and

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http://dx.doi.org/10.1523/JNEUROSCI.3127-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608276PMC
July 2014

Increased expression of microRNA-29a in ALS mice: functional analysis of its inhibition.

J Mol Neurosci 2014 Jun 4;53(2):231-41. Epub 2014 Apr 4.

Centre for the Study of Neurological Disorders, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1007/s12031-014-0290-yDOI Listing
June 2014

Harnessing system models of cell death signalling for cytotoxic chemotherapy: towards personalised medicine approaches?

J Mol Med (Berl) 2014 Mar 30;92(3):227-37. Epub 2014 Jan 30.

Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland,

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http://link.springer.com/10.1007/s00109-014-1126-5
Publisher Site
http://dx.doi.org/10.1007/s00109-014-1126-5DOI Listing
March 2014

Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis.

J Cell Sci 2014 Feb 27;127(Pt 3):609-19. Epub 2013 Nov 27.

Centre for Systems Medicine and Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://jcs.biologists.org/content/joces/127/3/609.full.pdf
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http://jcs.biologists.org/cgi/doi/10.1242/jcs.137158
Publisher Site
http://dx.doi.org/10.1242/jcs.137158DOI Listing
February 2014

Unsupervised mitochondria segmentation using recursive spectral clustering and adaptive similarity models.

J Struct Biol 2013 Dec 30;184(3):401-8. Epub 2013 Oct 30.

Centre for Image Processing and Analysis, Dublin City University, Glasnevin 9, Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2013.10.013DOI Listing
December 2013

Molecular imaging in the development of a novel treatment paradigm for glioblastoma (GBM): an integrated multidisciplinary commentary.

Drug Discov Today 2013 Nov 20;18(21-22):1052-66. Epub 2013 Jun 20.

Department of Physiology and Medical Physics & Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.drudis.2013.06.004DOI Listing
November 2013

Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location?

EMBO J 2013 Nov 25;32(23):3014-6. Epub 2013 Oct 25.

Centre for the Study of Neurological Disorders, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1038/emboj.2013.238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844957PMC
November 2013

Angiogenin induces modifications in the astrocyte secretome: relevance to amyotrophic lateral sclerosis.

J Proteomics 2013 Oct 3;91:274-85. Epub 2013 Aug 3.

Institut de Génomique Fonctionnelle, CNRS UMR 5203, F-34094 Montpellier, France; INSERM U661, F-34094 Montpellier, France; Université Montpellier I, F-34094 Montpellier, France; Université Montpellier II, F-34094 Montpellier, France; Royal College of Surgeons in Ireland, Dept. of Physiology and Medical Physics, Dublin 2, Ireland.

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http://dx.doi.org/10.1016/j.jprot.2013.07.028DOI Listing
October 2013

Glucose-starved cells do not engage in prosurvival autophagy.

J Biol Chem 2013 Oct 6;288(42):30387-98. Epub 2013 Sep 6.

From the Cell Death Regulation Group, IDIBELL (Bellvitge Biomedical Research Institute), L'Hospitalet de Llobregat, Barcelona, 08908 Spain.

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http://dx.doi.org/10.1074/jbc.M113.490581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798503PMC
October 2013

The indirect activation model of mitochondrial outer membrane permeabilisation (MOMP) initiation requires a trade-off between robustness in the absence of and sensitivity in the presence of stress.

Mol Biosyst 2013 Sep;9(9):2359-69

Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons, 123 St. Stephens Green, Dublin 2, Ireland.

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http://xlink.rsc.org/?DOI=c3mb70076c
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http://dx.doi.org/10.1039/c3mb70076cDOI Listing
September 2013

Systems modelling methodology for the analysis of apoptosis signal transduction and cell death decisions.

Methods 2013 Jun 19;61(2):165-73. Epub 2013 Apr 19.

Centre for Systems Medicine and Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://dx.doi.org/10.1016/j.ymeth.2013.04.007DOI Listing
June 2013

In vivo bioluminescence imaging validation of a human biopsy-derived orthotopic mouse model of glioblastoma multiforme.

Mol Imaging 2013 May;12(3):161-72

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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May 2013

AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1.

J Neurochem 2013 Mar 26;124(5):721-34. Epub 2012 Dec 26.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1111/jnc.12108DOI Listing
March 2013

CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures.

Brain 2013 Feb 29;136(Pt 2):577-92. Epub 2013 Jan 29.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1093/brain/aws337DOI Listing
February 2013

Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-κB signaling in neurons.

J Cell Sci 2012 Dec 24;125(Pt 24):6058-70. Epub 2012 Oct 24.

Centre for the Study of Neurological Disorders (CSND), Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland 123 Saint Stephen's Green, Dublin 2 Ireland.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.111880
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December 2012

Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.

J Biol Chem 2012 Nov 4;287(49):41546-59. Epub 2012 Oct 4.

Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1074/jbc.M112.411827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510850PMC
November 2012

Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase.

Front Neurosci 2012 19;6:167. Epub 2012 Nov 19.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland Dublin, Ireland.

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http://dx.doi.org/10.3389/fnins.2012.00167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500830PMC
November 2012

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis.

Neurobiol Aging 2012 Sep 30;33(9):2200-9. Epub 2011 Jul 30.

Experimental Neurosurgery, Center for Neurology and Neurosurgery, Goethe University Hospital, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.06.012DOI Listing
September 2012

Analyzing proteasomal subunit expression reveals Rpt4 as a prognostic marker in stage II colorectal cancer.

Int J Cancer 2012 Aug 8;131(4):E494-500. Epub 2011 Nov 8.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1002/ijc.26468DOI Listing
August 2012

Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy.

Gut 2012 May 14;61(5):725-33. Epub 2011 Nov 14.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 Saint Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1136/gutjnl-2011-300433DOI Listing
May 2012

'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.

Biochim Biophys Acta 2012 May 7;1817(5):744-53. Epub 2012 Feb 7.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1016/j.bbabio.2012.01.016DOI Listing
May 2012

Motoneurons secrete angiogenin to induce RNA cleavage in astroglia.

J Neurosci 2012 Apr;32(15):5024-38

Department of Physiology and Medical Physics, Centre for Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://dx.doi.org/10.1523/JNEUROSCI.6366-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622103PMC
April 2012

A structured approach to the study of metabolic control principles in intact and impaired mitochondria.

Mol Biosyst 2012 Mar 5;8(3):828-42. Epub 2012 Jan 5.

Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://xlink.rsc.org/?DOI=c2mb05434e
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March 2012

Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.

J Neurosci 2012 Feb;32(5):1847-58

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://dx.doi.org/10.1523/JNEUROSCI.2345-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703363PMC
February 2012

Rapamycin protects against dominant negative-HNF1A-induced apoptosis in INS-1 cells.

Apoptosis 2011 Nov;16(11):1128-37

Department of Endocrinology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.

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http://dx.doi.org/10.1007/s10495-011-0641-xDOI Listing
November 2011

In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury.

J Cereb Blood Flow Metab 2011 May 2;31(5):1196-210. Epub 2011 Mar 2.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1038/jcbfm.2011.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099642PMC
May 2011

Mathematical modelling of the mitochondrial apoptosis pathway.

Biochim Biophys Acta 2011 Apr 13;1813(4):608-15. Epub 2010 Oct 13.

Department of Physiology and Mental Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://dx.doi.org/10.1016/j.bbamcr.2010.10.004DOI Listing
April 2011

Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release.

Mol Syst Biol 2011 Mar;7:470

Systems Biology Group, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://msb.embopress.org/cgi/doi/10.1038/msb.2011.2
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http://dx.doi.org/10.1038/msb.2011.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094064PMC
March 2011

Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.

Eur J Neurosci 2011 Feb 31;33(3):401-8. Epub 2010 Dec 31.

Department of Physiology and Medical Physics and RCSI Neuroscience Research Centre, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1111/j.1460-9568.2010.07538.xDOI Listing
February 2011

Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition.

Mol Cell Biol 2010 Dec 4;30(23):5484-501. Epub 2010 Oct 4.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1128/MCB.00575-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976426PMC
December 2010