Jochen Gaedcke

Jochen Gaedcke

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Jochen Gaedcke

Publications by authors named "Jochen Gaedcke"

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72Publications

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Enhancer of Zeste Homolog 2 in Colorectal Cancer Development and Progression.

Authors:
Sebastian C B Bremer Lena-Christin Conradi Nicolae-Catalin Mechie Ahmad Amanzada Eirini Mavropoulou Julia Kitz Michael Ghadimi Volker Ellenrieder Philipp Ströbel Elisabeth Hessmann Jochen Gaedcke Hanibal Bohnenberger

Digestion 2019 Nov 6:1-9. Epub 2019 Nov 6.

Institute of Pathology, University Medical Center Goettingen, Georg-August-University, Goettingen, Germany.

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http://dx.doi.org/10.1159/000504093DOI Listing
November 2019

The impact of preoperative biliary stenting in pancreatic cancer: A case-matched study from the German nationwide pancreatic surgery registry (DGAV StuDoQ|Pancreas).

Authors:
Louisa Bolm Ekaterina Petrova Lukas Woehrmann Jens Werner Waldemar Uhl Natascha Nuessler Michael Ghadimi Dirk Bausch Hryhoriy Lapshyn Jochen Gaedcke Orlin Belyaev Jan G D'Haese Thomas Klier Tobias Keck Ulrich F Wellner

Pancreatology 2019 Oct 18;19(7):985-993. Epub 2019 Sep 18.

Department of Surgery, University Medical Center Luebeck, Germany; DGAV STuDoQ|Pancreas Registry of the German Association for General and Visceral Surgery, Germany.

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http://dx.doi.org/10.1016/j.pan.2019.09.007DOI Listing
October 2019

NO /RUNX3/kynurenine metabolic signaling enhances disease aggressiveness in pancreatic cancer.

Authors:
Limin Wang Wei Tang Shouhui Yang Peijun He Jian Wang Jochen Gaedcke Philipp Ströbel Azadeh Azizian Thomas Ried Matthias M Gaida Harris G Yfantis Dong H Lee Ashish Lal Benoit J Van den Eynde H Richard Alexander B Michael Ghadimi Nader Hanna S Perwez Hussain

Int J Cancer 2019 Oct 14. Epub 2019 Oct 14.

Pancreatic Cancer Section, Laboratory of Human Carcinogenesis, CCR, NCI, Bethesda, MD.

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http://dx.doi.org/10.1002/ijc.32733DOI Listing
October 2019

Correction: A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells.

Authors:
Alexander Wolff Michaela Bayerlová Jochen Gaedcke Dieter Kube Tim Beißbarth

PLoS One 2019;14(10):e0224062. Epub 2019 Oct 24.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224062PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812779PMC
October 2019

Combined targeting of HER-2 and HER-3 represents a promising therapeutic strategy in colorectal cancer.

Authors:
Lena-Christin Conradi Melanie Spitzner Anna-Lena Metzger Merle Kisly Peter Middel Hanibal Bohnenberger Jochen Gaedcke Michael B Ghadimi Torsten Liersch Joseph Rüschoff Tim Beißbarth Alexander König Marian Grade

BMC Cancer 2019 Sep 5;19(1):880. Epub 2019 Sep 5.

Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany.

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http://dx.doi.org/10.1186/s12885-019-6051-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727342PMC
September 2019

Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer.

Authors:
Hannah Flebbe Feda H Hamdan Vijayalakshmi Kari Julia Kitz Jochen Gaedcke B Michael Ghadimi Steven A Johnsen Marian Grade

Cancers (Basel) 2019 Aug 9;11(8). Epub 2019 Aug 9.

Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, 37075 Goettingen, Germany.

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https://www.mdpi.com/2072-6694/11/8/1142
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http://dx.doi.org/10.3390/cancers11081142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721540PMC
August 2019

ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells.

Authors:
Madhobi Sen Xin Wang Feda H Hamdan Jacobe Rapp Jessica Eggert Robyn Laura Kosinsky Florian Wegwitz Ana Patricia Kutschat Fereshteh S Younesi Jochen Gaedcke Marian Grade Elisabeth Hessmann Argyris Papantonis Philipp Strӧbel Steven A Johnsen

Clin Epigenetics 2019 Jun 19;11(1):92. Epub 2019 Jun 19.

Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Gastroenterology Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1186/s13148-019-0690-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585056PMC
June 2019

Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites.

Authors:
Melanie S Patzak Vijayalakshmi Kari Shilpa Patil Feda H Hamdan Robert G Goetze Marius Brunner Jochen Gaedcke Julia Kitz Duncan I Jodrell Frances M Richards Christian Pilarsky Robert Gruetzmann Petra Rümmele Thomas Knösel Elisabeth Hessmann Volker Ellenrieder Steven A Johnsen Albrecht Neesse

EBioMedicine 2019 Feb 30;40:394-405. Epub 2019 Jan 30.

University Medical Center Goettingen, Department of Gastroenterology and Gastrointestinal Oncology, Goettingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.01.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413477PMC
February 2019

Risk stratification for postoperative pancreatic fistula using the pancreatic surgery registry StuDoQ|Pancreas of the German Society for General and Visceral Surgery.

Authors:
Ekaterina Petrova Hryhoriy Lapshyn Dirk Bausch Jan D'Haese Jens Werner Thomas Klier Natascha C Nüssler Jochen Gaedcke Michael Ghadimi Waldemar Uhl Orlin Belyaev Olga Kantor Marshall Baker Tobias Keck Ulrich F Wellner

Pancreatology 2019 Jan 24;19(1):17-25. Epub 2018 Nov 24.

Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1016/j.pan.2018.11.008DOI Listing
January 2019

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness.

Authors:
Vijayalakshmi Kari Sanjay Kumar Raul Jana Maria Henck Julia Kitz Frank Kramer Robyn Laura Kosinsky Nadine Übelmesser Wael Yassin Mansour Jessica Eggert Melanie Spitzner Zeynab Najafova Holger Bastians Marian Grade Jochen Gaedcke Florian Wegwitz Steven A Johnsen

Clin Epigenetics 2019 01 7;11(1). Epub 2019 Jan 7.

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1186/s13148-018-0601-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323691PMC
January 2019

[Incidence and Predictive Factors for Bilaterality in Patients with Papillary Thyroid Carcinoma].

Authors:
Peter Jo Hatice Kesruek Manuel Nietert Carsten Oliver Sahlmann Jochen Gaedcke Michael Ghadimi Jens Sperling

Zentralbl Chir 2018 Aug 22;143(4):361-366. Epub 2018 Aug 22.

Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Georg-August-Universität Göttingen.

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http://dx.doi.org/10.1055/a-0651-0878DOI Listing
August 2018

A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells.

Authors:
Alexander Wolff Michaela Bayerlová Jochen Gaedcke Dieter Kube Tim Beißbarth

PLoS One 2018 16;13(5):e0197162. Epub 2018 May 16.

Dept. of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197162PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955523PMC
July 2018

Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery.

Authors:
Yue Hu Jochen Gaedcke Georg Emons Tim Beissbarth Marian Grade Peter Jo Meredith Yeager Stephen J Chanock Hendrik Wolff Jordi Camps B Michael Ghadimi Thomas Ried

Genes Chromosomes Cancer 2018 03 28;57(3):140-149. Epub 2017 Nov 28.

Section of Cancer Genomics, Genetics Branch, National Cancer Institute, Bethesda, MD, 20892.

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http://dx.doi.org/10.1002/gcc.22512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778444PMC
March 2018

Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.

Authors:
Georg Emons Melanie Spitzner Sebastian Reineke Janneke Möller Noam Auslander Frank Kramer Yue Hu Tim Beissbarth Hendrik A Wolff Margret Rave-Fränk Elisabeth Heßmann Jochen Gaedcke B Michael Ghadimi Steven A Johnsen Thomas Ried Marian Grade

Mol Cancer Res 2017 11 15;15(11):1481-1490. Epub 2017 Aug 15.

Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Germany.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772978PMC
November 2017

ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage.

Authors:
Lukas Perkhofer Anna Schmitt Maria Carolina Romero Carrasco Michaela Ihle Stephanie Hampp Dietrich Alexander Ruess Elisabeth Hessmann Ronan Russell André Lechel Ninel Azoitei Qiong Lin Stefan Liebau Meike Hohwieler Hanibal Bohnenberger Marina Lesina Hana Algül Laura Gieldon Evelin Schröck Jochen Gaedcke Martin Wagner Lisa Wiesmüller Bence Sipos Thomas Seufferlein Hans Christian Reinhardt Pierre-Olivier Frappart Alexander Kleger

Cancer Res 2017 10 8;77(20):5576-5590. Epub 2017 Aug 8.

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0634DOI Listing
October 2017

Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity.

Authors:
Nai-Ming Chen Albrecht Neesse Moritz Lino Dyck Benjamin Steuber Alexander O Koenig Clara Lubeseder-Martellato Thore Winter Teresa Forster Hanibal Bohnenberger Julia Kitz Kirsten Reuter-Jessen Heidi Griesmann Jochen Gaedcke Marian Grade Jin-San Zhang Wan-Chi Tsai Jens Siveke Hans-Ulrich Schildhaus Philipp Ströbel Steven A Johnsen Volker Ellenrieder Elisabeth Hessmann

Gastroenterology 2017 05 8;152(6):1507-1520.e15. Epub 2017 Feb 8.

Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.01.043DOI Listing
May 2017

Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy.

Authors:
Peter Jo Azadeh Azizian Junius Salendo Frank Kramer Markus Bernhardt Hendrik A Wolff Jens Gruber Marian Grade Tim Beißbarth B Michael Ghadimi Jochen Gaedcke

Int J Mol Sci 2017 May 27;18(6). Epub 2017 May 27.

Department of General-, Visceral-, and Pediatric Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075 Goettingen, Germany.

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http://dx.doi.org/10.3390/ijms18061140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485964PMC
May 2017

Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer.

Authors:
Jian Wang Shouhui Yang Peijun He Aaron J Schetter Jochen Gaedcke B Michael Ghadimi Thomas Ried Harris G Yfantis Dong H Lee Matthias M Gaida Nader Hanna H Richard Alexander S Perwez Hussain

Clin Cancer Res 2016 Dec 8;22(24):5992-6001. Epub 2016 Jul 8.

Pancreatic Cancer Unit, Center for Cancer Research, NCI, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161709PMC
December 2016

Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies.

Authors:
Peter Jo Manuel Nietert Linda Gusky Julia Kitz Lena C Conradi Annegret Müller-Dornieden Philipp Schüler Hendrik A Wolff Josef Rüschoff Philipp Ströbel Marian Grade Torsten Liersch Tim Beißbarth Michael B Ghadimi Ulrich Sax Jochen Gaedcke

Sci Rep 2016 10 18;6:35589. Epub 2016 Oct 18.

Department of General, Visceral and Pediatric Surgery, University Medical Center, Goettingen, Germany.

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http://dx.doi.org/10.1038/srep35589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067705PMC
October 2016

Heterogeneity of KRAS Mutation Status in Rectal Cancer.

Authors:
Peter Jo Alexander König Markus Schirmer Julia Kitz Lena-Christin Conradi Azadeh Azizian Markus Bernhardt Hendrik A Wolff Marian Grade Michael Ghadimi Philipp Ströbel Hans-Ulrich Schildhaus Jochen Gaedcke

PLoS One 2016 11;11(4):e0153278. Epub 2016 Apr 11.

Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153278PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827807PMC
August 2016

Inducible nitric oxide synthase enhances disease aggressiveness in pancreatic cancer.

Authors:
Jian Wang Peijun He Matthias Gaida Shouhui Yang Aaron J Schetter Jochen Gaedcke B Michael Ghadimi Thomas Ried Harris Yfantis Dong Lee Jonathan M Weiss Jimmy Stauffer Nader Hanna H Richard Alexander S Perwez Hussain

Oncotarget 2016 Aug;7(33):52993-53004

Pancreatic Cancer Unit, Laboratory of Human Carcinogenesis, CCR, NCI, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.10323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288163PMC
August 2016

A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2.

Authors:
Shouhui Yang Peijun He Jian Wang Aaron Schetter Wei Tang Naotake Funamizu Katsuhiko Yanaga Tadashi Uwagawa Abhay R Satoskar Jochen Gaedcke Markus Bernhardt B Michael Ghadimi Matthias M Gaida Frank Bergmann Jens Werner Thomas Ried Nader Hanna H Richard Alexander S Perwez Hussain

Cancer Res 2016 07 20;76(13):3838-50. Epub 2016 Apr 20.

Pancreatic Cancer Unit, National Cancer Institute, Bethesda, Maryland. Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930741PMC
July 2016

Relevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer.

Authors:
Markus A Schirmer Claudia M Lüske Sebastian Roppel Alexander Schaudinn Christian Zimmer Ruben Pflüger Martin Haubrock Jacobe Rapp Cenap Güngör Maximilian Bockhorn Thilo Hackert Thomas Hank Oliver Strobel Jens Werner Jakob R Izbicki Steven A Johnsen Jochen Gaedcke Jürgen Brockmöller B Michael Ghadimi

J Natl Cancer Inst 2016 May 8;108(5). Epub 2016 Feb 8.

Affiliations of authors:Institute of Clinical Pharmacology (MAS, CML, SR, AS, CZ, RP, JB), Institute of Bioinformatics (MH), Clinic of General and Visceral Surgery (CML, SR, JR, SAJ, JG, BMG), and Clinic of Radiotherapy and Radiation Oncology (MAS), University Medical Center Göttingen , Göttingen , Germany ; Department of General, Visceral, and Thoracic Surgery, University Hospital Hamburg-Eppendorf , Hamburg , Germany (CG, MB, JRI); Department of General, Visceral, and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany (THac, THan, OS, JW).

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http://dx.doi.org/10.1093/jnci/djv387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859408PMC
May 2016

MicroRNA in rectal cancer.

Authors:
Azadeh Azizian Jens Gruber B Michael Ghadimi Jochen Gaedcke

World J Gastrointest Oncol 2016 May;8(5):416-26

Azadeh Azizian, B Michael Ghadimi, Jochen Gaedcke, Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany.

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http://dx.doi.org/10.4251/wjgo.v8.i5.416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865709PMC
May 2016

Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer.

Authors:
Azadeh Azizian Ingo Epping Frank Kramer Peter Jo Markus Bernhardt Julia Kitz Gabriela Salinas Hendrik A Wolff Marian Grade Tim Beißbarth B Michael Ghadimi Jochen Gaedcke

Int J Mol Sci 2016 Apr 15;17(4):568. Epub 2016 Apr 15.

Department of General, Visceral, and Pediatric Surgery, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany.

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http://dx.doi.org/10.3390/ijms17040568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849024PMC
April 2016

[Recurrent seizures of unknown aetiology].

Authors:
Martha Krauß Heiner Berkermann Michael Ghadimi Jochen Gaedcke Tobias Bürger

Dtsch Med Wochenschr 2016 Apr 28;141(9):631-3. Epub 2016 Apr 28.

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http://dx.doi.org/10.1055/s-0041-103982DOI Listing
April 2016

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.

Authors:
Yuehan Wu Suk-Hee Lee Elizabeth A Williamson Brian L Reinert Ju Hwan Cho Fen Xia Aruna Shanker Jaiswal Gayathri Srinivasan Bhavita Patel Alexis Brantley Daohong Zhou Lijian Shao Rupak Pathak Martin Hauer-Jensen Sudha Singh Kimi Kong Xaiohua Wu Hyun-Suk Kim Timothy Beissbarth Jochen Gaedcke Sandeep Burma Jac A Nickoloff Robert A Hromas

PLoS Genet 2015 Dec 18;11(12):e1005675. Epub 2015 Dec 18.

Department of Medicine and the Cancer Center, University of Florida Health, Gainesville, Florida, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684289PMC
December 2015

Volumetric intensity-modulated arc therapy vs. 3-dimensional conformal radiotherapy for primary chemoradiotherapy of anal carcinoma: Effects on treatment-related side effects and survival.

Authors:
Hanne Elisabeth Weber Leif Hendrik Dröge Steffen Hennies Markus Karl Herrmann Jochen Gaedcke Hendrik Andreas Wolff

Strahlenther Onkol 2015 Nov 8;191(11):827-34. Epub 2015 Jun 8.

Dept. of Radiotherapy and Radiooncology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00066-015-0859-6DOI Listing
November 2015

Reduced toxicity in the treatment of locally advanced rectal cancer: a comparison of volumetric modulated arc therapy and 3D conformal radiotherapy.

Authors:
Leif Hendrik Dröge Hanne Elisabeth Weber Manuel Guhlich Martin Leu Lena-Christin Conradi Jochen Gaedcke Steffen Hennies Markus Karl Herrmann Margret Rave-Fränk Hendrik Andreas Wolff

BMC Cancer 2015 Oct 20;15:750. Epub 2015 Oct 20.

Department of Radiotherapy and Radiation Oncology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1186/s12885-015-1812-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617910PMC
October 2015

Preoperative Prediction of Lymph Node Status by Circulating Mir-18b and Mir-20a During Chemoradiotherapy in Patients with Rectal Cancer.

Authors:
Azadeh Azizian Frank Kramer Peter Jo Hendrik A Wolff Tim Beißbarth Robert Skarupke Markus Bernhardt Marian Grade B Michael Ghadimi Jochen Gaedcke

World J Surg 2015 Sep;39(9):2329-35

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany,

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http://dx.doi.org/10.1007/s00268-015-3083-8DOI Listing
September 2015

MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP.

Authors:
Xin Zhang Ramona Schulz Shelley Edmunds Elke Krüger Elke Markert Jochen Gaedcke Estelle Cormet-Boyaka Michael Ghadimi Tim Beissbarth Arnold J Levine Ute M Moll Matthias Dobbelstein

Mol Cell 2015 Jul 2;59(2):243-57. Epub 2015 Jul 2.

Institute of Molecular Oncology, University Medical Center Göttingen, 37077 Göttingen, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765150040
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http://dx.doi.org/10.1016/j.molcel.2015.05.036DOI Listing
July 2015

Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition.

Authors:
Ronan Russell Lukas Perkhofer Stefan Liebau Qiong Lin André Lechel Fenja M Feld Elisabeth Hessmann Jochen Gaedcke Melanie Güthle Martin Zenke Daniel Hartmann Guido von Figura Stephanie E Weissinger Karl-Lenhard Rudolph Peter Möller Jochen K Lennerz Thomas Seufferlein Martin Wagner Alexander Kleger

Nat Commun 2015 Jul 29;6:7677. Epub 2015 Jul 29.

Department of Internal Medicine I, Ulm University, Albert-Einstein-Allee 23, Ulm 89081, Germany.

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http://dx.doi.org/10.1038/ncomms8677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532798PMC
July 2015

The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.

Authors:
Robert Liefke Indra M Windhof-Jaidhauser Jochen Gaedcke Gabriela Salinas-Riester Feizhen Wu Michael Ghadimi Sebastian Dango

Genome Med 2015 30;7(1):66. Epub 2015 Jun 30.

University Medical Center, Department of General-, and Visceral Surgery, D-37075 Göttingen, Germany ; Division of Newborn Medicine and Program in Epigenetics, Department of Medicine, Boston Children's Hospital, Boston, MA 02115 USA ; Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA.

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http://genomemedicine.com/content/7/1/66
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http://dx.doi.org/10.1186/s13073-015-0180-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517488PMC
July 2015

5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.

Authors:
Upadhyayula Sai Srinivas Jerzy Dyczkowski Tim Beißbarth Jochen Gaedcke Wael Y Mansour Kerstin Borgmann Matthias Dobbelstein

Oncotarget 2015 May;6(14):12574-86

Institute of Molecular Oncology, University Medical Center Göttingen, Germany.

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http://www.oncotarget.com/fulltext/3728
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494959PMC
http://dx.doi.org/10.18632/oncotarget.3728DOI Listing
May 2015

Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity.

Authors:
Shiv K Singh Nai-Ming Chen Elisabeth Hessmann Jens Siveke Marlen Lahmann Garima Singh Nadine Voelker Sophia Vogt Irene Esposito Ansgar Schmidt Cornelia Brendel Thorsten Stiewe Jochen Gaedcke Marco Mernberger Howard C Crawford William R Bamlet Jin-San Zhang Xiao-Kun Li Thomas C Smyrk Daniel D Billadeau Matthias Hebrok Albrecht Neesse Alexander Koenig Volker Ellenrieder

EMBO J 2015 Feb 13;34(4):517-30. Epub 2015 Jan 13.

Department of Gastroenterology II, University Medical Center Goettingen, Goettingen, Germany

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http://dx.doi.org/10.15252/embj.201489574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331005PMC
February 2015

High-resolution analysis of DNA copy number alterations in rectal cancer: correlation with metastasis, survival, and mRNA expression.

Authors:
Jérôme Doyen Eric Letouzé Laetitia Marisa Aurélien de Reyniès Gérard Milano Marie-Christine Etienne-Grimaldi Sylviane Olschwang Jochen Gaedcke Michael Ghadimi Jean-Pierre Gérard

Strahlenther Onkol 2014 Oct 26;190(11):1028-36. Epub 2014 Apr 26.

Department of Radiation Oncology, Centre Antoine-Lacassagne, 33 avenue de Valombrose, 06189, Nice, France,

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http://dx.doi.org/10.1007/s00066-014-0659-4DOI Listing
October 2014

CFTR, SPINK1, PRSS1, and CTRC mutations are not associated with pancreatic cancer in German patients.

Authors:
Stephanie Schubert Frank Traub Kai Brakensiek Kathrein von Kopylow Britta Marohn Madeleine Maelzer Jochen Gaedcke Hans Kreipe Manfred Stuhrmann

Pancreas 2014 Oct;43(7):1078-82

From the Institutes of *Human Genetics and †Pathology, Hannover Medical School, Hannover, Germany; ‡Department of Andrology, University Hospital Hamburg-Eppendorf, Hamburg, Germany; and §Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1097/MPA.0000000000000166DOI Listing
October 2014

Selective targeting of KRAS-mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-mutant cells.

Authors:
Toshifumi Hara Matthew F Jones Murugan Subramanian Xiao Ling Li Oliver Ou Yuelin Zhu Yuan Yang Lalage M Wakefield S Perwez Hussain Jochen Gaedcke Thomas Ried Ji Luo Natasha J Caplen Ashish Lal

Oncotarget 2014 Sep;5(17):7635-50

Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.2284DOI Listing
September 2014

Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer.

Authors:
Jochen Gaedcke Andreas Leha Rainer Claus Dieter Weichenhan Klaus Jung Julia Kitz Marian Grade Hendrik A Wolff Peter Jo Jérôme Doyen Jean-Pierre Gérard Steven A Johnsen Christoph Plass Tim Beißbarth Michael Ghadimi

Oncotarget 2014 Sep;5(18):8123-35

Department of General and Visceral Surgery, University Medical Center Goettingen, Goettingen, Germany.

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http://dx.doi.org/10.18632/oncotarget.2347DOI Listing
September 2014

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.

Authors:
Melanie Spitzner Birte Roesler Christian Bielfeld Georg Emons Jochen Gaedcke Hendrik A Wolff Margret Rave-Fränk Frank Kramer Tim Beissbarth Julia Kitz Jürgen Wienands B Michael Ghadimi Reinhard Ebner Thomas Ried Marian Grade

Int J Cancer 2014 Feb 3;134(4):997-1007. Epub 2013 Sep 3.

Department of General and Visceral Surgery, University Medicine Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1002/ijc.28429DOI Listing
February 2014

Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury.

Authors:
Julia Beck Sarah Bierau Stefan Balzer Reiner Andag Philipp Kanzow Jessica Schmitz Jochen Gaedcke Onnen Moerer Jan E Slotta Philip Walson Otto Kollmar Michael Oellerich Ekkehard Schütz

Clin Chem 2013 Dec 23;59(12):1732-41. Epub 2013 Sep 23.

Chronix Biomedical, Göttingen, Germany;

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December 2013

FOXL1, a novel candidate tumor suppressor, inhibits tumor aggressiveness and predicts outcome in human pancreatic cancer.

Authors:
Geng Zhang Peijun He Jochen Gaedcke B Michael Ghadimi Thomas Ried Harris G Yfantis Dong H Lee Nader Hanna H Richard Alexander S Perwez Hussain

Cancer Res 2013 Sep 25;73(17):5416-25. Epub 2013 Jun 25.

Pancreatic Cancer Unit, Laboratory of Human Carcinogenesis, Center for Cancer Research and Genetics Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766408PMC
September 2013

Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.

Authors:
Geng Zhang Peijun He Hanson Tan Anuradha Budhu Jochen Gaedcke B Michael Ghadimi Thomas Ried Harris G Yfantis Dong H Lee Anirban Maitra Nader Hanna H Richard Alexander S Perwez Hussain

Clin Cancer Res 2013 Sep 5;19(18):4983-93. Epub 2013 Aug 5.

Authors' Affiliations: Pancreatic Cancer Unit, Laboratory of Human Carcinogenesis, Center for Cancer Research, Genetics Branch, National Cancer Institute, NIH, Bethesda; Pathology and Laboratory Medicine, Baltimore Veterans Affairs Medical Center, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Division of Surgical Oncology, The Department of Surgery and the Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and Department of General and Visceral Surgery, University Medicine, Göttingen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778077PMC
September 2013

Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.

Authors:
Junius Salendo Melanie Spitzner Frank Kramer Xin Zhang Peter Jo Hendrik A Wolff Julia Kitz Silke Kaulfuß Tim Beißbarth Matthias Dobbelstein Michael Ghadimi Marian Grade Jochen Gaedcke

Radiother Oncol 2013 Sep 7;108(3):451-7. Epub 2013 Aug 7.

Department of General and Visceral Surgery, University Medical Center Göttingen, Germany.

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http://dx.doi.org/10.1016/j.radonc.2013.06.032DOI Listing
September 2013

Molecular patterns in the evolution of serrated lesion of the colorectum.

Authors:
Timo Gaiser Sandra Meinhardt Daniela Hirsch Jonathan Keith Killian Jochen Gaedcke Peter Jo Immaculada Ponsa Rosa Miró Josef Rüschoff Gerhard Seitz Yue Hu Jordi Camps Thomas Ried

Int J Cancer 2013 Apr 17;132(8):1800-10. Epub 2012 Oct 17.

Section of Cancer Genomics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/ijc.27869DOI Listing
April 2013

Frequency of HER-2 positivity in rectal cancer and prognosis.

Authors:
Lena-Christin Conradi Hanna Styczen Thilo Sprenger Hendrik A Wolff Claus Rödel Manuel Nietert Kia Homayounfar Jochen Gaedcke Julia Kitz Recca Talaulicar Heinz Becker Michael Ghadimi Peter Middel Tim Beissbarth Josef Rüschoff Torsten Liersch

Am J Surg Pathol 2013 Apr;37(4):522-31

Department of General and Visceral Surgery, University Medical Center, Göttingen, Germany.

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http://dx.doi.org/10.1097/PAS.0b013e318272ff4dDOI Listing
April 2013

Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma.

Authors:
Naotake Funamizu Chaoxin Hu Curtis Lacy Aaron Schetter Geng Zhang Peijun He Jochen Gaedcke Michael B Ghadimi Thomas Ried Harris G Yfantis Dong H Lee Jeffrey Subleski Tim Chan Jonathan M Weiss Timothy C Back Katsuhiko Yanaga Nader Hanna H Richard Alexander Anirban Maitra S Perwez Hussain

Int J Cancer 2013 Feb;132(4):785-94

Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, MD.

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http://dx.doi.org/10.1002/ijc.27736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488363PMC
February 2013

PAM4 enzyme immunoassay alone and in combination with CA 19-9 for the detection of pancreatic adenocarcinoma.

Authors:
David V Gold Jochen Gaedcke B Michael Ghadimi Michael Goggins Ralph H Hruban Mengling Liu Guy Newsome David M Goldenberg

Cancer 2013 Feb 16;119(3):522-8. Epub 2012 Aug 16.

Center for Molecular Medicine and Immunology, Garden State Cancer Center, Morris Plains, NJ 07950, USA.

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http://doi.wiley.com/10.1002/cncr.27762
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502643PMC
February 2013

The rectal cancer microRNAome--microRNA expression in rectal cancer and matched normal mucosa.

Authors:
Jochen Gaedcke Marian Grade Jordi Camps Rolf Søkilde Bogumil Kaczkowski Aaron J Schetter Michael J Difilippantonio Curtis C Harris B Michael Ghadimi Søren Møller Tim Beissbarth Thomas Ried Thomas Litman

Clin Cancer Res 2012 Sep 31;18(18):4919-30. Epub 2012 Jul 31.

Department of General and Visceral Surgery, Medical Statistics, University Medical Center, Göttingen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298229PMC
September 2012

DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma.

Authors:
Geng Zhang Aaron Schetter Peijun He Naotake Funamizu Jochen Gaedcke B Michael Ghadimi Thomas Ried Raffit Hassan Harris G Yfantis Dong H Lee Curtis Lacy Anirban Maitra Nader Hanna H Richard Alexander S Perwez Hussain

PLoS One 2012 20;7(2):e31507. Epub 2012 Feb 20.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031507PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282755PMC
June 2012

Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant.

Authors:
Markus Anton Schirmer Caroline Patricia Nadine Mergler Margret Rave-Fränk Markus Karl Herrmann Steffen Hennies Jochen Gaedcke Lena-Christin Conradi Peter Jo Tim Beissbarth Clemens Friedrich Hess Heinz Becker Michael Ghadimi Jürgen Brockmöller Hans Christiansen Hendrik Andreas Wolff

Int J Radiat Oncol Biol Phys 2012 May 12;83(1):149-57. Epub 2011 Oct 12.

Department of Clinical Pharmacology, University Medical Center, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2011.05.063DOI Listing
May 2012

CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer.

Authors:
Peter Jo Klaus Jung Marian Grade Lena-Christin Conradi Hendrik A Wolff Julia Kitz Heinz Becker Josef Rüschoff Arndt Hartmann Tim Beissbarth Annegret Müller-Dornieden Michael Ghadimi Regine Schneider-Stock Jochen Gaedcke

Surgery 2012 Apr 14;151(4):564-70. Epub 2011 Oct 14.

Department of General and Visceral Surgery, University Medicine Göttingen, Germany.

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http://dx.doi.org/10.1016/j.surg.2011.08.013DOI Listing
April 2012

Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers.

Authors:
Elad Sharon Jingli Zhang Kevin Hollevoet Seth M Steinberg Ira Pastan Masanori Onda Jochen Gaedcke B Michael Ghadimi Thomas Ried Raffit Hassan

Clin Chem Lab Med 2012 Apr;50(4):721-5

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA.

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http://dx.doi.org/10.1515/CCLM.2011.816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309905PMC
April 2012

The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies.

Authors:
Marian Grade Hendrik A Wolff Jochen Gaedcke B Michael Ghadimi

Langenbecks Arch Surg 2012 Apr 2;397(4):543-55. Epub 2012 Mar 2.

Department of General and Visceral Surgery, University Medical Center Göttingen, Robert-Koch Str. 40, 37075 Göttingen, Germany.

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http://link.springer.com/10.1007/s00423-012-0929-5
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314820PMC
April 2012

Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy.

Authors:
Emil Kendziorra Kerstin Ahlborn Melanie Spitzner Margret Rave-Fränk Georg Emons Jochen Gaedcke Frank Kramer Hendrik A Wolff Heinz Becker Tim Beissbarth Reinhard Ebner B Michael Ghadimi Tobias Pukrop Thomas Ried Marian Grade

Carcinogenesis 2011 Dec 8;32(12):1824-31. Epub 2011 Oct 8.

Department of General and Visceral Surgery, University Medical Center, Göttingen 37075, Germany.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgr222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254167PMC
December 2011

Retraction for Garman et al: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities.

Authors:
Katherine S Garman Chaitanya R Acharya Elena Edelman Marian Grade Jochen Gaedcke Shivani Sud William Barry Anna Mae Diehl Dawn Provenzale Geoffrey S Ginsburg B Michael Ghadimi Thomas Ried Joseph R Nevins Sayan Mukherjee David Hsu Anil Potti

Proc Natl Acad Sci U S A 2011 Oct 3;108(42):17569. Epub 2011 Oct 3.

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http://dx.doi.org/10.1073/pnas.1115170108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198325PMC
October 2011

The IT-infrastructure of a biobank for an academic medical center.

Authors:
Andrea Dangl Sara Y Demiroglu Jochen Gaedcke Krister Helbing Peter Jo Fabian Rakebrandt Otto Rienhoff Ulrich Sax

Stud Health Technol Inform 2010 ;160(Pt 2):1334-8

University Medical Center, Goettingen, Germany.

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April 2011

A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets.

Authors:
Marian Grade Amanda B Hummon Jordi Camps Georg Emons Melanie Spitzner Jochen Gaedcke Patrick Hoermann Reinhard Ebner Heinz Becker Michael J Difilippantonio B Michael Ghadimi Tim Beissbarth Natasha J Caplen Thomas Ried

Int J Cancer 2011 Mar;128(5):1069-79

Department of General and Visceral Surgery, University Medicine Göttingen, Georg-August-University, Göttingen, Germany.

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http://dx.doi.org/10.1002/ijc.25453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008507PMC
March 2011

Phosphoglycerate kinase 1 promoting tumor progression and metastasis in gastric cancer - detected in a tumor mouse model using positron emission tomography/magnetic resonance imaging.

Authors:
Derek Zieker Ingmar Königsrainer Jürgen Weinreich Stefan Beckert Jörg Glatzle Kay Nieselt Sarah Bühler Markus Löffler Jochen Gaedcke Hinnak Northoff Julia G Mannheim Stefan Wiehr Bernd J Pichler Claus von Weyhern Björn L D M Brücher Alfred Königsrainer

Cell Physiol Biochem 2010 24;26(2):147-54. Epub 2010 Aug 24.

Department of General, Visceral and Transplant Surgery, Comprehensive Cancer Center, University of Tuebingen, Tuebingen, Germany.

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https://www.karger.com/Article/FullText/320545
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December 2010

A new sensitivity-preferred strategy to build prediction rules for therapy response of cancer patients using gene expression data.

Authors:
Klaus Jung Marian Grade Jochen Gaedcke Peter Jo Lennart Opitz Heinz Becker B Michael Ghadimi Tim Beissbarth

Comput Methods Programs Biomed 2010 Nov 10;100(2):132-9. Epub 2010 Apr 10.

Department of Medical Statistics, University Medicine Göttingen, 37099 Göttingen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01692607100006
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http://dx.doi.org/10.1016/j.cmpb.2010.03.016DOI Listing
November 2010

Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.

Authors:
Jochen Gaedcke Marian Grade Klaus Jung Jordi Camps Peter Jo Georg Emons Anastasia Gehoff Ulrich Sax Markus Schirmer Heinz Becker Tim Beissbarth Thomas Ried B Michael Ghadimi

Genes Chromosomes Cancer 2010 Nov;49(11):1024-34

Department of General and Visceral Surgery, University Medicine, Göttingen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535184PMC
http://dx.doi.org/10.1002/gcc.20811DOI Listing
November 2010

A gene expression signature for chemoradiosensitivity of colorectal cancer cells.

Authors:
Melanie Spitzner Georg Emons Frank Kramer Jochen Gaedcke Margret Rave-Fränk Jens-Gerd Scharf Peter Burfeind Heinz Becker Tim Beissbarth B Michael Ghadimi Thomas Ried Marian Grade

Int J Radiat Oncol Biol Phys 2010 Nov;78(4):1184-92

Department of General and Visceral Surgery, Georg-August-University, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2010.06.023DOI Listing
November 2010

Impact of RNA degradation on gene expression profiling.

Authors:
Lennart Opitz Gabriela Salinas-Riester Marian Grade Klaus Jung Peter Jo Georg Emons B Michael Ghadimi Tim Beissbarth Jochen Gaedcke

BMC Med Genomics 2010 Aug 9;3:36. Epub 2010 Aug 9.

Department Medical Statistics, University Medicine Göttingen, Humboldtallee 32, 37073 Göttingen, Germany.

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http://bmcmedgenomics.biomedcentral.com/articles/10.1186/175
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http://dx.doi.org/10.1186/1755-8794-3-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927474PMC
August 2010

Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer.

Authors:
Derek Zieker Ingmar Königsrainer Isabel Tritschler Markus Löffler Stefan Beckert Frank Traub Kay Nieselt Sarah Bühler Michael Weller Jochen Gaedcke Russell S Taichman Hinnak Northoff Björn L D M Brücher Alfred Königsrainer

Int J Cancer 2010 Mar;126(6):1513-20

Department of General Visceral, Transplant Surgery Comprehensive Cancer Center, University of Tuebingen, D-72076 Tuebingen, Germany.

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http://dx.doi.org/10.1002/ijc.24835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811232PMC
March 2010

KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy.

Authors:
Jochen Gaedcke Marian Grade Klaus Jung Markus Schirmer Peter Jo Christoph Obermeyer Hendrik A Wolff Markus K Herrmann Tim Beissbarth Heinz Becker Thomas Ried Michael Ghadimi

Radiother Oncol 2010 Jan 11;94(1):76-81. Epub 2009 Nov 11.

Department of General and Visceral Surgery, University Medical Center, Georg-August-University Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.radonc.2009.10.001DOI Listing
January 2010

High-grade acute organ toxicity during preoperative radiochemotherapy as positive predictor for complete histopathologic tumor regression in multimodal treatment of locally advanced rectal cancer.

Authors:
Hendrik Andreas Wolff Jochen Gaedcke Klaus Jung Robert Michael Hermann Hilka Rothe Markus Schirmer Torsten Liersch Markus Karl Alfred Herrmann Steffen Hennies Margret Rave-Fränk Clemens Friedrich Hess Hans Christiansen

Strahlenther Onkol 2010 Jan 28;186(1):30-35. Epub 2009 Dec 28.

Department of Radiotherapy and Radiooncology, University Medicine Göttingen, Göttingen, Germany.

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January 2010

Chromosomal copy number changes of locally advanced rectal cancers treated with preoperative chemoradiotherapy.

Authors:
Marian Grade Jochen Gaedcke Danny Wangsa Sudhir Varma Jaje Beckmann Torsten Liersch Clemens Hess Heinz Becker Michael J Difilippantonio Thomas Ried B Michael Ghadimi

Cancer Genet Cytogenet 2009 Aug;193(1):19-28

Department of General and Visceral Surgery, University Medicine, Georg-August-University, Robert Koch Str. 40, 37075 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.cancergencyto.2009.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714587PMC
August 2009

Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis.

Authors:
Silke Kaulfuss Peter Burfeind Jochen Gaedcke Jens-Gerd Scharf

Mol Cancer Ther 2009 Apr;8(4):821-33

Institute of Human Genetics, Department of General and Visceral Surgery, University of Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0058DOI Listing
April 2009

Preoperative chemoradiotherapy in locally advanced rectal cancer: correlation of a gene expression-based response signature with recurrence.

Authors:
Torsten Liersch Marian Grade Jochen Gaedcke Sudhir Varma Michael J Difilippantonio Claus Langer Clemens F Hess Heinz Becker Thomas Ried B Michael Ghadimi

Cancer Genet Cytogenet 2009 Apr;190(2):57-65

Department of General and Visceral Surgery, University Medical Center, Georg-August-University, Robert Koch Str. 40, 37075 Göttingen, Germany.

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https://www.sciencedirect.com/science/article/pii/S016546080
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http://dx.doi.org/10.1016/j.cancergencyto.2008.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766806PMC
April 2009

A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities.

Authors:
Katherine S Garman Chaitanya R Acharya Elena Edelman Marian Grade Jochen Gaedcke Shivani Sud William Barry Anna Mae Diehl Dawn Provenzale Geoffrey S Ginsburg B Michael Ghadimi Thomas Ried Joseph R Nevins Sayan Mukherjee David Hsu Anil Potti

Proc Natl Acad Sci U S A 2008 Dec 2;105(49):19432-7. Epub 2008 Dec 2.

Institute for Genome Sciences and Policy and Department of Medicine, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1073/pnas.0806674105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592987PMC
December 2008

Predominance of the basal type and HER-2/neu type in brain metastasis from breast cancer.

Authors:
Jochen Gaedcke Frank Traub Simone Milde Ludwig Wilkens Alexandru Stan Helmut Ostertag Mathias Christgen Reinhard von Wasielewski Hans H Kreipe

Mod Pathol 2007 Aug 1;20(8):864-70. Epub 2007 Jun 1.

Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany.

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http://dx.doi.org/10.1038/modpathol.3800830DOI Listing
August 2007

Distinct chromosomal profiles in metastasizing and non-metastasizing colorectal carcinomas.

Authors:
B Michael Ghadimi Marian Grade Carsten Mönkemeyer Bettina Kulle Jochen Gaedcke Bastian Gunawan Claus Langer Torsten Liersch Heinz Becker

Cell Oncol 2006 ;28(5-6):273-81

Department of General Surgery, University Medical Center, Göttingen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618002PMC
http://dx.doi.org/10.1155/2006/529190DOI Listing
February 2007