Jochen Gaedcke

Jochen Gaedcke

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Jochen Gaedcke

Jochen Gaedcke

Publications by authors named "Jochen Gaedcke"

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72Publications

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Enhancer of Zeste Homolog 2 in Colorectal Cancer Development and Progression.

Digestion 2019 Nov 6:1-9. Epub 2019 Nov 6.

Institute of Pathology, University Medical Center Goettingen, Georg-August-University, Goettingen, Germany.

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http://dx.doi.org/10.1159/000504093DOI Listing
November 2019

The impact of preoperative biliary stenting in pancreatic cancer: A case-matched study from the German nationwide pancreatic surgery registry (DGAV StuDoQ|Pancreas).

Pancreatology 2019 Oct 18;19(7):985-993. Epub 2019 Sep 18.

Department of Surgery, University Medical Center Luebeck, Germany; DGAV STuDoQ|Pancreas Registry of the German Association for General and Visceral Surgery, Germany.

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http://dx.doi.org/10.1016/j.pan.2019.09.007DOI Listing
October 2019

Combined targeting of HER-2 and HER-3 represents a promising therapeutic strategy in colorectal cancer.

BMC Cancer 2019 Sep 5;19(1):880. Epub 2019 Sep 5.

Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany.

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http://dx.doi.org/10.1186/s12885-019-6051-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727342PMC
September 2019

Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer.

Cancers (Basel) 2019 Aug 9;11(8). Epub 2019 Aug 9.

Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, 37075 Goettingen, Germany.

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https://www.mdpi.com/2072-6694/11/8/1142
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http://dx.doi.org/10.3390/cancers11081142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721540PMC
August 2019

[Incidence and Predictive Factors for Bilaterality in Patients with Papillary Thyroid Carcinoma].

Zentralbl Chir 2018 Aug 22;143(4):361-366. Epub 2018 Aug 22.

Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Georg-August-Universität Göttingen.

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http://dx.doi.org/10.1055/a-0651-0878DOI Listing
August 2018

Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery.

Genes Chromosomes Cancer 2018 03 28;57(3):140-149. Epub 2017 Nov 28.

Section of Cancer Genomics, Genetics Branch, National Cancer Institute, Bethesda, MD, 20892.

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http://dx.doi.org/10.1002/gcc.22512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778444PMC
March 2018

Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy.

Int J Mol Sci 2017 May 27;18(6). Epub 2017 May 27.

Department of General-, Visceral-, and Pediatric Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075 Goettingen, Germany.

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http://dx.doi.org/10.3390/ijms18061140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485964PMC
May 2017

A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2.

Cancer Res 2016 07 20;76(13):3838-50. Epub 2016 Apr 20.

Pancreatic Cancer Unit, National Cancer Institute, Bethesda, Maryland. Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930741PMC
July 2016

Relevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer.

J Natl Cancer Inst 2016 May 8;108(5). Epub 2016 Feb 8.

Affiliations of authors:Institute of Clinical Pharmacology (MAS, CML, SR, AS, CZ, RP, JB), Institute of Bioinformatics (MH), Clinic of General and Visceral Surgery (CML, SR, JR, SAJ, JG, BMG), and Clinic of Radiotherapy and Radiation Oncology (MAS), University Medical Center Göttingen , Göttingen , Germany ; Department of General, Visceral, and Thoracic Surgery, University Hospital Hamburg-Eppendorf , Hamburg , Germany (CG, MB, JRI); Department of General, Visceral, and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany (THac, THan, OS, JW).

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http://dx.doi.org/10.1093/jnci/djv387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859408PMC
May 2016

MicroRNA in rectal cancer.

World J Gastrointest Oncol 2016 May;8(5):416-26

Azadeh Azizian, B Michael Ghadimi, Jochen Gaedcke, Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany.

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http://dx.doi.org/10.4251/wjgo.v8.i5.416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865709PMC
May 2016

Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer.

Int J Mol Sci 2016 Apr 15;17(4):568. Epub 2016 Apr 15.

Department of General, Visceral, and Pediatric Surgery, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany.

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http://dx.doi.org/10.3390/ijms17040568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849024PMC
April 2016

[Recurrent seizures of unknown aetiology].

Dtsch Med Wochenschr 2016 Apr 28;141(9):631-3. Epub 2016 Apr 28.

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http://dx.doi.org/10.1055/s-0041-103982DOI Listing
April 2016

Volumetric intensity-modulated arc therapy vs. 3-dimensional conformal radiotherapy for primary chemoradiotherapy of anal carcinoma: Effects on treatment-related side effects and survival.

Strahlenther Onkol 2015 Nov 8;191(11):827-34. Epub 2015 Jun 8.

Dept. of Radiotherapy and Radiooncology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00066-015-0859-6DOI Listing
November 2015

Preoperative Prediction of Lymph Node Status by Circulating Mir-18b and Mir-20a During Chemoradiotherapy in Patients with Rectal Cancer.

World J Surg 2015 Sep;39(9):2329-35

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany,

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http://dx.doi.org/10.1007/s00268-015-3083-8DOI Listing
September 2015

The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.

Genome Med 2015 30;7(1):66. Epub 2015 Jun 30.

University Medical Center, Department of General-, and Visceral Surgery, D-37075 Göttingen, Germany ; Division of Newborn Medicine and Program in Epigenetics, Department of Medicine, Boston Children's Hospital, Boston, MA 02115 USA ; Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA.

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http://genomemedicine.com/content/7/1/66
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http://dx.doi.org/10.1186/s13073-015-0180-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517488PMC
July 2015

High-resolution analysis of DNA copy number alterations in rectal cancer: correlation with metastasis, survival, and mRNA expression.

Strahlenther Onkol 2014 Oct 26;190(11):1028-36. Epub 2014 Apr 26.

Department of Radiation Oncology, Centre Antoine-Lacassagne, 33 avenue de Valombrose, 06189, Nice, France,

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http://dx.doi.org/10.1007/s00066-014-0659-4DOI Listing
October 2014

CFTR, SPINK1, PRSS1, and CTRC mutations are not associated with pancreatic cancer in German patients.

Pancreas 2014 Oct;43(7):1078-82

From the Institutes of *Human Genetics and †Pathology, Hannover Medical School, Hannover, Germany; ‡Department of Andrology, University Hospital Hamburg-Eppendorf, Hamburg, Germany; and §Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1097/MPA.0000000000000166DOI Listing
October 2014

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.

Int J Cancer 2014 Feb 3;134(4):997-1007. Epub 2013 Sep 3.

Department of General and Visceral Surgery, University Medicine Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1002/ijc.28429DOI Listing
February 2014

FOXL1, a novel candidate tumor suppressor, inhibits tumor aggressiveness and predicts outcome in human pancreatic cancer.

Cancer Res 2013 Sep 25;73(17):5416-25. Epub 2013 Jun 25.

Pancreatic Cancer Unit, Laboratory of Human Carcinogenesis, Center for Cancer Research and Genetics Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766408PMC
September 2013

Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.

Clin Cancer Res 2013 Sep 5;19(18):4983-93. Epub 2013 Aug 5.

Authors' Affiliations: Pancreatic Cancer Unit, Laboratory of Human Carcinogenesis, Center for Cancer Research, Genetics Branch, National Cancer Institute, NIH, Bethesda; Pathology and Laboratory Medicine, Baltimore Veterans Affairs Medical Center, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Division of Surgical Oncology, The Department of Surgery and the Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and Department of General and Visceral Surgery, University Medicine, Göttingen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778077PMC
September 2013

Molecular patterns in the evolution of serrated lesion of the colorectum.

Int J Cancer 2013 Apr 17;132(8):1800-10. Epub 2012 Oct 17.

Section of Cancer Genomics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/ijc.27869DOI Listing
April 2013

PAM4 enzyme immunoassay alone and in combination with CA 19-9 for the detection of pancreatic adenocarcinoma.

Cancer 2013 Feb 16;119(3):522-8. Epub 2012 Aug 16.

Center for Molecular Medicine and Immunology, Garden State Cancer Center, Morris Plains, NJ 07950, USA.

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http://doi.wiley.com/10.1002/cncr.27762
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http://dx.doi.org/10.1002/cncr.27762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502643PMC
February 2013

Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers.

Clin Chem Lab Med 2012 Apr;50(4):721-5

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA.

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http://dx.doi.org/10.1515/CCLM.2011.816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309905PMC
April 2012

The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies.

Langenbecks Arch Surg 2012 Apr 2;397(4):543-55. Epub 2012 Mar 2.

Department of General and Visceral Surgery, University Medical Center Göttingen, Robert-Koch Str. 40, 37075 Göttingen, Germany.

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http://link.springer.com/10.1007/s00423-012-0929-5
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http://dx.doi.org/10.1007/s00423-012-0929-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314820PMC
April 2012

The IT-infrastructure of a biobank for an academic medical center.

Stud Health Technol Inform 2010 ;160(Pt 2):1334-8

University Medical Center, Goettingen, Germany.

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April 2011

A new sensitivity-preferred strategy to build prediction rules for therapy response of cancer patients using gene expression data.

Comput Methods Programs Biomed 2010 Nov 10;100(2):132-9. Epub 2010 Apr 10.

Department of Medical Statistics, University Medicine Göttingen, 37099 Göttingen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01692607100006
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http://dx.doi.org/10.1016/j.cmpb.2010.03.016DOI Listing
November 2010

A gene expression signature for chemoradiosensitivity of colorectal cancer cells.

Int J Radiat Oncol Biol Phys 2010 Nov;78(4):1184-92

Department of General and Visceral Surgery, Georg-August-University, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2010.06.023DOI Listing
November 2010

KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy.

Radiother Oncol 2010 Jan 11;94(1):76-81. Epub 2009 Nov 11.

Department of General and Visceral Surgery, University Medical Center, Georg-August-University Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.radonc.2009.10.001DOI Listing
January 2010

Chromosomal copy number changes of locally advanced rectal cancers treated with preoperative chemoradiotherapy.

Cancer Genet Cytogenet 2009 Aug;193(1):19-28

Department of General and Visceral Surgery, University Medicine, Georg-August-University, Robert Koch Str. 40, 37075 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.cancergencyto.2009.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714587PMC
August 2009

Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis.

Mol Cancer Ther 2009 Apr;8(4):821-33

Institute of Human Genetics, Department of General and Visceral Surgery, University of Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0058DOI Listing
April 2009

Predominance of the basal type and HER-2/neu type in brain metastasis from breast cancer.

Mod Pathol 2007 Aug 1;20(8):864-70. Epub 2007 Jun 1.

Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany.

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http://dx.doi.org/10.1038/modpathol.3800830DOI Listing
August 2007